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Clinical characteristics of hidradenitis suppurativa patients in Okinawa, Japan : Differences between East Asia and Western countries
Get PDF琉球大学博士(医学)学位論
Preventive effects of Okinawan subtropical plants-derived compounds on metabolic diseases and analysis of their action mechanism
No full text琉球大学博士（理学）学位論
健常若年者におけるパターン分離能力に関連したヒト海馬体積測定による分析
Get PDFIntroduction: Hippocampal dentate gyrus related to pattern separation has attracted attention as an area for neurogenesis. However, the associations between the pattern separation and the volumes of hippocampal subfields in humans remain unknown.
Methods: 58 young adults were examined the memory task (pattern separation, pattern completion) and the hippocampal volumes. Subjects were asked to determine whether the visual image is a new stimulus, or a similar but different stimulus (pattern separation), or the same stimulus (pattern completion), compared to preceding stimuli, and response time and correct response were measured. The volumes of the whole brain, hippocampus 6 subfields and perihippocampus 5 subfields, were measured using FreeSurfer 6.0.
Results: Negative associations between the pattern separation task and the volumes of whole brain areas were found in bilateral cerebellar cortex, fourth ventricle, left hippocampus, left thalamus, left ventral diencephalon, and brainstem. Simple linear regression analysis revealed a significant association with the left hippocampalamygdaloid transition area only, while no significant associations were found in any of the subfield volumes when adjusted with covariates.
Conclusions: The principle “bigger is better”―an idea that the larger the volume the better the function―could not be applied to the relation between the pattern separation ability and the dentate gyrus.博士(医学)琉球大
マウス脊髄前角におけるミクログリアの活性化とKCC2 の発現低下を介した緩い坐 骨神経結紮後の神経変性及び再生の緩徐な進行
Get PDFPeripheral nerve injury affects motor functions. To reveal the mechanisms underlying motor dysfunction and recoveryafter nerve compression, which have not been precisely examined, we investigated the temporal relationshipamong changes in motor function, nerve histopathology, and marker molecule expression in the spinal cordafter loose ligation of the mouse sciatic nerve. After ligation, sciatic motor function suddenly declined, and axonsgradually degenerated. During degeneration, galanin was localized in motor neuron cell bodies. Then, in the ventralhorn, microglia were activated, and expression of choline acetyltransferase (ChAT), a synthetic enzyme ofacetylcholine, and potassium chloride co-transporter 2 (KCC2), which shifts the action of γ-amino butyric acid(GABA) and glycine to inhibitory, decreased. Motor function recovery was insufficient although axonal regenerationwas complete. ChAT levels gradually recovered during axonal regeneration. When regeneration was nearlycomplete, microglial activation declined, and KCC2 expression started to increase. The KCC2 level sufficiently recoveredwhen axonal regeneration was complete, suggesting that the excitatory action of GABA/glycine mayparticipate in axonal regeneration. Furthermore, these changes proceeded slower than those after severance,suggesting that loose ligation, compression, may mediate slower progression of degeneration and regenerationthan severance, and these changes may cause the motor dysfunction and its recovery.博士(医学)琉球大
