Central Asian Journal of Medical and Natural Science
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Assessment of Biological and Anti-Cancer Activity, Design of Some Novel Heterocyclic Compounds, And Synthesis Based on Indole-Dione
No full textThis search included synthesized new hertocyclic derivatives from Isatin (T) via reaction with 4-aminobenzoic acid to give (T2) ,and with SOCl2 to give compound (T1) , esterfication to give (T3), reacted with hydrazine to give (T4) compound ,and with anhydrides to give(T5,T6) .The schiff base (T10) prepared from benzylaldehyde and (T9) perpared fram (T2) and thiocarbohydrazide .(T8) compound synthesized fram (T2) and semicarbzide by aring closer reaction in NaOH. This (T1-T10) compounds were measured biological and anticancer activity and give high good activity with (IC50=42.18,45.02 for compounds 12 and 3)
Evaluation of Some Immunological Aspects of Women with Polycystic Ovary Syndrome in Wasit Governorate
No full textThe aim of the study the Study immune linkage for the occurrence of cysts and Analyzing the results statistically to determine the extent of the immunological causes of the occurrence of polycysticovaries.Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders affecting many females in reproductive period which start from menarche till the menopause and commonly caused infertility around the world, and is characterized by irregular menstrual cycle, Hyperandrogensim and polycystic ovary; it can be considered a conditions involving reproductive, metabolic and cardiovascular components leading to lifelong health implication. Its prevalence among infertile women is between (15% to 20%). There is evidence that PCOS is a pro inflammatory disorder, characterized by the presence of low grade chronic inflammation that correlated with obesity or insulin resistance (IR). The present study aims to determine the role of immunological and physiological response in the pathogenesis of PCOS. The current study included 100 females diagnosed with PCOS, there were recruited from Kamal Al-kut hospital in Wasit during November 2022 until January 2023 , the diagnosis of polycystic ovary syndrome was based on the Rotterdam 2003 criteria. The control group consists of 50 fertile women who have regular menstrual cycle with no sign of hyperandrogenism and subjected to ultrasound examination and have normal hormonal levels. The age was identical in both groups and it was between (20-40) years.
The present study was carried out in two parts: immunological study. ELISA technique has been used to determine the serum level of Interlukine-15and IL6.
The results of immunological study demonstrated that IL-15 andIL6 serum level were significantly increased (p<0.005)in pcos patients in comparison to control group. The mean level of that interleukin in patients and control group were (33.991±.57) pg/mL and (36.041±.03) and IL6 (85.944±.29), (84.24±6.39) pg/mL respectively.
Conclusions: In patients with pcos, The plasma level of IL-15, IL-6 is a major independent inflammatory predictor. Also, a ncrease in this hormone levels is an important indicator in predicting polycystic ovary syndrome
БОЛЕЗНЬ ФУРНЬЕ – РЕДКОЕ ЗАБОЛЕВАНИЕ В ХИРУРГИИ
No full textБолезнь Фурнье представляет собой некроз кожи мошонки и половых органов, характеризующийся распространением в переднюю брюшную стенку, развивающийся в результате гнойно-некротических фасциитов. Клиника заболевания впервые была описана в 1883 году французским дерматологом Альфредом Фурнье. Данное заболевание часто встречается у мужчин молодого и среднего возраста. В редких случаях встречается у женщин, сопровождаясь гнойно - некротическим поражением половых органов. В литературе мало информации об этом заболевании и существует большая неопределенность в этиопатогенезе, диагностике и лечении. Под нашим наблюдением находились 27 больных с болезнью Фурнье. В диагностике болезни Фурнье имеется определенные трудност
The Association Between Vitamin D Level with IgA Plasma Level in Pregnant COVID-19 Patients
No full textBackground: Coronavirus disease (COVID-19) has emerged as a harmful pandemic this century, brought on by severe acute respiratory illness coronavirus-2. An ecological study has shown that greater levels of vitamin D intake are inversely linked with the occurrence and/or death of COVID-19 in communities with a genetic predisposition towards low micronutrient levels. IgA, the predominant immunoglobulin of the respiratory system, is the main entry point for a variety of bacteria..
Aim: The IgA plasma levels of COVID-19 pregnant patients were examined to see if there was a relationship with their vitamin D levels..
Patients and methods: At Bint -Alhuda teaching hospital, Obstetrics and Gynecology department and a private obstetrical clinic carried out a case control study from January to December 2022 to compare the levels of vitamin D and IgA in pregnant women with COVID-19 to those who did not have the virus. The study's objective was accomplished using a sample of 179 patients split into two groups. Group B comprised 77 healthy pregnant women who served as the control group, while Group A comprised 102 pregnant women who had COVID-19 at any point throughout their pregnancy...
Results: The mean of trimester, parity, family history of COVID-19, presence of COVID-19, and immunization history were found to differ significantly (p<0.05) in this study. When compared to the control group, pregnant women with a COVID-19 infection were shown to have significantly reduced levels of vitamin D and IgA (P=0.0001). It's interesting to note that, independent of group, a small but statistically significant positive association was found between both Vit D levels and IgA levels. Further investigation revealed a correlation between an IgA level above >2.1 and a case's sensitivity of 72%, specificity of 63%, and accuracy of 68%..
Conclusion: COVID-19 infection among pregnant women was found to result in lower levels of Vitamin D and IgA. Both groups showed significant correlation between levels of Vit D and IgA
Evaluation of the Quality of the Early Postoperative Period with the Use of the Hemostatic Agent Chemoben in Combination with Laser Influence in Thyroid Surgery
No full textThe article presents the results of clinical application of the method of local intraoperative hemostasis and improvement of reparative processes during operations on the thyroid gland. For clinical evaluation of the effectiveness of the proposed method, two study groups were formed for 237 patients with mixed, nodular and diffuse toxic goiter. The main group consisted of 98 patients, and the comparison group - 139. In the main group of operated patients, hemostasis was carried out according to the method developed by us, and in the comparison group, by traditional methods. Surgery included thyroidectomy, hemithyroidectomy, and subtotal thyroidectomy. In the main group of patients, for the purpose of hemostasis, Hemoben powder crystals with a size of 25-50 microns were used at the rate of 200 mg per area of 8-9 cm2, which was applied over the wound with a thin layer until a thin translucent film was formed, followed by irradiation of the wound with low-energy laser radiation (Sogdiana apparatus) with a wavelength of 0.89 microns, a frequency of 500 Hz for 2 minutes at a distance of 5 cm from the wound; then, for 5-7 days, percutaneous irradiation sessions with the same laser at a frequency of 80 Hz were performed daily in the projection of the surgical wound. The study showed that the use of the domestic hemostatic agent Hemoben provides complete hemostasis, and the addition of the technique by treating the surgical field with low-intensity laser radiation enhances the reparative properties of the drug. The proposed method of local hemostasis and improvement of reparative processes during operations on the thyroid gland is characterized by a quick, effective and stable stop of bleeding, and also due to intra- and postoperative laser exposure, the course of the early postoperative period improves
Immunological Indicators of Blood and Saliva in Diseases of the Oral Cavity Mucosa in Patients with Covid-19 Complicated by Stage I and II AG
No full textRelevance of the topic: Viral diseases on the basis of arterial hypertension in recent years are one of the pressing problems of Medicine. According to experts from the World Health Organization, 80% of infectious diseases are called by viruses and certain changes occur in the mucous membrane of the oral cavity. In December 2019, a new etiological agent for COVID-19 ("coronavirus disease 2019"), SARS-CoV-2, was found to be a new coronavirus in Wuhan, China. As of March 2020, more than 187 countries have reported COVID-19. In this regard, the use of modern methods of timely and early diagnosis of COVID-19 infection, the improvement of treatment and preventive measures, the Prevention of deaths remain priority areas of practical medicine
Изучение Гепатопротективного Свойства Биологически Активной Добавки «Гепанорм»
No full textПроблема вирусных гепатитов (ВГ) и цирроза печени на сегодняшний день остро стоит перед мировой системой здравоохранения. Статья посвящена актуальному состоянию проблемы ВГ в Республике Узбекистан на сегодняшний день. Успехи вакцинопрофилактики (против вирусных гепатитов В) позволили достичь результатов в виде значительного снижения заболеваемости среди населения, но этого как оказалось недостаточно, так как выявлен, что в последние годы отмечается прогрессивный спад охвата населения вакцинацией. Главным образом, это связано со снижением осведомленности пациентов и медработников о необходимости своевременной вакцинации, а также введением ограничительных мер по профилактике новой коронавирусной инфекции и актуальности проблемы в этом направлении. Широкая регистрация препаратов гепатопротекторного действия для лечения пациентов с хроническими гепатитами и циррозом печени позволяет решить эту проблему в какой-то степени. Однако высокая стоимость лекарств ставит перед государством задачу необходимости внедрения отечественных препаратов для обеспечения доступности лечения всем слоям населения. Таким образом, несмотря на значительные успехи в отношении стратегии элиминации хронических гепатитов и цирроза печени, ряд проблем остается актуальным и доставляет значительные трудности в достижении глобальной цели
Determination of Lead and Aluminum in Selected Antiperspirant using Atomic Absorption Spectrometry in Baghdad City / Iraq
No full textThe concentrations of metals (Al, Pb) were determined in Seven antiperspirant brands promoted in the City of Baghdad were purchased. The study was aimed at providing information on the concentration of metals in some antiperspirant products. The concentrations of metals in the samples were measured by atomic absorption spectrometry after digestion with a mixture of nitric acid, hydrochloric acid. The concentrations of Al and Pb in selected antiperspirant cosmetics ranged between (201.2 – 355.4 mg / L) and (2.688–5.311 mg / L) respectively for all the antiperspirant samples analyzed. (The concentrations of Al and pb were above the suggested safe limits for skin protection. The margin of safety values obtained were greater than 100 which indicated that the concentrations of the metals investigated in these facial cosmetics do not present considerable is to the users except in the case of face powders
Interrelation of Viability and Productivity Indicators with Ethological Characteristics in the Growth and Development of Sur Karakol Lambs
No full textThe article presents information about the variability of qualitative and quantitative indicators of Sur-Karakol lambs of different ages in connection with the ethological characteristics of Karakol sheep
Phytotherapy, Treatment of Cutaneous Leishmaniasis
No full textThe study examined the efficacy of aloe extract in the topical application of zoonotic leishmaniasis. To date, specific drug prevention of leishmaniasis has not been developed.
Due to drug trial and side effects of leishmaniasis treatments, achieving treatment efficacy through unique side effects and greater benefits is of paramount importance. The present study was aimed at a retrospective analysis of aloe vera leaf exudate for Leishmania major in in vivo models on patients with different wound sizes.
There are certain difficulties in the treatment of leishmaniasis, such as drug resistance and side effects of standard drugs