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Comptes Rendus
Chimie
Pierre Braunstein
Editorial January 2024 for Comptes Rendus Chimie
Volume 27 (2024), p. 1-5
Online since: 20 February 2024
https://doi.org/10.5802/crchim.296
This article is licensed under the
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C EN T R E
MER S ENN E
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Mersenne Center for open scientific publishing
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Comptes Rendus. Chimie
2024, Vol. 27, p. 1-5
https://doi.org/10.5802/crchim.296
Editorial
Editorial January 2024 for Comptes Rendus Chimie
Pierre Braunstein
The decision made by the Académie des sciences
to provide since January 1, 2020 a fully open ac-
cess worldwide to its well-established publications
Comptes Rendus, including of course Comptes Ren-
dus Chimie (“diamond model”) was acclaimed by
the entire scientific community, authors and readers
alike.
Most of you are familiar with our editorial pol-
icy. Chemistry is a very rich and diverse science, and
we aim to cover all its aspects, from fundamental
concepts to applications, whether in the core of the
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We publish original research articles and accounts
(short reviews focused on the authors’ recent sci-
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and welcome by our readers because they allow an
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thors and guest editors because they are responsi-
ble for the success of this journal and its increasing
visibility.
The thematic issues published in 2023 covered the
following topics:
• Louis Pasteur: to celebrate his 200th anniver-
sary, various articles were published here in
collaboration with Comptes Rendus Biolo-
gie, the Notes Académiques de l’Académie
d’agriculture de France, and the Bulletin de
l’Académie vétérinaire, which illustrated
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As practised by most major scientific journals and
in order not to overload our referees unduly, only
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tentially meet the criteria given above are sent out to
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erate frustrations, but this is the only way to proceed
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torial Office. To be able to rely on high-level scientific
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sential for a scientific journal and we know that these
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cerely thank them for their contribution to the suc-
cess of Comptes Rendus Chimie and we are particu-
larly grateful to our 10 most active referees listed in
Table 1.
The quality and diversity of the contributions
published in Comptes Rendus Chimie explains the
international awareness they have generated, with
most views originating from the USA, France, China
and India (source: Centre Mersenne). The 15 most
viewed and downloaded articles in 2023 are listed in
Tables 2 and 3, respectively.
ISSN (electronic) : 1878-1543 https://comptes-rendus.academie-sciences.fr/chimie/
2 Pierre Braunstein
Table 1. Our 10 most active referees in 2023
Janine Cossy (ESPCI Paris, France)
Pierre Grandclaudon (ENSC Lille, France)
Salah Jellali (Sultan Qaboos University, Muscat, Oman)
Ralph Puchta (University of Erlangen–Nuremberg, Germany)
Olivier Thomas (National University of Ireland Galway, Ireland)
Abdeslam-Hassen Meniai (University of Constantine 3, Algeria)
Ryan Osterloh (University of Houston, USA)
Edouard Freund (former R&D director at Institut Français du Pétrole, Rueil-Malmaison, France)
Monika Jain (Banda University of Agriculture & Technology, Banda, India)
Besma Khiari (National School of Engineers of Carthage, Tunis, Tunisia)
Table 2. The 15 articles (published since 1 January 2020) most viewed in 2023 (source: Centre Mersenne)
Title Authors
Huiles essentielles et chiralité moléculaire Louisa Aribi-Zouioueche, Françoise Couic-Marinier
Les noms des éléments nous racontent leur histoire Pierre Avenas
Tableau périodique des éléments chimiques et
actinides
Robert Guillaumont
The influence of particle(s) size, shape and
distribution on cake filtration mechanics—a short
review
S. S. Haramkar, G. N. Thombre, S. V. Jadhav,
B. N. Thorat
Les scénarios énergétiques à l’épreuve du stockage
des énergies intermittentes
Marc Fontecave, Dominique Grand
Théorie cinétique de l’équilibre chimique Mathieu Lazerges, Sylvain Marque
Scanning electron microscopy—a powerful imaging
technique for the clinician
D. Bazin, E. Bouderlique, M. Daudon, V. Frochot,
J.-P. Haymann, E. Letavernier, F. Tielens, R. Weil
Louis Pasteur face à la maladie du ver à soie
(1865–1870) : du chimiste au biologiste
Yves Carton
Louis Pasteur : de la physico-chimie à la biologie Hervé This
Urinary tract infection inducing stones: some
clinical and chemical data
M. Daudon, M. Petay, S. Vimont, A. Deniset,
F. Tielens, J.-P. Haymann, E. Letavernier, V. Frochot,
D. Bazin
Randall’s plaque as the origin of idiopathic calcium
oxalate stone formation: an update
E. Van de Perre, D. Bazin, V. Estrade, E. Bouderlique,
K. M. Wissing, M. Daudon, E. Letavernier
Whitlockite structures in kidney stones indicate
infectious origin: a scanning electron microscopy
and Synchrotron Radiation investigation
D. Bazin, R. J. Papoular, E. Elkaim, R. Weil,
D. Thiaudière, C. Pisapia, B. Ménez, N. S. Hwang,
F. Tielens, M. Livrozet, E. Bouderlique,
J.-P. Haymann, E. Letavernier, L. Hennet, V. Frochot,
M. Daudon
(continued on next page)
Pierre Braunstein 3
Table 2. (continued)
Title Authors
The crucial contribution of X-ray fluorescence
spectroscopy in medicine
D. Bazin, E. Foy, S. Reguer, S. Rouzière, B. Fayard,
H. Colboc, J.-P. Haymann, M. Daudon, C. Mocuta
Cystinuria and cystinosis are usually related to
L-cystine: is this really the case for cystinosis?
A physicochemical investigation at micrometre and
nanometre scale
D. Bazin, M. Rabant, J. Mathurin, M. Petay,
A. Deniset-Besseau, A. Dazzi, Y. Su, E. P. Hessou,
F. Tielens, F. Borondics, M. Livrozet, E. Bouderlique,
J.-P. Haymann, E. Letavernier, V. Frochot,
M. Daudon
Le foisonnement éolien : les limites d’un mix
électrique à forte proportion d’énergies
renouvelables intermittentes
Dominique Grand, Marc Fontecave
Table 3. The 15 articles (published since 1 January 2020) most downloaded in 2023 (source: Centre
Mersenne)
Title Authors
Huiles essentielles et chiralité moléculaire Louisa Aribi-Zouioueche, Françoise Couic-Marinier
Deciding which is the best 1H NMR predictor for
organic compounds using statistical tools
W. H. Mah, N. H. A. Nazuan, W. S. Yeap,
F. H. Fakharudin, I. Faye, C. D. Wilfred
Synthesis and characterization of original
fluorinated bis-cyclic carbonates and xanthates
from a fluorinated epoxide
A. Alaaeddine, V. Ladmiral, W. El Malti, L. Haydar,
S. Caillol, B. Améduri
Editorial January 2023 for Comptes Rendus Chimie Pierre Braunstein
Preparation of hyperbranched
4-dimethylaminopyridine catalyst for the efficient
synthesis of vitamin E succinate
H. Li, T. Zhang, K. Tang, B. Li, X. Zhang, B. Zhao,
J. Wang
Liquid–liquid extraction: thermodynamics–kinetics
driven processes explored by microfluidics
F. Olivier, A. A. Maurice, D. Meyer, J-C. P. Gabriel
Scanning electron microscopy—a powerful imaging
technique for the clinician
D. Bazin, E. Bouderlique, M. Daudon, V. Frochot,
J.-P. Haymann, E. Letavernier, F. Tielens, R. Weil
Zeolite-based catalysis for isobutene conversion
into chemicals and fuel additives. A review
Vasile Hulea
The crucial contribution of X-ray fluorescence
spectroscopy in medicine
D. Bazin, E. Foy, S. Reguer, S. Rouzière, B. Fayard,
H. Colboc, J.-P. Haymann, M. Daudon, C. Mocuta
Nickel oxide-based catalysts for ethane oxidative
dehydrogenation: a review
Ştefan-Bogdan Ivan, Adriana Urdă, Ioan-Cezar
Marcu
Tableau périodique des éléments chimiques et
actinides
Robert Guillaumont
Louis Pasteur bactériologiste : de l’atténuation de la
virulence à la vaccination
Henri Monteil
(continued on next page)
4 Pierre Braunstein
Table 3. (continued)
Title Authors
Théorie cinétique de l’équilibre chimique Mathieu Lazerges, Sylvain Marque
Different routes of MgAl–LDH synthesis for tailoring
the adsorption of Pb(II) pollutant from water
M. Mureseanu, A. Eliescu, E.-C. Ignat, G. Carja,
N. Cioatera
Using micro computed tomographic imaging for
analyzing kidney stones
J. C. Williams, J. E. Lingeman, M. Daudon, D. Bazin
Table 4. The 15 most cited articles (all years) in 2023 (source: Web of Science as consulted on 22
December 2023)
Title Authors
Sacrificial electron donor reagents for solar fuel production Yann Pellegrin, Fabrice Odobel
Green solvents from ionic liquids and deep eutectic solvents
to natural deep eutectic solvents
H. Vanda, Y. Dai, E. G. Wilson, R. Verpoorte,
Y. H. Choi
Some aspects of green solvents Katharina Haeckl, Werner Kunz
Hexavalent chromium quantification in solution:
Comparing direct UV-visible spectrometry with
1,5-diphenylcarbazide colorimetry
Arnaud Sanchez-Hachair, Annette Hofmann
Removal of fluoride from groundwater using natural clay
(kaolinite): Optimization of adsorption conditions
N. Nabbou, M. Belhachemi, M. Boumelik,
T. Merzougui, D. Lahcene, Y. Harek,
A. A. Zorpas, M. Jeguirim
Water as a green solvent combined with different techniques
for extraction of essential oil from lavender flowers
A. Filly, A. S. Fabiano-Tixier, C. Louis,
X. Fernandez, F. Chemat
Synthesis, chemistry, physicochemical properties and
industrial applications of amino acid surfactants: A review
D. B. Tripathy, A. Mishra, J. Clark, T. Farmer
Light-induced spin crossover — Solution and solid-state
processes
G. Chastanet, M. Lorenc, R. Bertoni,
C. Desplanches
Comprehensive morpho-constitutional analysis of urinary
stones improves etiological diagnosis and therapeutic
strategy of nephrolithiasis
M. Daudon, A. Dessombz, V. Frochot,
E. Letavernier, J.-P. Haymann, P. Jungers,
D. Bazin
Occurrence, fate and removal efficiencies of
pharmaceuticals in wastewater treatment plants (WWTPs)
discharging in the coastal environment of Algiers
Amine Elmouatezz Bellah Kermia, Djamila
Fouial-Djebbar, Mohamed Trari
Thermodynamical aspects of the spin crossover
phenomenon
William Nicolazzi, Azzedine Bousseksou
Limonene as an agro-chemical building block for the
synthesis and extraction of bioactive compounds
M. Aissou, Z. Chemat-Djenni, E. Yara-Varon,
A.-S. Fabiano-Tixier, F. Chemat
(continued on next page)
The most cited articles in 2023 are listed in
Table 4.
We wish to congratulate our authors for their
scientific success and are proud to contribute
Pierre Braunstein 5
Table 4. (continued)
Title Authors
Low-cost ceramic membranes: Synthesis, classifications,
and applications
Mansour Issaoui, Lionel Limousy
Spin-crossover nanoparticles and nanocomposite materials Lionel Salmon, Laure Catala
Nanosized zeolites: Quo Vadis? Svetlana Mintova, Julien Grand,
Valentin Valtchev
enhancing the visibility of their work through a
fully Open Access worldwide journal!
Of course, our authors, guest editors and referees
are responsible for the success of this journal and its
increasing visibility and we are most grateful to them
for their commitment and welcome their suggestions
to ensure that this journal meets their needs and
expectations.
Finally, I would like to warmly thank the members
of the editorial board of Comptes Rendus Chimie,
the editorial and production staff, in particular
Julien Desmarets (scientific secretary), for their sup-
port and cooperation.
I wish you all a fruitful and scientifically most re-
warding and successful New Year and look forward to
receiving your manuscripts!
Pierre Braunstein
Editor-in-Chief
Strasbourg
braunstein@unistra.fr


Editorial January 2024 for <i>Comptes Rendus Chimie</i>

Lucas Bacheley

Gérard Guillamot

Phannarath Phansavath

Virginie Ratovelomanana-Vidal

Comptes Rendus
Chimie
Lucas Bacheley, Gérard Guillamot, Phannarath Phansavath and Virginie
Ratovelomanana-Vidal
Direct ring fluorination of 3-substituted 5-(1,3-dioxane) acetal isoxazoles:
application to the formal synthesis of a bioactive fluorinated isoxazole
Volume 27, Special Issue S2 (2024), p. 33-38
Online since: 9 February 2024
Issue date: 11 July 2024
Part of Special Issue: Women Chemists in France in 2024
Guest editor: Janine Cossy (ESPCI Paris – PSL, CNRS, 75005 Paris, France)
https://doi.org/10.5802/crchim.278
This article is licensed under the
Creative Commons Attribution 4.0 International License.
http://creativecommons.org/licenses/by/4.0/
C EN T R E
MER S ENN E
The Comptes Rendus. Chimie are a member of the
Mersenne Center for open scientific publishing
www.centre-mersenne.org — e-ISSN : 1878-1543
Comptes Rendus. Chimie
2024, Vol. 27, Special issue S2, p. 33-38
https://doi.org/10.5802/crchim.278
Research article
Women Chemists in France in 2024
Direct ring fluorination of 3-substituted
5-(1,3-dioxane) acetal isoxazoles: application to the
formal synthesis of a bioactive fluorinated isoxazole
Lucas Bacheley a,b, Gérard Guillamot b, Phannarath Phansavath ∗,a and Virginie
Ratovelomanana-Vidal ,∗,a
a PSL University, Chimie ParisTech, CNRS UMR 8060, Institute of Chemistry for Life
and Health Sciences, CSB2D Team, 75005 Paris, France
b SEQENS, 2-8 rue de Rouen, ZI de Limay-Porcheville, 78440 Porcheville, France
E-mails: phannarath.phansavath@chimieparistech.psl.eu (P. Phansavath),
virginie.vidal@chimieparistech.psl.eu (V. Ratovelomanana-Vidal)
Abstract. The access to a novel variety of 4-fluorinated isoxazoles bearing an aryl or alkyl group at the
C-3 position and an acetal fragment at the C-5 position has been achieved through a direct fluorination
using N-fluorobenzenesulfonimide (NFSI) with yields up to 75%. This method was transposed to
gram-scale and has been applied to the formal synthesis of a bioactive compound that increases CFTR
(Cystic Fibrosis Transmembrane Conductance Regulator) activity.
Keywords. Fluorination, Isoxazoles, Heterocycles.
Funding. This work was supported by the Ministère de l’Enseignement Supérieur et de la Recherche
(MESR) and the Centre National de la Recherche Scientifique (CNRS). LB is grateful to SEQENS for a
grant (2021–2024).
Manuscript received 24 November 2023, revised and accepted 6 December 2023.
1. Introduction
Heterocyclic scaffolds represent the largest family of
organic compounds and have a role in many fields of
sciences such as medicinal chemistry [1,2], biochem-
istry [3] or agrochemistry [4,5]. More specifically, the
isoxazole skeleton is a very important motif found in
natural products or synthetic products such as an-
tibiotics [6], analgesics [7], antirheumatic [8], anti-
inflammatory [9] or antidepressant compounds [10].
∗Corresponding authors
Furthermore, the interest of fluorine and its meth-
ods of introduction are still gaining increasing in-
terest as fluorination of an organic molecule sig-
nificantly impacts its biological characteristics. In
spite of the significant fascination for fluorine, the
challenge of integrating this element into essen-
tial building blocks has postponed the examination
and comprehension of its impacts as well as its
utilization. Nonetheless, notable advancement has
been achieved in the field over the previous decade.
Considering the size of the fluorine atom and its
electronegativity, the incorporation of a fluorine or
a trifluoromethyl group profoundly modifies both
the pharmacodynamics and pharmacokinetics of the
compounds such as lipid solubility, metabolic stabil-
ISSN (electronic): 1878-1543 https://comptes-rendus.academie-sciences.fr/chimie/
34 Lucas Bacheley et al.
ity or acidity [11]. Moreover, it can increase the po-
tency of a substance’s engagement with a specific tar-
get protein.
Roughly 30% of all agrochemicals and 20% of
all pharmaceuticals encompass fluorine [12] within
their structures.
With the aim of continuing our investigations into
the synthesis of fluorinated carbocycles and hetero-
cycles [13–17], we envisaged to focus on a synthetic
pathway for the fluorination of an isoxazole function-
alized at C-5 by an acetal fragment, an area that has
been relatively overlooked in the literature despite
numerous molecules of interest featuring this motif
(Figure 1) [18–23]. The synthesis of 4-fluorinated
3,5-disubstituted isoxazole was reported by either
condensation of 2-fluoro-1,3-diketone [24,25] or
gold-catalyzed cascade cyclization-fluorination of 2-
alkynone O-methyl oximes [26] but only one method
for the direct fluorination in this position was re-
ported relying on the use of Selectfluor as the fluori-
nating agent and delivering the desired products in
moderate chemical yields ranging from 16% to 44%
(Figure 2) [27,28]. Furthermore, the products gener-
ated during the reaction cannot undergo additional
post-functionalization. In this context, the direct flu-
orination at the C-4 position of the 3,5-disubstituted
isoxazole core, as a late-stage functionalization, was
explored. With the substitution of an acetal group
at the C-5 position, the resulting fluoroisoxazoles
can undergo deprotection, opening-up numerous
possibilities for additional functionalization.
2. Results and discussion
A range of 3,5-disubstituted isoxazoles 1a-1k were
prepared from diversely substituted chloroximes
and bromovinyl acetals, according to a three-
step procedure developed previously [29]. Hav-
ing those substrates in hand, our study started with
a series of optimization experiments on 5-(1,3-
dioxan-2-yl)-3-phenylisoxazole 1a (Table 1). The
first experiment required 3.5 equiv of base and N-
fluorobenzenesulfonimide (NFSI) to afford the flu-
orinated isoxazole 2a in 47% yield for a conversion
of 63% at −78 °C (Table 1, entry 1). Other commer-
cially available electrophilic fluorinated agent such
as Selectfluor or N-fluoropyridinium triflate were
tested but no conversion was observed under these
Figure 1. Examples of bioactive molecules
containing a 4-fluorinated isoxazole core.
conditions. Reducing the quantity of base and flu-
orinating agent to 1.2 and 2.0 equiv respectively led
to better conversions (72–74%) and higher yields in
2a (60–62%) (Table 1, entries 2–3). Subsequently,
the impact of the starting material concentration in
THF on the reaction outcome was examined. The
concentration was gradually increased step by step
from 0.1 mol/L to 1.0 mol/L (Table 1, entries 4–9),
leading to an optimized yield of 75% at 0.4 mol/L
(Table 1, entry 6). In fact, for a concentration higher
than 0.6 mol/L, the reaction medium reaches such
a viscosity that stirring stops after addition of the
electophile.
Carrying out the reaction at −40 °C to achieve a
full conversion led to complete degradation of the
Lucas Bacheley et al. 35
Table 1. Optimisation of the reaction conditionsa
Entry Base Solvent x (equiv) c (mol/L) T t (h) Conversionb (%) Yieldc (%)
1 n-BuLi THF 3.5d 0.05 −78 °C 20 63 47
2 n-BuLi THF 2.5e 0.05 −78 °C 20 72 62
3 n-BuLi THF 2.0 0.05 −78 °C 2 74 60
4 n-BuLi THF 2.0 0.1 −78 °C 2 78 61
5 n-BuLi THF 2.0 0.2 −78 °C 2 82 73
6 n-BuLi THF 2.0 0.4 −78 °C 1 85 75
7 n-BuLi THF 2.0 0.6 −78 °C 0.5 89 71
8 n-BuLi THF 2.0 0.8 −78 °C 0.5 91 70
9 n-BuLi THF 2.0 1.0 −78 °C 0.5 90 70
10 n-BuLi THF 2.0 0.2 −40 °C 1 100 0f
11 n-BuLi Et2O 2.0 0.2 −78 °C 3 20 nd
12 n-BuLi MeTHF 2.0 0.2 −78 °C 1 58 nd
13 LiHMDS THF 2.0 0.4 −78 °C 0.5 0 nd
14 LiHMDS THF 2.0 0.4 0 °C 0.5 0 nd
15 LiTMP THF 2.0 0.3 −78 °C 0.5 100 0f
16 LDA THF 2.0 0.1 −78 °C 1.5 81 67
17 NaH THF 2.0 0.1 0 °C 2 0 nd
aReaction conditions: (1a, 0.43 mmol, 1.0 equiv), nBuLi (0.52 mmol, 1.2 equiv), NFSI (0.86 mmol,
2.0 equiv), THF (0.4 M, 1.1 mL), −78 °C to rt, under argon.
bAfter NMR 1H analysis of the crude reaction mixture.
cAfter isolation by column chromatography.
d3.5 equiv of base were used.
e1.5 equiv of base were used.
fOnly degradation was observed.
starting material (Table 1, entry 10). Other solvents
were tested such as Et2O or 2-MeTHF, but lower con-
versions were observed (20% and 58% respectively,
Table 1, entries 11 and 12). The influence of the base
was also studied. The starting material was fully re-
covered when treated with LiHMDS at −78 °C and
0 °C or with NaH at 0 °C (Table 1, entries 13, 14 and
17). Unfortunately, LiTMP led to a complete degra-
dation of the isoxazole (Table 1, entry 15). Using LDA
gave an encouraging result of 81% conversion and
67% yield in 2a but was still inferior when n-BuLi was
used (Table 1, entries 16 vs 6).
Having these optimized conditions in hand, we
further explored the scope and limitations of the
reaction with 3,5-disubstituted isoxazoles previously
synthesized. This process allowed us to obtain the
corresponding fluorinated isoxazoles bearing vari-
ous electron-donating or -withdrawing substituents
in the para-position of the aryl ring such as t-butyl-
2b, chlorine 2c, fluorine 2d or trifluoromethyl 2e
groups in yields between 59–70%. Compounds 2g
and 2h having a 3-chloro-4-fluorophenyl or a 2,6-
dichlorophenyl substituent were obtained in 44%
and 21% yield, respectively (Figure 3). Having a
36 Lucas Bacheley et al.
Figure 2. Synthesis of a 4-fluorinated 3,5-
disubstituted isoxazoles by direct fluorination.
methyl in meta-position (1f ) led to 75% isolated yield
of the corresponding fluorinated product 2f. To ex-
tend the feasibility of our process, a bulky group such
as a naphthyl or a 2,2-difluorobenzodioxole was also
investigated and afforded the products 2i and 2j in
20% and 60% yields, respectively. The reaction was
also suitable for isoxazoles bearing a non-aromatic
substituent at the C-3 position and compound 2k,
bearing a n-butyl chain, was synthesized in 25%
yield.
Furthermore, our goal was to obtain a range of flu-
orinated isoxazoles that could be subsequently mod-
ified after deprotection of the acetal fragment at the
C-5 position. In this context, the acetal was depro-
tected in acidic media (HCl 1N, 5 equiv), in a mix-
ture of water/acetone (1/1) for 4 days at 90 °C afford-
ing the corresponding aldehyde 3a in 65% yield (Fig-
ure 4).
Isoxazole 3a is an intermediate in the preparation
of a bioactive compound that increases Cystic Fibro-
sis Transmembrane Conductance Regulator (CFTR)
activity [15]. Cystic fibrosis is a result of genetic mu-
tations in the CFTR gene, responsible for encoding
Figure 3. Scope of the fluorination.
a chloride channel that spans multiple cell mem-
branes in epithelial tissues. The loss of a functional
CFTR channel leads to a reduced lung function and
increases mucus viscosity resulting in chronic infec-
tion and inflammation [30]. Besides respiratory im-
pairment, CFTR also affects the regular operation of
additional organs such as the pancreas, intestine, or
gall bladder.
The effectiveness of this fluorination process
was supported by a scale-up experiment conducted
Lucas Bacheley et al. 37
Figure 4. Formal synthesis of a bioactive com-
pound that increases CFTR activity.
Figure 5. Scale-up experiment of the fluorina-
tion of 1a.
under the defined standard conditions using 5-
(1,3-dioxan-2-yl)-3-phenylisoxazole 1a (Figure 5) to
obtain the desired fluorinated product 2a in 61%
yield.
3. Conclusion
In conclusion, we succeeded in synthesizing a range
of new 4-fluorinated 3,5-disubstituted isoxazoles
bearing various substituents on the aromatic ring
at the C-3 position in 20–75% yields. This process
was also tolerant to bulkier substituents such as a
naphthyl or a difluorodioxobenzene and even a non-
aromatic substituent such as a n-butyl fragment. The
objective of this project was also to obtain a substrate
that could be subsequently functionalized. This was
achieved through the deprotection of the acetal, re-
sulting in a much more advantageous aldehyde for
subsequent post-functionalization. The usefulness
of this method was demonstrated through the formal
synthesis of a bioactive compound that increases
CFTR activity.
Declaration of interests
The authors do not work for, advise, own shares in, or
receive funds from any organization that could bene-
fit from this article, and have declared no affiliations
other than their research organizations.
Acknowledgement
We thank Dr. C. Fosse (Chimie ParisTech - PSL) for
HRMS analysis.
Supplementary data
Supporting information for this article is available on
the journal’s website under https://doi.org/10.5802/
crchim.278 or from the author.
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