5153 research outputs found
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Novel Therapeutic Inhibitors Having Sugar Moiety Targeting HER2/EGFR as Anticancer Agent
No full textSeveral effective small-molecule inhibitors of HER2 or EGFR have been developed to treat metastatic cancer, and some of those drugs are dual HER2/EGFR inhibitors. To investigate the mechanism of the dual inhibition of the receptor tyrosine kinases HER2 and EGFR1, we carried out virtual screening for benzimidazole derivatives having sugar moiety. Based upon virtual screening and HER2/EGR1 assays data simulation, we confirmed and chosen the benzimidazole skeleton which NO2 functional groups as a key skeleton for the dual inhibition towards HER2/EGFR1 (8.81 µM, Figure 6) to design novel tyrosine kinases inhibitors. After selection of the core skeleton, we designed our novel inhibitors, targeting both HER2/ EGFR1 and having a benzimidazole skeleton including a sugar moiety as aiming to balance their hydrophilic and hydrophobic properties and to increase cell penetration including the pharmacokinetics properties. We are investigating the synthesis of target agent (T-1) and biological properties of these agents against cancer cell line
Enterprise Data Security Strategy against Cryptographic Ransomware
No full textThis study proposes a decision model for Data Security Strategy supporting risk management of ransomware. Ransomware is an emerging threat targeting valuable sensitive information inside enterprise networks. The attack either encrypts all data and backups with strong algorisms or exfiltrates for exposure in order to ransom the victims
Crash Alert System
No full textThere is a growing number of fatalities due to car accidents in the United States. An influential indicator of survival rates is the time between the occurrence of the accident and the arrival of emergency responders to the scene. Reductions in this time may decrease the numbers of fatalities. Therefore, we want to build an Arduino-based warning system that gives visual and audio warning to drivers before collision. If the driver fails to avoid collision, the alert system is triggered and will alert authorities. Sensors and the accelerometer will determine if an accident occurred via text, email or phone call. With rising deaths associated with car accidents, responding swift can curve this alarming trend
An integrative review of the challenges in 3D bioprinting
No full textAs a method of scaffold fabrication, 3D bioprinting uses a combination of natural and synthetic materials for useful tissue scaffold. The formulation of advanced bioink is getting widespread attention. However, there is a challenge associated with bioink and their printing using varied printing nozzles. Printing of biomaterials ink is a customized method to provide a chance to diffuse different cell types at desired locations. Materials that can be printed and then seeded with cells after printing, but are not directly formulated with cells, which needs external stimuli for crosslinking. The major purpose of this integrative review poster is to look at how material selection, synthesis methodologies, computational navigation of printer, environmental conditions, and post-printing effects on in-vitro 3D printed scaffolds
First-Year Experience (FYE) & Student Success and Engagement Among First-Generation Students
No full textThis research focuses on how we can use first-year experience (FYE) seminars to support first-generation students in college. There is a heavy focus on how integrating student support services into a classroom setting can help promote social engagement, academic success, and retention among first-generation students by giving them all of the tools they need under one curriculum
Neural Models for 3D Face Generation and Recognition
No full textThis work introduces a new technique for 3D point clouds generation using a neural modeling system to handle the differences caused by heterogeneous depth cameras, and to generate a new face canonical compact representation. The proposed system reduces the stored 3D dataset size, and if required, provides an accurate dataset regeneration. Furthermore, the system generates neural models for all gallery point clouds and stores these models to represent the faces in the recognition or verification processes. For the probe cloud to be verified, a new model is generated specifically for that particular cloud and is matched against prestored gallery model presentations to identify the query cloud. This work also introduces the utilization of Siamese deep neural network in 3D face verification using generated model representations as raw data for the deep network, and shows that the accuracy of the trained network is comparable to all published results on Bosphorus dataset
Blockchain Adaptability in Internet of Thing (IoT) Environments
No full textBlockchain is a considered to be a disruptive technology as like an Internet. The features of blockchain are giving more expectations in their applications. Internet of Things is emerging day by day with millions of connecting devices. Even though Internet of Things is evolving, the security of the internet of things is questionable with its architecture
Autonomous Network of Robots
No full textThe main focus of this project is to create a network of autonomous, four-wheeled robots whose main purpose is to transport packages within a shipping warehouse. We are utilizing inexpensive open source hardware and software to make our robots perform different tasks that are required in a shipping warehouse. The main goals for this project are to implement a collision avoidance program, create optimal paths and schedules for the robots to carry and direct the packages to the appropriate location in the warehouse. The design of our robots will consist of, Arduino Microcontroller, ultrasonic Sensors, Servo motors and a Servo Motor Shield
Blockchain and Cryptocurrency Challenges: Toward Environment-Friendly Mining Process
No full textBlockchain technology is one of the most disrupted innovations developed in the 21 century. It was basically proposed by Satoshi Nakamoto in 2009 as a solution to the double-spending risk associated with peer-to-peer payment systems[2]. The mechanism of blockchain technology relies on a chain of digital signatures that uses the private and public keys to secure transactions between two parties in the form of blocks. Each block hashed into the blockchain based on the proof of work concept, which is basically a vote of a group of participant nodes (CPUs). Nevertheless, to maintain the continuity of blockchain, a reward system in the form of bitcoin has been developed to motivate miners to execute transactions, which leads to high energy consumption and related environmental impacts present an imminent threat to blockchain survival. This research project aims to further investigate this challenge and provide a scientific-based solution that could help reduce the environmental impact of mining while maintaining the prosperity of blockchain technology
Water Injection of a Small Engine
No full textThe main objective of this project is to create a water injection system for a small air cooled engine. The design involves a 6.5 hp 4 stroke engine, with a displacement of 196cc. The design intent is to design an injection system to inject a water/methanol mixture at a given rate to assist the air cooling of the engine and increase the density of the intake air by decreasing the temperature. These systems are common on high performance, large 4 stroke water cooled engines in cars. Some benefits of using a water/methanol mixture is that it cools the intake air and reduces the emission of NOx from combustion. Our design is focused on creating an intake tube that will be easily bolted onto the intake of any small engine, and an injection system to inject the water mist into the tube. The solution to be injected is a water mist, which will cool the intake charge and cause the air to be denser. There will be two temperature sensors, one for the incoming air and one for the treated air with the mixture. Due to our budget constraint of $400, there will not be a NOx sensor on the exhaust to measure the emissions. In order to use the NOx emission reduction, the intake charge must have a sizable temperature reduction in the intake tube before proceeding into the engine. Our simplistic design will be able to record the temperature difference between the incoming air and treated water/methanol vapor mixture. The design also incorporates a small nozzle of size 0.003” for the mixture passageway into the tube, limiting the flow from the electric pump to prevent too much flow into the engine. The pump, which is a 12v DC powered pump, will have a potentiometer to adjust the resistance and therefore adjust the flow from the pump into the system