Indian Journal Of Clinical Practice
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Dermato-Metabolic Syndrome
Get PDFWe define the term ‘dermato-metabolic syndrome’ as the dermatologic (skin, hair, and nail) conditions associated with metabolic syndrome. These abnormalities can be classified as metabolic (hyperinsulinism, hyperandrogenism, hyperuricemia), mechanical (involvement of epidermal, dermal, sebaceous and sweat glands, subcutaneous tissue), mitogenic, miasmatic (infections) and microvascular/venous insufficiency. This construct highlights the importance of skin, and its related appendages, as a site of target organ damage in metabolic syndrome. The concept underscores the need for team-based approach towards dermato-vigilance in metabolic patients, metabolic vigilance in dermatologic patients, and management of both dermatological and metabolic manifestations of dermo-metabolic syndrome
31st Annual Scientific Meeting of Indian National Association for Study of the Liver (INASL 2023)
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Clinical Spectrum of Recurrent Urinary Tract Infections: A Single-Center Study
Get PDFA retrospective observational study was undertaken to evaluate the clinical profile of recurrent urinary tract infections (UTIs)in a tertiary care hospital. Patients <18 years, kidney-transplant recipients, those on immunosuppressive agents and pregnantpatients were excluded. Patients with ≥2 episodes of culture positive UTIs were included. Demographic details, investigationsand treatment were recorded. Out of total 48 patients, 18 were female and 30 male. The common manifestations were acutepyelonephritis (52%), emphysematous pyelonephritis (20%) and cystitis (25%). Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (48%) was the most frequent organism isolated followed by Klebsiella spp. (29%) and Pseudomonasspp. (23%). Recurrent episodes of UTI with same organisms were noted in 62% patients. Death occurred in 12.5% patientsdue to septic shock. Renal calculi (24%) and double J (DJ) stent placement (30%) were associated with recurrent UTIs,though this was not statistically significant. Resistance to higher antibiotics (colistin, carbapenems, piperacillin-tazobactam,cefoperazone-sulbactam, third-generation cephalosporins) (65.4%, r = 0.81), diabetes (62.5%, r = 0.79), urological procedure(39.5%, r = 0.68), prior hospitalization (75%, r = 0.84), history of UTI prior to the study period (44%, r = 0.72) and need forper urethral catheter (PUC) beyond 7 days (35%, r = 0.74) had significant correlation with recurrent UTIs
Adolescent Obesity and Type 2 Diabetes Mellitus: Synaptics and Heuristics
Get PDFThe adolescent population is the foundation for a Nation’s progress. Their shoulders therefore must be emboldened withhealth and dignity to ensure a developed Nation. However, the multitude of prevailing epidemics have left nostone unturnedto enfeeble their strength. Type 2 diabetes mellitus (T2DM) and obesity stand amongst the top shotguns. There is a dire needto execute preventive as well as therapeutic actions to contain the epidemic, for which one must be well versed with theattributable risk factors. In this article, we will understand the synaptics of adolescent obesity and T2DM and what strategiesare recommended by the health authorities to prevent and overcome this rising epidemi
The Lips of Truth shall be Recognized Forever, a Lying Tongue is but for a Moment
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Clinical Evaluation of an Ayurvedic Preparation “Sangfer” for the Treatment of Anemia in Pregnant Women: An Open-labeled Clinical Study
Get PDFBackground: Iron deficiency during pregnancy is one of the primary causes of anemia in infants and young children. Ithas a negative impact on maternal and fetal health throughout pregnancy with higher likelihood of adverse maternal andfetal outcomes. Maternal iron supplementation is a critical tool to address the global problem of iron deficiency and preventits negative consequences. Method: An open-label non-comparative prospective clinical trial was carried out to evaluatethe effectiveness of “Sangfer” liquid in 16 pregnant women with anemia. “Sangfer” is a polyherbal Ayurvedic proprietarymedication containing elemental iron and zinc and four medicinal herbs viz. Withania somnifera, Emblica officinalis, Asparagusracemosus and Pueraria tuberosa. The aim of the study was to examine its efficacy and safety in treating anemia in pregnantwomen. The dose administered was 10 mL twice daily after food for 12 weeks (84 days). Patients were evaluated at screening(Visit 1 at Day 0), baseline (Visit 2 at Day 1) and during follow-ups (Visit 3 at Day 28, Visit 4 at Day 56 and Visit 5 atDay 84). Results: There was a significant increase in mean hemoglobin levels from 8.08% at Day 1 to 11.19% at the finalvisit at Day 84. The anemia sign and symptom scores also significantly reduced from Day 1 to different follow-up visits.The mean Physician Global Assessment (PGA) score was found to reduce from 1.0 at Day 1 to 0.0 at the final follow-upvisit. Conclusion: “Sangfer” is highly effective for the treatment of anemia during pregnancy. No adverse effects includingserious adverse effects were observed during the study period
Clinical Outcomes of Slow versus Rapid Enteral Feeding Advancement in Very Low Birth Weight Neonates at a Tertiary Care Center
Get PDFIn India, every year around 3.5 million babies are born premature, accounting for almost 13% of total livebirths in the country as compared to 5% to 7% incidence in the West. Preterm is defined as babies born before 37 weeks ofpregnancy. The rapidity of feed volume increments involves controversies like faster weight gain, shorter hospital stays, therisk of necrotizing enterocolitis and vice versa. Methods: The present study was a randomized controlled trial conducted fromJune 1, 2018 to October 31, 2019. All infants in the study were randomized to slow and rapid feeding protocols by a stratifiedblock randomization sequence of 2, 4, 6 blocks. Group 1 or the slow advancement group included 64 newborns babies andGroup 2 or the rapid advancement group included 69 newborns babies. Results: The average weight gain in Group 1 was4.41 ± 0.9 g and in Group 2 it was 6.33 ± 1.3 g, the difference was statistically significant (p < 0.02). Sixty out of 64 newbornsregained birth weight within 16.87 ± 0.9 days in Group 1, while 64 out of 69 newborns regained birth weight within 13.63 ±0.9 days in Group 2. The difference was statistically significant. Increment in the mean occipitofrontal circumference perweek was 0.29 ± 0.27 cm Group 1, while in Group 2 it was 0.42 ± 0.05 cm; the difference was statistically significant. Meanaverage length increment per week was found to be 0.55 ± 0.04 cm and 0.69 ± 0.05 cm in Group 1 and Group 2, respectively,the difference was statistically significant (p < 0.005). The mean duration of hospital stay was 27.47 ± 3.33 days in Group 1while in Group 2, the duration of stay was 23.15 ± 2.22 days, the difference was statistically significant. Conclusion: Ourstudy supports enteral nutrition by rapid enteral feeding regimen in stable preterm neonates with very low birth weigh
