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Self-management in solid organ transplantation:From measurement to nurse-led intervention
No full textOrgan transplantation is the preferred treatment performed in cases of end-stage organ failure. Statistics from the Dutch Transplant Foundation show that in 2023, 1434 patients in the Netherlands received an organ. The majority of these were kidney transplants (71%). Survival rates and graft survival rates have improved in the past decades (1-3). Yet organ transplant recipients can encounter various challenges, such as consistently taking medication to prevent rejection, as well as dietary restrictions or anxiety and depression. Not all people are able to deal with these challenges, which can negatively impact their quality of life. This requires attention from both the healthcare professional and the patient on how to cope with living with an organ, as quality of life is a valuable indicator for the relative success of an organ transplantation (4)
Molecular mechanisms of vascular aging and aneurysm formation:Toward therapeutic strategies
No full textThis thesis explores the molecular mechanisms of vascular aging and evaluates potential therapeutic interventions, utilizing mouse models that capture various aspects of this complex process
The age of biomarkers:Predicting age-related decline with molecular signatures
No full textPeople age differently, and these differences go beyondchronological age. Biological age indicates how quicklyor slowly an individual’s body is aging, with highervalues than peers indicating unhealthy aging and lowervalues healthy aging. Biological age can be assessed andpredicted through biomarkers (measurable indicatorsof biological states or processes), which provide apersonalized measure of aging and, thereby, valuableinsights into its variability across individuals.The main goal of this thesis is to improve the predictionof biological aging. To achieve this, we evaluatedexisting biomarkers for biological age (Part I), developednew biomarkers (Part II), and explored their potentialapplications (Part III).<br/
Exploiting human leukocyte antigens for the treatment and diagnosis of gastrointestinal disesaes
No full textThe aim of this thesis was to allocate opportunities to exploit HLA complexes for both diagnosis and rational therapeutic vaccine design for gastrointestinal diseases that currently have dire outcomes. To this end, I have taken a dual approach to:1) Investigate how we can exploit dendritic cells as highly skilled antigen-presenting cells to further refine the design of novel therapeutic vaccines (part I of this thesis)2) Explore the diagnostic and therapeutic value of soluble HLA complexes and their peptide cargo in circulation of patients suffering from gastrointestinal disease (part II of this thesis
Procedural aspects of limitation of liability for maritime claims
No full textLimitation of liability is an essential principle of maritime law, implemented to shield shipowners and other maritime actors from ruinous financial liabilities arising from the risks associated with international shipping. While the current global rules regulating this principle, such as the International Convention on Limitation of Liability for Maritime Claims (LLMC 1976/1996) has significantly harmonized the substantive aspects of the rules, the procedural aspects for enforcing this right remain largely unharmonised and unregulated at the international level. Therefore, this thesis identifies a critical gap in legal research, exploring how national procedures interpret various aspects of these rules with the aim to provide insights into these procedural divergences towards enhancing predictability and clarity.<br/
A tale of inclusive cities:On the branding, implementation, and evaluation of inclusive city
No full textIn recent years, “inclusive cities” has become one of the core issues in global urbangovernance. From the policy recommendations issued by international organizationssuch as the United Nations, World Bank and the OECD, to the urban development plansand city branding, “inclusion” has been widely used to address the increasingly seriousproblems of urban inequality and exclusion. However, the actual development is notas expected. Globally, cities have not become more inclusive as a result, but are facingincreasingly severe challenges: housing crisis, racial tensions, institutional exclusionof marginalized groups, and the aggregation of populist politics and fiscal austeritypolicies. Although the discourse of inclusive cities has gained popularity, its connotationis vague, its evaluation standards are scattered, and its policies and practices aredisconnected. In this context, this thesis is committed to exploring the three dimensionsof discourse, operation and reflection of the concept of “inclusive cities” in urban governance.It aims to offer a more critical and institutionally grounded analytical frameworkand respond to the theoretical tension and practical dilemma of inclusion in today’surban transformation
Community and connection in the gig economy:A bottom-up approach to understanding identification among workers
No full textIdentification represents a fundamental human need, yet little is known about how it is experienced in the gig work context that is characterized by individualization and atomization. In organizational communication studies, identification is commonly defined through a social psychological lens as: “the perception of oneness with or belongingness to some human aggregate” (Ashforth & Mael, 1989, p. 21). It tends to be strong when individuals perceive many similarities between themselves and the group or relationship they identify with (Dutton et al., 1994). Gig work can be understood as labor arrangements of short duration in which workers are compensated per task or project as opposed to a wage-based employment contract (Cropanzano et al., 2023). Though the gig economy has surged with the emergence of online labor platforms, extant research has insufficiently engaged with the relational, cognitive, and affective experiences of gig workers (Wu & Huang, 2024). Vice versa, organizational scholars have called for more research on identification in non-standard work settings and outside organizational boundaries (Ashforth et al., 2020). Therefore, this dissertation explores how and where gig workers experience identification, and in what ways contextual factors shape these experiences. In answering these twin overarching research questions, the dissertation takes a social constructionist, multimethodological approach to social identity theory. This means going beyond dominant conceptualizations of identification as a cognitive state to recognizing the fluid, dynamic, and context-dependent nature of identification (Scott et al., 1998). The use of multiple methods, including qualitative, quantitative, and computational methods, allows for the analysis of different aspects of the gig work context. Based on these findings, this dissertation argues that the diminished presence of traditional organizational loci does not limit identification in the gig economy. Instead, identification experiences emerge in ‘non-traditional’ spaces, notably (online) communities of gig workers, which serve as sources of stability and mutual support. These communities provide a sense of oneness and belonging within a work environment otherwise marked by precarity, individualization, and social atomization
International investment law from below:Taking local community rights seriously
Full text linkThis thesis challenges the traditional conception of extractive investment disputes as only affecting states and foreign investors, and instead takes a view of such disputes ‘from below’, centring the interests and experiences of local communities affected by extractive foreign investment projects. Interviews with affected local community members reveal how investment arbitration is more than an elite legal process abstracted from the disputed ground. Instead, the lives of affected communities are bound up in the goings-on of investment tribunals, in the stories that are being told about them, the fight they put their souls into, and the future of their homes. Incorporating a qualitative methodology into the study of investment arbitration brings a human aspect to an epistemic community that tends to uphold traditional black-letter and doctrinal boundaries. Taking a strictly legalistic view of such cases works to obscure the real-world impacts of how the international economic regime is ordered. If the rights and interests of local communities are made visible, we can start conceptualising them as important in the design of investment projects and resolution of disputes, and stop pretending that they do not matter
Voices from a messy practice:Conversation with Jeannette Pols
No full textVoordat we op het Malieveld gaan demonstreren tegen de bezuinigingen in het hoger onderwijs en onderzoek, spreek ik met Jeannette Pols, hoogleraar antropologie van de alledaagse ethiek in de gezondheidszorg aan de Universiteit van Amsterdam en Amsterdam UMC. In haar boek Reinventing the Good Life: An empirical contribution to the philosophy of care betoogt ze dat ideeën over het goede leven en goed bestuur door de opkomst van de sociale en economische wetenschappen zijn getransformeerd tot algemene en rationeel hanteerbare begrippen