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Enhancement of succinic acid production by Actinobacillus succinogenes in an electro-bioreactor
No full textThis work examines the electrochemically enhanced production of succinic acid using the bacterium Actinobacillus succinogenes. The principal objective is to enhance the metabolic potential of glucose and CO2 utilization via the C4 pathway in order to synthesize succinic acid. We report on the development of an electro-bioreactor system to increase succinic acid production in a power-2-X approach. The use of activated carbon fibers as electrode surfaces and contact areas allows A. succinogenes to self-initiate biofilm formation. The integration of an electrical potential into the system shifts the redox balance from NAD+ to NADH, increasing the efficiency of metabolic processes. Mediators such as neutral red facilitate electron transfer within the system and optimize the redox reactions that are crucial for increased succinic acid production. Furthermore, the role of carbon nanotubes (CNTs) in electron transfer was investigated. The electro-bioreactor system developed here was operated in batch mode for 48 h and showed improvements in succinic acid yield and concentration. In particular, a run with 100 µM neutral red and a voltage of −600 mV achieved a yield of 0.7 gsuccinate·gglucose−1. In the absence of neutral red, a higher yield of 0.72 gsuccinate·gglucose−1 was achieved, which represents an increase of 14% compared to the control. When a potential of −600 mV was used in conjunction with 500 µg∙L−1 CNTs, a 21% increase in succinate concentration was observed after 48 h. An increase of 33% was achieved in the same batch by increasing the stirring speed. These results underscore the potential of the electro-bioreactor system to markedly enhance succinic acid production
Zeitlos : Gestaltung eines Sitzmöbels als Teil einer Produktfamilie mit Bezug auf die Nachhaltigkeit
No full textOnomico-Chair ist ein Drehstuhl, der zeitlos klassisch erscheint und unter der Berücksichtigung von Nachhaltigkeit gefertigt wird.
Onomico-Chair bietet sowohl Funktionalität als auch Stil. Inspiriert von zeitlosen Designs moderner Designklassiker, bietet der Stuhl ein anpassungsfähiges Aussehen, das jedes zu Hause, Büro, oder Hotel verschönert und lebenslang Freude bereitet. Als Teil der Onomico-Produktfamilie, die auch einen Schreibtisch beinhaltet, verstärkt er den Eindruck einer harmonischen und durchdachten Gesamtkomposition.
Sowohl die Zeitlosigkeit des Designs, als auch die Verwendung hochwertiger, langlebiger Materialien und Fertigungsverfahren tragen zur Umweltfreundlichkeit bei.
Die Torsion in der Holzlehne des Onomico Chair bietet dem Kunden ein interessantes Alleinstellungsmerkmal, was durch die subtile Abweichung von traditionellen Stuhlformen für eine individuelle Note sorgt
Automatic generation and orchestration of active asset administration shells with IO-Link
No full textThis paper presents a proof of concept for automatically generating and orchestrating active asset administration shells (AAS) with IO-Link. AAS are software-based representations of physical assets that enable interoperability and standardised communication across different industrial systems. IO-Link is a widely adopted communication protocol for sensors and actuators in industrial automation. Our method uses an approach to generate AASs based on the IO-Link device description files. The generated AASs can then be orchestrated to form a distributed system that provides dynamic information about the status and performance of the connected assets. We demonstrate the effectiveness of our method through a proof of concept that involves the automatic generation and orchestration of AASs for a fluid processing unit equipped with pressure and flow sensors and a pump. The results show that our approach reduces the time and effort required to create and maintain active AASs
Optimal particles for highly sensitive biosensing application in mixed frequency excitation: Insights from a fundamental simulative approach
No full textMagnetic nanoparticles (MNP) are widely investigated for biomedical applications in diagnostics (e.g. imaging), therapeutics (e.g. hyperthermia) and general biosensing. For all these applications, the MNPs’ unique magnetic relaxation mechanism in an alternating magnetic field (AFM) is stimulated to induce desired effects. Whereas magnetic fluid hyperthermia (MFH) and magnetic particle imaging (MPI) are the most prominent examples for biomedical application, we investigate the relatively new biosensing application of frequency mixing magnetic detection (FMMD) from a fundamental perspective. Generally, we ask how specific MNP parameters (core size, magnetic anisotropy) influence the signal, specifically we predict the most effective MNP core size for signal generation. In FMMD, simultaneously two AFM are applied: a low-frequency magnetic driving field, driving MNP close to saturation, and a high-frequency excitation field that probes MNP susceptibility: . Resulting from the nonlinear magnetization of the MNP, harmonics of both individual incident frequencies as well as intermodulation products of these frequencies are generated. In this work, we present numerical Monte-Carlo(MC)-based simulations of the MNP relaxation process, solving the Landau-Lifshitz-Gilbert (LLG) equation to predict FMMD signals: As Figure 1 shows for the first four intermodulation signals , with , we can clearly see that larger core sizes generally increase the signal intensity. Same trend is predicted by a simple Langevin-function based thermal equilibrium model. Both predictions include a lognormal size distribution. The effect of core size distribution presumably dominates the effect of magnetic anisotropy. The findings are supported by comparison with experimental data and help to identify which MNP are best suited for magnetic biosensing applications using FMMD
THESEEDLINGPROJECT : Setzlingsproduktion für Hobbygärtner:innen und Selbstversorger:innen
No full textDas heutige Nahrungsmittelsystem steht unter immensem Druck durch verschiedenste Herausforderungen. Klimawandel, Bevölkerungswachstum und Bodenerosion haben das Potenzial, die gesicherte Nahrungsmittelversorgung zu destabilisieren. Dies ist in Politik und Gesellschaft nicht unbemerkt geblieben und viele wollen an einer nachhaltigen Veränderung teilhaben. Die eigene Nahrungsmittelproduktion ist ein möglicher Weg, sie kann nachhaltig gestaltet werden und gewährt eine Unabhängigkeit von der konventionellen Landwirtschaft. Um im Gartenbau höhere Erträge zu erzielen, sind Setzlinge unverzichtbar. Diese brauchen ein auf sie angepasstes Umfeld, um optimal zu gedeihen. THESEEDLINGPROJECT setzt hier an und ermöglicht es, Stecklinge im Eigenheim einfacher herzustellen. Nutzer:innen haben so Kontrolle über alle Aspekte der Aufzucht und gewinnen an Unabhängigkeit von der industrialisierten Landwirtschaft
Prüfungsordnung für die Bachelorstudiengänge „International Business Studies“, Studienbeginn ab Wintersemester 2023/24
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Prüfungsordnung für die Masterstudiengänge „Biotechnologie“ und „Biotechnologie mit Praxissemester“, Studienbeginn ab Wintersemester 2024/25
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