International Journal of Progressive Sciences and Technologies
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Oncolytic Viruses: A New Frontier in Cancer Therapy
Full text linkOncolytic viruses (OVs) have surfaced as a promising approach for combating tumors owing to their ability to selectively proliferate within cancer cells, trigger apoptosis, and activate immune responses. Nevertheless, the therapeutic potency of individual OVs is hindered by the intricate and immunosuppressive characteristics of the tumor microenvironment (TME). To tackle these obstacles, the engineering of OVs has become a pivotal area of research. This review spotlights engineering techniques and multimodal combination therapies for OVs aimed at overcoming delivery challenges, viral engulfment, and antiviral immune responses in cancer treatment. The engineering strategies examined involve amplifying in vivo immune responses, enhancing replication efficacy within tumor cells, boosting safety profiles, and refining targeting capabilities , while summarizing ongoing clinical trial data. By persistently refining engineering techniques , we can realize enhanced treatment outcomes and improved quality of life for cancer patients
Activité Hypoglycémique De L’extrait Aqueux De Syzygium Guineense Subsp Guineense (Wild) Dc Chez Des Souris Diabétiques Induite Par L’Alloxane
Full text link Syzygium guineense subsp guineense (Wild) est utilisé en médecine traditionnelle dans le traitement du diabète par le peuple Wongo du secteur Kipuku au Territoire d’Idiofa Province du Kwilu enRDC. Le but de cette étude était d'évaluer l'activité l'hypoglycémique de l'extrait aqueux de l’écorce de tronc de cette plante médicinale sur les souris (Mus musculus). L’extrait a été préparé dans de l'eau bouillante et le filtrat aqueux a été lyophilisé et conservé. Syzygium guineense subsp guineense est une plante capable d’induire une hypoglycémie chez les souris diabétiques. Alloxane a été administré en dose unique (80 mg/Kg P.c) par injection intrapéritonéale. Des souris femelles et mâles (n = 42) pesant 20 ± 2g divisés en 5 groupes de 6 souris par groupe, ont reçu des doses différentes (250 mg/Kg P.c, 500 mg/Kg P.c, 1000 mg/Kg P.c) par voie orale. Cette opération est répétée tous les jours pendant 10 jours. La glycémie a été prélevée à l’aide d’un glucomètre ( ACCU Chek). Seul l’extrait aqueux des différentes doses ont diminuée le taux du glucose sanguins comparativement au groupe control. Dans la présente étude, le potentiel hypoglycémiant de Syzygium guineense subsp guineense est démontré chez les souris. Ces résultats confirment l'utilisation de cette plante comme antidiabétique par le peuple Wongo de Kipuku du territoire d’Idiofa
Effects of aqueous extract of Amblygonocarpus andongensis (Fabaceae) stem bark on acute kidney injury induced by unilateral ureteral obstruction in Wistar rats
Full text linkObjective: The aim of this study was to evaluate the mechanism of action of Amblygonocarpus andongensis on acute kidney injury (AKI) induced by unilateral ureteral obstruction (UUO). Methods: 36 rats were divided into six groups of six animals each. AKI was induced by UUO on all animals except those in the normal and sham control groups, under anaesthesia. The animals were treated with 5 ml/kg distilled water (normal, sham and negative controls), aqueous extract of A. andongensis stem bark (AEAASB) at doses of 125, 250 and 500 mg/kg (test groups), daily for 3 days. Urinary, haematological, serum and oxidative stress parameters were assessed. Histological sections of the kidneys were taken. Results: AEAASB caused a significant decrease in the mass of obstructed kidneys, leucocyte count (p < 0.001), urinary protein and serum creatinine levels and consequently increase urinary creatinine level and the value of renal creatinine clearance (p < 0.001). Additionally, this extract, significantly decreased malondialdehyde levels (p < 0.05) and increased superoxide dismutase, catalase, reduced glutathione and nitric oxide levels (p < 0.001). Microphotographs showed that this extract prevented renal tissue damage induced by UUO. Principal component analysis and agglomerative hierarchical clustering showed that AEAASB has therapeutic effects on AKI associated with UUO and that the 500 mg/kg dose was the most effective. Conclusion: AEAASB has nephroprotective effects which are thought to result from its vasodilatory and inhibitory action on the renin-angiotensin-aldosterone system, via an increase in nitric oxide production
Comparative Analysis of Classical and Post-Quantum Cryptographic Methods for Secure Digital Signature Implementation in the Quantum Era
Full text linkRapid improvements in quantum computing have posed substantial hurdles to conventional cryptography systems, which depend on the computational intractability of resolving intricate mathematical issues. Digital signatures, fundamental to data security, guarantee the authenticity and integrity of digital communications. Nevertheless, traditional cryptography techniques, like RSA and ECC, are becoming more susceptible to quantum attacks owing to the substantial computing capabilities of quantum computers. Post-Quantum Cryptography (PQC) has developed as a crucial domain dedicated to the creation of quantum-resistant algorithms that can endure these dangers. This research examines the relative efficacy of conventional and quantum cryptography techniques, concentrating on the processes of digital signature creation and validation. Experimental findings underscore the trade-offs between the two methodologies regarding computing efficiency and security strength. Although classical cryptography has superior execution speeds, it is deficient in the robustness necessary to withstand quantum assaults. In contrast, PQC approaches, although somewhat more resource-demanding, provide superior security via sophisticated algorithms like lattice-based, hash-based, and multivariate polynomial cryptography. The research demonstrates that PQC mitigates the weaknesses of conventional cryptographic systems while providing a scalable and pragmatic solution for secure communication in the quantum age. This study underscores the need for ongoing research and enhancement of PQC approaches to augment their computing efficiency and facilitate smooth incorporation into current infrastructures. The results provide an essential foundation for the shift to quantum-resistant encryption, safeguarding sensitive information in a swiftly changing digital environment
Examining Regional Elections (Pilkada) Through Strategic Leadership Theory: Integrating The Total People's Defense System And Grassroots-Oriented Policies
Full text linkRegional elections, commonly referred to as Pilkada in Indonesia, serve as a vital democratic mechanism for selecting regional leaders and influencing policy directions that impact local development and national priorities. Traditionally viewed as arenas for political competition, Pilkada holds the potential to transcend elite-focused dynamics and become a transformative platform for fostering inclusive governance, strengthening social cohesion, and advancing national resilience. This article examines Pilkada through the lens of strategic leadership theory, emphasizing its capacity to integrate developmental and defense-oriented objectives within the framework of the Total People's Defense System (Sistem Pertahanan Rakyat Semesta, SPRS). By employing a conceptual and analytical approach, this study explores how adaptive leadership, inclusivity, and grassroots participation can be leveraged to align Pilkada outcomes with both local needs and broader national interests. It identifies strategic leadership as a critical component in ensuring that Pilkada transitions from a focus on electoral competition to a mechanism for producing leaders capable of addressing complex regional challenges, promoting participatory governance, and contributing to sustainable development. Furthermore, the integration of SPRS principles into Pilkada processes is highlighted as a means to enhance regional resilience by embedding defense and security considerations into governance frameworks. The findings underscore the importance of policy recommendations aimed at institutionalizing grassroots engagement, fostering collaboration between stakeholders, and enhancing public literacy on the democratic and developmental roles of Pilkada. This abstract offers a strategic framework for transforming Pilkada into a more effective and productive platform for national development, governance reform, and societal empowerment
Sharia-Based Cooperatives: Empowering Indonesian Workers in Pulau Pinang, Malaysia
Full text linkThe sharia cooperative formation assistance programme for the Indonesian migrant worker (TKI) community in Pulau Pinang, Malaysia, implemented by the Faculty of Economics and Business, Sultan Ageng Tirtayasa University, is a strategic international community service effort in providing sustainable solutions for economic management based on sharia principles. In three days, 50 participants who are MSME players from various sectors and are members of the Pertubuhan Masyarakat Indonesia di Pulau Pinang (PERMAI) participated in a series of intensive seminars and workshops on the main concepts of sharia cooperatives, such as profit-sharing systems (mudharabah), business cooperation (musyarakah), and efforts to avoid the practice of riba, gharar, and maysir. The participants were given an in-depth understanding of the practical steps of establishing a cooperative, from forming the establishment committee, drafting the articles of association, collecting initial capital, to opening an account at an Islamic bank. In addition, to strengthen the competitiveness of cooperatives in the digital era, participants were also introduced to the application of digital marketing strategies aimed at expanding the market network and increasing the visibility of Islamic cooperatives. While the programme succeeded in providing applicable insights and concrete steps in the establishment of cooperatives, the main challenges faced were limited understanding of Islamic financial terminology as well as limited access to Islamic financial services in Pulau Pinang. The programme proved to have a positive impact in improving the economic capacity of the community, with the hope of continued mentoring and ongoing collaboration with Islamic financial institutions in Malaysia, to ensure the sustainability and development of Islamic cooperatives as an inclusive economic model that can sustainably empower migrant workers
Conception Et Dimensionnement Des Ouvrage D’Assainissement Dans La Ville De Kinshasa : Cas Du Quartier Musey
Full text linkL’homme est à la base de changement de la topographie du terrain suivant sa manière de développé son environnement avec la construction des bâtiments à divers usages. Suite à ce changement l’homme ne peut pas oublier les infrastructures qui font partie de facteur du développement de son milieu. La ville province de Kinshasa connait de problème lié au manque des infrastructures dans la grande partie de son territoire, cela entraine des catastrophes liées à la gestion de ruissellement. Le quartier Musey l’un de quartier de la commune de NGALIEMA n’est pas épargné, car il a été remarqué la présence de quelques collecteurs sur la chaussée d’une seule avenue, tant disque les restent des avenues n’en ont pas. Pendant les averses les avenues sont inondées étant à la base d’une mauvaise circulation, les eaux usées sont jetées sur les avenues comme conséquence la création de moustique qui favorise les maladies tel que : la typhoïde, la malaria, …Pour arriver à résoudre ce problème cet article a fait une étude de son bassin versant enfin de déterminé l’eaux qui inonde cette agglomération ensuite de concevoir et dimensionner les ouvrages d’un réseau secondaire qui vont collecter et évacuer les eaux de ruissellement.
Dégradation Environnementale Due Aux Aléas Hydro- Climatiques Au Quartier Ndanu, Commune De Limete
Full text linkLe quartier Ndanu fait face à des nombreuses crises d’inondation saisonnière récurrente. Elles sont à l’origine des conséquences socio-économiques souvent grave et coûteuse. Quant ‘il pleut à Kinshasa, cette zone se transforme comme une marée où un marécage à cause de la stagnation d’eau pluviales. Ces eaux stagnantes exposent à la population aux maladies hydriques et vectorielles ainsi que une aggravation de phénomènes d’effondrement et éboulement des maisons. Puis, la pression démographique a fait pousser les constructions anarchiques, sans réseau de drainage d’eau pluviale et usée. Du point de vue méthodologie, nous avons recouru à la méthode descriptive, l’observation participative et la technique d’enquête.Nous avons abouti au résultat ci-après :- Soit 40% des facteurs favorisant d’inondation au quartier Ndanu sont liés aux aléas comme les pluies torrentielles, les eaux de ruissellement à forte vitesse, les crues de rivières locales et du fleuve ;- Près de 25% de facteurs de risque d’inondation sont dues à la nature du sol ; Ndanu à un sol hydromorphe avec une nappe phréatique qu’est superficielle autrement dit nappe libre. Le niveau d’eau de précipitation de cette zone est d’environ 450mm d’eau, soit près du tiers des précipitations annuelles de Kinshasa (H : 3 à 5 m¨) ;- Environ de 20% de cas d’inondation sont attribuées à la mauvaise gestion des déchets. les déchets sont renversés dans les rivières et caniveaux ;- Près de 15 % de facteurs de risque d’inondation au quartier Ndanu sont dus aux constructions anarchique
The use of functions f:D_1×D_2→R^2 for encrypting and decrypting data in a plane
No full textThe study of cryptosystems is significant, and valuable scientific works are dedicated to them. Cryptosystems are mathematical structures that deal with data encryption and decryption, focusing on confidentiality and authenticity. Cryptography plays a crucial role in meeting these requirements, with numerous researchers proposing various solutions and developing algorithms that have contributed to the security of data confidentiality, integrity, and authentication. However, the issue of securing the internet through modern cryptography has also become increasingly complex. Modern encryption systems rely on complex mathematical algorithms and employ a combination of symmetric and asymmetric key encryption schemes to ensure secure communication. The use of for image encryption provides an effective and secure method for protecting the privacy, security, and confidentiality of sensitive data, such as artwork or sketches.The use of functions operating in two-dimensional space encrypts images in a way that makes it difficult for unauthorized individuals to decipher their shape and structure.The use of encryption functions for images has the potential to be applied in industries such as product design, computer graphics, virtual reality, engineering, and many other fields
Organisation De L'Entrepreneuriat Féminin En République Démocratique Du Congo
Full text linkA la suite de la crise générale que connait le pays depuis cinq décennies, nombreuses sont des femmes congolaises qui sont parvenues à créer leurs propres petits et moyennes entreprises (PME).La présente étude sur l'organisation de l'entrepreneuriat en RDC a eu pour objectif d'évaluer l'organisation des PME créées et gérées par les femmes congolaises. Pour cela, notre préoccupation a consisté à connaître si ces entreprises sont organisées et gérées selon les principes scientifiques de gestion managériale. En termes de réponse anticipée à cette interrogation, nous avons postulé que les PME créées et gérées par les femmes congolaises appliqueraient les principes de gestion managériale.Pour récolter les données sur le terrain, nous avons eu recours aux techniques de questionnaire et de la documentation.Il résulte de l'enquête que les PME créées et gérées par les femmes congolaises appliquent les principes de gestion managériale par l'établissement du document qui définit les attributions de chaque personnel (72%) ; ont un horaire de travail (84%) et enfin, procède au recrutement du personnel (72%)