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Rushlight: 2019 Spring
No full textCamera flash while caught mid-chew / Christina Smith -- The Moon is a Black Woman (Acrylic Paint) / Angel Bird -- Girl Seeking God / Petra -- The Frozen Leaf /Christopher Stack -- Fern Fantasy (Photography) / Lily Fiore -- rose-colored sky / Sydney Evans -- Pitchforks /Shannon Connolly -- Untitled (Photography) / Maia Hay -- Intentionally Random (Ink) / Bailey DeBiase -- Untitled / Faheem Dyer -- Temptress (Pen and Photoshop) / Gracie Vicente -- serve god, love me, and mend / Mazie Starratt -- Wilted / Emily Gray -- A Love Poem / Anonymous -- Salvation in a Highway Motel (Photography) / Caroline Chaffiotte -- A Poet’s Sunrise /Christopher Stack -- The Stories of Strangers / Gracie Vicente -- Traveling Monster (Pen and Marker) / Timothy McCormack -- hot takes from the Target changing room / Christina Smith -- A Grievance from One Burdened by the Knowledge of an Ever Present Sense of Oblivion / Caroline Chaffiotte -- The Anatomy Lesson / Hannah McIssac -- Tchaikovsky (Photography) / Nadia Joan -- I wandered lonely as a fish / Rebecca Spadacenta -- Rule: Night Bed Start Prowl Floor / Caroline Fournier Dyhrberg -- epiphany at noon (Watercolor and Pen) / Emily Gray -- to the person looking at the same painting that i am right now / Mazie Starratt -- Canty Bay (Photography) / Maia Hay -- Continental Drift / Eliza Browning -- The Matador’s Lament / Eli Teitelman -- Nautilus (Pen and Ink) / Min Bae -- Seagrass / Eric R. Pfeiffer -- Essential Foundations / Shannon Connolly -- King’s Sunset / Sierra Proft -- Cloud Creator / Jessica Heberlein -- a poem for the mist and my morning tea / Emily Gray -- Lost in Thought? (Relief Printmaking) / Bhavika Dugar -- The Streets of Quebec / Gracie Vicente -- Sana, Sana, Culito de Rana... / Tessa Demko -- Almost Like Home (Ink) / Bailey DeBaise -- field notes / Sydney EvansWheaton College (Norton, MA) student literary magazine.camera flash while caught mid-chewThe Moon is a Black Woman (Acrylic Paint)Girl Seeking GodThe Frozen LeafFern Fantasy (Photograph)rose-colored skyPitchforksUntitled (photograph)Intentionally Random (Ink)UntitledTemptress (Pen and Photoshop)serve god, love me, and mendWiltedA Love PoemSalvation in a Highway Motel (Photography)A Poet's SunriseThe Stories of StrangersTraveling Monster (Pen and Marker)hot takes from the Target changing roomA Grievance from One Burdened by the Knowledge of an Ever Present Sense of OblivonThe Anatomy LessonTchaikovsky (Photograph)I wandered lonely as a fishRule: Night Bed Start Prowl Floorepiphany at noon (Watercolor and Pen)to the person looking at the same painting i am right nowCanty Bay (Photograph)Continental DriftThe Matador's LamentNautilus (Pen and Ink)SeagrassEssential FoundationsKing's SecretCloud Creatora poem for the mist and my morning teaLost in Thought? (Relief Printmaking)The Streets of QuebecSana, Sana, Culito de Rana...Almost Like Home (Ink)field note
Effects of Amyloid Beta protein fragment 25-35 on lysosomal shape in Gallus gallus embryonic sympathetic neurons.
No full text9 pages; 3 figures
A First-Principles Investigation of the Crystal-Field and Racah Parameters of Transition Metal Ions: Cr3+ in Alumina
No full text4 pages; BW IllustrationsDistributed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.24 pages; color illustrations
Structural modification of a natural angiotensin converting enzyme inhibitor and the effect on activity.
No full textIncludes bibliographical references (leaves 50-54).54 leaves : illustrationsHypertension is a leading risk factor for mortality that affects nearly a third of adult US residents, and it is primarily combatted through the use of angiotensin converting enzyme inhibitors (ACEIs). In addition to ACEIs currently approved as anti- hypertension drugs, there are a number of natural ACEIs that have not been studied, some of them more effective than others. This study sought to alter the structure of alanine- valine-phenylalanine (AVF), a natural, relatively ineffective ACEI, to create modified peptides that would hopefully act as more effective inhibitors. After a literature analysis, phenylalanine-valine-alanine (FVA) was determined to be more likely to act as an effective inhibitor, so four novel peptides were synthesized. One novel peptide was designed to contain unmodified phenylalanine while the other three contained one of the following para-substituted, N-protected, L-phenylalanine amino acids: L-Phenylalanine, N-benzoyl-4-methyl, L-Phenylalanine, N-benzoyl-4-methoxy-, L-Phenylalanine, N- benzoyl-4-fluoro-. In implementing these peptide modifications, first the respective modified phenylalanine amino acids were synthesized, then the FVA peptides were synthesized, with naturally occurring phenylalanine as well as the three modified phenylalanine amino acids. NMRs confirmed the identities of all products and HPLCdata confirmed the stereochemistry of the chiral amino acid intermediates.1 Introduction -- 1.1 Statement of the problem -- 1.2 Hypertension -- 1.2.1 Renin angiotensin system -- 1.2.2 Angiotensin converting enzyme inhibitors -- 1.2.3 Alanine-valine-phenylalanine -- 1.3 Modifications to AVF -- 1.4 Chirality -- 1.4.1 Chirality in drug synthesis -- 1.4.2 Chiral catalytic reduction -- 1.5 Peptide synthesis -- 1.6 In vitro assay -- 2 Results and discussion -- 2.1 Amino acids synthesis -- 2.2 Peptide synthesis -- 3 Experimental procedures -- 3.1 Synthesis of amino acids -- 3.2.1 Synthesis of oxazolones -- 3.2.2 Synthesis of enamide esters— 3.2.3 Synthesis of n-protected amino acid esters -- 3.2.4 Synthesis of n-protected amino acid -- 3.3 Peptide synthesis -- 3.3.1 Synthesis of FVA peptides -- 4 Conclusion -- 5.1 Conclusions and future researc
Using eclipses to probe physical conditions along the jet in SS433.
No full textIncludes bibliographical references (leaves 94-99).vi, 99 leaves : illustrationsThe Galactic X-ray binary SS 433 is the only known astrophysical object to exhibit strong relativistically red- and blue-shifted lines from elements such as S, Si, Fe, Ni. The X-ray emission lines originate in a jet outflow that is launched somewhere very close to the compact accretion (a black hole or a neutron star). During 2018 August 10-14, SS433 was observed using the High Energy Transmission Grating Spectrometer system on the Chandra X-ray observatory. A total of 116 ksec of Chandra HETGS observation was made during 2018 August 10-14, which was split in one 20 ksec and one 96 ksec observation. The 20 ksec observation started at an orbital phase of 0.802, three days before an eclipse and the 96 ksec observation started at an orbital phase of 0.109 in the middle of the eclipse. The observations were designed to take advantage of the eclipse and carry out time-resolved spectroscopy and timing studies to infer spatial variation of physical properties such as composition, temperature, and density at different distances among the jet. In addition to phenomenological fits to determine properties of the observed emission lines, we will present results from fitting collisionally ionized plasma models. The observation indicates that the redshift of the western jet was 0.034 while the predicted redshift value is -0.0097. This suggests the independent motion of the two jets. The disappearance of the FeXXV line from the Eastern jet and the high photon index of the power law at the end of the long observation suggest the accretion might not has come out of the eclipse.1.1 The general introduction and the layout -- 1.2 X-ray binaries -- 1.2.1 Introduction to X-ray binaries -- 1.2.2 Accretion processes in x-ray binaries -- 1.2.3 The components of the x-ray binaries -- 1.2.4 Maximum luminosity during accretion: The eddington limit -- 1.2.5 Jets -- 1.3 Introduction to SS 443 -- 1.3.1 The moving lines -- 1.3.2 Relativistic jets -- 1.3.3 SS 433 as an X-ray binary -- 1.3.4 The uniqueness of SS 433 -- 1.3.5 X-ray observations of SS 433 -- 1.4 Some unanswered questions about the jets of SS 433 -- 2 The Chandra telescope and analyzing x-ray spectra obtained with chandra -- 2.1 Introduction to the chandra x-ray observatory -- 2.1.1 Main components of the chandra telescope -- 2.2 High resolution x-ray spectral analysis -- 2.2.1 Data preparation -- 2.2.2 Choosing the right fit statistic -- 3 Phenomenological modeling of our HETGs data -- 3.1 Introduction to our observation -- 3.2 The 20 ksec observation on August 10, 2018 -- 3.2.1 Method -- 3.2.2 Results -- 3.3 The 95 ksec observation on August 13-14 2018 -- 3.3.1 Results -- 4 Plasma model -- 4.1 Four-temperature plasma model -- 4.2 The 20 ksec observation -- 4.3 The 96 ksec observation -- 5 Discussion -- 5.1 Discrepancies in the observed redshifts of the jets -- 5.2 Line widths and positions -- 5.3 Jet emission line fluxes -- 5.4 Power law and photon index -- 6 Conclusio
Investigation of Purcell Factor for an Activator Ion due to Surface Plasmon Modes
Get PDF3 pagesDistributed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.24 pages; color illustrations
Chronic exposure to methylmercury adversely affects response to oxidative stress.
No full textIncludes bibliographical references (leaves 22-28).ii, 34 leaves : illustrationsMethylmercury (MeHg) is an environmental neurotoxicant that has been shown to lead to physiological inefficiencies. Environmental contamination is a major concern, due to the high amounts of mercury pollution that affects a variety of food webs. Chronic exposure to MeHg has been shown to lead to the generation of reactive oxygen species (ROS) and inhibition of cell defense systems. The specific activities of three antioxidant enzymes, thioredoxin reductase (TrxR), glutathione peroxidase (GPx), and glutathione reductase (GR) are altered after chronic exposure to MeHg. Prior studies have shown generally, after MeHg exposure, the activity of TrxR and GPx decrease, while GR activity increases. These data imply that the glutathione system upregulates in the presence of MeHg, compensating for the inhibited activity of TrxR. This current study used kinetic spectroscopic methods to measure the activity and concentration of TrxR, GPx, and GR in Fundulus Heteroclitus exposed to MeHg in food at a rate of 35% of body weight per day for 3.5 weeks. We hypothesized that chronic exposure to MeHg lowers the activities of TrxR and GPx, and increases the activity of GR in brain and liver tissue. Results demonstrate that TrxR activity is unaffected after MeHg exposure in the liver of F. heteroclitus, whereas GPx and GR activity significantly decreased. Both TrxR and GPx activity decreased in the brain following MeHg treatment, while GR activity decreased only in males and remained unaffected in females. These findings provide insight into F. heteroclitus as an in vivo model for analyzing cellular responses to MeHg toxicity and how redox enzymes are affected by metal pollutants.1 Abstract -- 2 Introduction -- 2.1 Mercury as an environmental contaminant -- 2.2 Formation and mechanisms of MeHg toxicity -- 2.3 Redox enzymes effected by mercury -- 2.4 Mercury’s effects on redox enzymes in vivo and in vitro -- 2.5 Current study -- 3 Methods and materials -- 3.1 Animals -- 3.2 MeHg treatment -- 3.3 Tissue homogenization and preparation -- 3.4 Enzymes assays -- 3.5 Data analysis -- 4 Results and discussion -- 5 Conclusion -- 6 Acknowledgments -- 7 Citations -- 8 Tables and Figur
Analysis of ciliary gene expression in sea urchin development.
No full textIncludes bibliographical references (leaves 61-63).72 leaves : illustrationsCilia are important cellular organelles tied to many disease states due to their pivotal roll in important cellular processes, including early organism development. In this Honors Thesis, cilia were studied in developing Strongylocentrotus purpuratus embryos during the blastula stage of development. The blastula stage is when the sea urchin embryos develop motile cilia. The upstream DNA regions of 37 ciliary genes expressed during the blastula stage of development were analyzed using a motif discovery algorithm MEME and further analyzed with a motif comparison algorithm TOMTOM, in search of shared regulatory elements related to transcription factor binding proteins. This experiment resulted in three promising motifs aligned with known transcription factors Klf6, Klf11, Klf2, and Glis-3. Our data supports a model were Klf6, Klf11, and Klf2 may be transcriptional enhancers of the blastula cluster genes while Glis-3 may be a transcriptional repressor. These transcription factor proteins may play a roll in regulating the ciliary phenotype in S.p..Analysis of ciliary gene expression in sea urchin development -- 1 Introduction -- 1.1 Cilia structure and function -- 1.3 Cis regulatory elements and transcription factors -- 1.4 Information theory and motif discovery -- 2 Material and methods -- 2.1 Extracting upstream regulatory regions -- 2.2 Precautions of the curation process -- 2.3 Curation protocol -- 2.3.1 Using EchinoBase to download the FASTA sequence to perform BLAST -- 2.3.2 Using the echinobase FASTA file to BLAST and find the current location of the gene -- 2.4 Reconciling curation data -- 2.4.1 Comparing curation notes -- 2.3 Installing the MEME suite -- 2.4 Running MEME -- 2.5 Running TOMTOM -- 3 Results -- 3.1 Perspective on the complexity of analyzing upstream regulatory regions -- 3.2 MEME output -- 3.2 Positional groupings -- 3.3 TOMTOM results for hypothetical motifs -- 4 Discussion -- 4.1 Interpreting MEME results -- 4.2 TOMTOM results -- 5 References -- 6 Appendix -- 6.1 Curation process background -- 6.2 Processing files scripts -- 6.2.1 Main file -- 6.2.2 Process file
Introduction to: Kathryn Mills: C. Wright Mills Through his Letters � His Time in Innsbruck and the Making of The Sociological Imagination
No full text2 pagesDistributed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.24 pages; color illustrations
