Northeastern University London Repository
Not a member yet
1286 research outputs found
Sort by
A role for MIRO1 in motility and membrane dynamics of peroxisomes
Get PDFPeroxisomes are dynamic organelles which fulfil essential roles in lipid and ROS metabolism. Peroxisome movement and positioning allows interaction with other organelles and is crucial for their cellular function. In mammalian cells, such movement is microtubule-dependent and mediated by kinesin and dynein motors. The mechanisms of motor recruitment to peroxisomes are largely unknown, as well as the role this plays in peroxisome membrane dynamics and proliferation. Here, using a combination of microscopy, live-cell imaging analysis and mathematical modelling, we identify a role for Mitochondrial Rho GTPase 1 (MIRO1) as an adaptor for microtubule-dependent peroxisome motility in mammalian cells. We show that MIRO1 is targeted to peroxisomes and alters their distribution and motility. Using a peroxisome-targeted MIRO1 fusion protein, we demonstrate that MIRO1-mediated pulling forces contribute to peroxisome membrane elongation and proliferation in cellular models of peroxisome disease. Our findings reveal a molecular mechanism for establishing peroxisome-motor protein associations in mammalian cells and provide new insights into peroxisome membrane dynamics in health and disease
Spaces on the temporal move: WeimarGeopolitikand the vision of an Indian science of the state, 1924–1945
Get PDFThe termination of the Great War hailed a universally modern moment and a new ‘global’ condition. Early to recognize this was the Bavarian scholar and general Karl Haushofer (1869–1946), who built his Geopolitik school on temporal expectation. Defying its reduction to Hitler and Nazism, Haushofer’s Geopolitik aimed to gain revolutionary momentum from anti-colonial nationalisms in the East. In Haushofer’s vision, geopolitical spaces themselves acquired motion as the long-dormant East rose with a globally resounding ‘energism’. Haushofer’s Zeitschrift für Geopolitik (‘Journal for Geopolitics’) made India a particular model for Germans seeking to ‘catch up’ on world affairs. The world signified exposure, but, if harnessed correctly, rejuvenation for the nation. In his attempt to de-orientalise the German mind to prepare it for geopolitical momentum, Haushofer drew on the vision of a dynamic East offered by the Indian sociologist Benoy Kumar Sarkar (1887–1949). This flipped the temporality of colonialism. Geopolitical temporality offered the promise of a history that would not manifest itself in time, but in space. In 1933, for Haushofer, the centre of emancipatory dynamism shifted to the fascist countries as champions of a just spatial order against the ‘status quo’ of British or US hegemony
Nader Hashemi and Danny Postel (eds.) Sectarianization: Mapping the New Politics of the Middle East London: C. Hurst & Co., 2017, 320 pp. £18.99 pbk
Get PDF
ILLUSORY ENDS IN CHRÉTIEN DE TROYES’ EREC ET ENIDE
Get PDFThere have been countless attempts to theoriseune mout bele conjointure, the formulation used by Chrétien de Troyes to describe his compositional technique in the prologue toErec et Enide. Yet the term bele conjointure perhaps more accurately defines the ideal result of this distinctively medieval poetic practice: that is, an elegant sequence consisting of skilfully conjoined but diverse elements. Whatever the exact significations of this phrase – and it has long been an issue of contention for Chrétien scholars from Wendelin Foerster and W. A. Nitze to Eugène Vinaver and Douglas Kelly – most agree that it describes th
Emotions and the ‘Other’: Emotional characterizations of Muslim protagonists in narratives of the Crusades (1095–1192)
No full text
Sequences of purchases in credit card data reveal lifestyles in urban populations
Get PDFZipf-like distributions characterize a wide set of phenomena in physics, biology, economics, and social sciences. In human activities, Zipf's law describes, for example, the frequency of appearance of words in a text or the purchase types in shopping patterns. In the latter, the uneven distribution of transaction types is bound with the temporal sequences of purchases of individual choices. In this work, we define a framework using a text compression technique on the sequences of credit card purchases to detect ubiquitous patterns of collective behavior. Clustering the consumers by their similarity in purchase sequences, we detect five consumer groups. Remarkably, post checking, individuals in each group are also similar in their age, total expenditure, gender, and the diversity of their social and mobility networks extracted from their mobile phone records. By properly deconstructing transaction data with Zipf-like distributions, this method uncovers sets of significant sequences that reveal insights on collective human behavior