UAB Digital Commons (Univ. of Alabama at Birmingham)
Not a member yet
32303 research outputs found
Sort by
Learning Through Leadership
Get PDF2025 ASEM 620 Capstone Projecthttps://digitalcommons.library.uab.edu/asem/1000/thumbnail.jp
Accelerating Drug Repurposing for Rett Syndrome Project
No full textRett Syndrome is a rare, debilitating genetic disorder that has very limited treatment options. Rett primarily affects females and is caused by a mutation in a gene (MECP2) that plays a critical role in neurodevelopment. Children born with Rett appear to reach their milestones in infancy, but however eventually start regressing and losing ability to speak, as well as loss of motor skills, seizures, and repetitive hand movements. Many families and researchers are continuously searching for new treatments and cures for Rett, however the challenge is efficiently identifying which drugs are mechanistically suitable for Rett, as well as safe to use for the Rett population. Furthermore, time is limited, and drug discovery in general takes at least twelve years. With the combination of a rapid rise of artificial intelligence and new innovative databases such as PharmAlchemy, drug discovery and repurposing could potentially be accelerated, giving the next generation of individuals with rare disorders a potential, quicker cure
Endocrine Gene Divergence Reflects Precipitation-Driven Adaptation in Sonoran Desert Rattlesnakes
No full text2025 Fall Expo Poster Presentation Biological & Life Scienceshttps://digitalcommons.library.uab.edu/sp-expo/1162/thumbnail.jp
Social Media and Self-Esteem
No full text2025 Fall Expo Online Poster Presentation Social & Behavioral Scienceshttps://digitalcommons.library.uab.edu/sp-expo/1168/thumbnail.jp
