RepoMed (Medizinische Hochschule Hannover)
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    3024 research outputs found

    Generation of two human NRF2 knockout iPSC clones using CRISPR/Cas9 editing.

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    The nuclear factor erythroid 2-related factor 2 (NFE2L2, known as NRF2) regulates the expression of antioxidative and anti-inflammatory proteins. In order to investigate its impact during viral infections and testing of antiviral compounds, we applied CRISPR/Cas9 editing to eliminate NRF2 in the human iPS cell line MHHi001-A and generated two NRF2 knockout iPSC clones MHHi001-A-6 and MHHi001-A-7. After differentiation into epithelia or endothelial cells, these cells are useful tools to examine the antiviral effects of activators of the NRF2 signaling pathway

    Midwifery students witnessing violence during labour and birth and their attitudes towards supporting normal labour: A cross-sectional survey.

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    Highlights Midwifery students: observe both, midwives and physicians, perpetrating violence towards labouring women. suffer because of their experiences with symptoms of acute and posttraumatic stress. consider dropping out of training due to their experiences and distress. may need access to professional support to cope with the experiences. Low-intervention births/individual care may reduce violence towards labouring women. Communication plays a key role in avoiding violence towards labouring women

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