IYTE GCRIS Database (Izmir Institute of Technology)
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Convenient Site Selection of a Floating Pv Power Plant in Türkiye by Using Gis-Fuzzy Analytical Hierarchy Process
No full textFloating photovoltaics (FPVs) are appearing as a promising and an alternative renewable energy opinion in which PV panels are mounted on floating platforms in order to produce electricity from renewable energy on water such as seas, dams, rivers, oceans, canals, fish farms, and reservoirs. So far, such studies related to the body knowledge on financial, technical, and environmental aspects of installation of FPV have not been performed in Turkey while expanding steadily in other countries. In this study, suitable site selection for installation of FPV power plants on three lakes in Turkey was studied by performing geographic information system (GIS) and the fuzzy analytic hierarchy process (FAHP) as multi-criteria decision-making (MCDM) method. This detailed study revealed that the criterion of global horizontal irradiance (GHI) was determined as the most crucial criterion for the installation of FPV on Beysehir Lake, Lake of Tuz, and Van Lake. Additionally, it was clearly seen that the Beysehir Lake had the highest value approximately 52% among other lakes for installation, that is why Beysehir Lake is selected as the best option for installation of an FPV system with this multi-criteria approach
Preparation of Vaccine Formulations for Melanoma Using Potent Adjuvant Candidate Astragaloside Vii and Investigation of Anti-Tumor Activities of Formulations in Mouse Cancer Models
No full textKanser, genomdaki nokta mutasyonların birikmesi sonucu ortaya çıkan ve yapısal değişikliklerle ilerleyen bir hastalıktır. Kanser immünoterapisinin ana kategorilerinden biri, vücudun kansere karşı kendi bağışıklık sistemini harekete geçiren kanser aşısıdır. Geleneksel tedaviler güvenlik sorunları ve bağışıklık sisteminin uygun olmayan modülasyonu nedenleriyle etkili olmadığından, nanotıp temelli yaklaşımların uygulanması bu sorunların çözümü için bir potansiyel oluşturmaktadır. Bir taşıyıcı malzeme içinde immünostimülatör ajanların/adjuvanların formülasyonları, hedef hücreler tarafından alımı sağlar, sistemik etkiyi değiştirir, güvenli bir profil sağlar ve immünoterapötiklerin terapötik etkinliğini arttırır. Bu bakış açısıyla bu tez kapsamında, Astragalus polisakkariti temelli bir nanotaşıyıcıya MPLA/Astragaloside-VII entegre edilerek yeni bir adjuvan sistemi (MA-NP) tasarlanmış ve geliştirilmiştir. MA-NP'nin in vitro ve in vivo immünomodülatör özellikleri ve ardından iki fare melanoma modelinde profilaktik ve terapötik etkinliği araştırılmıştır. Biyouyumlu, 20-50 nm boyutunda, negatif yüklü, dendritik hücreler tarafından etkin bir şekilde alınabilen MA-NP başarılı bir şekilde üretilmiştir. Çoklu peptitler ile formülize edilen MA-NP, doğal ve kazanılmış bağışıklık hücreleri aktive etmiş, öncelikli olarak merkezi bellek CD8+ T hücre yanıtı gösteren antijen spesifik sitotoksik T hücre popülasyonunu arttırmış, fonksiyonel IFN-+CD8+ T hücrelerini indüklemiş, tümör içi CD4+, CD8+ T hücre, dendritik hücre ve M1 makrofajlarını arttırmış ve güçlü bir şekilde tümör büyümesini inhibe etmiştir. Ayrıca MA-NP ile oluşturulan nanoaşı, anti-PD1 antikorları ile birlikte farelere uygulandığında yerleşik B16-F10 tümörlerini ortadan kaldırmıştır. Bu bulgular, kanser aşılarında kullanılabilecek yeni bir saponin temelli adjuvan sistemini ve kanser immünoterapi yaklaşımını geliştirmek için umut verici bir kombine terapiyi ortaya koymaktadır.Cancer is a disease caused by the accumulation of point mutations in the genome and further progresses by structural alterations. One of the major categories in cancer immunotherapy is cancer vaccine, which activates body's immune system against cancer. As traditional therapies are not effective due to safety issues and non-proper immune system modulation, the application of nanomedicine-based approaches is a potential solution to address these problems. The formulations of immunostimulatory agents/adjuvants in a carrier material facilitate uptake by target cells, alter systemic exposure, provide a safer profile, and increase the therapeutic efficacy of immunotherapeutics. With this perspective, in the context of this thesis, a new adjuvant system (MA-NP) containing MonophosphoryllipidA/Astragaloside-VII in Astragalus polysaccharide-based nanocarrier was designed and developed. The in vitro and in vivo immunomodulatory properties and, subsequently, prophylactic and therapeutic efficacy of MA-NP in two murine melanoma models were investigated. Biocompatible, negatively charged, and 20-50 nm sized MA-NP with efficient uptake by dendritic cells was successfully prepared. MA-NP formulation including multi-peptides activated innate and adaptive immune cells, enhanced antigen-specific cytotoxic T lymphocytes primarily exhibiting central memory CD8+ T cell response, induced functional IFN-g+CD8+ T cells, increased intratumoral CD4+, CD8+ T cells and M1-like macrophages, dendritic cells, and potently inhibited tumor growth. Moreover, MA-NP eliminated established B16-F10 tumors when combined with anti-PD-1 treatment. These findings revealed a highly effective new saponin-based adjuvant system to be used in cancer vaccines and a promising combinatory therapy to improve cancer immunotherapy
Nanoparticle Manipulation and Sorting by Phased Modulated Interference Pattern of Gaussian Evanescent Waves
No full textThe utilization of Gaussian Evanescent Waves (GEWs) in particle manipulation provides a three-dimensional force distribution that is significantly high at the vicinity of the surface and exponentially decreases as one moves away, hence enabling 3D particle manipulation, unlike plane waves. By coherently interfering four GEWs in various phase combinations, symmetric evanescent field distributions can be obtained, which allows the manipulation of nanoparticles for many applications. With the simulation we conducted, the dynamics of various-sized spherical silicon particles in a continuously flowing liquid setup have been investigated. We present the optimal phase-delayed configurations for trapping, sorting, separating, and rotating the particles. © 2024 Elsevier B.V
The Unlimited Joy, 'once You Start You Can't Stop': Masculinity in Domestic Technology Commercials in Turkey
No full textRecently, studies have begun examining men's interaction with domestic space to explore changing forms of masculinity and domesticity, arguing that housework has become a leisure activity for men, with domestic technologies serving as tools (toys) for them to engage with. In this article, we explore how men in Turkish television commercials of domestic technologies are portrayed and how these portrayals construct and reconstruct discourses of domesticity and masculinity. We aim to understand men's relationship with masculinity, home and domestic work in these commercials. Alongside leisure and fun, we explore the construction of discourses of masculinity and domesticity through specific themes such as the naughty scientist, the self-seeking purchaser, and the flirtatious chef. We argue that seeing more men on screen does not democratise domesticity since the equal share of workload at home is still far from being realised even in these portrayals. We also argue that domesticity is aestheticized with the participation of men and technology. Finally, women are used as instruments by men in reconstructing their masculinity through heterosexuality
Mantar Enfeksiyonlarının Gelişmiş Tespiti İçin Görüntü Dönüştürücüleri Kullanılarak Mikroskobik Mantar Görüntülerinin Sınıflandırılması
No full textMantarlar, hem çevresel sürdürülebilirliğe temel katkıda bulunarak, hem de önemli hastalık etmenleri olarak hizmet ederek, ekosistemimizde ve insan sağlığında kritik bir rol oynamaktadırlar. Mantarların hassas olarak tespiti, etkili hastalık yönetimi, tarımsal verimlilik ve küresel gıda güvenliğinin korunması açısından önemlidir. Bu araştırma, çeşitli mantar türlerinin mikroskobik görüntülerinin sınıflandırılmasında görüntü dönüştürücü tabanlı mimarilerin etkinliğini keşfetmekte ve mantar enfeksiyonlarının tespitini geliştirmeyi amaçlamaktadır. Çalışma, önceden eğitilmiş temel görüntü dönüştürücü (ViT) ve Swin dönüştürücü modellerini karşılaştırmış, özellik çıkarma ve ince ayarlanma yeteneklerini değerlendirmiştir. Nakil öğrenme ve ince ayar stratejilerinin, özellikle veri artırımı ile birlikte, model performansını önemli ölçüde artırdığı belirlenmiştir. Veri artırımı yapılmış ve yapılmamış kapsamlı bir veri setini kullanarak yapılan çalışma, ince ayar yapıldığında Swin dönüştürücünün (%98,36), ViT modeline kıyasla (%96,55) üstün doğruluk sergilediğini ortaya koymuştur. Bu bulgular, mantar enfeksiyonlarının tanısını otomatikleştirmede ve iyileştirmede vizyon dönüştürücü tabanlı modellerin potansiyelini vurgulamakta, tıbbi görüntüleme analizinde önemli ilerlemeler vaat etmektedir
Evaluating Adoption Factors for Robotic-Assisted Surgery With the Analytical Hierarchical Process
No full textThe objective of this master's dissertation is to evaluate adoption factors for robotic-assisted surgery (RAS) using the Analytical Hierarchy Process (AHP) as its evaluation methodology. Robotic-assisted surgery is used in various surgical fields. It is mainly used as a tool in numerous disciplines' minimally invasive surgery procedures (MIS). Since it has so many different application areas and actors, the determination of its adoption factors and evaluation process of these factors' priorities for surgeons is a highly complex issue that includes multicriteria of decision-making and numerous surgeons. A comprehensive list of these possible adoption factors recognized by conducting an extensive literature review, was picked and chosen. First, we had 310 factors mentioned in the literature that have a potential impact on the adoption process of the RAS. We have reduced these to 20 factors that are categorized under five different main criteria. By this, a unique AHP tree that is this thesis' contribution to the literature was developed. The research data was collected by an online survey from the surgeons of various disciplines working in Türkiye. Our final sample to evaluate priorities consisted of forty-one surgeon responses in total. The evaluation process consists of three steps: analyzing individual-based pairwise comparison matrices, their consistency rations, and their priority vectors. We executed the same workflow for the aggregated analysis for disciplined-based and all aggregation. Results are examined in detail and concluded with insightful interpretations. © 2024 PICMET
Anti-Microbial Properties and Biochemical Characterization of Maillard Reaction Products From Legume Protein Hydrolysates and D-Glucose
No full textBu tez, çeşitli termal koşullarda (175°C ila 275°C) D-glukoz ile reaksiyona sokulan nohut, bakla, adi fasulye ve soya fasulyesi protein hidrolizatlarından elde edilen Maillard Reaksiyon Ürünlerinin (MRP'ler) antimikrobiyal özelliklerini ve biyokimyasal karakterizasyonunu araştırmaktadır. Çalışmada bu MRP'lerin Escherichia coli, Staphylococcus aureus, Lactococcus lactis, Candida albicans, Saccharomyces var. boulardii ve Saccharomyces cerevisiae'ye karşı antimikrobiyal aktivitesi değerlendirilmiştir. Sonuçlar nohut MRP'lerinin en yüksek antimikrobiyal aktiviteyi sergilediğini, bunu bakla MRP'lerinin izlediğini, bakteri ve maya sayılarında önemli azalmalar olduğunu göstermiştir; antimikrobiyal etkinlik işleme sıcaklığına göre değişiklik göstermiş ve belirli koşullarda optimum aktiviteye işaret etmiştir. UV-Vis spektroskopisi, FTIR, HPLC ve NMR analizleri kullanılarak yapılan biyokimyasal karakterizasyon, melanoidin içeriğinde ve yapısal özelliklerinde baklagil kaynağına ve ısıl işleme bağlı olarak farklılıklar olduğunu ortaya koymuştur. Kolorimetrik analiz ve esmerleşme indeksi tayini, daha yüksek sıcaklıkların daha koyu MRP'lere yol açtığını ve esmerleşme indekslerinin arttığını göstermiştir. Bu bulgular, baklagil bazlı MRP'lerin gıda muhafazasında doğal antimikrobiyal ajanlar olarak potansiyele sahip olduğunu ve gelişmiş sağlık yararları ve güvenliği ile yeni gıda ürünlerinin geliştirilmesine katkıda bulunduğunu göstermektedir.This thesis investigates the antimicrobial properties and biochemical characterization of Maillard Reaction Products (MRPs) derived from chickpea, faba bean, common bean, and soybean protein hydrolysates reacted with D-glucose at various thermal conditions (175°C to 275°C). The study assessed the antimicrobial activity of these MRPs against Escherichia coli, Staphylococcus aureus, Lactococcus lactis, Candida albicans, Saccharomyces var. boulardii, and Saccharomyces cerevisiae. Results demonstrated that chickpea MRPs exhibited the highest antimicrobial activity, followed by faba bean MRPs, with significant reductions in bacterial and yeast counts—the antimicrobial efficacy varied with the processing temperature, indicating optimal activity at specific conditions. Biochemical characterization using UV-Vis spectroscopy, FTIR, HPLC, and NMR analyses revealed differences in melanoidin content and structural properties based on the legume source and thermal treatment. Colorimetric analysis and browning index determination showed that higher temperatures led to darker MRPs with increased browning indices. These findings suggest that legume-based MRPs have potential as natural antimicrobial agents in food preservation, contributing to developing novel food products with enhanced health benefits and safety
A Facile Method for Boosting the Graphitic Carbon Nitride's Photocatalytic Activity Based on 0d/2d S-Scheme Heterojunction Nanocomposite Architecture
No full textGraphitic carbon nitride (g-C 3 N 4 ) has received significant interest as a metal -free photocatalyst. The S -scheme photocatalytic system has great potential to improve the charge separation in semiconductor photocatalysts. In this study, we have fabricated non-toxic and low-cost photocatalytic nanocomposites of 0D/2D S -scheme heterojunction composed of iron oxide and graphitic carbon nitride by a facile method. The developed facile method provides a sustainable way with a high atom economy to further enhance the photocatalytic performance of exfoliated g-C 3 N 4 . The 0D -iron oxide/2D-C 3 N 4 exhibited nearly 10 times better than bulk g-C 3 N 4 and almost 60 % better than exfoliated g-C 3 N 4 under simulated solar light irradiation. The experimental results demonstrated that the effective charge -carrier mechanism led to an improved generation of reactive oxygen species (ROSs), resulting in an impressive photocatalytic performance. A serial photocatalytic test was also conducted to understand photocatalytic reaction mechanisms with various scavengers
Fabrication of Bioactive Helix Aspersa Extract-Loaded Chitosan-Based Bilayer Wound Dressings for Skin Tissue Regeneration
No full textIn recent years, there has been a notable shift toward exploring plant and animal extracts for the fabrication of tissue engineering structures that seamlessly integrate with the human body, providing both biological compatibility and physical reinforcement. In this particular investigation, we synthesized bilayer wound dressings by incorporating snail (Helix aspersa) secretions, comprising mucus and slime, into chitosan matrices via lyophilization and electrospinning methodologies. A nanofiber layer was integrated on top of the porous structure to mimic the epidermal layer for keratinocyte activity as well as acting as an antibacterial barrier against possible infection, whereas a porous structure was designed to mimic the dermal microenvironment for fibroblast activity. Comprehensive assessments encompassing physical characterization, antimicrobial efficacy, in vitro bioactivity, and wound healing potential were conducted on these bilayer dressings. Our findings revealed that the mucus and slime extract loading significantly altered the morphology in terms of nanofiber diameter and average pore size. Snail extracts loaded on a nanofiber layer of bilayer dressings showed slight antimicrobial activity against Staphylococcus epidermidis and Escherichia coli. An in vitro release study of slime extract loaded in the nanofiber layer indicated that both groups 1 and 2 showed a burst release up to 6 h, and a sustained release was observed up to 96 h for group 1, whereas slime extract release from group 2 continued up to 72 h. In vitro bioactivity assays unveiled the favorable impact of mucus and slime extracts on NIH/3T3 fibroblast and HS2 keratinocyte cell attachment, proliferation, and glycosaminoglycan synthesis. Furthermore, our investigations utilizing the in vitro scratch assay showcased the proliferative and migratory effects of mucus and slime extracts on skin cells. Collectively, our results underscore the promising prospects of bioactive snail secretion-loaded chitosan constructs for facilitating skin regeneration and advancing wound healing therapies
Doha’da Enerji Verimli Bina Kabuğu Tasarımı için Biyomimetik Yaklaşım
No full textBu çalışmada dünya genelinde artan nüfusa bağlı olarak yapılı çevrenin her geçen gün artan enerji talebine karşılık binaların enerji tüketimini doğrudan etkileyen bina kabuk tasarımları için bir yaklaşım önerilmektedir. Çalışma kapsamında doğadan ilham alan yaklaşımla oluşturulan bina kabuk sisteminin hem tasarım hem de simülasyon süreçleri birlikte ele alınarak enerji verimliliği noktasında iyileştirme hedeflenmektedir. Ekstrem hava koşullarına sahip Doha, Katar'da hayali bir ofis binasının güney cephesinde yer alan ofis birimi için geliştirilen bu kabuk sisteminin tüm mimari entegrasyon süreci ele alınmaktadır. Çalışma boyunca oluşturulan simülasyon çıktıları ile birlikte geliştirilen biyomimetik kabuk tasarımının soğutma yükü ve gün ışığı parametreleri üzerine etkileri analiz edilmektedir. Çalışma sonucunda biyomimetik yaklaşımla oluşturulan bina kabuk sisteminin binayı enerji verimliliği açısından iyileştirdiği gözlemlenmiştir