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Assessing Perceived Need for Mental Healthcare Among Adults in Germany
No full textObjectives To describe the prevalence and distribution of perceived need for mental healthcare among adults in Germany and examine its association with more objective indicators of need as well as mental health literacy. Methods We used data from 6,558 adults randomly sampled from a health insurance company as well as nationally representative survey data from 10,676 adults. Prevalence estimates were calculated, also by sex, age and education. Bivariate and multivariate associations between perceived need and sociodemographic characteristics, psychopathological symptoms, functional impairment and F-diagnoses as well as mental health literacy were examined. Results Approximately one-sixth of adults perceived a need for mental healthcare in the previous 12 months. Perceived need was associated with female sex (bivariate association only), younger age, high educational attainment, psychopathological symptoms, mental health-related functional impairment and mental health literacy. Those with perceived need were also twice as likely to have a documented F-diagnosis than those without. Conclusion Perceived need should be monitored within mental health surveillance to inform healthcare planning from a patient perspective and address the mental health treatment gap
Refinement of intermediate-risk Karyotypes according to the IPSS-R in patients with myelodysplastic neoplasms (MDS)
No full textAbstract MDS patients show a heterogenous prognosis which can be stratified by the IPSS-R in order to derive therapeutic implications. Based on 618 patients with myelodysplastic neoplasms belonging to the cytogenetic intermediate-risk group according to IPSS-R, we show that this group is heterogeneous in terms of overall survival and cumulative risk of AML. The group can be reorganized into subgroups according to their prognostic impact. A small subgroup of patients with isolated -X or der(1;7) can be regarded as very-low-risk patients with a median survival time of 112 months and a cumulative AML progression rate of 9% after 2 years. A larger group of patients with either diverse aberrations of one chromosome or -Y + one additional aberration shows a benign course of the disease with a median survival time of 46 months and a cumulative AML progression rate of 26% after 2 years. A very large group of patients presenting with either + 8, +19, i(17q), + 21, +mar, del(9q), + 8 plus one other aberration, or del(7q) have a poor prognosis with a median survival time of 26 months and a cumulative AML progression rate of 32% after 2 years. In a very small set of patients with trisomy 11 the course of disease was similar to very-high-risk patients with a median survival time of 17 months only and a cumulative AML progression rate of 100% after 2 years. These findings could lead to a refinement of prognostic scoring systems such as the IPSS-R and the IPSS-M
Contrasting fine root-induced rhizosphere priming effects between coniferous and broadleaved trees
No full textNational Key Research and Development Program of ChinaNatural Science Foundation of Zhejiang Province http://dx.doi.org/10.13039/501100004731Chongqing Science and Technology Commission http://dx.doi.org/10.13039/50110000286
Nuts about trees? Tree quantity, species richness, and key species in smallholder agroforestry systems and their associations with groundnut (Arachis hypogaea) yields in Senegal
No full textAbstract In the Sahel region, agroforestry potentially increases crop yields, alongside restoring and retaining soils. However, little is known about how diverse agroforestry systems perform across adoptedagricultural systems of smallholders in the region. We therefore investigate how varying smallholder agroforestry systems in the Senegalese Groundnut Basin associate with groundnut yields. We distinguish agroforestry systems by (a) tree quantity per hectare, (b) tree species richness and (c) quantities per hectare of the most frequently reported tree species in our data. Using data of 492 groundnut farmers, collected in the Groundnut Basin from December 2022 to January 2023, we estimate log-linearized Cobb–Douglas-production functions through ordinary least squares regression. 53 tree species were reported by 93.8% of smallholders. We identify Faidherbia albida , Cordyla pinnata , Adansonia digitata , Anogeissus leiocarpa , and Ziziphus mauritiana as the most frequently reported species. Our results indicate that groundnut yields initially increase with tree quantity and species richness. However, higher tree densities are associated with lower groundnut yields, possibly reflecting increased competition between trees and crops for space, light, water, or soil nutrients. Faidherbia albida trees seem associated with higher groundnut yields only when present in greater numbers. For the species Cordyla pinnata and Anogeissus leiocarpa , additional trees initially associate with increases in groundnut yields. The tree species Ziziphus mauritiana and Adansonia digitata show no clear association with groundnut yields, which may be partly due to their relatively low abundance in the sample. Our results suggest a remaining potential for increasing tree cover and tree species richness, as well as introducing or expanding certain tree species in established agroforestry systems to support groundnut production. Graphical abstractDeutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659Georg-August-Universität Göttingen http://dx.doi.org/10.13039/50110000338
Unravelling the pedogenetic development of forest soils in Northern Patagonia, Argentina
No full texthttp://dx.doi.org/10.13039/501100005908 Bundesministerium für Ernährung und Landwirtschafthttp://dx.doi.org/10.13039/501100010771 Federal Agency for Agriculture and Foo
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
No full texthttp://dx.doi.org/10.13039/501100001711 Swiss National Science Foundationhttp://dx.doi.org/10.13039/501100009708 Novo Nordisk Foundationhttp://dx.doi.org/10.13039/501100002347 Federal Ministry of Education and Research Bonn Officehttp://dx.doi.org/10.13039/501100003042 Else Kroner-Fresenius Foundationhttp://dx.doi.org/10.13039/501100000781 European Research Councilhttp://dx.doi.org/10.13039/501100011747 Novo Nordisk Foundation Center for Basic Metabolic Researchhttp://dx.doi.org/10.13039/501100001659 German Research Foundationhttp://dx.doi.org/10.13039/100010663 European Research Counci
Plant‐Inspired High‐Performance Hydrovoltaic Electricity Generation in Janus Aerogel Fibers with Gradient Nanostructures
No full textAbstract While plant transpiration offers abundant hydrovoltaic energy, its intrinsic non‐directional water transport significantly constrains output efficiency. To overcome this, we developed bioinspired gradient Janus aerogel fibers using multi‐channel microfluidic spinning. These fibers feature asymmetric cellulose density, with a dense outer layer and a sparse inner core, complemented by carbon‐black surface layers. The resulting Laplace pressure gradients synergistically enhance both axial (4.36 mm s −1 ) and radial (0.38 mm s −1 ) water transport, thereby amplifying streaming and double‐layer potentials at the carbon–cellulose interfaces. A single 1.5‐cm fiber with a 0.1 cm 2 evaporation area achieves an impressiveoutput of 0.6 V and 4500 nA, representing a 4.6‐fold increase in voltage and a 19.7‐fold increase in current compared to natural Musa basjoo leaves exceeding 3000 cm 2 in area. Moreover, these fibers sustain over 95% efficiency across diverse conditions (−20 to 60 °C, 10–90% humidity, wind speeds up to 8 m s −1 ) and can power wearable electronics like watches, light‐emitting‐diodes, and bulbs via sweat‐based energy harvesting when integrated into textiles, showcasing unprecedented scalability for miniaturized hydrovoltaic systems. This research establishes a new paradigm for high‐performance energy harvesting inspired by nature, achieved through structural and material anisotropy engineering.National Natural Science Foundation of China https://doi.org/10.13039/50110000180
Allogeneic haematopoietic cell transplantation in peripheral T-cell lymphoma: recommendations from the EBMT Practice Harmonisation and Guidelines Committee
No full textNeighbourhood diversity increases tree growth in experimental forests more in wetter climates but not in wetter years
No full textAllium ursinum as a Centuries-old Medicinal Plant. Short Review of Anti-inflammatory and Antimicrobial Properties of the Rare Garlic Species
No full textAbstract Wild garlic (Allium ursinum) is a wild plant growing in Middle and Eastern Europe that has been traditionally applied in local cuisine and herbal medicine practices. The leaves of the plant contain numerous bioactive compounds, i.e., flavonols, flavanols, phenolic acids, and thiopolysulfides. The aim of the study is to present the antioxidant, anti-inflammatory, and antimicrobial properties of this plant. The leaves of Allium ursinum possess strong antioxidant activity, which varies depending on extractant use and plant origin. The plant has limited capacity for ferric ion reduction in a FRAP test, as well. The previous studies showed that the high content of phenolic compounds was prevalently responsible for the high antiradical capacity. On the other hand, the thiopolysulfides present in the plant are responsible for its anti-inflammatory effect, observed as inhibition of TNF-α and interleukins, and as a bactericidal effect against skin pathogenic microflora. Wild garlic has a negative effect on cancer cell line viability, while it enhances the viability of non-cancerogenic tissue cells. All these effects clearly show that wild garlic is an interesting and potent raw material that should be more often applied in todayʼs functional foods, as well as a novel additive for dietary supplements, herbal remedies, or materials with topical anti-bacterial action