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Access Denied: An Argument Against King’s Propositional Access Principle
No full textAccounts of propositions face a problem that originates in the ontology of numbers: If propositions are abstract and causally isolated, then it’s unclear how agents cognitively access them. Jeff King presents a solution to this problem for his theory of propositions. King’s solution follows from a more general principle of cognitive access, which this paper challenges
Molecular Mechanisms of L-Type Calcium Channel Dysregulation in Heart Failure
No full textThe L-type calcium channels (LTCCs) function as the main entry points that convert myocyte membrane depolarization into calcium transients, which drive every heartbeat. There is increasing evidence to show that maladaptive remodeling of these channels is the cause of heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). Recent experimental, translational, and clinical studies have improved our understanding of the roles LTCC expression, micro-domain trafficking, and post-translational control have in disrupting excitation–contraction coupling, provoking arrhythmias, and shaping phenotype specific hemodynamic compromise. We performed a systematic search of the PubMed and Google Scholar databases (2015–2025, English) and critically evaluated 17 eligible publications in an effort to organize the expanding body of work. This review combines existing data about LTCC density and T-tubule architecture with β-adrenergic and Ca2⁺/calmodulin-dependent protein kinase II (CaMKII) signaling and downstream sarcoplasmic reticulum crosstalk to explain how HFrEF presents with contractile insufficiency and how HFpEF shows diastolic calcium overload and stiffening. Additionally, we highlight the emerging therapeutic strategies aimed at restoring calcium homeostasis such as CaMKII inhibitors, ryanodine receptor type 2 (RyR2) stabilizers, and selective LTCC modulators without compromising systolic reserve. The review establishes LTCC dysregulation as a single mechanism that causes myocardial dysfunction while remaining specific to each phenotype, thus offering clinicians and researchers a complete reference for current concepts and future precision therapy approaches in heart failure
Fitness Changes, Dietary Practices and Sleep Quality in Non-Elite Through-hikers: A Case Series
No full textTopics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 13, 2025. Through-hikes on long distance backpacking routes have the potential to both improve physical fitness and pose health risks. PURPOSE: To quantify changes in cardiorespiratory fitness and body composition, while recording dietary intake and sleep habits in a sample of through-hikers. METHODS: Participants completed two lab visits consisting of a maximal graded treadmill test and body composition assessments. Hiking volume, energy expenditure, sleep duration, and sleep staging were estimated during the hike using a smart watch. Participants kept a journal of all food and beverage intake. RESULTS: Over the course of the hike, participants significantly increased their absolute VO2max (+0.5 ± 0.1 L/min, t = 5.242, p = 0.04) and relative VO2max (+12.1 ± 2.1 ml/kg/min, t = 5.708, p = 0.03). With respect to body composition, participants significantly decreased their body mass (-9.0 ± 1.4 kg, t = 6.67, p = 0.02) and fat mass (-6.8 ± 1.7 kg, t = 4.071, p = 0.05). There were no significant changes in lean mass (+1.09 ± 1.6 kg, t = 0.681, p = 0.57). Although all participants slept the recommended 7-9 hours per night on average, none met the advised amount of deep sleep per night. Hiker’s diets were lacking in energy sufficiency and were low in several micronutrients. CONCLUSION: Extended through-hiking may improve fitness while promoting low quality diets and sleep. Targeted dietary and sleep interventions could mitigate these effects and promote better health outcome
Robots as Social and Behavioral Change Agents in the Classroom
No full textThe use of robots in a multitude of contexts is becoming increasingly mainstream, both in society as a whole and educational contexts. One pressing concern about the integration of robots into a classroom is the short- and long-term effects on students’ social skill development. Research suggests that social skills may overall be impeded by extensive interactions with robots, as well as a blurring of the boundaries between human and non-human entities. Moreover, there is a lack of research examining the real-time effects of robots on students’ social skill development, as well as what the implications of developing social skills from a robot might mean for the future of humans as social creatures. Higher education staff and faculty are gatekeepers for students before they enter a public and social space beyond school, so it’s imperative that staff and faculty clearly delineate the benefits and drawbacks from using robotics and AI as a whole in classroom instruction. The objectives of this presentation are to engage in critical inquiry with higher education staff and faculty to evaluating students’ current social skills, reflect on the impact robotics or AI have on those social skills, and create a shared manifesto of aims and uses of robotics and AI that develop and nurture students’ social skill development while not inhibiting or harming those skills. Activities in this presentation include identifying key social skills, understanding how social skills present in classroom contexts, and examining current uses of robotics and AI in higher education classrooms
Design as Dialogue: Working with AI in Course Creation
No full textGenerative AI promises speed, but effective course design still demands human expertise. Drawing on our experience co-creating course materials with AI, this session examines how the nature of design work changes rather than disappears - shifting from content creation to critical curation, refinement, and decision-making. Participants will explore a practical prompt-building framework, analyze examples of raw and revised AI outputs, and leave with strategies to thoughtfully integrate AI into their own design workflows while recognizing where human judgment remains indispensable
Nevada Medical Residencies, 2025
No full textThis fact sheet highlights medical residency data for the 2021, 2022, 2023, 2024, and 2025 graduating classes of the Kirk Kerkorian School of Medicine at the University of Nevada, Las Vegas (UNLV) and the University of Nevada, Reno (UNR) School of Medicine. This fact sheet presents data on residency program matches at the Kirk Kerkorian School of Medicine at UNLV and the UNR School of Medicine, shows where Nevada medical school graduates pursue their residencies, and updates findings from a 2024 fact sheet exploring 2021, 2022, 2023, and 2024 graduating class data
The Role of Money in Elections
No full textWhat if your vote mattered less than a millionaire’s donation? In every election cycle, billions of dollars flow into campaign war chests but what does that mean? Let’s follow the money and see who is truly influencing our elections. Money plays a powerful role in shaping electoral outcomes and public policy in democratic systems. In the United States, campaign funding has become increasingly dominated by large donations. This is because in 2010, Citizens United v. FEC decision opened the doors for unlimited independent political spending, sparking widespread concerns about fairness, transparency, and the influence of wealthy donors in politics.https://oasis.library.unlv.edu/durep_posters/1254/thumbnail.jp
Developing a Trial Unique Sequencing Task for Mice
No full textThe hippocampus and the anterior cingulate cortex (ACC) play distinct yet complimentary roles in the performance of cognitively demanding tasks.
While rodent models cannot truly capture human cognition, there is a serious need to develop more cognitively demanding rodent tasks to better understand human cognition to develop new tools to fight neurodegeneration.
Sequencing tasks are some of the most difficult for rodents to perform and are notoriously difficult to train.
Cutting edge interactive touch screen technology allows us to test an endless array of sequences, in a sound-controlled enclosure featuring a simple behavioral response for the mice.
Study Aim: To create a standardized protocol that can be used to effectively assess cognitive performance during sequence memory tasks in mice.We used the ABET II software to devise a program coupled with the Second Generation Bussey-Saksida Touch Screen Chamber.
This setup will allow us to test new sequences each day and is readily adaptable for recording electrophysiological signals from the ACC and hippocampus.https://oasis.library.unlv.edu/durep_posters/1261/thumbnail.jp
Stress and Glucose Regulation in Adults at Risk for Type 2 Diabetes Mellitus: A Secondary Analysis From a Randomized Controlled Trial
No full textType 2 Diabetes Mellitus (T2DM) is a major public health concern, significantly increasing the risk of cardiovascular diseases (CVDs). Additionally, prediabetes is a critical precursor, as it elevates the risk of developing both T2DM and CVDs. (2)
Recent literature reveals among individuals with severe perceived stress, there is a higher likelihood of HbA1c% levels meeting the criteria for prediabetes (5.7– 6.4%) as compared to those with lower perceived stress. (3)
Studies show that psychological stress has hyperglycemic effects in individuals with T2DM, suggesting that stress is associated with poorer blood glucose control. (4)https://oasis.library.unlv.edu/durep_posters/1262/thumbnail.jp
Divided Attention With Long-Term Memory: Recollection and Familiarity for Musical Melodies
No full textObjective: Test whether the well-established effects of divided attention 1, 2. (DA) found with non-musical (i.e., verbal and pictorial) materials generalized to musical melodies.
Background: Few studies have used melodies to test recognition models (e.g., DPSD). Parks et al.2 showed stimulus complexity alters source memory reliance on recollection (R) and familiarity (F).
Method: Used a 2 (attention) x 2 (melody type) mixed design with an old-new recognition test to compare DA effects across well-known and novel melodies.
Experiment 1: Applied an n-back task to split participants’ attention; no significant DA effect was observed.
Experiment 2: Shortened melody length and added a simultaneous DA task to address ceiling performance issues from Experiment 1.https://oasis.library.unlv.edu/durep_posters/1268/thumbnail.jp