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Die verzerrte Realität : Wie soziale Medien unsere Körperwahrnehmung verändern
No full textSoziale Medien prägen unsere Selbstwahrnehmung in einem bisher ungekannten Ausmaß. Sie setzen unrealistische Schönheitsstandards, die tief in unser Bewusstsein eindringen. Das Projekt „Die Verzerrte Realität“ untersucht, wie Plattformen wie Instagram und TikTok diese verzerrte Wahrnehmung fördern. Es zeigt, wie Filter und Algorithmen Nutzer:innen in Filterblasen halten, die ungesunde Ideale verstärken. Ziel ist es, die Mechanismen hinter diesen Prozessen aufzudecken und ihre psychischen Auswirkungen wie Depressionen und Essstörungen zu beleuchten. Durch die Verwendung von Collagen und persönlichen Erzählungen soll das Bewusstsein geschärft und ein kritischer Umgang mit sozialen Medien gefördert werden. „Die Verzerrte Realität“ fordert uns auf, die Echtheit hinter den digitalen Fassaden zu hinterfragen und neue Sichtweisen auf Körperwahrnehmung zu entwickeln
Scoping review of active learning strategies and their evaluation environments for entity recognition tasks
No full textWe conducted a scoping review for active learning in the domain of natural language processing (NLP), which we summarize in accordance with the PRISMA-ScR guidelines as follows:
Objective: Identify active learning strategies that were proposed for entity recognition and their evaluation environments (datasets, metrics, hardware, execution time).
Design: We used Scopus and ACM as our search engines. We compared the results with two literature surveys to assess the search quality. We included peer-reviewed English publications introducing or comparing active learning strategies for entity recognition.
Results: We analyzed 62 relevant papers and identified 106 active learning strategies. We grouped them into three categories: exploitation-based (60x), exploration-based (14x), and hybrid strategies (32x). We found that all studies used the F1-score as an evaluation metric. Information about hardware (6x) and execution time (13x) was only occasionally included. The 62 papers used 57 different datasets to evaluate their respective strategies. Most datasets contained newspaper articles or biomedical/medical data. Our analysis revealed that 26 out of 57 datasets are publicly accessible.
Conclusion: Numerous active learning strategies have been identified, along with significant open questions that still need to be addressed. Researchers and practitioners face difficulties when making data-driven decisions about which active learning strategy to adopt. Conducting comprehensive empirical comparisons using the evaluation environment proposed in this study could help establish best practices in the domain
Ich sei Ich : Eine Annäherung an ein belastbares Selbst
No full textIn Deutschland herrscht weiterhin ein starker Heterosexismus, der Heterosexualität als überlegen ansieht und fast alle von klein auf prägt. Diese Situation erschwert es, andere Formen sexueller Orientierungen anzunehmen. Paul Herberg fiel es in seiner Jugend deshalb schwer, zu seiner Homosexualität zu stehen und seine sexuelle Identität zu entwickeln. Die Folgen waren ein jahrelanges Verstecken. Auch heute beeinflussen Minderwertigkeitsgefühle und die Angst vor Zurückweisung zeitweise noch sein Handeln. Seine Bachelorarbeit nutzte Paul Herberg, um zu mehr Selbstbewusstsein zu finden und seine Identität weiter zu definieren. Dies erfolgte, indem er im Zusammenspiel mit unterschiedlicher Literatur verschiedene Abschnitte seiner Entwicklung aufarbeitete und überlegte, wie in Zukunft noch mehr zu sich gefunden werden kann. Sein Fotobuch soll auch andere inspirieren und unterstützen
Concept : a dialogic instrument in architectural design
No full textConcept - this is a key term in architectural discourse. However, all too often it is used imprecisely or merely for marketing purposes. What is a concept actually? This publication moves between design theory and design practice and follows the history of the definition of concept in architecture, leading to the formulation of a specifically instrumental and operative definition. It bases concept in architecture on its strategic potential in design decision-making processes. In the changing profession of the designing architect, decisions are increasingly made in multidisciplinary groups. Concept can serve as a dialogic instrument in the process, making it possible to process heterogeneous information from a range of spheres of knowledge. The effective presentation of selected information becomes a relevant interface in the design process, which has a significant influence on the quality of the design
Viva la wie? : Dokumentarfilm über alternative Lebensweisen in Gemeinschaft
No full textDie Bachelorarbeit dokumentiert das Leben einer Lebensgemeinschaft in Norditalien, bestehend aus Auswanderern aus Deutschland. Die Mitglieder haben in Piemonte Grundstücke erworben und restaurieren gemeinsam über 200 Jahre alte Bauernhäuser. Ihr Leben ist autark, ohne Anschluss an ein Stromnetz, und sie nutzen Trinkwasser aus natürlichen Quellen. Die Arbeit untersucht die Motivationen und Herausforderungen dieser Lebensweise und beleuchtet alternative, nachhaltige Lebensmodelle. Durch Interviews und visuelle Aufnahmen wird ein umfassendes Bild der Gemeinschaft und ihrer Werte vermittelt. Ziel ist es, neue Perspektiven auf Nachhaltigkeit und Gemeinschaft zu schaffen und andere Menschen zu inspirieren, ähnliche Lebensweisen auszuprobieren
Wasch- und Reinigungsmittel enthaltend Protease (aus Fictibacillus arsenicus)
No full textDie Erfindung liegt auf dem Gebiet der Enzymtechnologie. Die Erfindung betrifft Proteasen aus Fictibacillus arsenicus, die insbesondere im Hinblick auf den Einsatz in Wasch- und Reinigungsmitteln verwendet werden können, alle hinreichend ähnlichen Proteasen mit einer entsprechend ähnlichen Sequenz zu SEQ ID NO:1 und für sie codierende Nukleinsäuren. Die Erfindung betrifft ferner deren Herstellung sowie Verfahren zur Verwendung dieser Proteasen, deren Verwendung als solche sowie diese enthaltende Mittel, insbesondere Wasch- und Reinigungsmittel
The use of predictive models to develop chromatography-based purification processes
No full textChromatography is the workhorse of biopharmaceutical downstream processing because it can selectively enrich a target product while removing impurities from complex feed streams. This is achieved by exploiting differences in molecular properties, such as size, charge and hydrophobicity (alone or in different combinations). Accordingly, many parameters must be tested during process development in order to maximize product purity and recovery, including resin and ligand types, conductivity, pH, gradient profiles, and the sequence of separation operations. The number of possible experimental conditions quickly becomes unmanageable. Although the range of suitable conditions can be narrowed based on experience, the time and cost of the work remain high even when using high-throughput laboratory automation. In contrast, chromatography modeling using inexpensive, parallelized computer hardware can provide expert knowledge, predicting conditions that achieve high purity and efficient recovery. The prediction of suitable conditions in silico reduces the number of empirical tests required and provides in-depth process understanding, which is recommended by regulatory authorities. In this article, we discuss the benefits and specific challenges of chromatography modeling. We describe the experimental characterization of chromatography devices and settings prior to modeling, such as the determination of column porosity. We also consider the challenges that must be overcome when models are set up and calibrated, including the cross-validation and verification of data-driven and hybrid (combined data-driven and mechanistic) models. This review will therefore support researchers intending to establish a chromatography modeling workflow in their laboratory
Seasonal weather changes affect the yield and quality of recombinant proteins produced in transgenic tobacco plants in a greenhouse setting
No full textTransgenic plants have the potential to produce recombinant proteins on an agricultural scale, with yields of several tons per year. The cost-effectiveness of transgenic plants increases if simple cultivation facilities such as greenhouses can be used for production. In such a setting, we expressed a novel affinity ligand based on the fluorescent protein DsRed, which we used as a carrier for the linear epitope ELDKWA from the HIV-neutralizing antibody 2F5. The DsRed-2F5-epitope (DFE) fusion protein was produced in 12 consecutive batches of transgenic tobacco (Nicotiana tabacum) plants over the course of 2 years and was purified using a combination of blanching and immobilized metal-ion affinity chromatography (IMAC). The average purity after IMAC was 57 ± 26% (n = 24) in terms of total soluble protein, but the average yield of pure DFE (12 mg kg−1) showed substantial variation (± 97 mg kg−1, n = 24) which correlated with seasonal changes. Specifically, we found that temperature peaks (>28°C) and intense illuminance (>45 klx h−1) were associated with lower DFE yields after purification, reflecting the loss of the epitope-containing C-terminus in up to 90% of the product. Whereas the weather factors were of limited use to predict product yields of individual harvests conducted for each batch (spaced by 1 week), the average batch yields were well approximated by simple linear regression models using two independent variables for prediction (illuminance and plant age). Interestingly, accumulation levels determined by fluorescence analysis were not affected by weather conditions but positively correlated with plant age, suggesting that the product was still expressed at high levels, but the extreme conditions affected its stability, albeit still preserving the fluorophore function. The efficient production of intact recombinant proteins in plants may therefore require adequate climate control and shading in greenhouses or even cultivation in fully controlled indoor farms