International Journal of Health and Information System
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Acute Oral Toxicity Assessment of Rutinoside on Renal Histopathology in Wistar Rats
Get PDFThis study aimed to evaluate the acute oral toxicity of rutinoside by assessing renal histopathological changes in Wistar rats. Twelve Wistar rats (Rattus norvegicus), consisting of equal numbers of males and females and aged approximately three months, were randomly assigned to control and treatment groups. After an acclimatization period under standard laboratory conditions, the treatment group received a single oral dose of rutinoside (5000 mg/kg body weight) via gastric gavage in accordance with OECD Guideline 423, while the control group received the vehicle only. Animals were observed daily for 14 days for mortality, behavioral changes, and clinical signs of toxicity. At the end of the observation period, rats were euthanized, and both kidneys were collected for histopathological evaluation. Kidney tissues were fixed in 10% buffered formalin, processed, and stained with hematoxylin and eosin. Histological examination was performed at 400× magnification using a standardized scoring system, and statistical analysis was conducted using the Mann–Whitney U test. No mortality or treatment-related clinical signs were observed during the study period. Histopathological findings demonstrated no significant differences between the control and rutinoside-treated groups. Renal structures, including glomeruli and tubules, remained intact, with no evidence of degeneration, inflammation, or other pathological alterations. In conclusion, acute oral administration of rutinoside at a high dose did not induce renal toxicity in Wistar rats, suggesting a favorable acute safety profile. Further studies are required to evaluate the safety of rutinoside following repeated or long-term exposure
Spatial Analysis and Risk Factor Association of Pneumonia Cases Among Under-Five Children in Surakarta City
Get PDFThe increasing number of pneumonia cases among under-five children in Surakarta City over the past three years indicates the need for preventive measures to curb the rise. Spatial analysis and risk factor assessment are essential tools for understanding the geographical distribution and contributing determinants of pneumonia in young children.; (1) Background: To analyze the spatial distribution and associations between risk factors and pneumonia cases among under-five children in Surakarta City.; (2) Methods: This research is a quantitative study with a cross-sectional design; (3) Results: Multivariate regression showed that poor nutrition, population density, rainfall, and humidity significantly influenced pneumonia prevalence.; (4) Conclusions: The prevalence of pneumonia in toddlers shows a high level of vulnerability in Sangkrah subdistrict. The Health Office of Surakarta City can intervene with priority level 1 area
Evaluation Of The Implementation Of Electronic Medical Records Using The Hot-fit Method In A Public Health Center In East Surabaya
Get PDFThe rapid development of information technology that has spread to various sectors of life including health can result in the development of a computer-based medical record system. Computer-based medical records or better known as EMR (Electronic Medical Record) have been used in various hospitals in the world as a complement or replacement for paper-based health records so that they can facilitate the process of managing, accessing, and distributing data or information. Based on the results of brief interviews with health workers working in health centers, it turns out that medical records for obstetric cases are still hybrid. The purpose of this study was to implement the application of Electronic Medical Records using the Hot-Fit method in East Surabaya Health Centers Indonesia. The research method used is descriptive research using a questionnaire sheet as a research instrument. The results of the study obtained data that the application of Electronic Medical Records in East Surabaya Health Centers from system quality, information quality, service quality, system use, organizational structure, facility conditions, and net benefits were categorized as good while for user satisfaction it was suggested to be satisfied and support was suggested to be supportive. So it can be concluded that the application of EMR was given well. Suggestions for the Health Center are the need to improve the system and network, the need to complete the information in the EMR in detail, the need to provide training to health workers in the use of EMR, and the need for socialization by superiors regarding the policy on the use of EMR
Correlation of Skin Pigmentation Changes as a Side Effect of Clofazimine Treatment with Anxiety Level in MDR-TB Patients at Dr. Soebandi Hospital
Get PDFClofazimine, used to treat Multidrug-resistant tuberculosis (MDR-TB), often causes skin pigmentation changes, potentially impacting patients' self-esteem and anxiety. Anxiety represents a common but often underrecognized comorbidity in MDR-TB patients, who are challenged by lengthy treatment regimens, social stigma, and distressing adverse effects. This study aimed to examine this correlation at Dr. Soebandi Hospital. The study utilized an observational analytic method with a cross-sectional design. The population was all MDR-TB patients in Dr. Soebandi hospital, presented from April to May 2024. We recruited 67 patients using a total sampling technique. We analyzed the primary data from the respondents: 1) Respondents' self-rating of skin pigmentation change; 2) Hamilton Anxiety Rating Scale (HARS) score. We also checked the medical records to analyze the respondents' treatment history. The data were analyzed using the chi-square test. Most respondents were male and in a productive age. The chi-square test results show a p-value of 0.822, indicating no significant correlation between skin pigmentation changes and anxiety levels in MDR-TB patients. Clofazimine-induced skin pigmentation changes had no significant correlation with the anxiety levels among MDR-TB Patients at Dr. Soebandi Hospital. Further studies should consider methodological improvements, including prospective design, larger sample size, mixed method, and involvement of dermatology experts in assessing the skin changes induced by clofazimine. Recognizing individual differences in psychological response highlights the need to offer reassurance, counseling, and psychosocial support for MDR-TB patients
Tobacco Dust Exposure Among Tobacco Workers in Jember Reduces Lung Function Capacity
Get PDFThis study investigated the association between urinary cotinine levels and lung function among tobacco workers in Jember Regency, a major tobacco-producing region in Indonesia. A total of 48 respondents were included based on specific inclusion and exclusion criteria. Urinary cotinine levels were measured using enzyme-linked immunosorbent assay (ELISA), and lung function was assessed via spirometry. Based on FEV1/FVC ratios, 58% of participants exhibited restrictive lung patterns, 29% showed obstructive patterns, and 13% had normal pulmonary function. Statistical analysis conducted using SPSS, with a significance level set at p < 0.05, indicated no statistically significant correlation between urinary cotinine levels and lung function
Designing of Decision Support System for Determining the Underlying Cause of Death in Mortality Codification
Get PDFInaccuracies are often encountered in determining the Underlying Cause of Death (UCoD), which can impact the quality of reported mortality data. In this case, a system is needed to assist coders in determining the UCoD. Clinical Decision Support System (CDSS) is a system designed to assist decision-making in patient clinical management, including in determining UCOD. The purpose of this study was to design a CDSS in determining UCOD mortality codification. The research method used is descriptive research with an Action Research design consisting of four stages: Diagnosing, Planning, Taking, and Evaluating Action. The objects of this study were SIMRS, medical record documents, and death certificates. Data were collected through interviews and documentation studies. The research results obtained were user requirements consisting of features, databases, and system displays. The design was carried out using UML modeling such as Flowcharts, Use Case Diagrams, Activity Diagrams, Class Diagrams, Data Flow Diagrams, and Prototypes. The evaluation results showed that the designed CDSS was acceptable to users as a tool in determining UCOD, with a value above the global average score (77). The conclusion of this study obtained that the CDSS design is considered effective in helping coders to determine UCoD
Qualitative Study: Management of the Prolanis Diabetes Mellitus Program at the Kramatsari Community Health Center in Pekalongan City
Get PDFDiabetes mellitus (DM) is a chronic disease that has a significant impact across the country and is a major focus of treatment in primary health care. This study aims to assess the implementation of the chronic disease management program (PROLANIS) related to DM at the Kramatsari Community Health Center in Pekalongan City. The method used was descriptive qualitative, with in-depth interviews conducted with four informants: the head of the community health center, the community health center coordinator, and two program participants. Data analysis was conducted using a thematic approach based on the Miles and Huberman model, which includes data reduction, presentation, and conclusion drawing, along with source triangulation to increase data validity. The findings of this study indicate that PROLANIS has successfully increased patient awareness of a healthy lifestyle, adherence to treatment, and control of blood pressure and blood sugar. However, several challenges remain, such as long queues, mobility difficulties for elderly participants, and limited access to administrative documents. Recommendations include the need for intersectoral collaboration and the provision of mobile health units to reach elderly participants. Overall, although this program has had a positive impact, improvements in infrastructure, documentation systems, and community support are needed to ensure the program's benefits are sustainable and equitable
The ADDIE Model As An Instrument for Designing HEMA-MAGZ (Healthy Motion Magazine) Media
Get PDFClean and healthy living behavior (PHBS) in the work environment is an important aspect which contributes to employees welfare and organizational productivity. However, the implementation of PHBS often faces challenges such as a lack of understanding and awareness of the importance of PHBS in the workplace. This research aims to develop and implement HEMA-MAGZ (Healthy Motion Magazine) as an effective communication, information, and educational media in supporting the implementation of PHBS in the work environment of Tefa House in Health Promotion Major, Jember State Polytechnic. This research method uses the R&D (Research and Development) model to design IEC PHBS media in the Hema-Magz work environment using the ADDIE (Analyze, Design, Development, Implementation, and Evaluation). HEMA-MAGZ is designed as an interactive magazine which contains educational content regarding 10 PHBS indicators, namely (Using Personal Protective Equipment (PPE), regular exercise, not smoking, washing hands with soap in daily activity, tips for defecating and urinating in the bathroom, exterminate mosquito larvae, throwing away rubbish on the right trash bin, avoiding drugs, consuming clean and healthy food and drinks, and not spitting anywhere. The research results show that HEMA-MAGZ has succeeded increasing employees awareness and understanding of PHBS, which is reflected increasing healthy living behavior in the work environment. Furthermore, this magazine also received positive responses from employees who felt the contents are attractive and easy to understand. This research concludes if HEMA-MAGZ is an effective media in conveying information and education
Analysis Hospital Competitor: A Market, Resources and Service Quality Based Framework Through Social Media
Get PDFThe increasing number of hospitals requires them to segment the market. Hospitals can optimize marketing efforts, improve customer satisfaction, and achieve business goals more effectively. The purpose of the study to identify competitors and analyze hospital competitors based on market commonality, resource similarity and service quality. This type of research is quantitative descriptive research with a cross-sectional study approach. The population of this study is all hospitals with a maximum distance of 20 km from A Hospital, amounting to 8 hospitals. All secondary data analized by descriptive statistic. According to market commonality, “An” dan “K” hospital are hospitals that are direct competitor. Based on resurces similarity, “An”, “C”, “K” hospital are hospitals that are direct competitors. The weakness of service quality of direct competitors lies in the specialist doctor arrivals which do not comply with the established operational schedule and the quality of service which is less than satisfactory, starting from registration to purchasing medicine. So the way for hospitals to compete with direct competitors who have the same target market and resources must increase responsiveness, reliability and tangible aspects
Supplementation Of Analog Rice İn Combination With Metformin Prevent Myocardial Cell Death İn Type 2 Diabetuc Rats
No full textType 2 diabetes (T2D) is an urgent health issue that leads to one of the most significant cardiovascular complications worldwide, diabetic cardiomyopathy (DCM), which is associated with high morbidity and mortality. Chronic hyperglycemia and oxidative stress are major contributor for DCM. Analog rice based of MOCAF and corn starch is a functional food recommended as nutritional supplementation to replace staple foods in T2D patients. Analog rice has a high fiber content, high resistant starch and low glycemic index, which can help lower blood sugar levels and prevent DM complications. MOCAF in analog rice is also rich in phenolic compounds, which has potential effect of antioxidant. Metformin is the first line oral therapy for T2D. The present study investigates the potential effects of an analog rice diet in combination with metformin, for the development of DCM. Type 2 diabetic rats were induced by HFD/STZ method and was treated by analog rice and metformin for 4 weeks. Myocardial cell death measured by pyknotic nuclei percentage was analysed. The study result demonstrate that analog rice and metformin prevent the myocardial cell damage observed in type 2 diabetic animals, highlighting analog rice potential as adjuvant therapy, for treating DCM has no clinical significance than metformin therapy alone