IYTE GCRIS Database (Izmir Institute of Technology)
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The Interplay Between Sirtuin 1 (Sirt1) and Autophagy/Mitophagy in Serum-Starved Sh-Sy5y Cells
No full textUnderstanding the Synthesis Mechanism of Arginine Functionalized Silver/Silver Chloride Nanoparticles Using Sugar Ligands
No full textIn this study, we performed a mechanistic study to understand how the sugar ligand chemistry affected the morphology, size and surface chemistry of Ag/AgCl_NPs synthesized in the presence of L-Arginine hydrochloride and L-Arginine/KCl mixture. The sugar ligands Lactose p-methoxyaniline (LMA) and Galactose 5-aminosalicylic acid (G5AS) resulted in formation of sheet-like Ag/AgCl_NPs while Lactose sulfanilic acid (LSA) and Lactose p-sulfonyldianiline (LPSA) caused the formation of anisotropic and film-like Ag/AgCl_NPs. The UV-Vis based mechanistic studies showed that the presence of Arginine posed a strong effect on how G5AS and LMA ligands interact with silver ions while the effect was more complicated for the LSA and LPSA ligands due to the fact that they form complexation with Ag+ ions. The mechanism was further investigated using infrared (IR) studies that showed the increases in Argine and chloride ion concentrations resulted in differentiation of the surface chemistry of the Ag/AgCl_NPs, and appearance of Arginine related IR bands became clearer in the case of co-introduction of Arginine and the sugar ligands. The characterized nanoparticles were then used as antibacterial agent for multidrug resistant Escherichia coli species for which less than 10 µM minimum inhibitory concentrations were obtained. The promising antibacterial activity, which could be assigned to the presence of Arginine, was independent from the sugar ligand chemistry and nanoparticles’ morphology and size. Particularly, large Ag/AgCl_NP film forming capacity can call further research to be exploited as coating materials for antibacterial application. © 2025 The Author
Influence of Oscillating Fiber Laser Welding Process Parameters on the Fatigue Response and Mechanical Performance of Butt-Jointed Twip980 Steels
No full textIn this study, the effect of laser power, welding speed, linear heat inputs on the mechanical performance of TWIP980 steels joined by oscillating fiber laser welding in butt welding configuration was investigated. Oscillating fiber laser welding were changed: laser power from 1.2 to 1.6 kW, welding speed from 20 to 30 mm s-1, linear heat input from 40 to 80 J mm-1. The tensile, hardness and fatigue tests were carried out to determine mechanical performance. A significant improvement in weld penetration, fatigue performance and mechanical properties was detected at linear heat inputs above 53.33 J mm-1. The best mechanical properties were obtained at 1.6 kW laser power and 25 mm s-1 welding speed. The study reveals that linear heat inputs, laser power, and welding speed have significant effects on mechanical performance and weld geometry. Furthermore, the results demonstrate that oscillating fiber laser welding enables good weldability even at low laser power
Adulteration of Pomegranate Molasses With Sugar Syrups: Application of FTIR-ATR Spectroscopy and Chemometrics
No full textIn this study, it was aimed to determine the adulteration ratio of pomegranate molasses (PM) with sugar syrups by using FTIR spectroscopy based upon chemometrics. With this intention, 34 pure PM samples were supplied from local manufacturers and adulterated with high fructose corn syrup (HFCS), glucose-fructose syrup (GFS) and beet sugar syrup (BSS) in varying ratios (5-50 %, w/w). Authentic and adulterated PM samples were analyzed in the range of 4000 and 400 cm(-1) wavenumber by FTIR spectroscopy. PCA was applied as a pretreatment for classification and regression analysis to select the spectral region and data reduction. Whereby the DD-SIMCA models were created using this information. The adulterated and authentic samples were classified correctly by the developed DD-SIMCA models. In the calibration and prediction model of DD-SIMCA, authentic and adulterated PM samples were correctly classified with high sensitivity (>= 0.91) and specificity (>= 0.94), and a clear distinction was observed with high efficiency (>= 0.94). Adulteration rates in PM samples were determined by PLS-R analysis. The correlation coefficients (R-2 >= 0.98) of models were also found quite high. As a consequence, FTIR spectroscopy in conjunction with chemometric approaches could be applied as a quick, dependable, non-destructive, and environmentally friendly tool for categorizing, distinguishing, and quantifying adulteration rates in PM samples
Petrogenesis and Comprehensive Thermal Assessment of the Dikili-Bergama Region, Western Anatolia
No full textVarious methods are available to evaluate the thermal properties and energy potential of geothermal fields. The heat flow method is crucial for thermal modeling and understanding geological evolution. It helps to assess the impact of geological formations on various processes, including hydrocarbon generation and structural modeling. This study focuses on the Dikili-Bergama geothermal region and presents heat flow trends based on thermal modeling. The analysis of volcanic rock petrogenesis data and a thermal model are presented based on data from deep and shallow boreholes. The geothermal gradient is found to vary between 66.28 degrees C km-1 and 121.68 degrees C km-1, according to the interpolated data. Additionally, the study investigates the geochemical and lithological properties of magmatic rocks in the Dikili-Bergama region. The Kozak pluton group's has been measured to have radioactive heat production of up to 7.4 mu Wm-3. Thermal conductivity properties and correlations, along with heat flow assessment, contribute to the understanding of geothermal potential. The mean dry thermal conductivity of the rocks in the study area is 2.33 Wm-1K-1. The data for the terrestrial heat flow and the radioactive heat flow values are up to 200 mWm-2. The integration of 3D geological models and thermal models has highlighted the south western area of the study as a promising location for unconventional geothermal operations
Review of the Relationship Between Growth Hormone and SARS-CoV-2 Infection
No full textRecent evidence suggests that SARS-CoV-2 is associated with the endocrine system, particularly growth hormone (GH). GH modifies immune responses and its deficiency could be responsible for the uncontrolled immunity that occurs in severe cases of COVID-19. Recent research shows that patients suffering from lung complications have significantly lower levels of GH and insulin-like growth factor-1 (IGF-1), which are proportionate to the severity of the disease. This relationship supports the hypothesis that GH regulates the immunity and inflammatory processes of the SARS-CoV-2 virus. However, variables such as age, gender, and comorbidities, such as diabetes and obesity, which are associated with lower GH levels, are strong predictors of COVID-19 outcomes. Older individuals and men, who tend to have lower GH levels, are disproportionately represented among severely ill patients. The available evidence suggests that GH supplementation therapy should be evaluated as a supportive measure to reduce the severity of the disease in high-risk individuals. The main goal of the research is to understand how COVID-19 is related to GH so that researchers can identify new mechanisms of pathology and develop better solutions for patients
Exploring Sainfoin (Onobrychis Viciifolia) Seed Flour as a Sustainable Plant-Based Food: Germination-Induced Changes in Nutritional Quality, Anti-Nutritional Factors, Phenolic Content, Bioaccessibility, and in Vitro Toxicity
No full textBackground and Objectives: Sainfoin is a drought-resistant perennial plant mainly used as animal feed, but its seeds remain underexplored as a food source. This study investigates the effects of germination on the nutritional quality of dehulled sainfoin seeds. Specifically, it examines changes in proximate composition, antinutrients (hydrocyanic acid, tannins, phytates, saponins, and trypsin inhibitors), in vitro starch digestibility, phenolic content, antioxidant capacity, and cytotoxicity. Findings: Germination significantly increased crude protein (up to 45%) and fat (up to 10%) contents. Despite low total starch (similar to 7%), 45-h germination reduced total digestible starch while increasing rapidly digestible starch. Antinutrient levels decreased significantly-tannins by 57%, phytates by 30%, saponins by 40%, and trypsin inhibitors by 29%-with the exception of hydrocyanic acid. Although total phenolics, flavonoids, and antioxidant capacity declined, their bioaccessibility improved. No cytotoxic effects were observed in either raw or germinated seeds. Conclusions: Germination improved the nutritional profile of sainfoin seeds by increasing protein and fat contents, while reducing most antinutrients. Despite a decrease in antioxidant levels, their bioaccessibility was enhanched. The absence of cytotoxic effects further supports the potential application of germinated sainfoin seeds in human nutrition. Significance and Novelty: Although few studies have focused on the green form of sainfoin, which is commonly used as livestock feed, this study reveals that sainfoin seeds offer substantial potential as food, with germination emerging as a simple and effective approach to improving their nutritional properties
Effect of Methionine and Lysine Supplementation on Performance and Intestinal Morphometrics of Finisher Broiler Chickens Fed Diets Containing Processed Cassava Peel Meal
No full textContext The current high prices of conventional feedstuffs in developing countries seems to warrant intensified efforts to find sustainable alternatives to the major feed ingredients that would support performance without compromising gut health, reduce cost of production and promote a sustainable environment.Aims The aim of the study is to evaluate the performance and health-related responses of finisher broiler chickens to the dietary replacement of corn with processed cassava peel meal (high- quality cassava peel meal) at 50% inclusion level, supplemented with methionine and lysine.Methods Three hundred and twenty Cobb500 broiler chickens were allocated to four dietary treatments on a weight equalization basis. Each treatment was replicated eight times. A control diet based on corn and soybean meal was formulated to meet the recommended digestible methionine and lysine specification of 4.0 and 0.96 g kg-1 respectively (VenCobb 500 Broiler Management Guide, Cobb-Vantress Inc., Siloam Spring, AR) for the finisher phase. The corn in the control diet was replaced with cassava peel meal at 50% replacement level in three other treatments (Diet 2-4). Diets 2-4 were then formulated to contain 100%, 112.5% and 125% of the recommended digestible methionine and 100%, 106.25% and 112.5% of the recommended digestible lysine, yielding 4.0, 4.4, and 4.8 g kg-1 digestible methionine respectively, and 0.96, 1.02, and 1.08 g kg-1 digestible lysine respectively, for the finisher phase.Key results The highest bodyweight gain, improved feed conversion ratio and increased duodenal and jejunal villus height:crypt depth ratio was found in birds fed Diet 4. The lactobacillus count was highest in birds fed Diet 4 and total bacteria counts was highest in birds fed Diet 2. The feed cost per kilogram weight gain was least for the birds fed diets containing the processed cassava peel meal. However, morphological changes were observed in the liver and intestinal tissues of the birds.Conclusion The study showed that the adequate supplementation of methionine and lysine to processed cassava peel meal can improve production performance of finisher broiler chickens but may not prevent morphological changes in the liver and intestine of the birds.Implication The result implied that processed and fortified cassava peel meal can reduce high dependence on maize in the production of finisher broiler chickens, while mitigating the enviromental challenges associated with the disposal of the agrowaste. The morphological changes in the liver and intestine of the birds require further investigation
Storage Tank Farming Planning Under Equipment and Port Operational Costs Through Mixed Integer Quadratically Constrained Programming
No full textThe study contributes a new method for managing crude oil tank farms, focusing on scheduling and optimizing storage tanks using mathematical modeling. The short-term continuous-time scheduling model reduces tank requirements and performs selection with convenient capacities. The nonconvex mixed-integer quadratically constrained programming (MIQCP) model is used to account for tank farm scheduling dynamics. It focuses on the integration of ships, storage tanks, charging tanks, and crude oil distillation units. The study examines 8 cases focusing on oil supply, arrival times, prices, and maximum flow rate constraints to show the impact of real-world volatility. By incorporating process intensification principles, the mathematical model emphasizes the importance of optimizing storage tank usage to minimize port operational costs of crude oils
Properties of Roman Structural Mortars in the Province of Asia (turkey)
No full textIn this study, the properties of Roman structural mortars composed of lime and natural aggregates from twentythree archaeological sites in Western Anatolia were determined in order to understand whether there was a common production technology of lime mortars in the Roman Empire by making a comparison between Europe and Western Anatolia. Their basic physical and mechanical properties, raw material compositions, microstructural and hydraulic properties, mineralogical and chemical compositions of their lime binder and fine aggregates were identified by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy coupled with energy dispersive spectroscopy, thermal gravimetric analysis analyses, bulk density, total porosity and compressive strength of mortars. The results indicated that these mortars mortars were produced by combining fat or lean lime with coarse aggregates (quartz, tuff) and predominantly fine pozzolanic rhyolitic and dacitic tuff aggregates. The lime/aggregate ratios of the mortars generally exhibited a range of values between 1:4 and 1.5:1 by weight, which closely paralleled the lime/aggregate ratios in other Roman mortars published in literature. The presence of lime lumps within the mortar matrices, exhibiting a spongy texture, may suggest the use of the hot lime mixing method in the preparation of the mortars. The mortars are hydraulic, possessing compressive strengths comparable to those observed in natural hydraulic lime mortars (NHL2, NHL3.5 and NHL5 types). The results indicate that the production of structural mortars in the province of Asia was similar to that in other regions of the Roman Empire, although the raw materials are similar, small differences in raw material composition could be due to the use of local raw material sources. This may be evidence of a common lime mortar technology that deliberately used pozzolanic aggregates with almost pure lime throughout the Roman Empire