RepoMed (Medizinische Hochschule Hannover)
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A synapse perspective on the function of the amyloid precursor protein
Full text linkThe amyloid precursor protein (APP) is a transmembrane protein widely expressed throughout the brain, where it plays critical roles in both physiological and pathological states. APP undergoes complex post-translational processing by various secretases, a process that can lead to amyloid plaque formation via its amyloidogenic pathway. Consequently, APP has been extensively studied in the context of Alzheimer's disease (AD). However, emerging evidence highlights its physiological functions and the diverse roles of its cleavage fragments. This review explores the dual role of APP and its fragments, focusing on their contributions to synaptic structure, function, and plasticity. We summarize the mechanisms by which APP and its fragments influence synaptic dynamics and plasticity in the hippocampal CA1 region. These insights underline the importance of APP beyond amyloidogenesis, emphasizing its role in fundamental neurobiological processes and potential implications for understanding early AD-related synaptic dysfunction
Genomics of human NAFLD: lack of data reproducibility and high interpatient variability in drug target expression as major causes of drug failures
Full text linkGenexpressionsanalysen im Kontext von Nierenalterung und -schädigung mittels RNA-Sequenzierung
Full text linkPost-stroke lesion correlates of errors in verbal and spatial production tasks
Full text linkIntroduction Traditional lateralization models assign post-stroke verbal impairments to the left hemisphere and spatial impairments to the right hemisphere. When considering error measures, this dichotomy may be too simplistic, as performance monitoring may involve domain-general and domain-specific components. Furthermore, the error-monitoring hypothesis predicts domain-incongruent specialization, with left hemisphere dominance for spatial and right hemisphere dominance for verbal errors. Methods We performed voxel-based lesion-behavior mapping in N = 110 acute stroke patients who completed a cognitively demanding, error-prone, five-point spatial design fluency task and a verbal word-fragment completion task. Results Significant associations were found between lesion location and error rates in both tasks, spatial fluency (correlation = 0.36, p < 0.001) and verbal completion (correlation = 0.31, p = 0.001). Right inferior frontal lesions correlated with errors in both tasks. In addition, left frontal white matter (WM) lesions were associated with spatial errors, whereas right frontal WM lesions were associated with verbal errors. After adjusting for demographics, the left WM cluster remained significant for spatial errors and the right WM cluster for verbal errors, while the right inferior frontal association with spatial errors was no longer significant. Discussion Post-stroke performance monitoring involves two distinct neural systems. One is a domain-general system, probably centered in the right inferior frontal region, that supports overall accuracy. The other is a widely distributed, reverse lateralized system, with left lesions associated with spatial accuracy and right lesions associated with verbal accuracy. This suggests that performance monitoring relies on more complex hemispheric interactions than traditional models suggest
Tackling gender in progressive supranuclear palsy: male patients present more apathy
No full textGender differences in progressive supranuclear palsy (PSP) may become relevant for clinical trials, treatment decisions and patient counseling. To study gender associated differences we conducted a retrospective data analysis of 191 male and 157 female PSP patients from a large multicenter observational cohort in Germany. While no differences in motor skills, disease severity, daily living abilities, global cognitive status and depressive symptoms were observed between genders, male patients showed significantly higher apathy scores, a finding also noted in other neurological diseases. In this study, apart from male patients exhibiting higher levels of apathy, no significant disease-specific gender differences were observed in PSP patients
Is helicopter transferal in the “drip-and-ship” approach for endovascular treatment the better choice? A retrospective analysis of transfer times
Full text linkDer Einfluss der Covid-19 Pandemie auf die Gesundheitsversorgung von Erwachsenen mit angeborenen Herzfehlern
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