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IFCC primary reference procedure for the measurement of catalytic activity concentrations of enzymes at 37 °C: Part 10: Reference procedure for the measurement of catalytic concentration of pancreatic α-amylase
Full text linkThis paper is the tenth in a series of publications dealing with reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C and the certification of reference materials. In the former publications the general concept for reference procedures for enzymes (Part 1), the measurement of the catalytic activity concentrations of creatine kinase (Part 2), lactate dehydrogenase (Part 3), alanine aminotransferase (Part 4), aspartate aminotransferase (Part 5), γ-glutamyltransferase (Part 6), total α-amylase (Part 8), and alkaline phosphatase (Part 9) are described. Part 8 describes the measurement of the catalytic activity concentration of total amylase, comprising the isoenzymes salivary derived α-amylase and pancreas derived α-amylase. The catalytic activity concentrations of the pancreatic isoenzyme provides more diagnostic selectivity in cases of differential diagnosis of pancreatitis and its monitoring. The current article describes the IFCC primary reference measurement procedure for pancreatic α-amylase enabling metrological traceability to SI
Respiratory symptom patterns in healthcare workers in Germany: a prospective study during the SARS-CoV-2 pandemic
Full text linkMiKneeSoTA MATLAB Code
No full textoai:https://https://mhh-publikationsserver.gbv.de/:mhh_mods_00003412This script processes motion capture data from gait trials to quantify knee kinematics while minimizing soft tissue artifacts. It loads marker trajectory data, identifies gait events, fits cylinders to the thigh and shank segments, and computes knee joint angles. This code is based on the original code written by Benjamin Fleischer-Lück and journal publication by Einfeldt et al. 2024: https://doi.org/10.1038/s41598-024-71409-z The original code was adapted for Matlab by Adrian Sauer and reviewed and revised by Ariana Ortigas Vasquez and Ann-Kathrin Einfeldt with special contributions from Eike Jakubowitz, Leandra Bauer, Federica Neri, and Negin Tschalaki. Currently the code works for data captured with Vicon Motion and further processed in Nexus. The corresponding Pipelines and Templates are found in the MiKneeSoTA_Vicon_Templates folder. CONTACTS: [email protected] [email protected] [email protected] [email protected]
Erhebung der Langzeitergebnisse und der Lebensqualität bei Erwachsenen nach Resektion einer angeborenen Choledochuszyste im Kindesalter
Full text linkUntersuchungen zur aberranten Expression von P-Cadherin in Metastasen des lobulären Mammakarzinoms im Kolon: über die Rolle des Gewebemikromilieus
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Integration der Fachdisziplin Allgemeinmedizin in eine universitäre Notaufnahme: wie hausärztlich ist eine allgemeinmedizinische Patientenversorgung in der Notaufnahme?
Full text linkThromboembolische Komplikationen bei Patienten mit metastasiertem Keimzelltumor: kann maschinelles Lernen Risikopatienten identifizieren?
Full text linkData Metamizole Acceptance Rat
No full textData concerning the following project/manuscript:No option for analgesia refinement: Sprague-Dawley rats reject voluntary ingestion of metamizole via drinking water or palatable carrier media Background: The non-opioid analgesic metamizole (MET) is widely used for pain management in humans and animals. In laboratory rodents, voluntary oral self-intake of MET might represent a non-invasive refinement measure. Therefore, this study evaluated the acceptance of MET in drinking water and in palatable carrier substrates in RjHan:SD rats (male, female). Results: Initially, a MET target dosage of 1000 mg/kg/24 h in the drinking water drastically decreased fluid consumption within 24 hours (-87.95%). Subsequent acceptance trials, including lower dosages, and different formulations, without and with sweetening of water, did not lead to improved acceptance. Regarding the palatable carrier substrates offered as an alternative delivery method, rats did neither show much interest in hazelnut spread nor peanut butter. Lactose-free cream induced gastrointestinal side effects and acceptance decreased after 2 days. Baby food, however, was readily consumed by 100% during a 5-day training. Nevertheless, the attractiveness was not sufficient to mask the aversive taste of 100 mg/kg MET per portion, resulting in limited intake and prolonged consumption time. Conclusions: In conclusion, voluntary oral intake of MET for analgesic therapy in RjHan:SD rats must be considered infeasible. Our results should be taken as a warning regarding the application in other rat strains or other animal species
