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カポジ肉腫関連ヘルペスウイルスがコードするORF42とORF55の相互作用の検証
Get PDFKaposi's sarcoma-associated herpesvirus (KSHV) causes Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman disease. The tegument is a structure unique to herpesviruses and includes the host and viral proteins, including ORF42 and ORF55. Alphaherpesvirus tegument proteins have been well studied; however, much is unknown regarding KSHV. Herein, we report an interaction between ORF42 and ORF55. ORF55 interacted with and recruited ORF42 from the nucleus to the cytoplasm. When ORF42 and ORF55 were simultaneously expressed in cultured cells, expression level of the two viral proteins were higher than those expressed independently. ORF55, but not ORF42, was polyubiquitinated, suggesting that an unidentified regulatory mechanism may be present. A recombinant virus with ectopic stop codon in ORF42 replicated genomic DNA normally, but released fewer virus particles than wild-type virus. A unique Rl36Q mutation in ORF42, which is found in the KSHV prevalent on Miyako Island, Okinawa Prefecture, Japan, further increased the expression of ORF42 Rl36Q and ORF55, when expressed simultaneously. However, the ORF42 Rl36Q mutation did not affect the localisation pattern of ORF42 itself and ORF55. In addition, experiments with recombinant viruses possessing the ORF42 Rl36Q mutation still showed lower viral production than wild-type, despite similar genome replication. In this study, we suggested that the Rl 36Q mutation in ORF42 plays an important role in ORF55 protein expression and virus production.博士（医学）琉球大学University of the Ryukyu
自閉スペクトラム症における抑うつ性混合状態の有病率と特徴
Get PDFPurpose: The present study aimed to clarify prevalence and profile of depressive mixed state (DMX) in depressed individuals with autism spectrum disorder (ASD).
Patients and methods: The Quick Inventory of Depressive Symptomatology Self-Report Japanese version (QIDS-SR-J) and global assessment of functioning (GAF) were administered to 182 consecutive patients (36 ASD and 146 non-ASD subjects) with a major depressive episode (MDE). DMX was categorically diagnosed according to the criteria for mixed depression (MD) by Benazzi and mixed features (MF) specifier by DSM-5. Severity of DMX was assessed by the self-administered 12-item questionnaire for DMX (DMX-12). Clinical backgrounds and incidence/severity of DMX were compared between the ASD and non-ASD groups.
Results: ASD patients showed higher prevalence of MD than non-ASD patients (36.1% versus 18.5%). Mood lability, distractibility, impulsivity, aggression, irritability, dysphoria and risk-taking behavior as mixed symptoms were more prevalent in ASD patients than those in non-ASD patients, together with higher scores of total DMX-12 and its disruptive emotion/behavior cluster. Multiple regression analysis revealed significant contribution of ASD to the disruptive emotion/behavior symptoms.
Conclusion: Careful monitoring and management of potential DMX are warranted in depressed ASD individuals.博士（医学）琉球大学University of the Ryukyu
持続可能な電力へのドライブ：高度な計算技術を用いたハイブリッド再生可 能エネルギー解決策の評価と最適化に関する堅牢なアプローチ
Get PDFThe ever-increasing need for policymakers to adopt sustainable measures to meet thegrowing demand for electricity cannot be overemphasized. This thesis delves into thepotential of harnessing a hybrid renewable energy system to address the power supplydeficit in any region but using Sierra Leone as a case study. Utilizing theMulti-objective Particle Swarm Optimization (MOPSO) technique within a Matlabframework, the study aimed to optimally size a grid ・connected hybrid systemcomprising ground-mounted Photo-voltaic (PV) panels, Onshore Wind Turbines (OWTs),a Biomass Combustion plant using sugarcane bagasse (SB), a Battery Energy StorageSystem (BESS), and a Diesel generation (DG) system as a backup power source.The primary objectives were to minimize the discrepancy between power generationand demand and to curtail the total system cost over a 20・year project lifespan. Thefindings underscored the significant potential of harnessing rooftop spaces ofgovernmental buildings to substantially mitigate Freetown's power supply deficit.Subsequently, a comprehensive analysis for the entire nation was undertaken. This8760-hour analysis evaluated four hybrid combinations over a 20'-year project horizon,emphasizing objec・tives such as minimizing the Diesel Energy Fraction (DEF), theDeficiency of Power Supply Probability (DPSP), life cycle costs (LCC), and CO2emissions. A rigorous decision-making criterion was established, and suitability factorswere integrated into the resource assessments. The results highlighted that thecombination of PV, wind, biomass, BESS, and DG yielded the most economical LCCvalues and exhibited moderately low CO2 emissions across a broad DPSP range(20%・50%). To further validate the efficacy of the MOPSO technique, this study alsocompared its performance with two other optimization algorithms: the Multi-objectiveEvolutionary Algorithm based on Decomposition (MOEA/D・M2), a decomposition-basedmulti-objective evolutionary algorithm that uses a modified crowding distance metricto improve the diversity of the population, and the SPEAII algorithm. The comparisonwas grounded on 3 broad criteria such as convergence speed, solution quality, andcomputational efficiency. This research offers apragmatic blueprint for suggesting aneffective approach for integrating renewable energy in Sub-Saharan Africa.博士（工学）琉球大学University of the Ryukyu
日本産樹木種の種子特性の地理的パターン : 種多様性に関係した発芽戦略の緯度･気候勾配
Get PDFPlant functional traits determine species distribution related to climate gradient, which plays an important role in shaping macroecological patterns of plant diversity. In this regard, I focus on geography of seed trait including seed dormancy of Japanese woody plants on East Asian islands across subtropical evergreen, temperate deciduous to hemiboreal coniferous vegetations. Specifically, I addresed that the geographical correlations of seed mass, seed dispersal mode and seed dormancy, and revealed seed traits driven species abundance pattern along latitudinal climate gradient.
In Chapter 2, To identify species-specific germination strategy related to seed traits, I focused on Viburnum furcatum as a model plant and examined its dormancy type, which is known to take a long time from seed dispersal to germination. Viburnum furcatum had deep simple epicotyl morphophysiological dormancy: Viburnum's seeds disperse with undeveloped embryo and there was a time lag about 120 days between root emergence and shoot emergence.
In Chapter 3, To investigate macroecological pattern of seed traits including reproductive traits, Icompiled seed size, weight, seed mass, domrnncy type, dispersal mode, flower size, fruit size, fruit type of Japanese woody plant species.
In Chapter 4, I identified geographical patterns of flower size, fruit size, fruit type, seed mass, and dispersal mode. Flower sizes increased and fruit and seed sizes decreased at higher latitudes. Color variability increased while variability in fruit size decreased toward higher latitudes. Higher human impact influenced fruit size positively and seed size negatively.
In Chapter 5, I clarified the relationship between the geographical patterns of seed dormancy types and climatic gradients, and analysed the interrelationships with the geographical patterns of other seed traits. Small-sized seed species with physiological and morpho-physiological dormancy were abundant at higher latitudes with increasing climate harshness. On the other hand, large-sized seed species with non-dormancy was abundant in both climatically warm and harsh areas.
In Chapter 6, I discussed geographical pattern of germination strategies along latitudinal and climatic gradients. The findings of dormant and non-dormant seeds of Japanese woody species diversify in relation to the latitudinal climatic gradient suggest different germination strategies associated with seed weight and seed dispersal mode.博士（理学）琉球大学University of the Ryukyu
ミドリイシ属サンゴの熱ストレスへの応答 : 順化とその種内変異
Get PDFCoral reefs are among the most vulnerable ecosystems in the face of climate change and are expected to change drastically in the coming decades. Because future sea surface temperatures are expected to increase in the following decades, understanding the effects of heat stress on corals is crucial. This dissertation aimed to investigate the responses of Acropora corals to heat stress by combining ecological and molecular approaches. The mechanisms and processes related to Acropora heat stress improvement examined in this dissertation were Symbiodiniaceae shuffling/switching, green fluorescent proteins, DNA methylation (DNAm), and their intraspecific variations. First, to evaluate the heat-stress acclimatization potential of Acropora, I distinguished individual Acropora colonies in fixed plots to visually estimate bleaching and post-bleaching mortality and growth rates in two consecutive bleaching events in 2016 and 2017. Second, I estimated the bleaching degree, post-bleaching recovery rates, and survivorship of tagged A. digitifera to determine the responses of individual Acropora corals to heat stress and the possible intraspecific variation. I also measured parameters as proxies of coral health, i.e., calcification rate and photosynthetic efficiency, in these colonies. Third, to assess the effects of heat stress and the symbiotic condition (symbiotic or aposymbiotic) on the global DNAm (whole DNAm rate of the coral holobionts) of A. digitifera, I conducted a factorial experiment to expose the symbiotic and aposymbiotic primary polyps to heat stress for ten days. The first result indicated that the naturally growing Acropora corals that survived moderate heat stress in 2016 could improve their heat-stress tolerance one year later. The second result showed that the response of A. digitifera colonies to heat stress was very variable among the colonies, which was evident in the differences in bleaching and green fluorescence degree exhibited by some colonies. Significant differences in calcification rate, photosynthetic efficiency rates, and post-bleaching recovery trajectories were also detected. In the third experiment, I found that the global DNAm rates of A. d函碑ra holobionts increased when exposed to heat stress and that the presence or absence of Symbiodiniaceae in corals is one of the major factors related to the global DNAm rates in the A. d窟itifera holobiont.
This dissertation revealed that the response of Acropora corals is complex and diverse because it involved different processes, such as acclimatization of individual colonies that resulted in an increase of the thermal tolerance of Acropora corals to following heat stress events. This dissertation also revealed a differential degree of bleaching and green fluorescence, and different post-bleaching recovery trajectories among conspecific colonies. Parameters that serve as proxy for coral fitness such as calcification and photosynthetic efficiency were also related to the Acropora heat stress response. Thus, different approaches, such as ecological and molecular, should be combined to better understand the Acropora responses to heat stress in a comprehensive way. Future studies should focus on understanding how the interplay between different ecological and molecular mechanisms of the coral holobiont interact to determine in a more comprehensive way the response of corals to heat stress, such as acclimatization. Interdisciplinary studies combining a wide array of different omics are recommended to fully elucidate how the interplay of different mechanisms influences the intraspecific variation of corals in response to heat stress.博士（学術）琉球大学University of the Ryukyu
海洋温暖化環境下におけるシャコガイ : 白化閾値、回復そして繁殖への影響
Get PDFGiant clams (sub-family Tridacninae) are in symbiosis with the photosynthetic zooxanthellae (family Symbiodiniaceae) which provide most of their energy. However, thermal stress, due to global warming, can disrupt the giant clam-zooxanthellae symbiosis which often leads to bleaching "expulsion of zooxanthellae" and even mortality in giant clams. Giant clam bleaching has been widely reported but only in tropical reefs. Although, recently, we observed bleached individuals in sub-tropical Okinawa during the 2022 coral bleaching event. Despite several reports on bleaching in giant clams, basic information such as their bleaching thresholds and recovery as well as the impacts of bleaching on their zooxanthellae community are not well understood, whereas the impacts of bleaching on their reproduction are unknown. Here, we first assessed the bleaching thresholds and recovery potential in Tridacna crocea from sub-tropical reefs in Okinawa, Japan by examining their photo-physiological responses during bleaching stress and recovery periods (Chapter 2), then we examined the composition of zooxanthellae and reproductive output in bleached and recovered T. crocea (Chapter 3) and third, we examined the reproductive output in bleached T. gigas from a tropical reef in the Philippines (Chapter 4).
We found that + 1 to 2° C for over 21 days of exposure did not cause notable bleaching in T. crocea but reduced the density and chlorophyll concentrations of their zooxanthellae, whereas +3 to 4° C resulted in bleaching and mortalities. Photosynthesis (Pg) was reduced whereas respiration (R) was maintained in bleached T. crocea. The Pg/R was also reduced in bleached T. crocea. Moreover, we found that T. crocea hosts several types of Symbiodinium or Cladocopium or both as well as backgrounds of Gerakladium. The composition of zooxanthellae showed changes during bleaching or recovery periods, even in control clams, but the dominant type was persistent in most T. crocea individuals at all sampling periods. In addition, we found that bleaching reduced the reproductive output in T. crocea and T. gigas from Okinawa and the Philippines, respectively, by disrupting their gametogenesis such as through egg resorption resulting in low fecundity. However, egg size was maintained in both species.
Moreover T. crocea can quickly recover their phototrophic potential in less than a month of recovery period, but not their normal reproductive processes, whereas most of the severely bleached T. gigas suffered mortalities or maintained bleaching with reduced reproductive output even after five months from thermal stress.
Our results showed that the T. crocea from the sub-tropical Okinawa are living close to their upper thermal limits and therefore vulnerable to bleaching, similar to the giant clams living in tropical reefs. In addition, mortalities and the reduction in reproductive output during bleaching, and the inability to quickly restore the normal reproductive processes after thermal stress in both species will decrease their next generation population and hinder their population recovery.博士（学術）琉球大学University of the Ryukyu
ナマコ類の個体群の現況、生態学的役割に関する研究および今後の保全に向けた検討
Get PDFSea cucumbers (Holothuria) are important ecological engineers in coastal marine environments. Recently, sea cucumber fisheries have become serious environmental problems at local scales around the world. However, basic field information for effective management is generally lacking from most regions. In this thesis, I aimed to accomplish three goals with regards to the status of sea cucumbers in Okinawa, Japan. Firstly, I aimed to examine the population density of Okinawan holothurians. As a result of my investigation, in Chapter 2, relatively low population densities of sea cucumbers were found at many sites around Okinawa-jima Island. On the other hand, sites I investigated in national parks had higher numbers of sea cucumbers. secondly, I aimed to estimate genetic connectivity of sea cucumbers among Ryukyu Islands. Using the ubiquitous species Holothuria atra, population genetic research through southern Ryukyu Islands was accordingly conducted in Chapter 3. Results showed several genetic breaks exist among the southern Ryukyu Islands. The national park sites had higher genetic indices compared to other sites, possibly reflecting protection from potential anthropogenic impacts such as coastal land filling or overharvesting. Thirdly, I aimed to reveal ecological role of Okinawan sea cucumbers at sites around Okinawajim a Island. In Chapter 4, investigations of the intestinal bacterial communities of H. atra revealed that Okinawan H. atra’s feces have significantly different bacterial community from ambient sediments. In addition, bacterial composition differed significantly between sites where scleractinian corals were abundant or scarce. Overall, this thesis has revealed that Okinawan sea cucumber populations need urgent management and perhaps even artificial enhancement efforts such as restocking. To take such actions, however, governmental efforts in collaboration with scientific support is mandatory. Therefore, it is strongly hoped that the results of this thesis will aid in forming sea cucumber conservation policies in Okinawa.ナマコ類は沿岸域において生態学的に重要な生物であるが、その食品としての需要の高まりから近年乱獲にさらされている。こうした現状に対し、有効な保全ルール策定のための基礎的な生態学的情報は世界的に不足しがちである。本稿の第２章では、極端に個体数の少ない一部地域（糸満市大度海岸）を含む、ナマコ類の比較的低い個体群密度が沖縄島から初めて報告された。一方、国立・国定公園地域では個体群密度が高いこともわかった。第３章では、第２章において最も多数の地点から発見されたクロナマコを用いて集団遺伝学的解析を行った。結果、中・南琉球列島においていくつかの分断された遺伝的集団が存在すること、また国立・国定公園地域で遺伝的多様性が高く保たれていることがわかった。第４章では同じくクロナマコの糞便を用いた腸内細菌叢推定を行った。結果、糞便内には周辺堆積物と有意に異なる細菌叢が含まれており、クロナマコ腸内でのエンリッチメントの結果であると考えられた。さらに、サンゴの多く見られた地点とそうでない地点との間でも有意差が見られ、今後真核生物のメタバーコーディングを含む追加調査が望まれた。総じて、沖縄島周辺におけるナマコ個体群の早急な保全が必要であることが浮き彫りになった。今後、本研究により得られた成果をもとに、官民一体となった対応が取られることを強く望む。博士（理学）琉球大学University of the Ryukyu
セメントペーストとモルタルおよび高流動コンクリートのレオロジ一定数の推定法に関する研究
Get PDF本研究は，セメントペースト（以後， ペーストと略す）とモルタルを対象にJIS R5201規定のフローコーンによるフロー試験結果と回転粘度計や球引き上げ試験で求めたレオロジ一定数の関係を検討し， より簡便なフロー試験によりレオロジ一定数の推定を可能にすること， さらに面流動コンクリートを対象として， 提案する骨材化モデル粘度式を用いてモルタルのレオロジ一定数やコンクリートの調合・材料物性などの情報から高流動コンクリートのレオロジ一定数を推定する手法を確立することを研究目的とする。ペーストを対象とする場合には， フロー試験結果とレオロジ一定数の関係について検討する足掛かりとして粘塑性有限要素法による流動解析を用いて様々な入力値（降伏値，塑性粘度，密度）におけるパラメトリック解析を行い， その結果から入力値と関係性が高い影響要因について相関分析による分析を行った。その後， ペースト試料を用いてフロー試験と回転粘度計を用いたレオロジ一試験を行い， その測定結果から， 関係性の高かった影響要因を確認し， ペーストのレオロジ一定数推定式を提案した。この提案式の有効性を検証するためMPS法による3次元流動解析を行い， 実測のフロー試験結果と比較を行った。その結果， ペーストにおいては提案式による推定値を用いたMPS解析にて実測のフロー試験結果の再現が確認できた。モルタルについては， ペーストと同様のフロー試験を行い， 球引き上げ試験で得られたレオロジ一定数とフロー特性（フロー値と150mmフロー到達時間）との関係よりレオロジ一定数推定式を提案した。この提案式の有効性についてもペーストと同様にMPS法による3次元流動解析によって確認している。高流動コンクリートについては， コンクリートの見かけの粘度式に， 流動に寄与しないモルタルを骨材とみなして扱う「骨材化モデル」を提案し， それを考慮した見かけの粘度式（骨材化モデル粘度式）による検討を行った。ここでは， 見かけの粘度式の未知数のうち形状係数Bについては骨材にモルタルが付着した状態を球状として仮定し， B=2. 5 で固定としにもう一つの未知数の骨材化係数aは， モルタル試料のモルタルフロ一試験とコンクリート試料のスランプフロー試験より得られるレオロジ一定数と機械学習(Random forest)を用いて決定した。なお，機械学習では説明変数をコンクリートの使用材料や調合およびモルタルのレオロジ一定数などの23項目としtc.c機械学習で得られたaをコンクリートの骨材化モデル粘度式に代入することで， 高流動コンクリートのレオロジ一定数を推定し， スランプフロー試験による推定値と比較検討を行った。また，説明変数の削減による推定精度の検証も併せて行った。その結果， 概ね良い精度で推定することができ， 提案する骨材化モデル粘度式による高流動コンクリートのレオロジ一定数の推定法の有効性が確認された。博士（工学）琉球大
水中音響通信による水中での安定的な無線通信の実現及び大容量化に関するシステム構築の研究
Get PDF近年メタンハイドレートなどの海底天然資源の海洋開発の進展により、深海探査が不可欠になっている。深海探査の他にも海洋養殖モニタリングやマリンレジャー等での水中ドローンも利用されており、世界中で自立型無人潜水機（AUV: Autonomous UnderwaterVehicle）の研究・開発が盛んになってきている。AUV の最大の利点はテザーケーブルを使用せずに完全に自立型で行動する無人潜水艦である。これらの研究・開発で必要不可欠となる水中音響通信は問題が多くあるが、その中でも以下の3 つの問題に焦点を当てた。(1) 問題1 : 有線長による探索エリアの制限現在の水中ドローンはほとんどの機種が有線接続で使用されており、探索エリアがワイヤーの長さによって制限されてしまう。有線接続での問題は探索範囲が制限されること以外にも岩場での断線の可能性などもあるため、無線化されたAUV が要求されている。(2) 問題2 : 定期的にAUV を母船へ回収する必要性問題1 でも提示した通り、現在使用されているAUV のほとんどが有線接続のため、テザーケーブルなしで使用するAUV を動作させるにはAUV 本体を定期的に回収し、中に入っているデータを回収する必要がある。(3) 問題3 : 海面や海底の反射波で発生するマルチパス水中で通信を行う際に発する送受信波は、垂直通信の場合、干渉はあまり発生せずに受信できるのだが、水平通信の場合は海面や海底に反射し、マルチパスが発生する。この問題が最も解決が困難とされており、マルチパス対策は必要不可欠となる。本研究はこれら3 つの問題に対して各自解決策を提案し、シミュレーション及び実験を行った。本論文は全6 章で構成されており、第1 章では研究背景と目的を述べる。第2 章では、本研究に使用する技術の基礎概要を述べている。第3 章では、問題1 と問題3 を解決するべくサイクリックプレフィックス（CP : CyclicPrefix）なしSTBC-MIMO OFDM による水平水中通信を提案した。従来、直交周波数分割多重（OFDM : Orthogonal Frequency Division Multiplexing）を使用する際はシンボル間干渉（ISI : Inter Symbol Interference）やキャリア間干渉（ICI : Inter CarrierInterference）を防ぐため、CP をOFDM シンボルの下部から上部に付加して使用する。しかし、CP を付加することでOFDM のデータ容量が減少してしまう。そこで、CP を付加することなく干渉を対策し、OFDM 通信を行う事が可能かどうかを検討した。ISI はLeft Null Space の直交基底を使用して削除できる。ICI は最小平均二乗誤差（MinimumMean Square Error）の重みを使用することで削除する事ができる。実際にMATLAB にて２送信３受信及び２送信４受信のシミュレーションを行い、マルチパスによる遅延を改善する事ができた。第4 章では、先行研究を基にCP なしSTBC-MIMO OFDM による水平水中通信の研究をさらに改良し、斜投影（OB : Oblique Projection）方式を採用した性能向上を提案した。この方式は、最小二乗法（LS 法 : Least Squares Method）及びハウスホルダー変換によるQR 分解ベースのOB 演算子を使用して構造化ノイズを完全に削除することができる。シiiiミュレーションでは2 送信3 受信及び2 送信4 受信で行い、2 マルチパスと多マルチパスの環境で比較を行った。両環境でもマルチパスによる遅延を抑圧する事ができた。実際に静岡県沼津市の内浦湾で行われた海洋実験では、従来通りのCP ありOFDM システム、何も対策していないCP なしOFDM システム、そして提案したCP なしSTBC OFDM システムのこれら3 つの環境で比較実験を行った。従来方式は何も問題なく通信する事が可能であり、何も対策していないCP なしOFDM システムは干渉の影響を最も受け通信が不可能だった。提案したCP なしSTBC OFDM システムでは遅延を抑圧する事ができており、従来方式同様安定した通信を可能とした。第5 章では、問題1 及び問題2 に焦点を当て、32kHz 帯域幅の水中小領域音響ネットワーク（USAAN : Underwater Small Area Acoustic Network）を使用したプロトタイプの無線水中ロボット制御システムを開発した。このテーマは沖縄高等工業専門学校、その他複数の民間企業と共同研究しており、水中ドローンチームとシステム開発チームに分かれて行った。琉球大学が担当したのはシステム開発チームである。時分割複信（TDD :Time Division Duplex）及びドップラー補正を使用したシステム構成となっており、1 つの基地局と複数のユーザー機器（UE : User Equipment）で無線サービスエリアを作成し、基地局は1.0 秒毎のダウンリンク（DL : Down Link）を送信する。そして、空きスロット中にUE の１つがDL 信号と同期し、アップリンク（UL : Up Link）信号を送信する方法である。今回はTDD-USAAN の有効性を確認すべく、CP は付加したまま行った。シミュレーション結果はドップラー補正が働いており、コンスタレーションの乱れは改善した。静岡県沼津市内浦湾のバージで行われた海洋実験では、16QAM のコンスタレーションは正常に確認された。その後、プロトタイプ無線水中ロボットに組み込み、水中ロボットを実際に制御することに成功し、水中ドローンで撮影した240x213 ピクセルの水中写真をリアルタイムでアップロードする事に成功した。第6 章では、問題1 から問題3 の全てに焦点を当て、2 つの先行研究を基にチャネル伝達関数（CTF : Channel Transfer Function）と初期同期を備えたUWA OFDM 通信システムを提案した。データを受信した際、初期伸び縮み係数β1 を検出するため、OFDM 信号の先頭へ2 つの長いチャープ信号を挿入して周波数差を検出する。その後その値を初期値に適用する事でドップラー補正を行う。CTF ではコンティニュアス・パイロットを使用して検出した値と本来の値のずれを計算し、修正したCTF を使用して等化した結果を出力する。シミュレーションでは提案する方式の方が安定して通信できており、コンスタレーションも歪みを改善する事ができた。無反響プールでの実験はCTF 補正ありとなしを比較し、CTF 補正ありの方がコンスタレーションもクリアに受信できた。最後に第7 章では本研究の成果についてまとめ、冒頭で掲げた3 つの問題点に対応した提案の有効性を明らかにする。そして、今後の展望を述べる。博士（工学）琉球大
A Strategic? Integrated Approach of Bridging Circular Economy and Artificial Intelligence ?(AI)for a Sustainable Energy Future
Get PDFThe recent trend towards modernization and lifestyle changes in society has led to growing concerns about sustainable development and mitigating climate change. The global energy landscape is also shifting, with renewable energy sources anticipated to become the new baseload, making up 50% of the energy mix by 2030 and 85% by 2050. These ambitious targets rely on smart decision-making and deploying intelligep.t technologies within the optimum circular economy to ensure long-term sustainability. This study addresses four correlated topics, focusing on shaping the future of sustainable energy through AI-enabled circular economy policies, AI ?coherent data ?driven forecasting modeling, harmonizing AI in energy from parameters to data, and a strategic?integrated approach for sustainable energy deployment. Artificial Intelligence(AI）is emerging as a critical driver of change, offering new ways to optimize energy systems operations, control, automation, etc. Developing a competitive policy framework aligned with circular economy practices to tackle the rapid revolution trends is crucial, shaping the future of energy and leading the sector toward a sustainable, equitable, and impartial direction. An AI ?driven policy framework is aligned with the circular economy business model to address the transformation trends in energy policy development through a multidisciplinary approach . That is followed by investigating the transformation of energy models to align with the machine learning requirements as a promising tool for optimizing the operation of combined cycle power plants. By modeling energy systems as a function of environmental and control variables, this methodology offers an innovative way to achieve energy-efficient power generation in the context of the data-driven application. The proposed numerical model in Python enhances efficiency by simulating various operating scenarios and adjusting optimal parameters, leading to a high-yield energy generation. A framework of integrating AI in energy sectors to handle multilateral endeavors via a single platform offers an emerging solution of policy, data science and AI, engineering practices, management process, business models, and social approaches as an intricate design and implementation reference. Lastly, a strategic-integrated approach for sustainable energy deployment covers the dimensions of managerial, technical, economic, sustainability, and efficiency. This research effort aims to provide an exhaustive roadmap for researchers, governments, and other stakeholders to navigate the future of energy and unlock the potential of AI for a sustainable energy future.博士（学術）琉球大