PPKE Publikacio (Pázmány Péter Catholic Univ.)
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MFIB 2.0: a major update of the database of protein complexes formed by mutual folding of the constituting protein chains
Full text linkWhile the majority of proteins with available structures are able to fold independently and mediate interactions only after acquiring their folded state, a subset of the known protein complexes contains protein chains that are intrinsically disordered in isolation. The Mutual Folding Induced by Binding (MFIB) database collects and classifies protein complexes, wherein all constituent protein chains would be unstable / disordered in isolation but fold into a well-defined 3D complex structure upon binding. This phenomenon is often termed as cooperative folding and binding or mutual synergistic folding (MSF). Here we present a major update to the database: we collected and annotated hundreds of new protein complexes fulfilling the criteria of MSF, leading to an almost six-fold increase in the size of the database. Many novel features have also been introduced, such as clustering of the complexes based on structural similarity and domain types, assigning different evidence levels to each entry and adding the evidence coverage label that allowed us to include complexes of multi(sub)domain monomers with partial MSF
A jövő nemzedékek szószólójának amicus curiae leveleiről és beadványairól az alkotmánybírósági eljárásban
Full text linkA középkori jogászok méltányosságról, igazságosságról és jogról alkotott felfogása
Full text linkThe medieval jurists believed that equity was inherent in the nature of things, as an immanent order and harmony which the emperor, or the judge or jurist, had to transform by his will, by the act of justice, into a legal norm, a prescription. Thus, by will, justice becomes a prescribed rule. Just as equity is the source and source of justice, the latter plays the same role with regard to the individual legal norms. Although jurisprudence has been confined to the texts, the numerous references to equity found in them have left sufficient space to adapt the corpus of law, which is regarded as unconditional autho-rity, to new circumstances. As far as the practical legal justification of servitude and private property was concerned, the natural law norms of freedom for all men and the common possession of goods continued to be valid, but only as guidelines rather than as binding legal norms of the natural law
European Union Media and Platform Regulations, the Autonomy of Member States and the Brussels Effect
Full text linkThe Member States of the European Union have necessarily given up part of their autonomy and sovereignty. This was done within the limits set by the Treaties establishing the Union, of the free will of the Member States that signed the Treaties. The European Commission and the European Parliament has in recent years constantly sought to extend its powers, to the detriment of the Member States. This is also true in the area of media and platform regulation. These bodies have argued that further and further legislative steps can be considered as derivable from the Treaties. Thus, over the last few years, fundamental changes have taken place in these areas, with the adoption of the Digital Services Act (DSA), Digital Markets Act (DMA) and European Media Freedom Act EMFA) regulations, the future impact of which cannot yet be measured. The article examines the question of whether the EU had the power to adopt these regulations in all cases, what room for maneuver was left to the Member States after the adoption of these regulations, and whether the regulations are capable of indirectly influencing the legislation of other non-EU states (the so-called ‘Brussels effect’). First, the adoption, legal basis and effects of the new European media regulation (EMFA), are examined. Then the central element of the new platform regulation (DSA), will be examined from the perspective of how far it excludes national legislation outside EU law. Later, the article considers the potential Brussels effect of the DSA and the DMA, the latter being a competition regulation also in the field of platform regulation. This is also a key issue for US-based platforms. On the Brussels effect, there is already experience with the previously adopted General Data Protection Regulation, the global impact of which is also reviewed
Have a rest or a second job instead? : Rest periods in EU law
Full text linkThe paper aims to approach the dilemmas of EU working time regulation from the novel perspective of rest periods. It examines the functions and nature of rest periods in EU law, with special regard to the ECJ’s recent judgment in the MÁV-Start case (477/21). The analysis goes on with the question whether rest periods should be regarded as a right or an obligation of the worker and visits the issue of the possible role of a separate right to disconnect. The paper argues that it should be possible to work in another employment relationship during the rest period
