RepoMed (Medizinische Hochschule Hannover)
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Quality of lower limb preoperative skin preparation using colorless versus colored disinfectants: results of an experimental, randomized study in a close to reality setting
Get PDFRetrograde elastic stable intramedullary nailing (ESIN) via a posterior approach to the radius as the principal cause of extensor pollicis longus tendon ruptures following pediatric forearm fractures
No full textForearm fractures are common pediatric injuries. Surgical intervention primarily comprises elastic stable intramedullary nailing (ESIN) or percutaneous K-wire osteosynthesis. Extensor pollicis longus (EPL) tendon rupture is a typical complication. Incidence ranges 0-16%, but sample sizes are critically low. Some questions are still not fully answered. Are EPL ruptures approach related? If so, are they procedure related and are there any references of intra- or postoperative tendon injury? We analyzed postoperative course of children with forearm fractures treated at a level 1 trauma center between 04/2011 and 09/2021. All patients had postoperative follow-up and underwent implant removal at the same center. Data was collected from clinical information system and picture archiving and communication system. Data was collected by the corresponding authors as well as one of the co-authors
Die Entwicklung der operativen Nierentumorchirurgie an der Medizinischen Hochschule Hannover von 2008 bis 2020
Get PDFCharakterisierung und Anwendung von 18F-Fluorethylthyrosin in der Darstellung der kardialen Immunreaktion nach Myokardinfarkt: eine Dissertation zur Evaluierung des Tracers als diagnostisches Werkzeug
Get PDFRhythmic Foot Embrocation According to Wegman/Hauschka for Alleviating Symptoms of Chemotherapy-Induced Peripheral Neuropathy: a Randomized Controlled Trial
Get PDFBackground Chemotherapy-induced peripheral neuropathy (CIPN) in patients treated with platinum-, taxane- or vinca alkaloid-based chemotherapy may cause symptoms such as tingling, numbness, pain, and paresthesia, particularly in patients' hands and feet. This study aimed to evaluate rhythmic embrocation (RE) of the feet according to Wegman/Hauschka in addition to an exercise program (EP) as a complementary treatment for CIPN symptoms. Methods This study was a prospective, randomized controlled, 2-center trial. A total of 57 patients with CIPN symptoms were randomly allocated into 2 groups, with 52 patients analyzed: the intervention group (n = 26) and the control group (n = 26). While the intervention group received 3 RE according to Wegman/Hauska and EP within 14 days, the control group performed only EP. CIPN symptoms (tingling, numbness, pain and cramps) were evaluated with the Numeric Rating Scale (NRS), and quality of life related to peripheral neuropathy was assessed with the EORTC QLQ-CIPN20 questionnaire. Results The mean NRS scores for total CIPN symptoms (tingling, numbness, pain, and cramps) decreased from baseline to 24 hours after the third intervention in both groups. However, the intervention group maintained lower scores 2 weeks later, whereas the scores in the control group returned to baseline levels. A significant time effect was observed for NRS scores with a medium effect size (P .05). Similarly, significant time effects were observed in the sensory and motor subgroups of the EORTC QLQ-CIPN20 (P .05). While the intervention group showed greater improvements, particularly at 2 weeks post-intervention, a statistically significant difference between the groups was not reached. Conclusion According to our study results, RE combined with exercise, particularly after 3 interventions, was more effective in reducing CIPN symptoms in the short-term than was exercise alone; however, symptoms increased again in the absence of interventions (standard care) by the end of the fourth week
Insertion of a transjugular intrahepatic portosystemic shunt leads to sustained reversal of systemic inflammation in patients with decompensated liver cirrhosis
Get PDFBackground/aims Systemic Inflammation (SI) is considered a key mechanism in disease progression and development of complications in decompensated liver cirrhosis. SI is mainly driven by portal hypertension and bacterial translocation. Transjugular intrahepatic portosystemic shunt (TIPS) insertion represents an effective treatment for portal hypertension. This study aims to investigate the impact of TIPS insertion on SI and bacterial translocation. Methods We prospectively included 59 cirrhotic patients undergoing TIPS insertion. Blood samples were collected at TIPS insertion and follow-up (FU) 1, 3, 6, and 12 months thereafter. At all time points, we performed a comprehensive analysis of SI including 43 soluble inflammatory markers (SIMs), and surrogates of bacterial translocation (sCD14, sCD163). To investigate long-term kinetics of SI, C-reactive protein (CRP) and white blood cells (WBC) were retrospectively analyzed in a cohort of 177 patients up to 3 years after TIPS insertion. Results At TIPS insertion, 30/43 SIMs, sCD14, and sCD163 measured significantly higher in cirrhotic patients compared to healthy controls. By FU6 25 SIMs and sCD14 measured at significantly lower levels compared to baseline. Interestingly, in patients with TIPS indication of refractory ascites, IL-6 decreased to levels documented in earlier stages of cirrhosis. In long-term follow-up, CRP levels significantly decreased after TIPS insertion, which translated into lower mortality in Cox regression analysis (HR 0.968, p=0.042). Notably, patients with residual ascites post-TIPS showed significantly higher CRP and IL-6 levels across all follow-ups compared to patients with resolved ascites. Conclusion Decreasing portal hypertension via TIPS insertion leads to a significant attenuation of SI and bacterial translocation over time
