RepoMed (Medizinische Hochschule Hannover)
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Clinical pathway of COVID-19 patients in primary health care in 30 European countries: Eurodata study.
Get PDFBackground Most COVID-19 patients were treated in primary health care (PHC) in Europe. Objectives To demonstrate the scope of PHC workflow during the COVID-19 pandemic emphasising similarities and differences of patient's clinical pathways in Europe. Methods Descriptive, cross-sectional study with data acquired through a semi-structured questionnaire in PHC in 30 European countries, created ad hoc and agreed upon among all researchers who participated in the study. GPs from each country answered the approved questionnaire. Main variable: PHC COVID-19 acute clinical pathway. All variables were collected from each country as of September 2020. Results COVID-19 clinics in PHC facilities were organised in 8/30. Case detection and testing were performed in PHC in 27/30 countries. RT-PCR and lateral flow tests were performed in PHC in 23/30, free of charge with a medical prescription. Contact tracing was performed mainly by public health authorities. Mandatory isolation ranged from 5 to 14 days. Sick leave certification was given exclusively by GPs in 21/30 countries. Patient hotels or other resources to isolate patients were available in 12/30. Follow-up to monitor the symptoms and/or new complementary tests was made mainly by phone call (27/30). Chest X-ray and phlebotomy were performed in PHC in 18/30 and 23/30 countries, respectively. Oxygen and low-molecular-weight heparin were available in PHC (21/30). Conclusion In Europe PHC participated in many steps to diagnose, treat and monitor COVID-19 patients. Differences among countries might be addressed at European level for the management of future pandemics
Evaluation of treatment-associated eye toxicity after irradiation in childhood and adolescence: results from the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK)
Get PDFIn-depth characterization of markers and cellular processes guiding in vitro differentiation of pluripotent stem cells towards cardiomyocyte subtypes
Get PDFNorovirus: a multidisciplinary approach to improve infection prevention and patient care
No full textDescribing the transition from late pregnancy into early labour - A prospective cohort study.
Get PDFObjective The time between self-assessed first symptoms and clinical confirmation of labour onset is marked by uncertainty, particularly for primiparas. Accordingly, primiparas often seek professional care to confirm their perceptions of labour onset. This paper describes the transition into early labour among primiparas considering their level of certainty in labour onset and their perception of labour onset symptoms prior to birth. Methods A prospective exploratory cohort study was conducted in Germany between July 2020 - March 2021 among a convenience sample of 69 primiparas. Respondents recorded in a non-validated questionnaire their perceptions of nine symptoms and degree of certainty about labour onset every day from 37 weeks gestation. Descriptive analysis included certainty in labour onset and dedicated symptoms in relation to days before birth. Results The participants (n=69) reported a little certainty of labour onset up to 32 days before birth and most of them became certain up to four days before birth. Associated symptoms were regular and irregular pain, symptoms of vaginal loss and emotional symptoms. Gastrointestinal symptoms and nausea were not indicated by a majority. Uncertainty of labour onset, however, was indicated up until the day of birth. Conclusion Although interpretation is based on a small sample size, primiparas are able to self-diagnose labour onset and report connected symptoms up to four days before birth. We suggest calling this time between self-diagnosis of labour onset and confirmed labour onset based on clinical parameters the transition into early labour
Ist „male depression“ wirklich geschlechterspezifisch?: multizentrische Studie zu etwaig geschlechterspezifisch depressiver Symptomäußerung auf der Grundlage des Konzepts „male depression“ im Kontext einer Untersuchung von auf Individualebene bezogenen Faktoren bei Patientinnen und Patienten mit unipolarer Depression
No full textWas macht eine gute Visite aus? Eine qualitative Interviewstudie zu Erfahrungen und Erwartungen von Teilnehmern einer kinderonkologischen Visite
No full textDie Funktion von Ena/VASP-Proteinen und Forminen bei der Assemblierung von filamentösem Aktin in makroendozytotischen Bechern von D. discoideum
No full textAnti-EGFR-basierte Therapie bei rezidiviertem oder metastasiertem HNSCC: was für einen Unterschied macht das?
No full textUse of elexacaftor/tezacaftor/ivacaftor leads to changes in detection frequencies of Staphylococcus aureus and Pseudomonas aeruginosa dependent on age and lung function in people with CF
No full textObjectives The impressive improvements of CFTR function by elexacaftor/tezacaftor/ivacaftor (ETI) result in changes in the detection frequencies of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA). We assessed determinants of the response to ETI with regards to SA and PA detection frequencies as documented in the German CF Registry for people with CF (pwCF) ≥12 years. Methods We evaluated changes in the detection frequencies of SA and PA for 21 months before and after initiation of ETI and used different statistical tests to identify determinants of detection changes. Results We included data from 1,092 pwCF with results from culture-dependent diagnostics for SA and PA detection from 7,944 microbiological samples prior and 6.845 microbiological samples after initiation of ETI. Detections of SA decreased from 54.3% to 44.3% and 40.2% and those of PA from 39.9% to 31.9% and 22.6% 3 and 21 months after initiation of therapy, respectively (all p<0.001). Reduction of SA and PA were observed in throat swabs and sputa, associated significantly with age, prior lung function and were dependent on pre-ETI colonization status. Conclusions The different patterns of reductions of SA and PA suggest that pathogen-specific biological processes govern the responsiveness of microbiological colonization towards ETI in pwCF