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Temperature-Dependent Regulation and Mitochondrial Targeting of the Cytochrome c Oxidase Subunit LmCOX4 in Leishmania
No full textThe Loss of Serotonin 2A Receptor (5-HT2AR) Activity Contributes to Aging Phenotypes and Ferroptotic Pressures in the Retinal Pigmented Epithelium (RPE)
No full textPP2A B\u27 subunit regulates synaptic development and cognition – A fly model to study intellectual disability (ID).
No full textBromelain-Based Enzymatic Debridement of a Third-Degree Burn to Skin-Grafted Bowel
No full textBurn injuries over previously grafted tissue present a formidable challenge for excision and debridement, particularly when there are critical underlying structures such as bowel. Enzymatic debridement with the recently approved anacaulase-bcdb, a bromelain-based enzymatic debridement gel (Nexobrid), presents an additional method of burn excision that may be useful in such a situation. This brief report presents the management of a complex third-degree burn over a remotely skin-grafted bowel mass using anacaulase-bcdb gel. This report is written with documented patient consent and approval by the Human Research Protection Program office in compliance with institutional policy. A 52-year-old man presented to our level I burn center with a third-degree 3% total body surface area contact burn to a remotely skin-grafted bowel mass. The patient was admitted with the decision to proceed with anacaulase-bcdb debridement of his wound to minimize the risk of compromising his underlying bowel. The patient underwent the debridement without any sign of succus emanating from the wound. Post-debridement, he was transitioned to a negative pressure wound dressing and discharged home. He continued receiving wound care at clinic follow-ups and eventually underwent complex open ventral hernia repair. This brief report provides a safe alternative to operative excision of wounds with underlying critical structures
Establishment of an inferior vena cava filter retrieval program: the effect on trauma and non-trauma patient populations
No full textPURPOSE: This study aimed to compare the effect of establishing an inferior vena cava filter (IVCF) retrieval program (IVCFRP) on the IVCF retrieval rates in trauma and non-trauma patients. METHODS: This was an institutional review board-approved retrospective study. IVCF retrieval in trauma and non-trauma patients was compared before and after the establishment of an IVCFRP in a single Level I Trauma Center. The IVCFRP at our institution was established in April 2020. All patients who underwent IVCF placement between January 2016 and March 2020 were compared with patients who had an IVCF placed between April 2020 and June 2024. A medical record review included the collection of demographic information, indication for IVCF insertion and retrieval, date of IVCF insertion and retrieval, IVCF retrieval rate, clinical outcomes, and complications. The patients were stratified into trauma and non-trauma groups. Univariate analyses were performed with a P value of \u3c 0.05 considered statistically significant. RESULTS: A total of 164 patients underwent IVCF placement between January 2016 and June 2024. Fifty-two IVCFs were implanted before and 112 after the establishment of the IVCFRP. The overall rate of IVCF retrieval was significantly higher following the establishment of an IVCFRP (33.3% vs. 51%, P = 0.047). In non-trauma patients, the retrieval rate was significantly higher after the establishment of an IVCFRP (37.5% vs. 61.3%, P = 0.03). The retrieval rate in trauma patients (22.2% vs. 21.4%) was not significantly changed by the establishment of an IVCFRP. Clinical outcomes and complications were similar between groups. CONCLUSION: IVCF retrieval rates significantly improved after the establishment of an IVCFRP. This increase in IVCF retrieval rate was driven by an increase in filter retrievals in the non-trauma patient population. The rate of IVCF retrieval in trauma patients was not affected by the implementation of an IVCFRP. Special considerations and changes in practice may need to be established to improve IVCF retrieval rates in trauma patients. CLINICAL SIGNIFICANCE: Implementation of a structured IVCFRP significantly improved retrieval rates in non-trauma patients but did not yield similar results in trauma patients, highlighting the need for alternative strategies in this population
A global overview of anatomical science education and its present and future role in biomedical curricula
No full textThe four main anatomical sciences, gross anatomy, histology, neuroanatomy, and embryology, are fundamental subjects for most health professionals and biomedical students. Usually taught as part of preclinical basic science training, the anatomical sciences provide a structural understanding of human or animal bodies at both macroscopic and microscopic levels. This overview characterizes how the anatomical sciences are currently taught around the globe, highlighting similarities, differences, and recent curricular transformations that were partially in response to the COVID-19 pandemic. Globally, educators of the anatomical sciences navigate similar pressures, including expectations of curricular integration and reduced time for anatomical teaching. Student-centered teaching approaches and e-learning technologies have been adopted across many regions, transforming how educators engage their learners. However, not all educators are provided with technological resources to facilitate such educational advancements, particularly in regions where economic inequality and poor infrastructure hinder access to the internet. Though ethical standards guiding the procurement of human bodies have evolved over time, the sources of human bodies that academic institutions use for anatomy education vary widely. Specific regional issues complicate many aspects of anatomical science education, challenging educators to adopt novel teaching approaches. Despite some differences, every global region appears to be moving in a similar direction. However, where academic institutions fall on that trajectory differs for specific regions/countries. How these educational and technological changes influence anatomy education should be carefully considered for the strengths and weaknesses they provide and the opportunities and threats they bring. (Figure presented.)
Proteomic analysis of cingulate cortex systems regulated by mifepristone in the context of alcohol dependence
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