Carolyn Wilson Digital Collections (Lipscomb Univ.)
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The Benefits of Leukocyte Depletion Filters for Blood Product Administration during Cardiopulmonary Bypass: A Scoping Review
Full text linkBackground: Cardiopulmonary bypass (CPB) is a critical component in cardiac surgery, enabling surgeons to perform complex procedures while maintaining systemic perfusion, oxygenation, and a bloodless field. Despite advancements in the CPB circuit design, prime solutions, and management strategies, complications such as inflammatory responses, coagulopathy, and organ dysfunction remain common. Therefore, identifying best practices that optimize perfusion parameters and improve patient outcomes is paramount.
Despite the best efforts, every patient has an inflammatory response to CPB, and it is not unusual to receive a blood product transfusion during CPB. A leukocyte depletion filter (LDF) is a device used in blood transfusions to minimize the reinfusion of white blood cells (leukocytes). Activated leukocytes and inflammatory mediators create an unwanted inflammatory response, however, these filters are not widely used during CPB. The rationale of some perfusionists may be due to the integrated filters in the cardiotomy and reservoir of the CPB circuit, but should a LDF be added when transfusing blood products on CPB?
Objectives: The study aim was to perform a scoping review on using a LDF for blood product administration during CPB and the benefits it may provide.
Design: This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. Three online databases were used to identify articles published between 2000-2025, from which 43 published articles were selected for review. These articles were from the United States, Netherlands, Germany, Greece, China, United Kingdom, Italy, and Finland.
Results: The use of a LDF is a subject that remains unclear with a variety of data. None of the articles reviewed during this scoping review discussed the use and benefits of LDF for blood product administration during CPB.
Conclusions: While various data are available on LDF, CPB, and/or blood transfusions, the scholarly community lacks research and evidence on the benefits of using LDF for blood transfusions during CPB. Practices are inconsistent due to the lack of evidence necessary to support this topic. This scoping review indicates the need for future studies to standardize best practices in cardiopulmonary perfusion
Adverse Health Effects of Waste Anesthetic Gases (WAGs): A Scoping Review of Genetic, Immunotoxic, and Reproductive Impacts
Full text link1 Background/Introduction: Occupational exposure to Waste Anesthetic Gases (WAGs) is a well-known concern for healthcare workers, especially those working in high-risk areas like the operating room (OR). Despite the implementation of safety measures such as WAG scavenging systems, there remains ongoing concern about the potential adverse health effects linked to exposure. This scoping review aims to map the existing evidence on the health risks associated with repeated WAG exposure, specifically focusing on genetic, immunotoxic, and reproductive health impacts. By synthesizing available data, this review seeks to better understand the extent of these risks and identify key gaps in the literature that require further exploration.
2 Methodology: This scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Statement. Three online databases were used to identify papers published between 1990 and 2024. Thirty-one observational studies that focused on various side effects of occupational exposure to WAGs were included for review.
3 Results: Of the 385 articles initially identified, 31 met the inclusion criteria. The majority of the studies used a cross-sectional design. The findings revealed genetic damage, including increased DNA instability, in healthcare workers exposed to WAGs. Several studies also reported heightened oxidative stress and antioxidant deficiency among exposed individuals, with some inconsistencies across studies. Concerns about reproductive health, including sperm motility and DNA fragmentation were also identified.
4. Discussion/Conclusions: The findings highlight the need for further research to investigate the long-term health consequences, especially for perfusionists, who are often overlooked in studies of WAG exposure. Future research should prioritize longitudinal studies and evaluate the efficacy of safety measures to reduce exposure, aiming to improve health outcomes and workplace safety for exposed healthcare workers.
Keywords: Waste Anesthetic Gases, Isoflurane, adverse health effects, negative health impact, DNA instability, genetic damage, cytotoxicity, oxidative stress, antioxidant deficiency, immunotoxicity, hepatotoxicity, neuroendocrine effects, reproductive impact
Investigating the use of indole compounds as potential therapeutics for the treatment of necrotizing enterocolitis
No full textNecrotizing enterocolitis (NEC) is a gastrointestinal inflammatory disease that primarily affects premature infants. In NEC, bacterial factors are thought to elicit an excessive immune system response.This robust inflammatory response leads to excessive apoptosis of the epithelial cells comprising the barrier between the lumen of the gastrointestinal tract and the underlying tissue allowing for bacterial invasion of the underlying tissue, leading to ischemia, necrosis, and potentially sepsis and death. Activation of the aryl hydrocarbon receptor (AhR), an immune system modulator, has been shown to be preventative against the pathogenesis of NEC in a murine model. However, no research has been conducted on the potential benefits of AhR activation following pathogenesis. We focused on the effects of AhR activation following pathogenesis within a model system: rat small-intestinal epithelial cells treated with lipopolysaccharide (LPS), a bacterial endotoxin implicated in NEC. RT-PCR revealed a decrease in AhR expression following LPS treatment. MTT assays indicated that treatment of the cells within our model with I3C rescued cytotoxicity. Surprisingly, scratch assays revealed a decrease in wound healing ability in the LPS + I3C treatment group, while no differences were observed with either treatment alone. Our recent work involving AhR ligand indole propionic acid (IPA) does not suggest a similar amelioration of LPS-induced cytotoxicity. Overall, our research indicates that I3C treatment, and potentially AhR activation, rescues LPS-induced cytotoxicity but not wound-healing ability
Questioning the effectiveness of environmental policy implementation related to ocean pollution.
No full textThe Influence of Giovanni Gabrieli on the Music of Heinrich Schütz
No full textTeachers often have a profound influence on their students. The influence of Giovanni Gabrieli on the music of his student Heinrich Schütz is particularly evident: Gabrieli and Schütz’s pieces are so similar that a listener may observe parallels even without the use of scores. The use of specific melodic and rhythmic patterns during cadences and the use of echoing phrases by both composers strongly suggest a musical link between them. There is currently no detailed theoretical analysis comparing specific elements found in the music of both Schutz and Gabrieli. My research aims to remedy this gap in knowledge by examining selected pieces for shared elements that connect the music of the two composers. I have endeavored through theoretical analysis to find specific melodic, harmonic, or rhythmic elements that are found frequently in the music of both Gabrieli and Schutz
Sincerely Yours: A Therapeutic Writing Approach to Grief
No full textGrief is a response to a traumatic event, which can include loss, abandonment, abuse, suicide, or any other experience that affects an individual emotionally or physically. Too few evidence-based interventions acknowledge the unique and individualized experiences of grief (Stroebe, 2017). Writing can help individuals explore the depths of their grief and traumatic experiences (Larsen, 2022). This project explores different writing interventions that have been used for coping strategies. Then, it proposes a therapeutic writing tool that can account for individual differences in grief and describe considerations for its application in clinical and non-clinical settings. The online letter-writing program, “Sincerely Yours,” could help participants address their grief by writing a letter to anyone of their choosing. It’s hypothesized that the intervention will yield therapeutic benefits such as self-disclosure, exposure to unresolved feelings and conflicts, and overall grief processing
Little Women Dramaturgical Research Packet
No full textThis will be an oral presentation reviewing a student\u27s dramaturgical research for Lipscomb University Theatre\u27s production of Little Women, including research collected, personal connection to the research, and production photos from the performances
Visualizing Religion in American Culture: Comics as Tools for Deep Learning in the Lipscomb LIFE Program
No full textThis session explores how visual learning is used in the course Religion in American Culture (HI 4013), part of the Lipscomb Initiative for Education (LIFE) Program, which provides higher education for incarcerated students. The program follows the Inside-Out model, bringing together Lipscomb University students and incarcerated students in a shared learning space. Instead of a traditional research project, this session highlights how the LIFE Program creates a unique learning community where all students engage deeply with course topics. A panel of students and professors will share how the class\u27s creative assignment—drawing comics to illustrate key themes from each course unit—puts students in charge of their own learning. The assignment encourages students to critique religious movements, social and cultural contexts, and historical arguments through art. By combining content knowledge with creative risks, the project helps students think critically and strengthen their understanding of course material. The panel will also discuss how the collaborative classroom environment fostered peer learning and showed how the Inside-Out model can promote dialogue, empathy, and equal access to education
Investigation of Aldehyde Oxidase Inhibition by Clopidogrel and its Thiol Metabolite
No full textAldehyde oxidase (AO) is an enzyme that metabolizes drugs containing aromatic azaheterocycles. Small thiol-containing molecules have been reported to inactivate AO. Clopidogrel is an antiplatelet agent used to treat cardiovascular diseases. Clopidogrel is a prodrug that is bioactivated in vivo by cytochrome P450 enzymes CYP3A4 and CYP2C19 into a thiol metabolite. Our research aims to explore whether the clopidogrel thiol metabolite can inhibit AO, leading to potential drug-drug interactions when co-administered with other drugs that are metabolized by AO. In order to determine whether the prodrug clopidogrel and/or its thiol metabolite inhibit AO, O6-benzylguanine (AO substrate) was incubated with human liver S9 (AO and cytochrome P450 enzyme source) in the presence and absence of clopidogrel or the clopidogrel thiol metabolite. AO activity was then determined by measuring formation of 8-oxo-benzylguanine via LC-MS/MS. An unknown concentration (≤ 250 uM) of the thiol metabolite produced 50-65% inhibition of AO activity, whereas 50 uM clopidogrel produced only 15-20% inhibition, regardless of the presence of NADPH (co-factor required for cytochrome P450-mediated conversion of clopidogrel to the thiol metabolite). In addition, the AO inhibition observed in the presence of the thiol metabolite was concentration-dependent. These preliminary studies indicate that the thiol metabolite of clopidogrel may inhibit AO, but additional experiments are required to confirm these data. Importantly, the clinical relevance of these findings will be highly dependent on the concentrations of thiol metabolite achieved in patients treated with clopidogrel relative to the concentrations required to inhibit AO
Importance of Sustainability within Children’s Hospitals
No full textAuthor: Ashley Newby
Presentation Type: Poster
Faculty Mentor: G. Dodd Galbreath
Discipline: Sustainability and Pediatric Nursing
Importance of Sustainability within Children’s Hospitals
Sustainability is an important aspect of every environment that one encounters. For pediatric patients entering a children’s hospital, it is probably not something that is important and at the top of their list when looking for healthcare. However, sustainable children’s hospitals have not only their patients as their first priority, but they also take the earth into account. Some might not realize that they are walking into a sustainable children’s hospital unless someone tells them.
Topics include:
-Look at the importance of sustainable children’s hospitals
-Dive in to see how sustainability is used in healthcare
-See how sustainability and healthcare can go hand-in-han