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Late Hokusai: Society, Thought, Technique, Legacy
No full textThis publication has been developed from ideas first presented at the international symposium Late Hokusai: Thought, Technique, Society, held at the British Museum in May 2017. The symposium was organised to enable specialists in a range of disciplines relating to early modern Japan to view and consider the critically acclaimed exhibition Hokusai: Beyond the Great Wave, then being presented at the British Museum. The exhibition brought together representative works by the artist Katsushika Hokusai (1760−1849) in the various media in which he worked – colour woodblock prints, woodblock-printed illustrated books, brush paintings on paper or silk, and brush drawings − that were produced between the age of 61 and his death aged 90.
Building on the themes of the exhibition, authors from the UK, Europe, Japan and USA have engaged with late Hokusai from a variety of perspectives, both intrinsic and extrinsic to his life and works. Essays have been grouped within the broad categories of ‘society’ – wider cultural interaction and patronage; ‘thought’ – Hokusai’s intellectual concerns and the ways his art brought these to life; and ‘technique’ – how the artist pursued excellence in all media, within a commercialised art market. A particular focus has been the collaborative relationship between Hokusai and his artist daughter Ei (art-name Ōi, c. 1800−after 1857?). A fourth section on ‘legacy’ looks at how stories of Hokusai have been as much generated by 130 years of scholarship, as they have by his works themselves. Challengingly, faked paintings and printed works have both contaminated and supported those stories. This innovative approach provides new insights into the work of one of the world’s most celebrated artists and suggests many new avenues for Hokusai research
Spatial network dataset for "Mapping the Caribbean Diaspora through Andrew Salkey"
No full textMicrosoft csv. file dataset created for Kepler mapping the geographical movement of correspondent
All Data for "Mapping the Caribbean Diaspora through Andrew Salkey's Correspondence"
No full textMicrosoft excel of all of the metadata created by the project
Kepler Dataset for "Mapping the Caribbean Diaspora through Andrew Salkey's Correspondence"
No full textDataset created in Kepler to map the movement of the Caribbean diasporic network present in Andrew Salkey's correspondence files
Molecular phylogenetics shed light on polyploid speciation in gorses ( <i>Ulex</i> , Fabaceae: Genisteae) and on the origin of the invasive <i>Ulex europaeus</i>
No full textHybridization and polyploidy are key evolutionary forces in plant diversification, and their co-occurrence in the context of allopolyploid speciation is often associated with increased ability to colonize new environments and invasiveness. In the genus Ulex (Fabaceae), the European gorse (Ulex europaeus subsp. europaeus) is the only invasive and the only polyploid that has recently spread in different eco-geographical regions across the world. Understanding what confers such ecological advantages to this species, compared to its diploid and polyploid congeners, first requires clarification of the ecogeographical and evolutionary context of its formation. To achieve this, the geographical distributions of all Ulex spp. were estimated from species occurrence records, and phylogenetic analyses including all Ulex spp. were performed based on four nuclear (ITS and ETS nrDNA) and plastid (rps12 intron and trnK-matK) regions. The resulting trees were dated using a secondary calibration. Patterns of DNA sequence variation and dated phylogenetic trees were then interpreted in light of previous knowledge of chromosome numbers in Ulex to infer past events of polyploid speciation in the genus. We show that: (1) most current Ulex spp. radiated in the Iberian Peninsula during the past 1–2 Myr; (2) the history of Ulex was punctuated by multiple whole-genome duplication events; and (3) U. europaeus subsp. europaeus is the only gorse taxon that was formed by hybridization of two well-differentiated lineages (which separated c. 5 Mya) with wide climatic ranges (currently represented by Ulex minor and Ulex europaeus subsp. latebracteatus), possibly contributing to the invasive nature and wider climatic range of U. europaeus subsp. europaeus. These findings provide a much-needed evolutionary framework in which to explore the adaptive consequences of genome mergers and duplication in Ulex
A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation.
No full textSETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of DNA methylation. is frequently mutated in cancer, however, the functional impact of loss and depletion on DNA methylation across cancer types and tumorigenesis is currently unknown. Here, we perform a pan-cancer analysis and show that both mutation and reduced expression are associated with DNA methylation dysregulation across 21 out of the 24 cancer types tested. In renal cancer, these DNA methylation changes are associated with altered gene expression of oncogenes, tumour suppressors, and genes involved in neoplasm invasiveness, including , and . This suggests a new role for loss in tumorigenesis and cancer aggressiveness through DNA methylation dysregulation. Moreover, using a robust machine learning methodology, we develop and validate a 3-CpG methylation signature which is sufficient to predict mutation status with high accuracy and correlates with patient prognosis
Hybrid Correspondence Network Processing Script
No full textThe Python code was developed to to interrogate the ways in which digital and analogue correspondence files (letters and e-mails) function within the Archive of Harold Pinter; reflecting upon what these patterns might mean for archivists, curators and researchers working with hybrid correspondence collections. This code is collection agnostic and its outputs are compliant with General Data Protection Regulation in the UK, meaning that interested parties at any collecting repository working with born digital or hybrid archives will be able to re-use the code for their own purposes and that the outputs can be shared within the sector and amongst the wider research community
Metals and pigments at Amara West: cross-craft perspectives on practices and provisioning in New Kingdom Nubia
No full textThis paper presents the results of elemental and lead isotopic analysis of copper alloys, copper-based pigments and an extremely rare tin-based alloy from the town of Amara West (Sudan), the centre for pharaonic control of occupied Upper Nubia between 1300 and 1070 BCE. It is the first assemblage of its kind to be analysed for Upper Nubia during this period. This research examines the selection and consumption of alloys in a colonial context, in light of earlier and contemporaneous practices and patterns in both Egypt and Nubia, to assess broader systems of resource management and metal production. Drawing on the complementary information obtained from pigment analysis, novel insights into interactions between different high-temperature crafts are obtained, particularly in terms of shared provisioning systems. From this unique perspective, pigment analysis is used for the first time to illuminate copper sources not reflected in metal assemblages, while scrap copper alloys are identified as a key colourant for Egyptian blue manufacture. The integrated application of strontium isotope analysis further highlights the potential for identifying links between glass, faience and Egyptian blue production systems within Egypt and for distinguishing these from other manufacturing regions such as Mesopotamia. The analysis of a tin artefact further expands our understanding of potential tin sources available during the New Kingdom and their role in shaping copper alloy compositions. Overall, this holistic approach to copper alloys and their application in other high-temperature industries ties together different strands of research, shaping a new understanding of New Kingdom technological practices, supply networks and material stocks circulating throughout the Nile Valley
Metagenomics Shines Light on the Evolution of ‘Sunscreen’ Pigment Metabolism in the Teloschistales (Lichen-Forming Ascomycota).
No full textFungi produce a vast number of secondary metabolites that shape their interactions with other organisms and the environment. Characterising the genes underpinning metabolite synthesis is therefore key to understanding fungal evolution and adaptation. Lichenised fungi represent almost one-third of Ascomycota diversity and boast impressive secondary metabolites repertoires. However, most lichen biosynthetic genes have not been linked to their metabolite products. Here we used metagenomic sequencing to survey gene families associated with production of anthraquinones, UV-protectant secondary metabolites present in various fungi, but especially abundant in a diverse order of lichens, the Teloschistales (class Lecanoromycetes, phylum Ascomycota). We successfully assembled 24 new, high-quality lichenised fungal genomes de novo and combined them with publicly available Lecanoromycetes genomes from taxa with diverse secondary chemistry to produce a whole-genome tree. Secondary metabolite biosynthetic gene cluster (BGC) analysis showed that whilst lichen BGCs are numerous and highly dissimilar, core enzyme genes are generally conserved across taxa. This suggests metabolite diversification occurs via re-shuffling existing enzyme genes with novel accessory genes rather than BGC gains/losses or de novo gene evolution. We identified putative anthraquinone BGCs in our lichen dataset that appear homologous to anthraquinone clusters from non-lichenised fungi, suggesting these genes were present in the common ancestor of the subphylum Pezizomycotina. Finally, we identified unique transporter genes in Teloschistales anthraquinone BGCs that may explain why these metabolites are so abundant and ubiquitous in these lichens. Our results support the importance of metagenomics for understanding the secondary metabolism of non-model fungi such as lichens
