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DEVELOPMENT OF STUDENTS’ CREATIVITY THROUGH AN INTEGRATIVE PEDAGOGICAL APPROACH
Get PDFThe article presents the results of an experimental pedagogical study on the development of students’ creativity based on an integrative approach. Conducted among 206 university students, the research tested a model that combines cognitive, motivational, and reflective components of learning. Quantitative data verified statistically significant improvements in creative thinking, self-activation, and professional readiness. The study emphasizes that integrative pedagogy enhances flexible thinking, self-reflection, and motivation for innovative learning in the context of Uzbekistan’s educational reforms.
KEYWORDS:
Creativity, integrative pedagogy, higher education, experimental research, creative competencies, innovative learning, Uzbekistan
APPLICATION OF BACILLUS MYCODIES-DERIVED EXOPOLYSACCHARIDES AS A NATURAL PRESERVATIVE COATING TO ENHANCE SHELF LIFE FOR VEGETABLES
Get PDFThe growing demand for safe and eco-friendly alternatives to chemical preservatives has intensified research into biopolymers such as exopolysaccharides (EPS) derived from microbial sources. This study explores the application of Bacillus mycodies-derived EPS as a natural preservative coating for vegetables, assessing its effectiveness in enhancing shelf life and maintaining quality. EPS was isolated and characterized through standard biochemical and structural analyses, confirming its purity and functional properties. Fresh vegetables, including tomatoes, cucumbers, and carrots, were coated with EPS-based solutions and stored under controlled conditions. Comparative analysis was conducted against uncoated samples and samples treated EPS coating. Key parameters such as moisture retention, weight loss, microbial growth, texture, and visual appearance were monitored over a 21-day storage period. The EPS-coated vegetables exhibited significantly reduced microbial spoilage, better moisture retention, and delayed senescence compared to controls. Furthermore, the EPS coating was found to be non-toxic and biodegradable, aligning with sustainability goals. Statistical analyses validated the significant differences (p < 0.05) between EPS-coated and uncoated groups in terms of shelf-life extension and quality preservation. This study highlights the promising potential of Bacillus mycodies EPS as an effective, natural, and eco-friendly alternative to synthetic preservatives in post-harvest technology.
KEYWORDS:
Bacillus mycodies, Exopolysaccharides, Natural preservative, Vegetable coating, Shelf-life extension
AN OVERVIEW OF NANOMATERIALS FROM MARINE ENVIRONMENTS
Get PDFSea water is a harsh environment with high ionic concentration, which allows nanomaterial’s (NMs) to change their behaviour dramatically. Rapid agglomeration, destabilization, and deposition may cause the NMs to disappear from surrounding water. Organic substances contacts with metal-bearing NMs may alter their dispersion, physical and chemical properties, and durability in the water columns. To assess human and ecological hazards and develop regulatory standards for modified NMs release, accurate and sophisticated detection of engineered nanostructures in marine environments is essential. Still, due to the inadequacy of NMs characterization techniques, comprehending their destiny and behaviour in marine habitats are still limited. Sulfur species, organic compounds, trace element cycling, distribution, and interaction between colloidal and dissolved phases have all been found to be crucial candidates for analysing the different ecological processes courses in marine habitats using electrochemistry strategies coupled with advanced spectroscopy and microscopy techniques.
Keywords
Marine environment, nanomaterial’s, nano/micromachines, carbon nanotubes, nanobots, robotic fish, marine debris and marine habitat
Organic Fertilization Effects on Physicochemical and Nutritional Parameters of Wheat Grain: A Comprehensive Review
Get PDFWheat (Triticum aestivum L.) is a globally important staple crop that provides essential carbohydrates, proteins, fiber, minerals, and vitamins to human diets. However, the widespread use of chemical fertilizers in wheat cultivation has raised concerns related to soil degradation, nutrient-use inefficiency, and chemical residue accumulation in food products. Organic fertilization offers a sustainable alternative by enhancing soil biological activity, improving nutrient cycling, and supporting gradual nutrient release throughout the plant growth cycle. This review synthesizes findings from recent studies to evaluate how organic fertilization influences the physicochemical properties and nutritional composition of wheat grain. Evidence indicates that organic amendments such as farmyard manure, vermicompost, green manures, and biofertilizers increase soil organic carbon, microbial biomass, and enzyme activities, leading to improved root development, efficient nutrient uptake, and enhanced grain filling. Wheat grown under organic fertilization commonly exhibits higher protein quality, enriched mineral content (particularly Fe, Zn, and Ca), and increased dietary fiber, along with reduced pesticide and chemical residues. Although organic systems may initially result in lower yields during the transition phase, yield stability typically improves over time as soil structure and fertility are restored. Overall, organic fertilization not only enhances grain nutritional quality but also promotes environmental sustainability, making it a valuable approach for resilient wheat production systems.
KEYWORDS:
Organic fertilization; Wheat grain quality; Soil health; Nutritional composition; Sustainable agriculture
A STUDY TO ASSESS THE EFFECTIVENESS OF SELF-INSTRUCTIONAL MODULE ON KNOWLEDGE REGARDING HUMAN RIGHTS OF MENTALLY ILL AMONG 3RD YEAR BSC NURSING STUDENTS IN SELECTED COLLEGE OF VADODARA CITY
Get PDFTo assess the existing knowledge level of students regarding Human Rights of Mentally Ill among 3rd year B.Sc nursing students
Reactive Oxygen Species Causing Gene Mutations Linking Heavy Metal Toxicity to Neurodegeneration
Get PDFBackground: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by combined upper and lower motor neuron loss. While most cases are sporadic, environmental and occupational exposures are increasingly recognized as important disease modifiers.
Case Presentation: A 57-year-old male presented with an insidious onset of asymmetric upper limb weakness, which gradually progressed to involve significant muscle wasting, fasciculations, and early bulbar symptoms. Electromyographic studies demonstrated fasciculations, fibrillations, and neurogenic recruitment patterns, findings consistent with motor neuron disease. The patient had a prolonged occupational history of manual labor at oil production sites, with chronic exposure to heavy metals, and was known to have chronic hepatitis B infection. Despite initiation of riluzole therapy and comprehensive multidisciplinary supportive management, the disease followed a progressive course, culminating in respiratory failure and end-stage disease.
Discussion: This case underscores the potential contribution of chronic heavy metal exposure as a molecular driver in the pathogenesis of amyotrophic lateral sclerosis (ALS). The underlying mechanisms may involve zinc displacement from DNA repair proteins, oxidative DNA damage, mitochondrial dysfunction, disrupted axonal transport, and neuroinflammatory cascades. Additionally, concomitant systemic comorbidities such as chronic hepatitis B infection and prolonged physical strain may have synergistically accelerated neurodegenerative processes, contributing to disease progression.
Conclusion: Environmental and occupational exposure to neurotoxicants may influence the clinical trajectory of amyotrophic lateral sclerosis (ALS) by exacerbating intrinsic neuronal vulnerabilities. Recognition of these pathogenic modifiers is crucial for comprehensive risk assessment, patient counseling, and the formulation of targeted therapeutic strategies, including antioxidant therapy, mitochondrial stabilization, and metal chelation approaches.
KEYWORDS:
Amyotrophic lateral sclerosis, electromyography, heavy metals, occupational exposure, neurodegeneration, oxidative stress
EVALUATION OF ANTIBACTERIAL EFFICACY OF LACTOBACILLUS PROBIOTIC ON STREPTOCOCCUS MUTANS – AN IN VITRO STUDY
Get PDFThe oral cavity consists of a highly diverse microbiome that plays significant role in maintaining oral and systemic health. Disruption in the microbial balance, known as dysbiosis, is a key factor in the development of dental caries. This study explores the concept of bacteriotherapy using probiotic strains of Lactobacillus to suppress the cariogenic pathogen Streptococcus mutans. We assessed the antibacterial efficacy and determined the Minimum Inhibitory Concentration (MIC) of three commercially available probiotics Lactobacillus rhamnosus GG, Lactobacillus plantarum, and Lactobacillus casei Shirota against S mutans MTCC-497. The results may help us in incorporating the probiotic-based strategies for oral health management and caries prevention.
Keywords
Dysbiosis, Lactobacillus, Bacteriotherapy, probiotics, caries prevention
Next Generation Antibody Drug Conjugates: Molecular Design Innovations and Overcoming Resistance
Get PDFAntibody drug conjugates (ADCs) represent the relevant merger between targeted therapy and cytotoxic pharmacology, which supports the targeted destruction of cancerous cells as a result of antibody-mediated identification of antigens attached to tumors. This effect is also central to the engineering of antibodies, linker stability, and an additional benefit of payload design based on the requirements of target sites, which have generally increased the precision and safety of ADCs in cancer biology. Nonetheless, the issues of resistant mechanisms, non-homogeneous expression of antigens, and inefficient intracellular delivery keep affecting their clinical performance.
We selected a systematic review of the recent developments in next-generation ADC development in this review, with a particular focus on site-specific conjugation innovations, adaptive linker technologies, and dual-payload structures to surpass tumor heterogeneity and drug resistance. Furthermore, we discussed the newly emerging artificial intelligence (AI) based molecular modeling and computational optimization that assist in the creation of potential ADCs by enhancing payload-antibody integration. As a set, these interdisciplinary advances augment the ability of ADCs to be translational by shedding light on the realization of more efficient, adaptive, and patient-centered therapeutic solutions in oncology
Tribonacci L-cordial labeling of some standard graphs
Get PDFIn this article, we defined Tribonacci L-cordial labeling and find the existence of the same on some standard graphs
IMPROVEMENT OF PROFESSIONAL METHODICAL TRAINING OF FUTURE ELEMENTARY SCHOOL TEACHERS BASED ON INDEPENDENT EDUCATION
Get PDFThis article focuses on the improvement of professional methodical
training for future elementary school teachers through the
implementation of independent education. The study explores the
benefits of empowering future educators to take charge of their own
learning and develop essential skills needed for effective teaching in
elementary schools. By emphasizing independent education, the
article aims to enhance the quality of teacher training programs and
prepare educators for the challenges of modern educational settings