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Spine label: Methylmercury promotes the growth and progression of breast cancer.
No full textii, 36 leaves: illustrations.Includes bibliographical references: leaves 30-36.Estrogen is a female sex hormone that is important in the development of secondary sex characteristics in females and promotes breast cancer growth and metastasis of estrogen receptor (ER)-positive breast cancer cells. Environmental estrogens, such as metalloestrogens, have also been shown to promote breast cancer growth. Methylmercury (MeHg) is a metalloestrogen whose role in breast cancer growth and progression has not been elucidated. MeHg is of interest because it is the main form of mercury in humans and aquatic life, as it accumulates through the aquatic food chain. To test whether MeHg promotes the growth of breast cancer cells in vivo, a Danio rerio embryo model was used. MCF-7 ER positive breast cancer cells were transplanted into a 2-day post fertilization embryos (dpf). Tumor growth and metastasis were observed on 7 dpf using fluorescent imagery. We hypothesized that ER-postivie breast cancer cells treated with MeHg would have increased tumor growth and more metastases compared to untreated embryos. MeHg treated embryos showed higher percentages of embryos with cancer, tumor count, and tumor area compared to untreated embryos. From these results, we conclude that MeHg may be acting as a metalloestrogen to promote the growth and progression of ER-positive breast cancer in xenografted Danio rerio embryos.Abstract – Chapter 1: Introduction – 1.1 Breast cancer – 1.2 Estrogen and ER – 1.3 Estrogen receptor in breast cancer – 1.4 Xenoestrogens and metalloestrogens – 1.5 Methylmercury – 1.6 Zebrafish – 1.7 ER in Zebrafish – 1.8 Hypothesis – Chapter 2: Materials and methods – 2.1 Cell lines and primary culture conditions – 2.2 Zebrafish embryo care – 2.3 MCF-7/GFP cell xenotransplantation – 2.3 MeHg treatment – 2.4 Zebrafish imaging – 2.5 Statistical analysis – 2.6 Tumor analysis – Chapter 3: Results – 3.1 20 nM MeHg treatment of danio rerio embryos significantly impacts survival rate – 3.1 Methylmercury promotes an increase in tumor growth and metastasis – Chapter 4: Discussion – Reference
Evidence of the effects of reactive oxygen species on axonal transport of mitochondria in Gallus gallus peripheral sympathetic neurons.
No full text12 pages; illustrations
The effects of mercuric chloride (HgCl2) on the laminin substratum regarding axonal outgrowth in Gallus gallus peripheral neurons.
No full text11 pages; illustrations
Evidence concerning exocytosis as a neuronal response to Pseudomonas aeruginosa endotoxin exposure.
Get PDF13 pages; illustrations
Assessing twenty years of change in the interdunal swale plant communities of Sandy Neck.
No full texti, 73 leaves: color illustrations.Includes bibliographical references: leaves 69-73.Interdunal swales occur between sand dunes and support a relatively high density and diversity of plants. In the mid-1990s, data were collected on the plant communities of various swales at Sandy Neck in Barnstable, MA. The very same methods were repeated, 20 years later (in this study) in a unique attempt to quantify change in these swale plant communities over time. Distinct patterns of succession emerged, and the removal of the highly invasive Phragmites australis, or common reed, had no long-term impact on the plant communities of invaded swales
Wheaton Magazine
No full textSummer 2018 issue of the Wheaton MagazineWheaton College (MA)Between the lines: Immersed in work, pg.2@DHANNO: History in the making, pg.3Around the Dimple: New dorm makes room for growth, pg.4Around the Dimple: A minute with... Christina DesVergnes '19, pg.6Around the Dimple: Focusing on first-gen students, pg.7Around the Dimple: Winter work break, pg.8Around the Dimple: Talking about healthy masculinity, pg.9Around the Dimple: An experiment in civics, pg.10Around the Dimple: Math association counts on professor to lead program, pg.11Conversation: Examining art and conflict, pg.12Publications, Honors and Creative Works, pg.13Lyons pride: Diving into my work, pg.14Campus scene: Fresh Check Day, pg.16Campus scene: MLK awards, pg.16Campus scene: Career fair, pg.16Campus scene: Going global, pg.17Campus scene: Risky business, pg.18Campus scene: Obstacle course, pg.22Campus scene: Now showing: Vision, drive, collaboration, pg.28Campus scene: Leadership transition, pg.30Alumni association network: Gathering to celebrate and reflect, pg.34Alumni association network: In the game, pg.35Class Notes, pg.36Class Notes: Reinventing the family business, pg.38Class Notes: Java and jobs, pg.39Class Notes: Sustaining the planet, pg.40Class Notes: Queen of the crop, pg.41Class Notes: Articulating politics, pg.42Class Notes (removed), pg.43In Memoriam, pg.62Perspective: Encore, pg.6
Cultural capital among zero waste consumers.
No full textii, 125 leaves.Includes bibliographical references: leaves 122-125.Ethical consumption has emerged as a prominent alternative consumption strategy designed to address the negative impacts of mass consumerism. The zero waste movement has been observed to be a distinct segment of this trend. While research has been done to address the context and motivations of the zero waste movement, there is a gap in our knowledge around the impact of socioeconomic class. Alternative consumption movements have been criticized on the basis that the cost of consuming alternative products is prohibitive, yet the zero waste movement emphasizes restraint from consumption, making it an ideal example by which class boundaries can be analyzed. Using a mixed methodological approach, this research aims to investigate how economic and cultural factors shape the opportunities and constraints that individuals face when living a zero waste lifestyle. Analysis of the data illustrates that we can understand the differences in how people participate in the zero waste movement with the concepts of cultural capital and habitus. The data reveals that those with lower cultural capital displayed a habitus that favored these actions while those with higher cultural capital had more difficulty. This counters previous claims of ethical consumption being exclusive to those with more cultural resources. By analyzing the dynamics of zero waste consumption empirically through this study, we can better understand how cultural and economic factors impact consumption practices. This research advances the literature on ethical consumption by exploring the ways that alternative consumption practices can expand beyond, or be hindered by, class boundaries
Evidence of chronic and acute exposure time effects of lipopolysaccharide on glial cell motility.
No full text7 pages; illustrations
Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin
No full text9 pages; Color IllustrationsDistributed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.24 pages; color illustrations