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    The effects of cannabinoids CBD and WIN 55 212-2 against oxidative stress in BR1 Astrocytes from a proteomic viewpoint

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    Oxidative stress is a common hallmark observed in neurodegenerative diseases, acting either as a triggering factor or as a consequence of the neurodegenerative process. Astrocytes play a crucial role in mediating oxidative stress caused by physiological processes, such as the byproducts of mitochondrial function during cellular respiration. Given the critical role of oxidative stress in the progression of many neurodegenerative diseases, identifying molecules capable of modulating this response and mitigating oxidative damage is of considerable interest. Cannabinoids such as cannabidiol (CBD) and WIN 55.212-2, known for their capability of influencing the endocannabinoid system through their interaction with cannabinoid receptors (namely, CB1R and CB2R), and therefore the Central Nervous System, are promising candidates for such modulation. This work aimed to explore, through proteomics, the potential effect that the mentioned cannabinoids might have against oxidative stress induced by hydrogen peroxide in astrocytes, possibly mitigating some of the oxidative damage

    One Mission. Mission Statement (Version 1)

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    Das Mission Statement der Arbeitsgruppe 04, „One Mission“, zum Hochschulentwicklungsplan (HEP) 2026–2030 der Hochschule Rhein-Waal leistet dreierlei: Erstens erfolgt eine Definition der „One Mission“ als Interpretation der Einheit von Studium, Lehre, Forschung und Transfer, dadurch versteht sich „One Mission“ auch als Beitrag zum Humboldt'schen Bildungsideal. Zweitens wird die Vision für die angestrebte Zielerreichung im Jahr 2030 beschrieben, wobei die „One-Mission“-Profilierung in Kombination mit weiteren identitären Eckpfeilern der Hochschule (Regionalität und Internationalität, Diversität und Nachhaltigkeitstransformation) als Alleinstellungsmerkmale projektiert wird. Drittens werden Gelingensbedingungen für „One-Mission“-Vorhaben in verschiedenen Skalierungen (vom Ad-hoc-Projekt bis zum transdisziplinären Studiengang) und Statusgruppen (Studierende, Lehrende, Forschende, Mitarbeitende) vorgeschlagen. Die fortlaufende Ergänzung und kontinuierliche Infragestellung der Inhalte, insbesondere der Gelingensbedingungen, ist dabei als work in progress ausdrücklich gewünscht

    Standardisierung der REST-Services in der IT-Landschaft des BLB NRW

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    Standardisierung der REST-Services in der IT-Landschaft des BLB NR

    Provenance influence on African Baobab (Adansonia digitata) mycorrhization potential.

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    African baobab (Adansonia digitata L.) tree parts are mostly harvested for nourishment and economic purposes. However, the products are only extracted from the wild and are threatened by depletion which necessitates research into the species domestication and cultivation. Mycorrhization involves promoting foreign and native mycorrhiza linkages to improve the roots’ efficiency in nutrients and moisture acquisition. While origin can impact the development of A. digitata, its impact on the species mycorrhization potential is not well understood, and was investigated in this thesis. A. digitata plants were grown from seeds of semi-arid, sub-humid and humid zone origins of Benin inside a controlled climate chamber. The seedlings from each origin received native soil, commercial mycorrhiza fungi (alternative) and control treatments. Growth parameters were determined before treatments application and at termination. Models combining the effects of treatment, zone origin, unique tree characteristics and block arrangement were used for statistics. Only seedlings of the humid zone origin had significantly higher initial leaf count than counterparts from other origins. Insignificant differences among origins and treatments were observed for all the other parameters. Inconsistent significant interaction of treatment and origins was observed for final leaf count, stem diameter, root collar diameter, fresh taproot and dry lateral root weights. The results indicated A. digitata seedlings’ ability to show morphological similarities when grown under uniform conditions irrespective of the genetic variations which might exist among seedlings. These growth trends were not 1 affected by the presence of commercial and native microbes. Inconsistent interaction effects warrant further investigation to ascertain specific individual tree seedlings which might have been significantly impacted by treatments

    Development of selection criteria and systematic methodology for the design of novel hydrogels

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    Hydrogels are a broad field of materials with applications in many niche areas. To advance the state of the art, research should explore new combinations of chemical and practical components to discover syntheses with novel emergent properties. However, given the vast amount of information available, it is challenging to systematically narrow the search to an effective comparison of a few select candidates. This work proposes a selection and evaluation methodology for building a comparative scope to decide on a set of hydrogel recipe components. Recipe design needs are determined using an existing bibliometric analysis of a hydrogel subfield, and available options are sourced from literature reviews, then assessed based on properties discussed in the literature. Candidates for the crosslinking initiation mechanism, the monomer system, and the crosslinking control method are evaluated separately and sequentially. Recipe permutations are possible as multiple choices are scored. The resultant recipe is a photoinitiated (LAP; irradiated at 380.5nm), thiol-ene (TMPMP-Maleimide), light-patterned (maskless PWM-DLP) hydrogel that swells and bends in response to water due to osmolyte (D-Sorbitol) diffusion. This novel formulation is not currently present in the literature; however, it does not exhibit any chemical or practical incompatibilities. A range of component concentrations, possible failure scenarios, and recommended fixes are provided for initial testing

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