RepoMed (Medizinische Hochschule Hannover)
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Ein modifiziertes Cuprizone-Modell zur Analyse eingeschränkter Remyelinisierung in der grauen Substanz: automatisierte Analyse von altersabhängigen Unterschieden unter toxischer De- und Remyelinisierung
Full text linkImaging the dynamics of fibroblast activation in relation to inflammation and ventricle remodeling after myocardial infarction and the value of FAPI-PET for assessing response to therapy
Full text linkDevelopment of Non-HLA Antibodies and Their Association With Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients
Full text linkAntibody-mediated rejection (ABMR) is the leading cause of long-term graft loss in pediatric kidney transplantation (KTx). While donor-specific HLA antibodies are established contributors, emerging evidence suggests a role for non-HLA antibodies in ABMR pathogenesis. In this descriptive study, we analyzed 60 non-HLA antibodies in 77 pediatric KTx recipients using serum samples collected pre-transplant, post-transplant, and at ABMR diagnosis. During a median follow-up of 4.83 years, 29.8% developed ABMR, with a median onset of 3.67 years. Non-HLA antibody presence prior to KTx was not influenced by pre-transplant dialysis; over half of the patients already had >15 positive non-HLA antibodies. The cumulative antibody profile remained stable 1-2 years post-KTx, with no association between late ABMR and antibody strength or breadth. However, ACTIN (higher risk) and CGB5 (lower risk) at 1-2 years post-KTx, as well as SNRPB2 pre-transplant, were significantly associated with ABMR (p < 0.05). IL-21 levels increased in controls over time (p < 0.05), although driven by five patients with notably high levels. Our findings support a potential involvement of non-HLA antibodies in pediatric ABMR. Nevertheless, larger studies are needed to validate the predictive value of individual non-HLA antibodies for clinical application
Investigation of compounds identified in a high-throughput screening in an in vitro model of Parkinson’s disease
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High-risk extracorporeal membrane oxygenation in immunocompromised children with acute respiratory failure: a retrospective cohort study
Full text linkExploring feminism in midwifery and maternity research: A scoping review.
Full text linkBackground The intersection of midwifery, maternity care, and feminist theory remains underexplored, particularly regarding its prevalence, contexts, and potential benefits for midwifery science. Feminist perspectives address sociocultural, economic and political factors at both individual and structural levels. In health care, these factors significantly influence women's health. Feminist perspectives offer approaches to better understand gendered experiences, address systemic inequalities, and gain deeper insights into sociocultural, economic and political dynamics. Aim The aim is to show how feminist perspectives are incorporated into midwifery research and how they are used. Methods A PRISMA-ScR-guided scoping review was conducted with systematic searches in Medline, MIDIRS, CINAHL, and SocINDEX, in December 2023. Studies over the last decade in English and German with the keyword "feminism" in midwifery and maternity care were included. Data were extracted and summarized descriptively. Patterns and underlying discourses were identified through iterative process to identify underlying themes. Findings From 1,523 records, 246 studies were included. These studies utilized feminist frameworks such as intersectional feminism, post-structural feminism, and feminist critical theory. Many studies focused on marginalized groups. Themes addressed included the experiences of women and families, healthcare needs, societal norms, ethical considerations, information and decision-making, and the role of technology. Discussion Feminist perspectives emphasize and contextualize the needs of women and marginalized groups, highlighting societal influences on health while providing approaches to analyse gender dynamics, power relations, and systemic inequalities. Conclusion This study highlights the potential for integrating feminist perspectives into midwifery science to develop more nuanced and equitable approaches to maternity care
