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Optimization of aluminum extrusion die using finite element analysis and experimental validation
No full textBu tez çalışmasında, alüminyum ekstrüzyon sürecinde kullanılan kalıpların tasarımı, sonlu elemanlar programı Inspire Extrude Metal kullanılarak analiz edilmiş ve iyileştirilmiştir. Üç farklı alüminyum alaşımı ve profil tipi için yapılan analizlerde, sıcaklık, malzeme akış hızı ve gerinim olmak üzere üç temel parametre ele alınmıştır. Analiz sonuçları doğrultusunda, ekstrüzyon kalıp tasarımları söz konusu parametrelere göre optimize edilmiş, böylece malzeme akışında homojenlik sağlanması, oluşabilecek hataların azaltılması ve kalıp ömrünün artırılması hedeflenmiştir. Simülasyon sonuçları ile elde edilen nihani ürün arasında yüksek uyum elde edilmesi, sonlu elemanlar yöntemiyle yapılan analizlerin geçerliliğini ortaya koymuştur. Bu çalışma, alüminyum ekstrüzyon prosesinde kalıp tasarımının sayısal yöntemlerle iyileştirilmesiyle, üretim kalitesinin artırılması, enerji verimliliği ve maliyet açısından önemli katkılar sağlamaktadır.In this thesis study, the design of dies u
Eligibility of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulator therapies: cohort of cystic fibrosis registry of Türkiye
No full textBackground. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) variants are essential for determining eligibility for CFTR modulator drugs (CFTRms). In contrast to Europe and the USA, the treatment eligibility profile of cystic fibrosis (CF) patients in T & uuml;rkiye is not known. In this study we aimed to determine the eligibility of CF patients in T & uuml;rkiye for the CFTRms. Methods. The Cystic Fibrosis Registry of T & uuml;rkiye (CFrT) data was used to determine the age of patients in the year 2021 and the genetic variants they were carrying. Age- and CFTR-variant appropriate modulator therapies were determined using the Vertex (R) algorithm. Results. Among a total of 1930 registered patients, CTFR gene analysis was performed on a total of 1841 (95.4%) patients. Mutations were detected in one allele in 10.7% (198 patients), and in both alleles in 79% (1455 patients) of patients. A total of 855 patients (51.7% for whom at least 1 mutation was detected) were eligible for the drugs. The most appropriate drug among genotyped patients was found to be elexacaftor/tezacaftor/ivacaftor for 486 patients (26.4%), followed by ivacaftor for 327 patients (17.7%) and lumacaftor/ivacaftor for 42 patients (2%). Conclusions. Only half of patients registered in CFrT were eligible for CFTRms, which is a significant difference from the CFTR variant profile seen in USA and Europe. However, access to treatment is hampered for some patients whose genes are not analysed. Further studies in CF populations, where rare mutations are relatively more common, will contribute to the field of CFTR modulator treatments for such rare mutations
Unveiling the nutritional value and potentially toxic elements in fish species from Miliç Wetland, Türkiye: A probabilistic human health risk assessment using Monte Carlo simulation
No full textThis study evaluates the nutritional value and health risks of fish from Mili & ccedil; Wetland, T & uuml;rkiye, focusing on potentially toxic elements (PTEs) in Esox lucius, Squalius cephalus, and Carassius gibelio. Using ICP-MS, mean PTE concentrations were determined, including Zn (4979 mu g/kg), Fe (4241 mu g/kg), and As (125 mu g/kg). Macro elements like K, P, and Ca were also assessed for nutritional profiling. A Monte Carlo-based risk assessment confirmed that PTE levels were below safety limits, indicating safe consumption. Chemometric techniques (PCA, PCC, HCA) helped trace contamination sources, identifying residential, agricultural, and lithogenic inputs. Esox lucius showed the highest essential nutrient levels. This research highlights the importance of combining chemometric analysis with regular monitoring for food safety and public health protection.Giresun University Scientific Research Office [FEN-BAP-A-290224-43]This research was funded by the Giresun University Scientific Research Office under award number FEN-BAP-A-290224-43
Reality in abstract sculpture
No full text'Soyut Heykelde Gerçeklik' adlı bu tez çalışmasında, 'soyut heykel sanatı' olarak değerlendirilen sanatsal ifade biçimi, 'gerçek ve gerçeklik' kavramları bağlamında irdelenmektedir. Yaşantımız içinde çok fark edilemese de en önemli olgulardan biri gerçeklik anlayışımızdır. Gerçeklik, çağdan çağa, kültürden kültüre olduğu kadar bireyin öznel yargılarına bağlı olarak da değişir ve dönüşür. Gerçeklik kavrayışımız, yaşantımız boyunca bir şeyleri algılama ve anlamlandırmada sürekli bizlere eşlik eder. Bir nesneye baktığımızda aslında ilgilendiğimiz şey sadece onun dış dünyada yer edinmiş şekli değildir. Gerçeklik, dış dünyada olanların ardında, ötesinde durmaktadır. Gerçeklik anlayışı insanoğlu var olduğundan itibaren sanatla iç içe olmuş ve farklı şekillerde yansıtılmıştır. Soyut sanat, nesnelerin dış görünümlerinden uzaklaşır, bizlere yalınlık içinde gerçekliği sunar, bu gerçeklik, dış dünyaya dair bir yansıma değildir. Soyut heykel, geleneksel heykel anlayışlarından bağımsız olarak, görünüşleri kopyalamaktan ziyade sanatçının duyguları, düşünceleri ve estetik arayışını da yansıtan farklı bir gerçeklik boyutuna sahiptir. Bilinen gerçeklik ile bir çeşit yüzleşme olarak da değerlendirilebilecek olan soyut heykel, izleyiciye sanatçısının özgün ve öznel iç dünyasının da etkin olduğu bir gerçeklik sunar.In this thesis titled 'R
Examining digital art in the context of art and technology relations
No full textTeknolojinin yaşamın tüm alanlarında dönüştürücü bir güç haline gelmesi, sanat pratiğini de derinden etkilemiş; bu bağlamda dijital sanat, çağın estetik, kavramsal ve toplumsal dönüşümünü yansıtan bir ifade alanı olarak öne çıkmıştır. Sanat-teknoloji ilişkisini yeniden tanımlayan dijital sistemler, geleneksel sanat anlayışlarının ötesine geçen süreçsel, çok katmanlı ve etkileşimli üretim biçimlerinin gelişmesini sağlamıştır. Bu tez, dijital sanatın tarihsel gelişimini Sanayi Devrimi'nden itibaren ortaya çıkan teknolojik kırılmalar üzerinden incelemekte; 20. yüzyıl başındaki deneysel sanat pratiklerinden bilgisayar teknolojileriyle kurulan ilk etkileşimlere kadar olan süreci analiz etmektedir. AR, VR ve AI gibi güncel teknolojilerin etkisiyle sanat eserlerinin kullanıcı katılımına açık, dinamik yapılara dönüştüğü ve sanatçı-izleyici ilişkisinin yeniden şekillendiği vurgulanmaktadır. Nitel yöntemle yürütülen çalışmada literatür taraması yapılmış ve seçili dijital sanat projeleri değerlendirilmiştir. Türkiye'de 2000'li yıllardan itibaren gelişmeye başlayan dijital sanat ortamı, sınırlı altyapı ve kurumsal desteklere rağmen bireysel ve kolektif çabalarla önemli bir ivme kazanmıştır. Elde edilen bulgular, dijital sanatın yalnızca teknik bir ifade değil, aynı zamanda kültürel üretim, toplumsal eleştiri ve katılımcı sanat anlayışları için yeni olanaklar sunduğunu göstermektedir. Ayrıca dijital sanatın etkileşimli yapısıyla geleneksel sanat tanımlarını dönüştürdüğü ve sürdürülebilir biçimde arşivlenmesi gerektiği sonucuna ulaşılmıştır.The transformative powe
Preparation of nano(micro)particles from Cotinus coggygria scop. Extracts and investigation of their antimicrobial effects in vivo Caenorhabditis elegans model
No full textCotinus coggygria Scop. (Anacardiaceae) is traditionally used in Turkiye for wound and burn treatment. A series of nano/micro-sized polymeric particles were prepared from aqueous and ethanol extracts of Cotinus coggygria leaves by reverse micellar microemulsion polymerization. Optimization studies were conducted with the effect of the solvent/surfactant, crosslinker, and extract components and their amount. Thermal Gravimetric Analysis, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, and Zeta Potential measurement were conducted. In vitro antimicrobial microdilution method was utilized with minor modifications against Staphylococcus aureus ATCC 6538. Polymeric particles' toxicity and in vivo antimicrobial effect were evaluated on the life span Caenorhabditis elegans assay and C. elegans-S. aureus infection model, respectively. Synthesized microparticles (GS04) in vitro antimicrobial activity was investigated against S. aureus ATCC 6538. GS04 (Minimum Inhibitory Concentration = 62.5 mu g/mL) microparticle was more effective against S. aureus, demonstrating no nematode survival changes at 500, 250, 125, 62.5, 31.25, and 15.625 mu g/mL concentrations, achieving anti-infective effect at 250-15.625 mu g/mL for GS04. Nanoparticles did not affect the colonization of S. aureus in the nematode model system. Therefore, concentrations of the selectively nontoxic anti-infective effect of synthesized nanoparticles from C. coggygria were identified for the first time against S. aureus ATCC 6538.Research Fund of the Trakya University (Turkiye) [2021/22]This work was supported by the Research Fund of the Trakya University (Turkiye) Project Number:(2021/22)
Addressing vaccine hesitancy among family physicians and Expanded Programme on Immunization managers: A quasi-experimental study
No full textObjective: To assess the capacity of family physicians and those associated with the Expanded Programme on Immunisation as managers to cope with cases of vaccine hesitancy. Method: The quasi-experimental study was conducted in Edirne, Turkiye, from May 20 to August 1, 2019, and comprised family physicians and Expanded Programme on Immunisation managers. After evaluating the subjects' capacity to address vaccine hesitancy, a training course was conducted that had 8 sessions for the physicians and 1 session for the managers. After the intervention, the capacity of the subjects was evaluated again. In assessing the effectiveness of the intervention, relative efficacy, attributed efficacy and efficacy were calculated. Data was analysed using SPSS 22. Results: There were 111 participants with mean age 45 +/- 8.9 years (range: 27-70 years) and mean professional experience 19 +/- 8.7 years (range: 1-37 years). The participants developed a positive attitude towards getting influenza vaccine for themselves, vaccinating their children with all vaccines, vaccinating their elderly or their relatives with chronic diseases (p<0.05). The participants were positively influenced by the training in terms of motivational interviewing with vaccine hesitancy cases and being prepared for their doubts about the vaccine's necessity, effectiveness, content, safety, side effects and conspiracy theories (p<0.05). Conclusion: Training of family physicians and Expanded Programme on Immunisation managers increased awareness regarding immunisation
Evaluation of color matching of three single-shade composites employing simulated 3D printed cavities with different thicknesses using CIELAB and CIEDE2000 color difference formulae
No full textThis study assessed the color-matching capability of three single-shade composites that employ simulated resin 3D-printed cavities with different cavity depths using CIELAB and CIEDE2000 formulas. A cylindrical model with standardized cavities was generated. One hundred and fifty blank specimens were fabricated and divided into three groups (n = 50) and then into five subgroups. The five subgroups included four groups of specimens with 0.5, 1, 2, and 4mm cavities and a control group of specimens without cavities (n = 10). Cavities were filled with Vittra Unique (VU), Omnichroma (OC), and OptiShade (OS). Color measurements were done using a clinical spectrophotometer. The color differences for all composites were calculated as Delta E and Delta E-00 using CIELAB coordinates. The color parameter data were analyzed (alpha = 0.05). OS had significantly lower E and E-00 values than the other composites for all layer thicknesses (p < 0.05). VU, OC, and OS had the lowest E and E-00 values at 0.5mm (p < 0.05). Color matching of monochromatic composites decreased as the layer thickness increased. OS achieved the best color matching in this study. Single-shade composites are important for reducing chairside time and gaining confidence in clinical practice. CIELAB and CIEDE2000 color difference formulae can be used in different studies with similar results
To Accept or to Ignore: School Leaders' Reactions to Errors
No full textErrors are present in every organization, or structure involving people. They are inevitable in schools where school leaders, teachers, students, and parents maintain close contact. School leaders are key persons in managing errors effectively. By managing errors, they can turn them into positive consequences like learning, change at school. Error management is not about preventing errors, but about avoiding the negative consequences of errors and reducing their effects. In this regard, this study aims to reveal the views of school leaders regarding error management and strategies in schools through qualitative research administering semi-structured interviews with ten school leaders. Findings indicate that school leaders' dominant perspective on error is that it is accepted, though a few ignore or deny errors. There are individual (neglect, lack of knowledge and skill, state of well-being) and collective (lack of communication, unclear legislation, school culture) sources of errors. The findings of this study have revealed that error management strategies can be categorized before an error (detailed explanation, setting rules, sharing past errors), after an error (immediate intervention, ignorance, enforcing legislation, mediating, taking advice and warning), and in terms of both cases (communicating, tolerant school culture). The participants regard errors as learning, benefit, and change at school. The study concludes that errors can be managed easily when they are seen as a part of human nature
Does Irisin Have an Effect on the Development of Type 2 Diabetes Mellitus and the Development of Atherosclerosis in Diabetic Patients?
No full textBackground: Type 2 diabetes mellitus (T2DM) is a prevalent public health problem with high mortality rate due to the complications it causes. However, recent data indicate that irisin may play an important role in preventing the development of T2DM and reducing the occurrence of atherosclerosis. The purpose of our study was to investigate the effect of irisin on the development of T2DM and carotid artery intima-media thickness (C-IMT), an early indicator of atherosclerosis in diabetic subjects without known cardiovascular disease (CVD). Methods: Our study included 41 healthy volunteers and 93 patients who were followed up with a diagnosis of T2DM. Irisin levels were determined by the sandwich enzyme-linked immunosorbent assay method using the Elabscience (R) Human Irisin Elisa Kit H6120. C-IMT measurement was performed using a Toshiba Aplio 500 brand ultrasonography device, a B-Mode USG, and a 7.5-18 MHz linear probe. In the T2DM group, patients were divided into those with or without subclinical atherosclerosis, in addition to those with low, medium, and high irisin levels, and the results were compared. Results: We found that patients with T2DM had significantly lower irisin levels than the healthy control group (P < .001). In our patient group, each 10-year increase in patient age increased C-IMT by 0.06 mm (95% confidence interval (CI): 0.030.08) mm, and being male increased C-IMT by 0.117 mm (95% CI: 0.068-0.166). A negative linear relationship was found between C-IMT and irisin levels, which did not reach statistical significance (r=-0.145, P = .165). Compared to patients with high irisin levels, patients with low irisin levels had 0.113 mm thicker C-IMT values (0.734 +/- 0.129 mm and 0.621 +/- 0.140 mm, respectively, P = .004). Conclusion: Our findings indicate that low irisin levels facilitate the development of T2DM and increase diabetic complications such as subclinical atherosclerosis and diabetic nephropathy