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Spinal Cord Stimulation for Low Back Pain: A Systematic Review
No full textPurpose of Review: Chronic low back pain (LBP) is a prevalent and debilitating condition affecting millions worldwide. Among emerging interventions, spinal cord stimulation (SCS) has gained attention as a potential alternative for managing chronic LBP, particularly when alternative approaches fail to provide adequate relief. Recent Findings: This systematic review focuses on both residual pain levels and ability to perform daily tasks after treatment with SCS. The present investigation includes a systematic search for studies from PubMed, Google Scholar, and Cochrane, and Embase. Sources were eligible for inclusion in the review if they were published from 2010 to present (May 1, 2024). 8 studies involving a total of 1,172 patients were evaluated. Summary: This systematic review demonstrated that SCS is superior to conventional medical management (CMM) for both short and long-term pain relief, functionality, psychological well-being, and opioid dependency. Furthermore, newer SCS approaches, such as high frequency (HF), differential target multiplexed (DTM), and multiphase SCS all demonstrated improved efficacy over traditional SCS for pain relief and functionality scores. Adverse event rates for all trials were low and represent the safety of SCS treatments. The present investigation provides insight into the capabilities of both traditional SCS and HF SCS, DTM SCS, and multiphase SCS as compared to baseline pain and functionality as well as conventional medical management (CMM). This review grants physicians a broader picture of the applicability of SCS, its safety profile, and the opportunities it offers for pain reduction and functionality over CMM
SAME DAY DISCHARGE OF OPEN AND MINIMALLY INVASIVE RENAL SURGERY IS FEASIBLE AND SAFE.
No full text25th annual meeting of the SUO; December 4 - 6, 2024; Dallas, T
Safety and preliminary efficacy of ivaltinostat, an HDAC inhibitor, plus capecitabine in patients with pretreated metastatic pancreatic adenocarcinoma (mPDAC): Results of a phase Ib study.
No full text2025 ASCO Genitourinary Cancers Symposium; January 23 - 25, 2025; San Francisco, C
Female patients report comparable results to males after the implantation of an aragonite-based scaffold for the treatment of knee chondral and osteochondral defects: a gender-based analysis of a RCT at 4 years\u27 follow-up.
Get PDFA Retrospective Cohort Study of Tranexamic Acid Administration for the Treatment of Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in the Emergency Department.
No full textA Practical Guide to Behavioral Treatment for Children with Disorders of Gut-Brain Interaction
No full textHeart Failure in Black Populations: Epidemiology, Pathophysiology, and Treatment Disparities
Get PDFHeart failure (HF) remains a significant health challenge globally, placing a heavy burden on individuals, families, and healthcare systems. The prevalence of HF continues to rise, posing substantial public health concerns. This burden is particularly pronounced among the Black Population, who face higher prevalence, earlier onset, and greater severity of HF compared to other racial and ethnic groups. This review explores the multifaceted landscape of HF in Black individuals by examining epidemiological patterns, pathophysiological mechanisms, clinical presentations, treatment disparities, and clinical outcomes. Black individuals exhibit distinct pathophysiological characteristics, such as genetic variations contributing to heightened susceptibility and severity of HF. Social determinants of health, including socioeconomic status, education, and healthcare access, further exacerbate these disparities. Despite advancements in medical science, Black individuals receive less optimal HF care, reflected in lower rates of guideline-directed medical therapy and cardiac rehabilitation. Addressing these disparities requires targeted interventions and a holistic approach that emphasizes social determinants of health, improved healthcare access, and health equity. This review synthesizes existing literature to illuminate the unique challenges faced by Black HF patients and advocates for evidence-based strategies to enhance management and outcomes, aiming to reduce disparities and improve the well-being of this vulnerable population
Informatics Approach Towards Targeting HTR1B Pathways in Neuropharmacology for Migraine Treatment
No full textINTRODUCTION: Migraine is a prevalent and debilitating neurological disorder, with current therapies often being ineffective and causing side effects. Recent studies in neuropharmacology present the serotonin 1B receptor (HTR1B) as a viable avenue of migraine treatment since it influences pain and vasoconstriction. METHODS: This research broadly uses computational approaches to explain the 5-hydroxytryptamine receptor 1B (HTR1B) pathways in neuropharmacology for migraine treatment. Text mining results reveal 25 essential genes, and network pharmacology provides complex mechanisms among genes and proteins, revealing a sophisticated network consisting of 41 nodes and 361 edges. The protein structure and function were elucidated through high-resolution protein modeling and validation, yielding significant new information. The structure has a resolution of 2.05 Å and a C-score of 0.30. The virtual screening explored the best ligands, which had binding affinities ranging from -13.8 to -9.6 kcal/mol from a set of 25 molecules. Docking results indicated that FDA-approved ligands showed high binding affinities, ranging from -11.4 to -12.5 kcal/mol among other natural and synthetic libraries. The pharmacokinetic profiles of the potential drugs showed significant diversity in their solubility and lipophilicity qualities (F(2,6) = 15.13, p = 0.004), suggesting different levels of safety and efficacy. MD simulation clarified the dynamic interactions between the protein and ligand at 100ns. RESULTS: The RMSD values were stable within the 6.0-7.5 Å range, indicating a consistent structure. RMSF values revealed areas of flexibility in the protein. The toxicity risk assessment of Xaliproden indicated modest risks. CONCLUSION: This study provides a foundation for targeted HTR1B-based migraine therapies and highlights the value of informatics tools in accelerating drug discovery in neuropharmacology
Trichosporon asahii and Candida guilliermondii as a Source of Orbital Infection in an Immunocompromised Individual
Get PDFA 47-year-old male with a history of immunosuppression and recent intensive care unit admission presented with progressive orbital swelling and pain. Blood cultures grew Trichosporon asahii and Candida guilliermondii, with matching positive cultures from peripheral and central venous samples. Given his fungemia and worsening orbital involvement, induction therapy with amphotericin B and isavuconazole was initiated. Within weeks, clinical improvement was noted, prompting a transition to long-term consolidation therapy with oral posaconazole and isavuconazole. At follow-up, the patient demonstrated sustained clinical stability with no recurrence of infection. Orbital involvement from fungemia due to T. asahii and C. guilliermondii is rare, and management requires early recognition, aggressive antifungal therapy, and careful monitoring