RepoMed (Medizinische Hochschule Hannover)
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Die Bronchiektasen-Erkrankung bei erwachsenen Patientinnen und Patienten mit Primärer Ciliärer Dyskinesie: Daten aus dem Deutschen Bronchiektasen-Register PROGNOSIS
No full textAdvancing translational ophthalmology in vitro: miR-302dmediated regulation of TGFB-induced epithelialmesenchymal transition in human RPE cells and real-time monitoring of AAV-mediated transduction efficiencies in ocular cells
No full textEinfluss von Lipoproteinrezeptoren und lipidsenkenden Medikamenten auf den Hepatitis-C-Replikationszyklus
No full textDer Einfluss von sechs Monaten Musikunterricht auf exekutive Funktionen, Gedächtnis, motorische Kontrolle und die Speech in Noise-Wahrnehmung bei älteren Menschen: eine longitudinale Studie mit 86 Probanden
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Rauchen und promotorspezifische Desoxyribonukleinsäuremethylierung des atrialen natriuretischen Peptidgens: Methylierung bei Rauchern und Nichtrauchern unterscheidet sich signifikant während des Entzuges
No full textNew translational mouse models for metabolic dysfunction-associated steatotic liver disease comparable to human MASLD with severe obesity
No full textObjective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease, in particular in patient with severe obesity. However, common mouse models for MASLD do neither represent a polygenetic background nor the metabolic changes in this population. Therefore, we investigated two new mouse models for MASLD with the polygenetic background for the metabolic syndrome. Methods: TALLYHO/JngJ mice and NONcNZO10/LtJ mice received a high-fat- high-carbohydrate (HF-HC) diet with a surplus of cholesterol diet. Results: After sixteen weeks of diet, both strains developed pronounced metabolic syndrome with severe obesity and histological manifestation of steatohepatitis. Subsequently, histological onset of MASH was associated with significantly increased intrahepatic CD8+cells, CD4+cells and Tregs, contributing to significant increase of pro-inflammatory and pro-fibrotic gene activation as well as ER stress and oxidative stress. Comparing with human transcriptomic signature, we could proof a good metabolic resemblance in particular for TH mouse model. Moreover, TH mice also developed sings of kidney injury as an extrahepatic comorbidity of MASLD. Conclusion: Overall, we developed two promising new mouse models, which are suitable for preclinical investigations of MASLD as they recapitulate most important hallmarks of MASLD
Low-value surgical innovation under peer-review: a sham study of abstracts on proximal humerus fractures submitted to scientific meetings
No full textBackground Innovation has in common the promise of benefit for patients; however, past experience has shown that this promise is not always delivered. Instead, low-value innovation might encourage treatment variation and dilute the available body of evidence. This study aims to investigate (1) whether the peer-review process is capable of filtering out low-value innovation appropriately, and (2) whether low-value surgical innovation would be preferred more often than nonoperative innovation by peer-reviewers in the treatment of proximal humeral fractures in the elderly. Materials and methods Two duplicated sham scientific abstracts, respectively introducing a low-value surgical innovation and a valuable nonsurgical innovation, were submitted to nineteen peer-reviewed scientific meetings worldwide for orthopedic trauma surgery with submission deadlines between 01/01/2022 and 31/12/2022. Decision regarding abstract acceptance was compared. Results There was a high acceptance rate for the abstract introducing low-value surgical innovation (12 out of 19 (63.2 %)), which was higher than that of a nonoperative duplicate (10 out of 19 (52.6 %)), but this difference was not statistically significant (p = 0.5). The majority of the ten meetings that accepted both abstracts placed both in equivalent programmatic tiers (oral presentation (4) and poster presentation (2)). In three meetings, the surgical abstract received superior program placement (oral presentation). In one case, it was the opposite. Conclusion There is a high acceptance rate for low-value surgical innovation among peer-reviewed scientific meetings. However, we can not conclude that low-value surgical innovation is preferred more often than nonoperative innovation by peer-reviewers as the differences in acceptance rate were small and not statistically significant. The peer-review process may be suitable as value-based medicine emerges. Scientists should be encouraged to pursue value-based innovation