Wheaton College (MA) Digital Repository
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The effects of 3-nitropropionic acid on mitochondrial abundance in glial cells of Gallus gallus.
No full text10 pages; illustrations
The adopted child's experience in schools and methods to improve it.
Get PDFii, 97 leaves.Includes bibliographical references: leaves 39-42
Preliminary study of effect of exogenous tau-441 on mitochondrial transport in glia.
No full text9 pages. 3 pages; illustrations
Zebrafish aging is a determining factor in breast cancer.
No full text46 leaves : color illustrations.Includes bibliographical references: leaves 37-42.Breast cancer is the most commonly diagnosed cancer in women and a leading cause of cancer death in women. Studies that examine the effects of certain environmental factors, which can mimic estrogen function and thus mediate breast cancer development, are crucial to broadening understanding of molecular cancer mechanisms. Subsequent translation from in vitro to in vivo studies and ultimately to possible clinical therapies requires the development of effective techniques to study mechanistic function at each stage. Here, we present data describing the use of zebrafish xenotransplantation as an in vivo model for studying breast cancer progression and metastasis. A younger (~0.5 year, median 2.9cm length) and an older (~1.5 years, median 4.1cm length) group of zebrafish were immunosuppressed by dexamethasone treatment and transplanted with MCF-7/GFP breast cancer cells. By fluorescent imagery, tumor area and metastasis in both groups were observed over 7 weeks to compare transplant efficacy. In addition, a systematic method, using python codes, was developed to analyze images. Throughout the study, the younger group showed significantly lower transplant efficacy, with most fish showing no signs of tumor presence by 2 weeks post injection. The older group showed high transplant efficacy, with all individuals within the group showing tumor present throughout the length of the trial period. We conclude that zebrafish age is a determining factor in transplant efficacy. We speculate that the variable immune robustness of younger versus older fish impacts dexamethasone immunosuppression. In turn, this effect determines xenotransplant efficacy
Wheaton Magazine
No full textFall 2017 issue of the Wheaton MagazineWheaton College (MA)Between the lines: Refreshing, pg.2@DHANNO: The right time, pg.3Around the Dimple: Making history: How the class banner gets created, pg.4Around the Dimple: Out of the classroom, into the office, pg.6Around the Dimple: A genius in the making, pg.7Around the Dimple: Give and go, pg.7Around the Dimple: Going places, pg.8Around the Dimple: Brand evolution, pg.9Around the Dimple: Bravo, Wheaton!, pg.9Around the Dimple: Touching base, pg.10Around the Dimple: STEM summit focuses on women, pg.11Conversation: Which way to the tropics? Start at Wheaton, John Kricher says, pg.12Publications, Honors and Creative Works, pg.13Lyons pride: Roar!, pg.14Campus scene: Ready, set, go, pg.16Campus scene: Lively discussion, pg.16Campus scene: Talent show, pg.16Campus scene: Good food, pg.17Campus scene: Farm Fest, pg.17Campus scene: Enterprising efforts, pg.17Campus scene: The royal treatment, pg.18Campus scene: Making room for ideas, pg.22Campus scene: Fighting cancer with innovation, pg.28Alumnae/i association news: Reunion, pg.32Alumnae/i assocation news: On board, pg.34Alumnae/i association news: Noteworthy, pg.35Class Notes, pg.36Class Notes: Making waves, pg.38Class Notes: A breath of fresh air, pg.39Class Notes: Connecting with purpose, pg.40Class Notes: Distinctive teaching, pg.41Class Notes: Ted Nesi '07 snags Emmy, pg.42Class Notes: Poetic send-off, pg.43Class Notes (removed), pg.44In Memoriam, pg.62Perspective: Why I am grateful to Wheaton, pg.6
Dynamic equilibrium via aquaporins and filtration systems.
No full text8 pages; illustrations.Includes bibliographical references
Golgi apparatus and Taichung Metropolitan Opera House.
No full text7 pages; illustrations.Includes bibliographical references
Signaling seen in nuclear pore complexes and the Panama Canal.
No full text6 pages; illustrations.Includes bibliographical references