Revista Jurídica Digital UANDES
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Medical documentation in humanitarian emergencies: building high-tech castles in the air?
No full textScalable Filtering Modules for Database Acceleration on FPGAs
No full textDatabase sizes are growing faster than the processing power in the post-Moore era due to the advent of big data applications, which make hardware acceleration mandatory. However, currently, database acceleration using FPGAs has mainly been static and with limited accelerator functionality, reducing the potential performance gains from customization on FPGAs. In this paper, we propose a dynamic stream processing architecture for SQL query execution on FPGAs. It achieves this by building pipelines based on scalable database accelerator primitives and partial reconfiguration. Further, we introduce novel optimization techniques to design a scalable filtering module for database restriction and boolean evaluation. It features multiple PEs that operate in parallel and implements DNF solver to implement boolean expression evaluation. Our evaluation shows that not only the system can support the acceleration of filtering in all TPC-H queries but provide up to 17.7GB/s throughput and scales linearly with datapath size
Real-time active suppression of directional wave components in acoustic waveguides The Journal of the Acoustical Society of America
No full textAcoustic pulse reflectometry (APR) is a method of non-destructive testing (NDT) used for locating and characterising features and defects in gas-filled objects such as tubes, pipes and ducts. A sound wave is emitted into the waveguide and travels in the axial direction until it is partially or fully reflected at changes in cross-section. The recorded reflection sequence is analysed to reveal time-of-flight, amplitude and reflection shape. Analysis of reflection sequences is problematic due to the presence of multiple repeated echoes. The principal contribution is the introduction and demonstration of a method of actively suppressing unwanted echoes by modifying the signal emitted by the speaker in real-time. Unlike previous work, the proposed system accounts for inter-transducer and does not require re-calibration for each test object. The proposed real-time active absorbing termination is implemented using a programmable embedded controller and shown to function effectively. A quantitativeevaluation of available wave separation techniques is provided using a known metric. A new metric for quantifying the performance of absorbing terminations is introduce
Research Software Development & Management in Universities: Case Studies from Manchester’s RSDS Group, Illinois’ NCSA, and Notre Dame’s CRC
No full textModern research in the sciences, engineering, humanities, and other fields depends on software, and specifically, research software. Much of this research software is developed in universities, by faculty, postdocs, students, and staff. In this paper, we focus on the role of university staff. We examine three different, independently-developed models under which these staff are organized and perform their work, and comparatively analyze these models and their consequences on the staff and on the software, considering how the different models support software engineering practices and processes. This information can be used by software engineering researchers to understand the practices of such organizations and by universities who want to set up similar organizations and to better produce and maintain research software
Genome-wide association study of breakfast skipping
No full textBackground: Breakfast timing is the most heritable across meals, and little is currently known about the contribution of genetic variation to food timing. As breakfast timing is not routinely assessed in epidemiological studies, alternative approaches may include analyses of phenotypically related dietary traits.Objective: We aimed to elucidate breakfast timing genetic variants through a genome-wide association study (GWAS) for breakfast cereals skipping, a more commonly assessed trait.Design: We leveraged the statistical power of the UK Biobank (n=193,860) to identify genetic variants related to breakfast cereals skipping as a proxy for breakfast skipping and applied an array of in silico approaches to investigate mechanistic functions and links to traits/diseases. Next, we attempted replication in other breakfast skipping GWAS in the TwinUK (n=2,006) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium (n=11,963).Results: We identified six independent GWAS variants associated with breakfast skipping, including those implicated for caffeine (ARID3B), carbohydrate metabolism (FGF21), schizophrenia (ZNF804A), and those encoding enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), which regulates the pace of the circadian clock. Expression of identified genes was enriched in the cerebellum. Genome-wide correlation analyses indicated positive correlations with anthropometric traits. Through Mendelian randomization (MR), we observed causal links between genetically determined breakfast skipping and higher BMI, more depressive symptoms, and smoking. In bidirectional MR, we demonstrate a causal link between being an evening person and skipping breakfast, but not vice versa. We observed independent replication of our signals in a previous breakfast skipping GWAS in another British cohort (P=0.032), TwinUK, but not in a meta-analysis of non-British cohorts from the CHARGE consortium (P=0.095).Conclusions: Overall, our comprehensive GWAS approach identified six genetic variants for breakfast/food timing and supports the potential beneficial role of regular breakfast intake as part of a healthy lifestyle.<br/
MICROSTRUCTURAL CHARACTERIZATION OF ALLOY 690TT EXPOSED TO PbCONTAINING CAUSTIC SOLUTIONS
No full textLead-induced stress corrosion cracking (PbSCC) is one of the secondary side degradation phenomena that has occurred in the steam generator (SG) of pressurized water reactors (PWR). In order to reproduce the conditions where PbSCC develops, C-rings of Alloy 690TT were loaded to the yield stress or to 6% plastic deformation and exposed at 315°C to caustic solutions (pHRT = 13.7) containing 1000 ppm of PbO. Two different surface finishes (as-received, with a local surface deformation, and Oxide Polishing Suspension) were tested to investigate the effect of the surface deformed layer on the SCC initiation propensity. Advanced electron microscopy (SEM, FIB and ATEM) examinations of the oxidized surface revealed that the surface-deformed layer promoted the formation of a protective passive layer, which, in turn, retarded crack formation. The role of stress, surface condition and environmental interactions on PbSCC are also discussed. <br/
Consensus paper from thoracic oncology experts about the definition of synchronous oligometastatic non-small cell lung cancer
No full textIntroduction: Improved outcome has been shown in patients with synchronous oligometastatic non-small cell lung cancer (sOM-NSCLC) when treated with radical intent. As a uniform definition of sOM-NSCLC is lacking, we developed a definition and diagnostic criteria by a consensus process. Methods: A pan-European multidisciplinary consensus group was established. Consensus questions were built based on current controversies, and definitions extracted from a survey, cases and a systematic review. This statement was formulated during a consensus meeting. Results: Defining sOM-NSCLC Definition of sOM-NSCLC is relevant when a radical treatment is technically feasible for all tumor sites with acceptable toxicity, that may modify the disease course leading to long term disease control. Based on the review, a maximum of 5 metastasesand 3 organs is proposed. Mediastinal lymph node involvement is not counted as a metastatic site. Staging of sOM-NSCLC A 18fluorodeoxyglucose-positron emission tomography (18F-FDG-PET-CT) and brain imaging were considered mandatory. A dedicated liver MRI is advised for a solitary liver metastasis, and thoracoscopy and biopsies of distant ipsilateral pleural sites for a solitary pleural metastasis. For mediastinal staging, a 18FDG-PET-CT is the minimum requirement, with pathological confirmation recommended if this influences the treatment strategy. Biopsy of a solitary metastatic location is mandated unless the multidisciplinary team is of the opinion that the risks outweigh the benefits. Conclusion: A multidisciplinary consensus statement on the definition and staging of sOM-NSCLC has been formulated. This statement will help to standardise inclusion criteria in future clinical trials
Setting the Foundations for Theoretical Progress toward Understanding the Role of Values:Commentary on “Values at Work: The Impact of Personal Values in Organizations” by Arieli, Sagiv, & Roccas, 2019.
No full textFirst International Conference on RASopathies and Neurofibromatoses in Asia:Identification and Advances of New Therapeutics
No full textThe neurofibromatoses, which include neurofibromatosis type I (NF1), neurofibromatosis type II (NF2), and schwannomatosis, are a group of syndromes characterized by tumor growth in the nervous system. The RASopathies are a group of syndromes caused by germline mutations in genes that encode components of the RAS/mitogen-activated protein kinase (MAPK) pathway. The RASopathies include NF1, Noonan syndrome, Noonan syndrome with multiple lentigines, Costello syndrome, cardio-faciocutaneous syndrome, Legius syndrome, capillary malformation arterio-venous malformation syndrome and SYNGAP1 autism. Due to their common underlying pathogenetic etiology, all these syndromes have significant phenotypic overlap of which one common feature include a predisposition to tumors, which may be benign or malignant. Together as a group, they represent one of the most common multiple congenital anomaly syndromes estimating to affect approximately one in 1000 individuals worldwide. The subcontinent of India represents one of the largest populations in the world, yet remains underserved from an aspect of clinical genetics services. In an effort to bridge this gap, the First International Conference on RASopathies and Neurofibromatoses in Asia: Identification and Advances of New Therapeutics was held in Kochi, Kerala, India. These proceedings chronicle this timely and topical international symposium directed at discussing the best practices and therapies for individuals with neurofibromatoses and RASopathies
