Indian Journal Of Clinical Practice
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A Controlled Clinical Study to Evaluate the Comparative Effect of Anuloma DS Tablet and Lactitol + Ispaghula Powder in Functional Constipation
Get PDFThe International Classification of Diseases (ICD) has described constipation as decrease in normal frequencyof defecation accompanied by difficult or incomplete passage of stool and/or passage of excessively hard, dry stool (ICD10-CM-K59). Overall, the average prevalence of constipation in adults has been estimated as 16% worldwide (varies between0.7% and 79%); in adults aged 60 to 110 years, the prevalence has been estimated to be 33.5%. Objective: To evaluate andcompare the efficacy of tablet Anuloma DS and lactitol + ispaghula powder in constipation. Materials and methods: Sixty‐twosubjects with constipation were divided into two groups: Group A with 32 subjects and Group B with 30 subjects. Group Areceived 1 Anuloma DS tablet at bedtime and Group B received lactitol + ispaghula powder 5 g at bedtime for 15 days.Results: Twenty-eight patients in Group A showed significant improvement in stool consistency, whereas just 8 patientsshowed improvement in consistency of stool in Group B. Twenty patients showed improvement in frequency of stool inGroup A, whereas only 3 patients showed this improvement in Group B. Twenty-nine patients in Group A reported goodimprovement in feeling after defecation compared to 9 patients in Group B. Pain in abdomen improved in 21 patients inGroup A versus 9 patients in Group B. Improvements were also seen in scores on the Constipation Assessment Scale, PatientAssessment Scale, and Quality of Life Questionnaire. Conclusion: Anuloma DS showed significant clinical benefits in thetreatment of constipation compared to lactitol + ispaghula powder
Dementia-associated Dyslipidemia Study
Get PDFIntroduction: As age advances, the risk of several noncommunicable diseases (NCDs) like diabetes, hypertension, heart disease,dyslipidemia, etc increases. Dementia is among the most common diseases of older adults and accounts for significant diseaseburden globally. Dyslipidemia is especially common in older adults with diabetes. In the current study, the aim was to assessif patients with dementia have dyslipidemia and if so, whether the frequency was different in age-matched control group.Material and methods: A total of 836 subjects over the age of 60 years were screened and of these, 536 (67.12 ± 4.5 years) subjectswho met the diagnostic criteria for diagnosis of dementia (Diagnostic and Statistical Manual-IV) were enrolled for the study. Atotal of 32 cognitively normal subjects above the age of 60 years, but without cardiovascular risk factors (65.12 ± 3.5 years) wereselected as controls. Selected patients underwent lipid profile assessment apart from detailed neuropsychological, neurological,and radiological examination. The frequency of dyslipidemia among cases and control was compared. Results: Totalserum cholesterol, very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL) in patients with dementia were234.56 ± 22.5 mg/dL, 136.58 ± 11.3 mg/dL, 35.5 ± 3.5 mg/dL, respectively, while high-density lipoprotein (HDL) was 28.7 ± 7.8mg/dL. Corresponding values in the healthy controls were: Total cholesterol (TC) = 156.36 ± 12.5 mg/dL, LDL = 86.15 ± 12.3mg/dL, VLDL = 25.5 ± 3.5 mg/dL, HDL = 37.7 ± 1.8 mg/dL. Comparison of means using paired t-test showed all biochemicalvalues (TC, LDL, VLDL, HDL) differed from controls (p < 0.0001). Out of 536 cases with dementia, 157 (29%) had deranged lipidprofile. Patients of Alzheimer\u27s disease (AD) with comorbid diabetes and hypertension were more likely to have dyslipidemiacompared to AD patients without these two comorbidities (p < 0.05). Conclusion: The current study indicates that patientswith dementia have a high frequency of dyslipidemia, and the frequency is higher compared to healthy controls (p ≤ 0.05)
Unravelling the Complexities of Diabetic Behavior: A Multifaceted Exploration of Psychological, Behavioral, and Societal Factors
Get PDFDiabetes management is a complex process influenced by various behavioral factors, which are crucial for developing effectiveinterventions that promote optimal disease management and improve patient outcomes. This article explores the diversebehavioral manifestations associated with diabetes, shedding light on the psychological, physiological, and societal factorsthat underpin this complex interplay. Utilizing the mnemonics "DIABETES" and "DISTORTION", we interpret the behavioraldimensions of diabetes, emphasizing the need for holistic approaches addressing both physical and mental health. Ourexploration reveals that diabetic behavior is shaped by a range of factors, including depression, impulsivity, anxiety, bingeeating, emotional dysregulation, externalizing problems, somatic symptoms, sleep problems, substance abuse, denial, insulinstigma, suppression, taboo, oppositional behavior, resistance to therapy, template thinking, imitative behavior, oppression,and negativism. These factors interact and influence one another, resulting in a complex web of behavioral challenges thathinder effective diabetes management. By unravelling the underlying psychopathology and cognitive distortions that shapediabetic behavior, we can develop more personalized, holistic, and culturally sensitive approaches to diabetes care. Thearticle highlights the need for integrated interventions that address the psychological, social, and cultural determinants ofhealth, promote patient empowerment, and foster a proactive approach to diabetes management. Ultimately, this multifacetedexploration of diabetic behavior can inform the development of innovative strategies that improve health outcomes, enhancequality of life, and reduce the burden of diabetes on individuals and society
Hormonoids and Hormones
Get PDFThe field of endocrinology is ever expanding. With a rapid increase in the understanding of different hormones andhormone-like substances, there is a need to update the nomenclature of these chemical messengers. The authors propose anovel term “Hormonoids”, defined as endogenous or exogenous substances that lead to hormone-like effects in the body.These may refer to various neurotransmitters, minerals, alkalis, acids, and vitamins that are not conventionally classified ashormones, but act upon receptors in target areas and are regulated by complex interlinked processes. These are requiredfor homeostasis, and an imbalance in their concentration or activity may lead to dysfunction and disease. They may also beused as pharmacotherapy for these associated disorders
Longevity and Antiaging Medicine: Inspiration from the Past, Aspiration for the Future
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Natural Plant-Based Topical Cream RA‐11(O) or Artrex® Significantly Improves Pain, Swelling, and Movement in a Randomized Clinical Trial in Osteoarthritis of the Knee
Get PDFOsteoarthritis (OA) affects millions of people worldwide. It causes severe pain, swelling, and stiffness, especially of theweight-bearing joints and hands, and aggravates with age and activity. Here we describe a unique, natural topical cream,RA-11(O) or Artrex® made up of seven Ayurvedic essential plant oils known to have multi-targeted anti-inflammatory andanalgesic properties. After toxicity testing, a multicentric, double-blind, placebo-controlled clinical trial was conducted withRA-11(O) to study its effect on knee pain in OA patients. Out of 96 enrolled subjects with knee pain (Visual Analog Scale[VAS] score for pain >40 mm), 80 subjects completed the trial. Each applied the cream thrice daily for 14 days, with noother oral or topical analgesic drugs. There was significant reduction of pain in active compared to placebo cream on Day 7(p < 0.05) and Day 14 (p < 0.05). Secondarily, a significant decrease in swelling, tenderness, and improvement of movementwas also seen in subjects treated with RA-11(O) at the end of 14 days (p < 0.001). Global assessments from both physiciansand patients showed significant improvement in all anti-inflammatory parameters. Thus, Artrex® is an effective plant-basedcream for the relief of OA knee pain, and similar results are expected in hand and hip joints of OA
Obesity Care: Inspiration from the Bhagavad Gita
Get PDFObesity has emerged as a major health challenge. While effective drugs are now available, intensive behavioral therapy (IBT)remains the keystone of obesity management. IBT is required to manage weight and maintain health. However, motivationaltherapeutics is a challenging field of medicine. In this editorial, we take inspiration from the Bhagavad Gita to help understandthe need to fight obesity, and the means of doing so. Arjuna can be viewed as a metaphor for the person living with obesity,who is confused about whether to attempt weight loss or not. Lord Krishna offers a balanced viewpoint, including an attitudeof equanimity, moderation in diet and exercise; focus on spiritual (and psychosocial) health, and use of evidence-basedperson-centered medicine
