International Journal of Basic & Clinical Pharmacology
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Long-COVID versus adverse event following COVID vaccination among students and staff of tertiary care teaching hospital
Get PDFBackground: Long COVID is an important public health concern requiring proper defining, quantifying and describing following SARS-CoV infection with differentiation from adverse events due to COVID vaccination. So, this study was planned to analyze adverse effect of COVID19 vaccination or drug for COVID treatment versus consequences of COVID19 infection.
Methods: Self-reported data was collected through questionnaire-based survey by voluntary participation of healthcare staff. Percentage of participant developing various events was analyzed by enlisting sign, symptom, co-morbidity and medication history. Association between COVID-19 infection with number of doses of COVID-19 vaccine taken was analyzed by Chi Square Test with p value <0.05. Association between presence of specific sign, symptom after COVID infection or side effect after COVID vaccination was analyzed by Chi-Square Test with p value <0.05.
Results: Overall total 985 (59.58%) participants were analyzed and among them maximum number of participants (60.30%) reported as COVID-19 positive during the third wave with history of diagnosed COVID positive twice (57.87%). Participants with presence of co-morbidity were more likely to develop symptoms (p<0.001). On analysis, fever, body ache, headache, sore throat and fatigue were significantly more likely to develop after COVID infection as compared to after COVID vaccination (p<0.001).
Conclusions: This study by exploratory survey highlights heterogeneity of Long COVID sign or symptom that’s seen predominantly in person with co-morbidity and a few of them were mimicking adverse events after COVID vaccinations
Perception, knowledge and attitudinal assessment of drug promotional literature among second year, medical undergraduate students: a questionnaire-based study
Get PDFBackground: WHO defines drug promotion literature (DPL) as “all informational and persuasive activities by manufacturers, the effect of which is to induce the prescription, supply, purchase and/or use of medicinal drugs”. Benefit driven marketing of new drugs by drug companies may lead to erroneous prescription due to insufficient understanding, knowledge of safety and therapeutic benefits of the drugs in the community. All these promotional activities influence the prescribing pattern of doctors. 2nd year of undergraduate medical course is the appropriate time to educate the medical undergraduate students about fundamentals of DPL and to train them accordingly for improving their prescribing behaviour eventually.
Methods: A prospective questionnaire-based study was conducted in Goa Medical College. The study participants consisted of 150 II-year undergraduate medical students. Approval from Institutional Ethics Committee was obtained. The feedback forms were collected from the students after they were completed and data was analysed and represented as counts and percentages.
Results: Among respondents 36% of students opined that the quality of details provided by medical representatives is biased and too commercial followed by others. 40.7% of students were of the view that the most important intervention needed to reduce the impact of drug promotion on prescribing was to formulate policies and guidelines for the health care authorities.
Conclusions: Promotional activities by manufacturers influence the attitude and prescribing pattern of doctors. So, it is of utmost importance to train medical graduates in order to enable them to develop the skill of critical analysis of DPL and consequently rational prescribing
Evaluation of the antiulcer and antimicrobial activities of methanol leaf extract of Helianthus annuus
Get PDFBackground: Medicinal plants are widely used in treating and preventing specific diseases and are known to play an important role in health care. Helianthus annuus is one of such plants whose therapeutic applications no doubt have numerous folkloric background. This study aimed at assessing Helianthus annuus methanol leaf extract for antiulcer and antimicrobial potentials
Methods: The antiulcer activity was evaluated using aspirin, ethanol and histamine methods in Wistar rats, while the antimicrobial activity was carried out on selected microorganisms. The acute toxicity test and phytochemical screening of the extract were also conducted.
Results: The methanol leaf extract exhibited significant (p<0.05 and p<0.01) antiulcer effect in both model. The ulcer protection effect of the extract is comparable to omeprazole. The extract also significantly inhibited the growth of test organisms. The acute toxicity test produced no lethality in rats, whereas the phytochemical analysis revealed the presence of alkaloids, saponins, tannins, flavonoids, terpenoids and steroids.
Conclusions: The findings confirm the ethnomedicinal use of H. annuus leaf as a valuable natural agent for the treatment of ulcer and microbial infections
A case of drug induced oral erythema multiforme
Get PDFErythema multiforme (EM) is an acute, self-limited, usually mild, and often relapsing mucocutaneous syndrome. It occurs predominantly in younger age group with slight male preponderance. The classical cutaneous target lesions and mucosal bullae or erosions are clinical manifestations of EM. Drug induced oral EM a rare clinical entity which involves only the lips and oral mucosa without skin involvement. These lesions are difficult in diagnosing with other oral ulcerative lesions with similar clinical manifestations. Here we are reporting a case of phenylbutazone induced oral EM. The causality of phenylbutazone in the reaction was “probable” as per Naranjo scale and seriousness of the reaction was “prolonged hospitalization”. The patient was managed by immediate withdrawal of the suspected drug along with conservative managements to prevent secondary infections. The patient was discharged successfully after 15 days of admission
Comparison of etomidate and propofol as an induction agent to study hemodynamic effects and serum cortisol level following endotracheal intubation in hypertensive patients
Get PDFBackground: The present study aimed to compare hemodynamic parameters (heart rate, blood pressure) and adverse effects (injection pain, myoclonus, postoperative nausea/vomiting) between Etomidate and propofol groups.
Methods: Patients were divided into two groups: Etomidate Group E and a Propofol Group P. All hemodynamic data were measured during induction, intubation, and post-intubation up to 15 min. Intravenous cortisol levels were measured at baseline, just after induction and at 24 hours after induction.
Results: At 3 min and 5 min SBP was decreased by 22.04% and 18.39% in Group P. At 3 min there was fall in DBP by 20.13% in group P whereas there was an increase in group E by 0.13% which is statistically significant (p<0.001). At 1 min, 3 min and 5 min after intubation, fall in the MAP by 26.07%, 21.08% and 18.60% in group P and 0.77%, 0.42% and 1.30% in group E (p value <0.001). Serum cortisol level immediate after surgery was decrease (54%) in Group E (p value <0.001). In Group P, 40% of the patients and in group E 16.66 % of the patients complained of pain on injection (p value 0.046).
Conclusions: The cortisol suppression by Etomidate may be beneficial for intubation stress response. Etomidate is better for its hemodynamic stability over propofol
Antibacterial activity of tekelan leaf ethanol extract (Chromolaena odorata (L.) R. M. King and H. Rob) against of Staphylococcus aureus bacteria
Get PDFBackground: Indonesia is a tropical country, so the prevalence of infectious diseases caused by bacteria still remains high. On the other hand, the intense use of antibacterial agent in Indonesia causes a tendency for bacterial resistance to existing antibacterial drugs. One of the herbal plants that is widely used by some people is tekelan leaves. The purpose of this study was to determine the activity of an ethanol extract of tekelan leaves on the growth of Staphylococcus aureus bacteria.
Methods: Simplisia of tekelan leaves was tested for secondary metabolites and simplisa characterization testing. Antibacterial activity testing is carried out by the disc paper method, where the disc paper is immersed in the test solution with a comparison of the test concentration.
Results: The results of phytochemical screening show that the secondary metabolites of tekelan leaves are alkaloids, flavonoids, steroids/triterpenoids, tannins, and glycosides. The results of the characterization of simplisia moisture content are 7.99%, water-soluble juice content is 13.29%, ethanol-soluble juice content is 12.18%, total ash content is 7.45%, and insoluble acid ash content is 0.92%. The observation of the antibacterial activity of the ethanol extract of tekelan leaves was carried out by the disc diffusion method. The test results showed that the ethanol extract of tekelan leaves was categorized as moderate at concentrations of 1% and 2% and as strong at concentrations of 4%, 5%, 10%, 20%, 40%, 60%, 80%, and 100%. The conclusion of this study is that ethanol extract had activity to inhibit the growth of Staphylococcus aureus and the MIC value obtained 0.7%.
Conclusions: The conclusion of this study is that ethanol extract had activity to inhibit the growth of Staphylococcus aureus
Investigating the possible neurological side effects follow the COVID-19 vaccine
Get PDFBackground: With the widespread of COVID-19 vaccination around the world, there are many case reports which referred to the neurological complications following vaccination. However, due to the lack of more information about this, especially in our country Iran, the aim of this study was to investigate the possible neurological side effects of the COVID-19 vaccine in patients.
Methods: This cross-sectional study was conducted on 1046 people injecting various types of COVID-19 vaccines, including Sinopharm, AstraZeneca, Sputnik V, CovIran-Barekat, Covaxin, SpikoGen, and PastoCovac plus, who were registered in the health system due to vaccine complications. These people were evaluated in terms of the overall incidence rate of neurological complications, types of neurological complications, and the relationship between the occurrence of neurological complications and the type of vaccine.
Results: Of all patients, 589 (56.3%) were female and 457 (43.7%) were male, and most of them were from the age group of 60 years and older (43.8%). 247 people (23.6%) had neurological complications that most of them related to the headache (16.6%).
Conclusions: The results of this study showed that the neurological side effects associated with the covid-19 vaccination were in mild level and most of them were seen in AstraZeneca vaccine and so, in line with the recommendation of the European medicines agency, the injection of this vaccine should be done with caution
Formulation and evaluation of herbal hair serum-a review
Get PDFIn the mammalian system the hair follicle is known to the most significant organ that determine, appearance, gender distinction, provides intense temperature protection and plays a role in self-defence. The younger generations have begun to suffer extreme hair loss problem due to many reasons. The hair loss is not temporary in most cases. but it results in alopecia. Many people suffering from hair loss is in search of multiple treatments due to extreme anxiety and tension. To improve hair growth and to prevent hair loss, hair root activation is required. Citrus sinensis is used to antidandruff protection hair care. It’s had antibacterial and anti-inflammatory properties. Nigella sativa improves the shine, strength, volume, and texture of hair. Flax seed is full of fatty acids and antioxidants that tend to remove pollutants and dead cells from the scalp. Coconut oil may help to moisturise and seal hair. They can help to prevent dry, flaky scalp and dandruff. This review article focuses on the materials required for the formulation of hair serum and various evaluation tests to evaluate hair serum
Rationale use of drugs in pregnancy induced hypertension at a tertiary care hospital
Get PDFBackground: Pregnancy induced hypertension known as preeclampsia is considered to be the second cause of death next to anaemia. There are significant sources of maternal and foetal mortality and morbidity. Antihypertensive medication reduces the progression of the course of hypertensive disorders. However, its effect on the outcomes of pregnancy may include development of preeclampsia, preterm delivery, foetal /neonatal demise, IUGR, low birth weight. Whether such associations are casual or confounded is unknown. Hence, we intended to study the rationale use of drugs in pregnancy induced hypertensive patients.
Methods: Patients diagnosed with hypertensive disorders in pregnancy were recruited. Pregnant women in the age group of 18-45 years who consented to participate were included. Non pregnant women and women with PCOD, depression and on any medications were excluded. Details on drug treatment, type of drugs, combination, dose, dosage and duration were noted.
Results: 105 patients were enrolled. 51% belonged to 18-25 years. 98% mothers received monotherapy and 2% received dual therapy. Labetalol was the most commonly prescribed drug. 50% of the patients received a combination of Nifedipine and Methyldopa while another 50% received Nifedipine with Labetalol. The outcome of new born babies born in mothers receiving antihypertensive drugs had complications of low birth weight and malformations. The dose of the medications prescribed was well within the range.
Conclusions: Proper counselling to the patients regarding life style management, regular follow ups and monitoring of blood pressure is important to understand, resolve the burden and complication
A prospective observational study of prescription pattern in dermatology outpatient department of associated hospitals of Rajasthan University of Health Sciences-college of medical sciences, Jaipur
Get PDFBackground: Skin diseases are chronic in nature and they require lifetime treatment. Prescription pattern reflects health professional attitude towards the disease and role of drugs in its treatment. The study of prescription pattern is important to make medical care rational and monitoring adverse drug reactions.
Methods: An observational and prospective study was carried out in Skin and VD department along with department of pharmacology, RUHS college of medical sciences, Jaipur. Data collection was done in three months after ethical approval. Data was entered and analysed with latest Microsoft Excel version. Descriptive statistics were used to analyse the results.
Results: During the study period, a total of 979 prescriptions were included and analysed, out of which the usage of dermatological drugs was maximum among males (n=520, 53.11%). Total 2848 drugs were prescribed in 6 different dosage forms. The most common dosage form prescribed was tablet (1267, 44.49%) followed by cream (685, 24.05%). Total 1632 (57.30%) drugs were prescribed through oral route and 1216 (42.70%) drugs were prescribed through topical route. the present study depicted that dermatophytosis (n=243, 24.82%) was one of the most common dermatological manifestations. antihistaminic (673, 23.63%) were the most commonly prescribed drug.
Conclusions: The study of drug use is an effective tool to promote rational drug prescribing. Such type of study will help in formulation of proper antibiotics, drugs policy, prescription of cost-effective drugs, improvement in the patient compliance and reduction in undesirable effect of drugs