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A Screening Tool for REE Data Quality Assessment
No full textThe growing availability of advanced analytical techniques has led to a rapid increase in published geochemical data, much of which is now accessible through curated, domain-specific synthesis databases. These resources offer significant opportunities for innovative research in geochemistry and related fields through the analysis of compositional data from rocks, minerals, and other natural materials. However, integrating and evaluating data that were collected over several decades using widely different analytical methods is a challenge.
The rare earth elements (REEs) are widely used in geochemistry as tracers of chemical transport, differentiation, and broader Earth system processes. To address common issues in REE data usability, we developed an automated method to identify scattered, anomalous, or potentially erroneous REE patterns. Our approach draws on the expected geochemical behaviour of REEs, focusing on the “smoothness” of normalised REE patterns, the detection of single or multiple outliers, and various forms of scatter.
We validated our method using large datasets from the GEOROC (n=176,611) and PetDB (n=30,659) databases. Distinct types of anomalous REE patterns are related to potential artefacts and data quality issues. Additionally, we test the application of our REE screening method on individual published data sets from various sources and dare to give some recommendations
Potential Benefits of Passive Exoskeletons for Reducing Physical Strain in Nursing Care: A Literature Overview
No full textIntegrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson’s disease
No full textAbstract Background Parkinson’s disease (PD) is associated with gut microbiome shifts. These shifts are mainly described at taxonomic level, but the functional consequences remain unclear. To obtain insight into the functional disruptions of the gut microbiome in PD, we used an integrated multi-omics approach, comparing gut microbiomes of individuals with PD, prodromal PD, and healthy controls. Results Meta-metabolomics, the most discriminatory and robust omics level, was selected to Guide the analysis. We identified 11 metabolites that were differentially abundant between the groups, among which β-glutamate was increased in PD and prodromal PD, and correlated with the transcriptional activities of Methanobrevibacter smithii and Clostridium spp. We identified decreases in transcripts, but not in gene abundances, related to glutamate metabolism, bile acids biosynthesis, chemotaxis, and flagellar assembly in PD, particularly in keystone genera such as Roseburia , Agathobacter , and Blautia . Our findings, integrated into the Expobiome map, reveal multifactorial microbiome alterations which converge with PD pathways. Conclusion Our study highlights the apparent disruption of microbial gene expression in PD, particularly in genes associated to mobility. Moreover, we showcase the importance of investigating the gut microbiome’s functional dimensions to better resolve microbiome-host interactions in health and disease.HORIZON EUROPE European Research Council https://doi.org/10.13039/100019180Fonds National de la Recherche Luxembourg https://doi.org/10.13039/501100001866Michael J. Fox Foundation for Parkinson's Research https://doi.org/10.13039/100000864Institute for Advanced Studies, Université of LuxembourgEuropean Union’s Horizon 2020 Widening FellowshipsDFG Research Unit FOR2488Rotary Club Luxembour
Utilization of interdisciplinary in-hospital early rehabilitation in COVID-19 patients - a multicenter cohort study in the National Pandemic Cohort Network (NAPKON) in Germany
No full textBackground Early rehabilitation in acute hospitals aims to prevent immobilization-related complications and improve the functional capacity of patients with severe or critical illness. Early rehabilitation can be a useful concept to improve functioning in COVID-19 patients. However, literature concerning early in-hospital rehabilitation in COVID-19 patients is scarce. Aim To analyze the utilization of in-hospital interdisciplinary early rehabilitation (IER) in COVID-19 patients and characterize the sample of IER patients. Design Prospective cohort study. Setting Hospitalized COVID-19 patient cases. Population This study used data from the National Pandemic Cohort Network (NAPKON) in Germany. Methods IER utilization rates were retrieved. Demographic and clinical data from hospitalized COVID-19 patients who had received IER during the course of their treatment were evaluated. Results Out of the 2,644 patients in the Cross-Sectoral Platform (German abbreviation: SUEP) cohort, 0.79% [95% CI: 0.51% to 1.22%] received IER during their stay in an acute care hospital. Among the subgroup of patients who had previously been treated in intensive care, 2.13% [95% CI: 1.16% to 3.63%] received IER. The most common comorbidities were cardiovascular diseases (66.7%) and neurological/psychiatric diseases (36.1%). The small sample size limited further analyses. Conclusion The low rate of early rehabilitation in acute hospitals for COVID-19 patients indicates an unmet need, particularly in severe cases. Structural changes in the health system are needed to close this gap. The WHO and the German Medical Council have recently acknowledged the necessity of early in-hospital rehabilitation and have issued a call for its implementation in acute hospitals.German Federal Ministry of Education and ResearchGerman Center for Infection Research 10000913
Developing an integrated conceptual framework of NewWork-settings: a systematic scoping review
No full textIntroduction The last few decades have seen drastic changes in the world of work. These global transformations of work towards more digital, decentralized and democratic forms are commonly referred to as NewWork (NW). NW is frequently described as a container term encompassing a broad set of concepts. In order to provide conceptual clarity, the aim of this review was to develop an integrated conceptual framework of NW-settings, i.e., workplaces that have implemented different NW measures. Methods A systematic scoping review was conducted, following the framework by Arksey and O’Malley and the Joanna Briggs Institute. Results Based on the synthesis of 99 included articles, we developed a multidimensional conceptual framework of NW-settings, which consists of four dimensions: flexibility, digitalization, democratization and agility , and 14 inter-related sub-dimensions. Discussion This framework facilitates a clearer understanding of NW and provides valuable insights for contemporary work practices and the broader social implications of digital and organizational transformations in our world of work
A global synthesis of naturalised and invasive plants in aquatic habitats
No full textGlobal databases have contributed to our understanding of alien, naturalised and invasive plant species distributions. Still, the role of species invasions in habitats, specifically in aquatic habitats, remains underexplored at the global scale. Accordingly, a comprehensive global synthesis of the status of plant invasions in aquatic habitats has been missing. Here, we focus on macroecological patterns of naturalised non-invasive and invasive plants in aquatic habitats using the recently built SynHab database. Amongst all the plant records compiled in SynHab, 592 are assigned to aquatic habitats, of which 183 are unique plant taxa (further termed ‘species’) belonging to 49 families. Of the total number of records, 462 refer to taxa with naturalised non-invasive occurrences and 130 to invasive occurrences. The species pool analysed here refers to 78 regions distributed across all botanical continents as defined by the World Geographical Scheme for Recording Plant Distributions. The number of naturalised non-invasive aquatic species is similar across different continents and biomes, but Tropical Asia had more and the Mediterranean zonobiome had fewer invasive species than expected. Tropical Asia, Temperate Asia and Africa have the highest proportions of naturalised species that have become invasive, while across continents, invasive proportions were highest for tropical and subtropical zonobiomes. New Zealand, Italy and California contained disproportionately more naturalised species than expected, given the area covered by aquatic habitat in those regions, whereas South Sudan, Papua New Guinea and Kyrgyzstan had disproportionately fewer species. In pairwise dissimilarity comparisons, all continents had distinct species compositions (from 0.73 to 0.92 of the Jaccard dissimilarity index) and so did zonobiomes (0.69 to 1.00). The high proportion of invasive species in Tropical Asia in comparison with terrestrial invasions in this region, indicates a greater susceptibility of warmer regions to aquatic plant invasions. This may be exacerbated by further naturalisations in the future, as data from temperate regions suggest a larger pool of available species
Devastating course—good outcome! Excellent results thanks to artificial urinary sphincter implantation despite perineal urethrostomy—a case report
No full textZusammenfassung Dieser Fall beschreibt zum ersten Mal die Implantation eines AMS-800©-Sphinkters (Boston Scientific Corporation, Marlborough, MA, USA) bei einem Patienten mit Belastungsinkontinenz nach radikaler Prostatektomie, der durch komplizierten Verlauf der vorherigen Inkontinenztherapie letztlich mit einer perinealen Urethrostomie versorgt wurde. Die Kontinenzsituation und die postoperative Lebensqualität nach Versorgung mit dem neu implantierten Sphinktersystem zeigen, dass eine Boutonnière keine Kontraindikation für die Versorgung mittels künstlichem Blasenschließmuskel darstellt.Abstract In this case report, we describe, for the first time, the implantation of an AMS-800 sphincter (Boston Scientific Corporation, Marlborough, MA, USA) in a patient with stress incontinence following radical prostatectomy, who was ultimately treated with an perineal urethrostomy due to a complicated course of previous incontinence therapy. The continence status and postoperative quality of life after treatment with the newly implanted sphincter system clearly demonstrate that a boutonnière deformity is not a contraindication for treatment with an artificial urinary sphincter.Zusammenfassung Dieser Fall beschreibt zum ersten Mal die Implantation eines AMS-800©-Sphinkters (Boston Scientific Corporation, Marlborough, MA, USA) bei einem Patienten mit Belastungsinkontinenz nach radikaler Prostatektomie, der durch komplizierten Verlauf der vorherigen Inkontinenztherapie letztlich mit einer perinealen Urethrostomie versorgt wurde. Die Kontinenzsituation und die postoperative Lebensqualität nach Versorgung mit dem neu implantierten Sphinktersystem zeigen, dass eine Boutonnière keine Kontraindikation für die Versorgung mittels künstlichem Blasenschließmuskel darstellt.Abstract In this case report, we describe, for the first time, the implantation of an AMS-800 sphincter (Boston Scientific Corporation, Marlborough, MA, USA) in a patient with stress incontinence following radical prostatectomy, who was ultimately treated with an perineal urethrostomy due to a complicated course of previous incontinence therapy. The continence status and postoperative quality of life after treatment with the newly implanted sphincter system clearly demonstrate that a boutonnière deformity is not a contraindication for treatment with an artificial urinary sphincter
