RepoMed (Medizinische Hochschule Hannover)
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Klinische und radiologische mittel- bis langfristige Ergebnisse nach einer Triple-Arthrodese
Full text linkVergleich unterschiedlicher Messmethoden zur Erfassung der Genauigkeit der Rekonstruktion der Transitionszone in der Orbitachirurgie
No full textPromotion of physical activity-related health competence using digital workplace-based health promotion: a pilot study for office workers
Full text linkIntroduction Engaging in health-enhancing physical activity (HEPA) can reduce the risk of developing chronic diseases, which is particularly important for office workers with sedentary lifestyles. Therefore, time- and location-independent interventions for increasing HEPA are necessary. Methods To achieve long-term changes in HEPA, interventions can be based on physical activity-related health competence (PAHCO). 48 office workers (83% female, 50 ± 8 years) completed an intervention consisting of bi-weekly exercise videos for 5 weeks, supplemented by PAHCO and anatomical education. The participants' HEPA levels were measured using the Physical Activity, Exercise, and Sport Questionnaire (Bewegungs- und Sportaktivität Fragebogen; BSA-F)and a physical activity diary, with follow-up measurements at 3 months. Results There was a significant increase in PAHCO (p = 0.002), especially in control competence (p < 0.001), after the intervention and at follow-up. The other sub-competences also increased, but not significantly. HEPA decreased after the intervention and at follow-up, but the decrease was not statistically significant. Discussion PAHCO increases after the end of the intervention, especially through the sub-competence of control competence. The other two sub-competences also improved, but not significantly. Participating in the study had no impact on HEPA as an outcome of the PAHCO model. Our study provides preliminary evidence that PAHCO can be enhanced through digital, time- and location-independent interventions. Future research should utilize a randomized controlled design to be able to causally attribute the effects of PA interventions in office workers to the intervention and objective measurements for HEPA should be employed
In vitro profiling of commonly used post-transplant immunosuppressants reveals distinct impact on antiviral T-cell immunity towards CMV
Full text linkImpact of postoperative delirium on long-term neurologic and neuropsychiatric outcome after cardiac surgery or percutaneous valve replacement-a prospective observational study
Full text linkBackground Patients undergoing cardiac surgery or percutaneous valve replacement may experience long-term neurologic and neuropsychiatric complications. The impact of postoperative delirium (POD) on these long-term complications remains controversial. We intended to illustrate the neurological and neuropsychiatric outcome associated with the occurrence of POD in patients undergoing elective cardiac surgery or percutaneous valve replacement. Methods We included 179 patients who underwent elective cardiac surgery or percutaneous valve replacement. Patients were evaluated postoperatively for delirium status. Neurological (score A) and neuropsychiatric (score B) outcomes were assessed using a structured examination protocol and interview at 1 year postoperatively and combined into a composite neurological and neuropsychiatric score (score A + B). Cognitive function was examined using the Montreal Cognitive Assessment (MoCA). Depression, fatigue and quality of life were assessed using the Beck's Depression Inventory (BDI), the Fatigue Impact Scale (FIS) and the Short-Form Health Survey (SF-12). Clinical outcome was assessed using the Barthel-Index (BI) and Frailty Index (FI). All data were collected prospectively. Results One year after cardiac surgery or percutaneous valve replacement, a high number of patients suffered from neurological and neuropsychiatric symptoms with depressive symptoms (n = 36, 20.1%) and symptoms of fatigue (n = 72, 40.2%). Multivariable regression analysis showed that POD was associated with higher values on the A + B composite score, indicating worse neurological and neuropsychiatric outcome (POD status: b:1.172; 95%-CI, 0.070-2.273, p = 0.037; age: b:0.134; 95%-CI, 0.086-0.182, p < 0.001; NYHA classification at 1 year: b:1.998; 95%-CI,1.169-2.828, p < 0.001; rehospitalization b:1.786; 95%-CI, 0.640-2.932, p = 0.002). Patients with POD had lower postoperative MoCA scores (p = 0.001) and lower scores on both the SF12 Physical (p = 0.022) and the SF12 Mental Component Summary (p = 0.048). POD was not associated with depressive symptoms (p = 0.855), fatigue (p = 0.122) or rehospitalization (p = 0.379). Conclusions POD in patients undergoing cardiac surgery or percutaneous valve replacement was independently associated with worse long-term neurological and neuropsychiatric outcome. POD may be a relevant prognostic marker indicating the need for specific follow-up services, whereas other clinical parameters were not predictive of outcome
Correlates of lasting immunity against SARS-CoV-2: a one year post infection period exploration
Full text linkWertigkeit nicht-invasiver Monitoring-Verfahren in der Detektion von intraabdomineller Hypertonie und abdominellem Kompartmentsyndrom
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