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Targeting histone demethylase KDM6B for treatment of neuroblastoma
No full textPresentation by Anoushka Mullasseril ('19) delivered at the Rhodes College Undergraduate Research and Creative Activity Symposium (URCAS) as part of the St. Jude Summer Plus Fellowship.Neuroblastoma is a cancer of the sympathetic neuron system that accounts for 15% of all childhood cancer-related deaths, an unusually high proportion based on the fact that it accounts for 7% of childhood malignancies. The survival rate for high-risk neuroblastoma is only 40% with current treatments including chemotherapy and radiation which cause unwanted side effects. There is growing interest to develop novel therapies by targeting epigenetic factors. KDM6B, a histone demethylase also known as JMJD3, is known to play a role in various types of cancer such as NOTCH1-mediated T-cell acute lymphoblastic leukemia. However, the role of KDM6B in neuroblastoma is largely unknown. Our previous studies indicate that KDM6B may serve as a new therapeutic target in neuroblastoma. We therefore hypothesize that pharmacologically targeting KDM6B could prove to be therapeutic in the treatment of neuroblastoma. To better understand the role of KDM6B, we utilized siRNA transfection and shRNA to inhibit KDM6B expression. We further tested a drug called GSK-J4 which targets the KDM6B protein. These studies have shown that genetic or pharmacologic inhibition of KDM6B could be a promising treatment for neuroblastoma, but more research is needed to understand the pathways involved
Fabric
No full textThis object was photographed and inventoried during summer 2019 by Julia Conway ('20) and Bailey Cook ('20) as part of a digital curation fellowship.�Please note that the date issued field refers to the date of the digital object's creation. The temporal coverage field contains date information for the actual physical object, when known.General Description: This is a piece of blue fabric with floral designs done in red, green and orange. It appears to be two piecs sewn together. All four edges are frayed and uneven. There is no border.Condition Description: Each of the edges are frayed and uneven. The fabric appears to be worn down in places. There are several places where there are stains. There is one circular stain on one corner of the fabric
Case
No full textThis object was photographed and inventoried during summer 2019 by Julia Conway ('20) and Bailey Cook ('20) as part of a digital curation fellowship.�Please note that the date issued field refers to the date of the digital object's creation. The temporal coverage field contains date information for the actual physical object, when known.General Description: This is a rectangular case with two sides that fold inward. On these two sides there are depictions of a bird and a grasshopper. One of the sides is brown and the other is white. The inside of the case is blue. The inside of the case also has a small slit that opens. It has a tassel that hangs done in purple and green. The other side of the case has a small white bead.Condition Description: Good condito
Figures
No full textThis object was photographed and inventoried during summer 2019 by Julia Conway ('20) and Bailey Cook ('20) as part of a digital curation fellowship.�Please note that the date issued field refers to the date of the digital object's creation. The temporal coverage field contains date information for the actual physical object, when known.General Description: Two standing figures that have been painted. A is holding something with two buckets attached. B is broken into three pieces, one that was once the base the figure stood on, one that was a drum she held, and then the figure itself. On the bottom of both the figures is written "made in Japan."Condition Description: A is in good condition. B is broken into three pieces
Plate
No full textThis object was photographed and inventoried during summer 2019 by Julia Conway ('20) and Bailey Cook ('20) as part of a digital curation fellowship.�Please note that the date issued field refers to the date of the digital object's creation. The temporal coverage field contains date information for the actual physical object, when known.General Description: A blue and white circular plate. There is a note that was with it that says it originates in Andalusia, Spain. The design of the plate is floral with some geometric.Condition Description: There is one large crack in the plate that has been repaired. There is chipping of the paint
Woven bag
No full textThis object was photographed and inventoried during summer 2019 by Julia Conway ('20) and Bailey Cook ('20) as part of a digital curation fellowship.�Please note that the date issued field refers to the date of the digital object's creation. The temporal coverage field contains date information for the actual physical object, when known.General Description: A woven bag of green, yellow and gold. There are four sides with panels featuring flower-like embroidery. There are green balls hanging off of the bottom. The opening has no tie or string.Condition Description: The bag opening has slight fraying
"Aggregate Optics of Make-A-Do" Opening Brochure
No full textThis item was uploaded to DLynx in the Visual Resources Center during the spring of 2019.This is a brochure and map of Erin Harmon's exhibition "The Aggregate Optics of Make-A-Do". Erin Harmon’s work dwells in the twilight zone between painting and sculpture. Filled with longing for places that do not actually exist, contradictions flourish with invocations of both the animated and the arrested, the joyful and the staid, the high and the low. Material and processes become sites for fantasy, illusion, and the interplay between flat and not-flat. The vibrant work in "Aggregate Optics of Make-A-Do" tinkers with scale to produce environments that we can project ourselves into as landscapes, even while confronting their qualities of un-nature.
Borne from Harmon’s previous body of painted paper collages, her new work is influenced by techniques common to theatrical painters, a lineage of shapes and images become a trail of breadcrumbs from one idea to another. These materials are scoured, drawn, painted, cut, and recycled over time, one idea begetting another, endlessly self-generating. Whether it be through ceramic, painted muslin, or projection animation (a collaborative video in which Harmon’s gouache-on-paper cut-outs have been animated by artist and musician Kyle Statham), the finished works encapsulate a romance with materials and processes
Fabric
No full textThis object was photographed and inventoried during summer 2019 by Julia Conway ('20) and Bailey Cook ('20) as part of a digital curation fellowship.�Please note that the date issued field refers to the date of the digital object's creation. The temporal coverage field contains date information for the actual physical object, when known.General Description: This is a piece of green fabric with silver detailing. The old inventory calls it brocade. It has a geometric linear design. The other side of the fabric has a light green floral design depicted.Condition Description: The edges of the fabric are fraying. There are several places where the fabric is worn on the front side
Hollow Gourd
No full textThis object was photographed and inventoried during summer 2019 by Julia Conway ('20) and Bailey Cook ('20) as part of a digital curation fellowship.�Please note that the date issued field refers to the date of the digital object's creation. The temporal coverage field contains date information for the actual physical object, when known.General Description: This is a hollowed out gourd that is tan and features a design in a dark brown, dull pink and yellow. It has a lid that has been cut out in a zig zag line. The lid opens to reveal a hollow inside. There appears to have been a nob at the top of the lid that has fallen off. The ornate design that covers the gourd features people and animals in a line that appear to be moving. Some are playing instruments, others hold weapons.Condition Description: The gourd is not completely round and has what appear to be some natural indentations. There appears to have been a nob on the top that has fallen off
Queens and Monsters Installation Images
No full textThis digital image was photographed by Chip Pankey and uploaded to DLynx by the Visual Resources Center in Fall 2019.This is an Installation Image taken by Chip Pankey of Melissa Wilkinson's "Queens and Monsters" exhibition in the Clough-Hanson Gallery. Comprised of two recent series of paintings, "Queens and Monsters" deconstructs and remixes pop and personal iconography, from Golden Era Hollywood to 70's and 80's tomboys, from the glamour of disco to the digital distance of private Tumblr accounts. Focusing on the interaction of parts, Wilkinson manipulates and mediates these images in an exploration of gender play, micro expressions, and her own coming of age as a queer person. She says, "Influenced heavily by glitch art and data moshing I create meticulous watercolor and ink wash paintings in order to investigate the line that is straddled by abstraction and representation. I work in water media on paper to create a vulnerable object and a tender presence through my touch...I am interested in creating a kind of alternate identity of highly mediated likenesses, one that corrupts and disturbs our understanding of these identities as public performers, gender stereotypes and gay icons."
There was an Artist's Lecture on October 24 in Blount Auditorium in Buckman Hall. Opening reception was October 25, 5:00 - 7:00pm, in the Clough-Hanson Gallery. The Exhibition was on view through December 4