Asian Journal of Advances in Medical Science
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CURRENT ADVANCEMENTS ON THE EFFICACY OF CONVALESCENT PLASMA AS A POTENTIAL PROMISING TREATMENT FOR COVID-19
Get PDFPurpose: No sooner had COVID-19 hit the world in December, 2019 in Wuhan, China, than the emergence of tremendous developments on the therapeutic interventions for the pandemic. No therapy has been proved successful up to date regardless potentiality of several intervention that are still in clinical trials. However Convalescent plasma demonstrated some sort of interest to be potential for the treatment of COVID-19 as we are still waiting for a specific therapy or vaccine. This review discusses current developments that supported the efficacy of convalescent plasma to attract its potentiality for treating COVID-19.
Methods: A systematic search with a search term “efficacy of convalescent plasma on COVID-19” was done on PubMed, Google Scholar, Science direct, Research Gate and clinicaltrials.gov database. A search was conducted based on all the literature discussing the current advancements on the use of convalescent plasma as a potential treatment for coronavirus, however only studies that discussed its efficacy were retrieved in this review.
Results: We retrieved a total of 24 articles discussing the current developments on the use of convalescent plasma as a potential treatment for COVID-19. 70% of the articles discuss its success, 20% of the articles evaluate current ongoing clinical trials for convalescent plasma while the remaining 10% present concerns on the inappropriate administration of convalescent plasma as a COVID-19 therapy.
Conclusion: Several discussed studies demonstrated much attention on the use of convalescent plasma as a potential promising therapy for COVID-19, although this has not been proven. However, other studies expressed concerns over the inappropriate administration of the therapy where COVID-19 patients ended up developing a pro- thrombotic disease
TRIGLYCERIDES VARIATIONS AMONG THE BLOOD OF ALCOHOLIC AND NON-ALCOHOLIC PEOPLES FROM DIFFERENT STATES OF INDIA
Get PDFDiabetes is a set of various disorders characterizes by hyperglycemia and glucose intolerance, due to the insufficiency of insulin and/or impaired effectiveness of insulin action. It is observed that every population in this world suffering from Diabetes Mellitus (DM) and other forms of glucose intolerance, mainly Impaired Glucose Tolerance (IGT). The present study estimates the Triglycerides variations among the blood of alcoholic and non-alcoholic peoples from different states of India. The study includes North Indian states such as Bihar, Uttar Pradesh, Uttrakhand, Himachal Pradesh, Punjab, Haryana and Rajasthan. Plasma Triglycerides level in female and male subjects of Bihar were found 182.63±32.24 and 143.52±11.18 respectively. The mean of Plasma Triglycerides Level in Uttar Pradesh Control nonalcoholic subjects was found to be 235.46±9.46 years. The difference in Plasma triglycerides in Rajasthan Control alcoholic and nonalcoholic subjects were 120.00±0.00 years (Mean ± SE) and 166.68±10.76 (Mean ± SE) respectively
EPIDEMIOLOGY OF CHRONIC LIVER DISEASE IN NIGERIA: A REVIEW
Get PDFChronic liver disease is one of the major health issues which occur throughout the world irrespective of age, sex, region or race. Liver diseases have being ranked the fifth most common cause of death and the second leading cause of mortality amongst all digestive diseases with approximately 2 million deaths per year worldwide. Aimed at determining the relative prevalence of chronic liver diseases in Nigeria, this shows that up to 46% of global diseases and 59% of the mortality is due to chronic liver diseases and almost 35 million people in the world die of chronic diseases with liver disease rate steadily increasing over the years. In Nigeria, (35 million) 2-20% of the population, are infected with hepatitis B and C virus with a prevalence rate of 4.3%-23.3% and 0.5-15% been reported respectively from different part of the country depending on the geographical location. A prevalence rate of 4.3% was reported from Port Harcourt, 5.7% from Ilorin, 11.6% from Maiduguri, and 8.3% from Zaria, 6.78% from Ado-Ekiti among pregnant women, 13.50% from Lagos, 11.50% from Abuja Urban among HIV Patients with a seroprevalence of 23.3% been reported among patients attending all clinics in Kano
COVID-19: UNLOCK 1.0 RISK, TEST, TRANSMISSION, INCUBATION AND INFECTIOUS PERIODS AND REPRODUCTION OF NOVEL COVID-19 PANDEMIC
Get PDFGlobally, novel COVID-19 has create an unbalanced atmosphere for people in every aspect. Infection of novel COVID-19 spreading all over the world and this condition is known as pandemic by the WHO. This pandemic is blocked many of economic activities due to communicable disease and has no cure till date to fight with corona. It has produced vital economic impact on the globe. It may turn out recession in many sectors of the world. In every sector in the globe, most of the products are imported from China, especially in medicine and manufacturing industry.COVID-19 caused a global pandemic resulting in about 20 millions of infections and around a million of deaths worldwide. Prevention strategies such as avoiding traveling to an infected area and avoiding eating wild animals can reduce the spread of novel coronavirus disease (COVID-19). This paper aims to understand the Risk, Transmission, Diagnosis and Reproduction of COVID-19
MATHEMATICS OF COVID-19 IN INDIA AND THEIR POSSIBLE CONTROL BY Allium sativum (L.)
Get PDFSARS-CoV-2 belongs to the betacoronavirus genus. Betacoronaviruses infect mammals, are zoonotic pathogens, and can cause severe respiratory disease in human being. Till date there are no drugs or vaccine to control the infection of this pandemic disease. The present comprehensive review is therefore an effort to give detailed information about Allium sativum (Garlic) against nCoronavirus. The ayurveda and other traditional system of medicine in India described garlic and other medicinal herbs are used against various epidemics time-to-time. Alternatively, a number of literature noted that compounds extracted from garlic and other group of alliums such as allicin, diallytrisulfide, azoene and quercetin exhibit antiviral activity
OVERVIEW ON CORONAVIRUS (COVID-19)
Get PDFCoronavirus (COVID-19) is an important public health emergency of international concern. Firstly COVID-19 was isolated from Wuhan market in China at 7 Jan. 2020. As of this time, there is no known effective pharmaceutical treatment; although it is much needed for patient contracting severs form of the disease. This virus causes respiratory infection in human including sneezing, coughing, cold and pneumonia while in animal it causes diarrhea and upper respiratory diseases. COVID-19 is transmitted human to human or human to animal via airborne droplets. This disease can be diagnosis on the basis of travel history from infected areas, common symptom or by laboratory confirmations. WHO advised to avoid public place, close contact to Coronavirus infected persons, wearing mask, sanitizing hands and maintain social distancing for prevention. It’s also advised infected pensions keep in quarantine center for 14 days or separate from other family member to single separate room, implementation of contact, droplet precaution, and airborne precaution, keep physical distances. Some countries are also using lopinavir/ritonavir, remdesivir, chloroquine and hydroxychloroquine drugs for treatment of Coronavirus but these are not efficient in cure of this disease. The aim of the systematic review of literature is to summarize the evidence regarding COVID-19, symptoms, pathogenesis and prevention/treatment
MAGNITUDE OF GENERALIZED ANXIETY AMONG HEALTH PROFESSIONALS WORKING ON COVID-19 AT DILLA REFERRAL HOSPITAL DILLA, ETHIOPIA
Get PDFBackground: In Ethiopia, Corona confirmed cases are increasing from time to time, and health care professionals were front line exposed risky groups for infection. The mental health of the health professional is vital for better care and treatment outcome patients. This study aimed to determine the health care professional’s current mental health status and associated factors in response to the pandemic.
Methods: A hospital-based cross-sectional survey using a consecutive sampling technique was employed from April 5-10, 2020. Generalized Anxiety Disorder-7 (GAD-7) was the assessment tool used to determine current anxiety symptoms. Multivariate Logistic regressions at 95% CI and p< 0.05 were used to identify factors associated with the outcome variable.
Results: This study enrolled a total of 326 respondents, and the overall prevalence of GAD was 40.2%. Variables associated with General anxiety disorder were being female, family size 3+, nurses, working in out-patient and emergency service, and ≤ 3years working experience at 95% confidence interval, p< 0.05.
Conclusions: This study found that more than one-third of the respondents had a general anxiety disorder in response to the pandemic, and identified groups of the participants were female, nurses, family size 3 +, and ≤ three years of working experience. So there should be immediate psychological intervention and training for an identified group of peoples to promote the mental health status of health professionals for better and quality health service.
 
PHYTOCHEMICAL INVESTIGATION OF PLANTS Acalypha indica (L.) AND Cocculus hirsutus (L.) FROM PRAKASAM DISTRICT, ANDHRA PRADESH, INDIA
Get PDFoai:ojs.mbimph.com:article/1367Objectives: The present study report the phytochemical analysis of chloroform, ethyl acetate, methanolic extracts of leaf, stem bark and root of Acalypha indica (L.) and Cocculus hirsutus (L.) plants.
Methods: Plants material used were collected from Kadaparajupalle at Dornala Mandal, Prakasam district, Andhra Pradesh, India. The authentication of the plant species was done by the taxonomist. The plant part extraction was done by using soxhlet apparatus. The preliminary phytochemical screening of this extracts was conducted by following the standard methods for the presence of the alkaloids, saponins, terpenoids & steroids, flavonoids, tannins, phenolic compounds, coumarins, quinones, resins, and glycosides.
Results: Results indicated the presence of alkaloids, saponins, terpenoids & steroids, tannins, anthocyanidins, phenolic compounds, coumarins, quinones, resins and glycosides in all the plant extracts and could be used for the treatment of wounds and burns.
Conclusion: The presence of high alkaloids, flavonoids and terpenoids of the plant extracts suggest their antioxidant potential and justifies their therapeutic action which could be used for the drug formulation