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O populismo literário (nota sobre Alfredo Bosi)
No full textA obra de Alfredo Bosi articula crítica literária, pensamento político e História. História concisa da Literatura Brasileira (1970) analisa romances do século XX brasileiro segundo a relação do herói com o mundo, criticando especialmente “romances proletários” de Jorge Amado. Para o crítico, Amado cria narrativas de “tensão mínima”, atribuindo atitudes românticas às personagens e lhes agregando matizes políticos, com histórias próximas do pitoresco e de um “populismo literário”. Em escritos posteriores, com o desafio do neoliberalismo, Bosi lida com o conceito de “resistência” e com o mal-estar das personagens perante a instabilidade social. Diante do resgate do nacionalismo neofascista no século XXI, é possível reavaliar a capacidade de o romancista narrar conflitos de classe e raça (mesmo estereotipados) que tinham lugar na época da “pseudoindustrialização”
Analyzing the CBF through the report ‘Coisas Extravagantes’ published in Revista Piauí
No full textEste artigo tem como objetivo analisar a reportagem ‘Coisas Extravagantes\u27, feita por Allan de Abreu e publicada pela Revista Piauí em abril de 2025, sob olhar dos critérios de noticiabilidade e valores-notícia propostos por Traquina. A partir disso, busca-se compreender as estruturas de funcionamento da Confederação Brasileira de Futebol e, também, o papel atual do jornalismo investigativo, em especial dentro da editoria de esporte. Como base, foi realizada uma pesquisa para mostrar como as relações entre cartolas e jornalistas ocorreram e ainda ocorrem durante a evolução do jornalismo esportivo, entendendo o impacto de diferentes fatores nesta relação e seu estado atual. Para isso, foram usadas publicações recentes sobre o tema e que tratavam de assuntos importantes para este artigo, como a cobertura dentro da CBF. Outra referência foi a dissertação O ‘Cartola’ e o Jornalista, considerada uma das pioneiras sobre jornalismo esportivo no Brasil e que continua sendo relevante, inclusive nos dias de hoje. Por fim, o próprio Allan de Abreu concedeu uma entrevista para contar sobre os processos que envolveram a publicação da reportagem.This article aims to analyze the report "Coisas Extravagantes", written by Allan de Abreu and published by Revista Piauí in April 2025, through the lens of the criteria of newsworthiness and news values proposed by Traquina. Based on this analysis, the goal is to understand the operational structures of the Confederação Brasileira de Futebol (CBF), as well as the current role of investigative journalism, particularly within the sports section. As a foundation, the research was conducted to show how the relationships between football executives and journalists have developed and still occur throughout the evolution of sports journalism, taking into account the impact of different factors on this relationship and its current state. Recent publications on the topic, particularly those addressing coverage of the CBF, were used as references. Another key source was the dissertation The ‘Cartola’ and the Journalist, considered one of the pioneering works on sports journalism in Brazil, and which remains relevant even today. Finally, Allan de Abreu himself gave an interview to share insights into the processes behind the publication of the report
Brazilian and original Globoplay series: territories and margins of the drama genre
No full textThe aim of this text is to carry out a narratological analysis of the fictional production of Brazilian Globoplay original series (2015-24), selecting works within the drama genre and examining their thematic clusters and aesthetic conventions. From a theoretical-methodological standpoint, the paper seeks to characterize and define these categories within the audiovisual context of SVoD streaming platforms and through the conceptual perspective of cultural and theoretical studies of television and film. More specifically, it analyzes the series Onde está meu coração (2021) and Os outros (2023-24).O objetivo deste texto é realizar uma análise narratológica da produção ficcional das séries brasileiras e originais Globoplay (2015-24), com seleção de obras de gênero drama, observando suas derivações por núcleos temáticos e convenções estéticas. O texto se propõe a, do ponto de vista teórico-metodológico, caracterizar e definir tais categorias no contexto audiovisual das plataformas de streaming SVoD e sob a perspectiva conceitual dos estudos culturais e teóricos de televisão e cinema. De modo mais específico, serão analisadas as séries Onde está meu coração (2021) e Os outros (2023-24)
Drogas y pornografía: análisis comparativo del consumocompulsivo y el trastorno por uso de sustancias
No full textObjetivo: este artículo pretende analizar los síntomas y efectos del consumo compulsivode pornografía a través de una revisión sistemática, comparándolos con otras adicciones,especialmente al alcohol y otras sustancias. Metodología: en cuanto al procedimientometodológico, se realizó una revisión sistemática utilizando dos portales de salud. Los criteriosde inclusión fueron: individuos consumidores de alcohol u otras drogas e individuos con consumo compulsivo de pornografía, en portugués o inglés. Resultados: fueron identificados 632 artículos y después de aplicar los criterios de inclusión y exclusión, 14 artículos fueron seleccionados para análisis. Los datos fueron procesados por un software de análisis textual, que clasificó los artículos en nueve grupos distintos basados en la similitud léxica. Conclusión: los resultados mostraron un predominio de estudios sobre la personalidad y el comportamiento de los individuos con adicción, centrándose en el diagnóstico, los efectos conductuales y los impactos cerebrales del consumo compulsivo de pornografía.Objetivo: o presente artigo tem por objetivo analisar ossintomas e efeitos do consumo compulsivo de pornografiapor meio de uma revisão sistemática, comparando-os comoutros vícios, especialmente com os transtornos por usoabusivo de álcool e outras substâncias. Metodologia: emtermos de procedimento metodológico, foi realizada umarevisão sistemática a partir de dois portais de saúde. Oscritérios de inclusão foram: indivíduos usuários de álcoolou outras drogas e indivíduos com consumo compulsivo depornografia, no idioma português ou inglês. Resultados:foram identificados 632 artigos e, após a aplicaçãodos critérios de inclusão e exclusão, 14 artigos foramselecionados para análise. Os dados foram processados porum software de análises textuais, que classificou os artigosem nove grupos distintos com base na similaridade lexical.Conclusão: os resultados evidenciaram uma predominânciade estudos sobre a personalidade e o comportamento deindivíduos com dependência, com foco no diagnóstico,nos efeitos comportamentais e nos impactos cerebrais doconsumo compulsivo de pornografia.Objective: this article aims to analyze the symptoms and effects of compulsive pornographyconsumption through a systematic review, comparing them with other addictions, particularlyalcohol and substance use disorders. Methodology: a systematic review was conducted usingtwo health databases. Inclusion criteria encompassed individuals with alcohol or other drug use disorders and individuals with compulsive pornography consumption, with studies published in Portuguese or English. Results: of 632 articles identified, 14 met the inclusion and exclusion criteria and were selected for analysis. Data were processed using textual analysis software, which classified the articles into nine distinct groups based on lexical similarity. Conclusion: the findings revealed a predominance of studies examining personality traits and behavioral patterns in individuals with addiction, with particular emphasis on diagnosis, behavioral effects, and neurological impacts of compulsive pornography consumption
Il Comunista de Guido Morselli e a Crise das Utopias
No full textEste artigo examina Il comunista (1964), de Guido Morselli, discutindo como a rotina parlamentar funciona como laboratório da erosão de sentido. O foco recai sobre Walter Ferranini, que, alheio ao debate, converte a observação de um outro parlamentar em gatilho de uma deriva introspectiva e de crescente ceticismo em relação a disciplina partida ria e a capacidade representativa das instituições. Argumento que o percurso do protagonista culmina numa experiência de desaparição de sentido (“signifying nothing”), próxima da voz monologante de Dissipatio H.G., mas produzida aqui por condições históricas e políticas específicas. Ao contrapor a crise historicizada de Il comunista a evacuação alegórica de Dissipatio, o artigo busca evidenciar duas modalidades morsellianas de estranhamento. O romance, assim, reconfigura o realismo político ao converter gestos banais em indício da falência da mediação institucional
Maqui berry cystatin inhibits cathepsin k activity and stimulates osteogenic differentiation of human dental pulp cells
No full textObjectives Cystatins, endogenous inhibitors of cysteine proteases, regulate extracellular matrix degradation. Their plant-derived homologs (phytocystatins) include MaquiCPI-3, a recombinant protein obtained from Aristotelia chilensis (maqui berry). This study aimed to investigate the inhibitory effect of MaquiCPI-3 on human cathepsin K (CTSK) activity and its cytotoxicity and impact on the proliferation, migration, and osteogenic differentiation of human dental pulp cells (hDPCs). Methodology The inhibitory activity of MaquiCPI-3 against CTSK was measured using a spectrofluorometer with the fluorogenic substrate Z-Phe-Arg-AMC. The hDPCs from third molars were characterized by flow cytometry for mesenchymal (CD90, CD73, CD105) and hematopoietic (CD34, CD45) markers. The hDPCs, either exposed to MaquiCPI-3 or left untreated (control), were assessed for viability (MTT assay), proliferation (bromodeoxyuridine incorporation), chemotaxis (Transwell assay), mineralized nodule formation (Alizarin Red S staining), alkaline phosphatase activity (thymolphthalein release), and expression of mineralization-related genes (qPCR). Data were analyzed using one- or two-way ANOVA with appropriate post hoc tests or nonparametric alternatives (α=0.05). Results MaquiCPI-3 potently inhibited CTSK (Ki=1.72 nM, Ki,app=2.08 nM), showed no cytotoxicity, and significantly enhanced ALP activity, mineralized nodule formation, and expression of BMP-2 and osteocalcin, stimulating no hDPC proliferation or migration when compared with the control. Conclusions MaquiCPI-3 increased no cell proliferation or migration, its ability to inhibit CTSK activity and induce an osteogenic phenotype shows promising potential therapeutic strategies aimed at repairing and regenerating pulp and periapical tissues and controlling bone resorption
Integrated analysis identifies CCNA2 as a candidate diagnostic and prognostic biomarker in oral tongue squamous cell carcinoma
No full textBackground Oral tongue squamous cell carcinoma (OTSCC) is an aggressive malignancy with poor prognosis, necessitating reliable biomarkers. Methodology Genes with significantly higher expression in OTSCC tumor tissues compared to normal tongue tissues were identified via integrated transcriptomic analysis of seven GEO datasets. To assess their diagnostic and prognostic potential, these genes were further characterized using multi-omic and clinical data from the TCGA-OTSCC and CPTAC-OTSCC cohorts. Results A total of 1,117 genes were found to be upregulated in OTSCC tissues, among which only CCNA2 (Cyclin A2) was significantly associated with both reduced overall survival (OS) and disease-free survival (DFS) in the TCGA-OTSCC cohort (n=128), based on Cox proportional hazards regression and Kaplan–Meier analyses. CCNA2 showed moderate prognostic performance (AUC=0.63 for OS; AUC=0.65 for DFS) and was significantly upregulated in higher-grade tumors (p=0.01) and in deceased patients (p=0.03). No somatic mutations or promoter methylation alterations were observed in CCNA2 based on TCGA data. In CPTAC-OTSCC samples (n=18), CCNA2 protein expression was significantly higher in tumor tissues than in non-tumoral tissues (p <0.0001), with a positive correlation between mRNA and protein levels (r=0.56, p=0.01). Both mRNA and protein forms showed strong diagnostic performance (AUC=0.92 and AUC=0.82, respectively), consistent with observations across multiple tumor types. While CCNA2 protein levels showed prognostic relevance for OS (AUC=0.69, p=0.01), the mRNA-based prediction did not reach statistical significance (AUC=0.63, p=0.36). Functional enrichment analysis of CCNA2 co-expressed genes predicted involvement in cell cycle, mismatch repair, and DNA replication pathways. Additionally, protein–protein interaction analysis positioned CCNA2 as a central hub, suggesting its potential role in OTSCC pathogenesis. Conclusions These findings indicate that CCNA2 is a promising diagnostic and prognostic biomarker candidate in OTSCC. Given the small size of the CPTAC validation cohort, further studies in larger, independent OTSCC cohorts are warranted to confirm its clinical utility
Saliva liquid biopsy: MMP2, MMP9, and TIMP2 as potential diagnostic biomarkers in oral squamous cell carcinoma. An observational case-control study
No full textOral squamous cell carcinoma (OSCC) is the most common malignant neoplasm in the oral cavity, characterized by high morbidity and mortality. Various proteins, including matrix metalloproteinases (MMPs), have been investigated as potential biomarkers for diagnosing and prognosing this disease. Objective: To evaluate the utility of MMP-2, MMP-9, and the tissue inhibitor of metalloproteinase-2 (TIMP-2) as biomarkers in diagnosing and prognosing OSCC. Methodology: This retrospective case-control study involved 60 cases and 30 controls from the University Hospital Fundación Santa Fe de Bogotá, part of the Colombian cohort of the InterChange/Headspace study. Saliva samples were collected using a 60-second mouth rinse with 10 mL of sterile saline solution, along with serum and oral tissue samples and clinical and sociodemographic data. MMP-9, MMP-2, and TIMP-2 concentrations in saliva were determined using ELISA, whereas tissue samples were analyzed by immunohistochemistry. MMP activity in saliva was quantified using a generic activity assay. Results: Salivary MMP-9 and MMP-2 concentrations were significantly higher in cases than in controls, whereas no significant differences were observed for TIMP-2. ROC curve analysis showed excellent discriminatory capacity for salivary MMP-9 (AUC=0.946; sensitivity=0.817; specificity=0.867), good performance for MMP-2 (AUC=0.708; sensitivity=0.717; specificity=0.633), and lower discriminatory ability for TIMP-2 (AUC=0.630; sensitivity = 0.617; specificity=0.500). Elevated MMP-9 concentrations were observed in 33% of the serological samples. The immunohistochemistry of MMP-2, MMP-9, and TIMP-2 showed differences between cases and controls. Conclusions: This study highlights salivary MMP-9 and MMP-2, together with MMP activity, as biomarkers of interest for OSCC that may contribute to the understanding of disease-related molecular changes detectable by liquid biopsy. While elevated salivary levels were observed in OSCC cases when compared to controls, these findings should be interpreted as exploratory. Elevated serological MMP-9 levels were observed in a small subset of cases. However, the limited sample size and the absence of a control group in this study preclude diagnostic interpretation. Larger, well-powered, and externally validated studies are required to determine the potential clinical utility of these biomarkers
Bat (Chiroptera, Mammalia) assemblages from three fragments in the threatened Pernambuco Endemism Center, northeastern Brazil
No full textFive centers of endemism are recognized in The Brazilian Atlantic Forest, including the Pernambuco center (PCE), which is located at the northern, and most impacted extreme of the biome, whose biodiversity is still relatively poorly-known. Using mist nets, we surveyed the bat assemblages of three privately-owned protected areas in the Brazilian state of Alagoas, located within the Pernambuco Centre of Endemism. The fragment areas ranged from 41 to 458 hectares. We compared the species composition, richness, and diversity of bat species among the areas. A total of 266 bats were captured, representing 21 species in five families, although 96% of the individuals captured belonged to species of the family Phyllostomidae. Six trophic guilds were recorded in the study. The highest species richness (14) and diversity were recorded at Madeira and Mata do Capiatã, although similarity was low among the assemblages of the three sites. The results of the study indicate that even small fragments of Atlantic Forest may support a considerable diversity of bats, especially at a landscape scale, and are thus vitally important for the maintenance of the ecosystem services provided by these mammals. Future research should adopt more comprehensive sampling methods, such as combining mist-nets with acoustic monitoring, to better represent the full spectrum of chiropteran diversity, particularly aerial insectivores.Five centers of endemism are recognized in The Brazilian Atlantic Forest, including the Pernambuco center (PCE), which is located at the northern, and most impacted extreme of the biome, whose biodiversity is still relatively poorly-known. Using mist nets, we surveyed the bat assemblages of three privately-owned protected areas in the Brazilian state of Alagoas, located within the Pernambuco Centre of Endemism. The fragment areas ranged from 41 to 458 hectares. We compared the species composition, richness, and diversity of bat species among the areas. A total of 266 bats were captured, representing 21 species in five families, although 96% of the individuals captured belonged to species of the family Phyllostomidae. Six trophic guilds were recorded in the study. The highest species richness (14) and diversity were recorded at Madeira and Mata do Capiatã, although similarity was low among the assemblages of the three sites. The results of the study indicate that even small fragments of Atlantic Forest may support a considerable diversity of bats, especially at a landscape scale, and are thus vitally important for the maintenance of the ecosystem services provided by these mammals. Future research should adopt more comprehensive sampling methods, such as combining mist-nets with acoustic monitoring, to better represent the full spectrum of chiropteran diversity, particularly aerial insectivores