International Journal of Research in Orthopaedics
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Article level metrics: a look beyond the journal impact factor
Get PDFThe journal Impact Factor (IF), developed by Eugene Garfield at the Institute for Scientific Information (ISI), reflects the average number of times articles from the journal published in the past two years have been cited in the Journal Citation Reports (JCR) year. The Impact Factor is calculated by dividing the number of citations in the JCR year by the total number of articles published in the two previous years. For example, if there were 200 papers published in a journal in 2013 and 2014 and there were 400 citations in that time period, then the 2015 IF for the journal would be 2. Impact Factor uses Thomson Reuters (ISI Web of Knowledge) citation data. The Impact factor citation data was first derived from the Science Citation Index, a citation index created by Garfield and produced by the Institute for Scientific Information (ISI). ISI was later acquired by Thomson Reuters along with the Science Citation Index, which Reuters grew into the Science Citation Index Expanded. That index is now housed in the Web of Science, a subscription-based scientific citation indexing service encompassing six other online databases. Today, Thomson Reuters calculates IFs using the data from all of the journals indexed in the Web of Science, and releases an IF listing on an annual basis in its yearly Journal Citation Reports, which is available with paid Web of Science subscriptions
Cumulative effect of systemic inflammation and oxidative stress in 40 known cases of active rheumatoid arthritis
Get PDFBackground: Oxidative stress has been implicated in the pathophysiology of a number of diseases such as cancer, hypertension and inflammatory diseases. Although previous evidences provided extensive literature about the biological role of antioxidant enzymes in rheumatoid arthritis (RA), there is a paucity of satisfactory explanation regarding the alteration in the level of antioxidant enzymes along with marker of systemic inflammation in RA. The objective of present study was to estimate the level of C-reactive protein (CRP), Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GSHPx) and Ceruloplasmin in active RA patients.Methods: 40 patients of either sex (30-50 years age group) suffering from active RA and 40 normal healthy individuals served as control; were included in the study. Above mentioned parameters were estimated using standard methods and data from patients and controls were compared by using Student’s t-test.Results: Erythrocyte SOD, CAT and GSHPx activity were significantly low in RA subjects (P<0.001) whereas plasma Ceruloplasmin level was found to be significantly high (P<0.001) as compared to healthy controls.Conclusions: These findings suggest that combined effect of inflammation and free radical generation is involved in the pathogenesis of active RA, characterized by imbalance in antioxidant enzyme status and enhanced CRP levels, which served as an excellent marker of oxidative stress and systemic inflammation in active RA
Outcome analysis of surgically managed unstable burst fracture
Get PDFoai:ojs.ijoro.org:article/1Background:Burst fractures are common injuries of dorsolumbar spine. In indicated cases, surgery is the treatment of choice. Significant controversy exists regarding surgical intervention for these fractures. Posterior decompression, anterior decompression and instrumentation, and combined anterior decompression and posterior instrumentation have been recommended in various studies. Here we are going to evaluate unstable burst fractures of thoracic and lumbar spine treated by isolated anterior decompression and instrumented fusion with TSM-Bone graft composite.Methods: Prospective study of thirty-six cases of unstable fracture of thoracic and lumbar spine treated in Sri Ramachandra Medical centre from January 2011 to January 2014. The inclusion criteria were burst fractures of thoracic or lumbar spine complete or incomplete neurological deficit and burst fractures of thoracic or lumbar spine without neurological deficit but with mechanical instability. The exclusion criteria were pathological fractures, chance fracture, stable burst, wedge compression and osteoporotic compression fractures. The results were analyzed during the follow-up using the Pain – Visual analogue scale, Fusion status and radiographic parameter – K-angle .For pain score were given as 3,2,1 for absent, moderate and severe pain respectively. Regarding fusion status score of 3,2,1 were given when fusion was good, fair and no sign of fusion respectively.Results:Mean pre-operative K-angle was 28o. Average loss of correction at final follow up was 3o.Mean correction of K-angle was 140.Moderate to severe loss of correction of K- angle was observed in 4 patients. Mild to moderate pain in 5 patients treated with analgesics. Average TSM subsidence was 3mm.Conclusions:Bone graft composite provides stable biomechanical support to deficient anterior column in burst fractures and allows early rehabilitation and mobilization. Neural recovery may occur after anterior decompression, stabilization and fusion with TSM-Bone graft composite in dorsolumbar burst fractures with incomplete cord injury