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Superiority of high sensitivity cardiac troponin I over NT-proBNP and adiponectin for 7-year mortality in stable patients receiving haemodialysis
Full text link福井大学博士(医学)2024doctoral thesi
An extension lecture of mathematics based on mathematical games, the report of “Become a master of the game!” in Fumufumu R4 and R5
Full text link本稿は，福井大学公開講座「体験ふむふむ数学クラブ」の実践報告である。この講座では，一般の社会人や中高生を対象に，グループによる体験的活動を通して数学を楽しみながら学んでもらうことを目的としている。本稿では，令和４年度と５年度に実施した，数理的なゲームを題材にした公開講座の事例を報告し，その教材化について考察する。departmental bulletin pape
Autonomous Teleoperated Robotic Arm Based on Imitation Learning Using Instance Segmentation and Haptics Information
Full text linkTeleoperated robots are attracting attention as a solution to the pressing labor shortage. To reduce the burden on the operators of teleoperated robots and improve manpower efficiency, research is underway to make these robots more autonomous. However, end-to-end imitation learning models that directly map camera images to actions are vulnerable to changes in image background and lighting conditions. To improve robustness against these changes, we modified the learning model to handle segmented images where only the arm and the object are preserved. The task success rate for the demonstration data and the environment with different backgrounds was 0.0% for the model with the raw image input and 66.0% for the proposed model with segmented image input, with the latter having achieved a significant improvement. However, the grasping force of this model was stronger than that during the demonstration. Accordingly, we added haptics information to the observation input of the model. Experimental results show that this can reduce the grasping force.journal articl
Synergistic inhibition of autophagic flux and induction of apoptosis in cervical cancer cells by Mito-TEMPO and hyperthermia
Full text linkBackground: Hyperthermia (HT), while a cancer treatment approach, isn’t always effective alone.
Therefore, identifying hyperthermiaenhancers is crucial. We demonstrated that Mito-TEMPO
([2-[(1-Hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) amino]-2-oxoethyl]-triphenylphosphanium,
MT) acts as a potent thermosensitizer, promoting cell death in human cervical cancer (HeLa) cells.
Methods: Cells were pretreated with 0.4 mM MT for 5 minutes, followed by exposure to hyperthermia
(42 °C for 60 minutes). The impacts of MT/HT on cell viability, proliferation,
apoptosis, endoplasmic reticulum (ER) stress, apoptosis-related proteins andautophagy,
autophagy-related proteins expression were measured. The relationships between autophagy
and apoptosis were further investigated using the specific autophagy inhibitor chloroquine (CQ)
and the autophagy inducer rapamycin (Rapa).
Results: The combined treatment reduced the mitochondrial membrane potential (MMP) and
increased ROS production. It also upregulated the pro-apoptotic protein Bax and downregulated
anti-apoptotic proteins such as Bcl-2 and MCL-1. As a result, Caspase-3was activated.
Additionally, the combined treatment upregulated the expression of p-PERK/PERK, ATF-4,
CHOP proteins. Moreover,the combined treatment also increased the expression of LC3 II
and p62, decreased expression of LAMP 1 and Cathepsin D andincreased lysosomal pH,
indicating coordinated changes in autophagy regulation. Notably, intensification of apoptosis
induced by the combined treatment was observed with CQ, whereas attenuation was seen with Rapa.
Conclusions: MT effectively enhanced HT-induced apoptosis in HeLa cells. Elevated ER stress
and interruption of autophagy flux arethe possible underlying molecular mechanisms for this
phenomenon. These findings suggested MT can act as a potentialthermosensitizer, highlighting
its versatility in cancer treatment strategies.journal articl
Glycemic Control after Initiation of Anti-VEGF Treatment for Diabetic Macular Edema
Full text link福井大学博士(医学)2024doctoral thesi
Dexamethasone is non-inferior to antihistamine plus dexamethasone premedication in preventing ramucirumab plus nab-paclitaxel infusion-related reactions in gastric cancer: a multicenter retrospective study
Full text link福井大学博士(医学)2024doctoral thesi
Expression of functionally glycosylated PSGL-1 in ALK-positive anaplastic large cell lymphoma
Full text link福井大学博士(医学)2025doctoral thesi
