Indian Journal Of Clinical Practice
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Vascular Calcification in Chronic Kidney Disease
Get PDFCardiovascular disease (CVD) is the major cause of death in chronic kidney disease (CKD). Of the various risk factors, vascular calcification has only recently come into prominence. CKD is associated with an increased risk of vascular calcification. In routine practice, clinicians usually overlook this finding. Screening for vascular calcification is often missed during first contact with nephrologists. With this article, we would like to reiterate the importance of preventing vascular calcification in early stages of CKD and once it starts appearing, its progression needs to be halted early with individualized treatment. The prevalence, sites of involvement, detection, quantification, pathogenesis, risk factors, clinical manifestations and management options have been discussed
An Open-labeled Clinical Study to Evaluate the Safety and Efficacy of “Anuloma DS” in Improving Constipation
Get PDFBackground: Constipation is a common gastrointestinal problem in the general population. Despite a plethora of well-established and safe treatment options, the improvement is not satisfactory for many patients. This has prompted interest in alternative therapeutic strategies for constipation. Methods: This open-label, non-comparative single-arm clinical study evaluated the efficacy and safety of the polyherbal formulation “Anuloma DS”, 1 tablet daily at bedtime, in improving bowel movements in 30 adult patients with functional constipation. Patients were evaluated at baseline (Visit 1, Day 0) and follow-ups during Visit 2 (Day 7 ± 2), Visit 3 (Day 14 ± 2) and Visit 4 (End of the Study) at Day 30 ± 2. Results: There was a significant increase in the mean of spontaneous bowel movement every week from day 7 to days 14 and 30. All constipation symptoms such as abdominal bloating (aadmana), abdominal pain/discomfort (aanaha), feeling of incomplete evacuation and straining during passing stool improved significantly as did the SGA and the PGA scores. Conclusion: Anuloma DS is highly effective for the treatment of chronic functional constipation. No treatment-related side effects were reported by the study participants
An Investigation of the Equivocal Relationship Between Daydreaming, Creativity and Well-Being
Get PDFAn extensive number of studies have been conducted on the relationship between daydreaming, creativity and well-being, with mixed results, nonetheless. Particularly, research has demonstrated both positive and negative effects of daydreaming on creativity and well-being, as well as of creativity on well-being. In addition, most studies have been conducted on adults. Therefore, the purpose of this survey-based study conducted in, Delhi University in May 2023 was to further explore the relationship among the aforesaid constructs on a sample of late adolescents. To this aim, 622 Indian were asked to complete three psychometrically validated scales. The following research hypotheses were proposed: H1) Daydreaming would be a statistically significant predictor of creativity; H2) Daydreaming would be a statistically significant predictor of overall distress, stress, anxiety and depression; H3) There would be a statistically significant difference in daydreaming among severity levels of stress, anxiety and depression; H4) Creativity would be a statistically significant predictor of overall distress, stress, anxiety and depression; and H5) There would be a statistically significant difference in creativity among severity levels of stress, anxiety and depression. Results showed that daydreaming was not a statistically significant predictor of creativity, but greater daydreaming was related to higher distress, stress, anxiety and depression. Furthermore, participants with higher creativity experienced greater anxiety. Nevertheless, creativity was not a statistically significant predictor of distress, stress and depression. Finally, participants with extremely severe depression displayed lower creativity than those with moderate depression. Further research is advised before practical implications are recommended
Biosimilars and Generics: A New Class Needed for Hormonal and Herbal Preparations
Get PDFStrict regulations are in place for the manufacture and approval of pharmaceutical products. Specific drugs such as biological products are governed by specific rules, which take cognizance of the extra diligence required for their production. This communication describes two classes of drugs: hormones and herbal products, which should be subject to stringent regulations. It explains the rationale behind this, and calls for added vigilance in regulatory oversight
Perception and Experience of Physicians Towards the Use of a Targeted Vitamin B-Complex Combination in Attaining Faster Recovery in Acute Illnesses Like Fever vs. Other Competing Combinations in the Market
Get PDFBackground: Vitamin B-complex aids in the development and maintenance of a healthy immune system and also helps to prevent or lessen various infections, especially cases of acute sickness like fever. This study investigates the opinions and experiences of doctors about the effectiveness and usefulness of the targeted vitamin B-complex combinations comprising of pyridoxine hydrochloride, cyanocobalamin, nicotinamide, chromium chloride, sodium selenite, L-lysine in hastening the recovery from acute diseases like fever and others. It offers insight on the perceived advantages, disadvantages and general efficacy of target vitamin B-complex combinations in comparison to other current medications by assessing doctors\u27 preferences, clinical observations and patient outcomes. Additionally, the study also outlines the role of selenium, chromium and L-lysine aiding in the faster recovery along with the targeted vitamin B-complex combination. Studies show that selenium supplementation can reduce mortality rates in viral infections, improve recovery rates in COVID-19 patients and improve the recovery rate. Chromium offers antioxidant properties, and influences immune response and hence helps in the faster recovery of several acute illnesses. Lysine serves as a pivotal building block for proteins, which in turn contribute significantly to the growth and restoration of bodily tissues following damage. Methods: The study was a retrospective study in July 2023 used a questionnaire-based survey to assess the efficacy and tolerability of vitamin B-complex combinations for faster recovery in acute illnesses, focusing on fever. The study used a validated questionnaire with 13 questions, and data was entered into asoftware database. Complete cases were analyzed, and missing data was excluded due to low occurrence. The final report was prepared after cleaning the data. Result: The study included 132 doctors from various medical specializations aimed to understand their perception and experience of using vitamin B-complex for faster recovery from acute illnesses. The most important factor contributing to choosing vitamin B-complex was the uses of micronutrients, which help produce red blood cells (40.2%), followed by use in treating mouth ulcers (31.1%) and are critical for pregnant ladies (28.8%). Antioxidants like selenium and chromium were found to be significantly effective (57.6%) for faster recovery in acute illnesses, while 39.4% considered them moderately effective. The study revealed that 88.6% of doctors considered the use of vitamin B-complex combination advantageous due to the presence of folic acid, L-lysine and selenium, and that 97.7% of doctors had a positive attitude about continuing to prescribe vitamin B-complex supplementation in the future. The study found that the current vitamin B-complex combination outperforms its competitors mostly (82%), especially in helping to recover from acute illnesses faster. It was also found to be friendly for the elderly, as no side effects were observed. Conclusion: Results suggest that the targeted vitamin B-complex combination can improve acute disease management and help health care professionals make informed decisions for optimal well-being. The findings contribute to a deeper understanding of the medical decisionmaking process and the nuanced considerations that impact the prescription of specific treatment options for acute illnesses. 
Sturge-Weber Syndrome Associated with Bilateral Angle-closure Glaucoma in a Young Adult
Get PDFSturge-Weber syndrome (SWS) is a phakomatosis involving the eyelids, conjunctiva, choroid and retina. The mechanism ofglaucoma in SWS involves developmental anomaly of the anterior chamber angle and elevated episcleral venous pressure.Here, we present a case of Roach’s type II SWS with bilateral angle-closure glaucoma (ACG) in a young adult, which to thebest of our knowledge, is the first-of-its-kind report in the literature. Though unusual, ACG may occur in young adults too.However, the underlying causes that make them develop the ACG are poorly understood. We also highlight the importanceof comprehensive clinical examination and appropriate investigations for early detection and proper treatment of such youngpatients with ACG