Journal Of Advanced Zoology
Not a member yet
3728 research outputs found
Sort by
Sustained Released Opthalmic in Situ Hydrogel Of Levofloxacin From A Ph-Triggered In Situ Gelling
Get PDFBackground: Most of eye diseases are treated with topical application of eye drops. The poor bioavailability and therapeutic response exhibited by these conventional eye drops due to rapid precorneal elimination of the drug may be overcome by the use of in situ gelling system that are instilled as drops into the eye drops and undergo a sol-to-gel transition in the cul-de-sac.
Objective: The purpose of the present work was to develop sustain ophthalmic delivery to levofloxacin from a ph-triggered in situ gelling system.
Method: Polyacrylic acid (Carbopol 934) was used as the gelling agent in combination with hydroxypropyl methylcellulose (Methocel K4M) and HPMC K100LV which acted as viscosity enhancing agent. Compatibility studies of the drug excipients were carried out using FTIR.
Result: The prepared formulation were characterized for clarity, pH, drug content, gelling capacity, rheological studies, in vitro drug release study, sterility study and stability study. It is observed that the formulated system provided sustained release of drug for more than 8 hrs period
Comprehensive Analysis: Phytochemical Screening and Antioxidant Activity of Bombax ceiba and Camellia sinensis
Get PDFThis study presents a thorough examination of the phytochemical composition and antioxidant activity of Bombax ceiba and Camellia sinensis. Through extensive phytochemical screening, we identify and analyze the diverse bioactive compounds present in both plants. The physiological study delves into the intricate details of the plants physiological attributes, shedding light on their unique characteristics. Furthermore, the antioxidant activity is meticulously assessed to gauge the potential health benefits associated with these plant extracts. This study focuses on the determination of the total flavonoid content and DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity of selected plant extracts. The total flavonoid content is assessed using a standardized method, providing insights into the concentration of flavonoids in the extracts. The total phenolic content is assessed for their traditional therapeutic uses by utilizing specific method or technique for the extraction and quantification of phenolic compounds. The DPPH scavenging activity is evaluated to understand the antioxidant potential of the plant extracts. The abstract summarizes the methodology and key findings related to the total flavonoid content and antioxidant activity, offering a concise overview of the study\u27s contributions to the understanding of the medicinal properties of Bombax ceiba and Camellia sinensis
Surgery Of Combined Lung And Liver Echinococcosis
Get PDFThis work includes the results of surgical treatment of 112 patients with combined lung and liver echinococcosis operated at the General Surgery Clinic of the Samarkand Medical University.
The clinical material is divided into three groups: in the first group (control), 36 (32.14%) patients underwent surgical interventions on the lungs and liver through separate wide accesses. At the same time, 34 (94.44%) patients underwent surgery in stages with an interval of 4-6 weeks, 2 (5.56%) – echinococcectomy from the lungs and liver was performed simultaneously with separate accesses; In the second group, 29 (25.89%) patients had echinococcal cysts removed from the right lung and liver simultaneously through thoracophrenolaparotomy; In the third group, 47 (41.97%) patients had cysts removed from the lungs and liver in stages. At the same time, in 35 (74.47%) cases, at certain stages of echinococcectomy, mini-accesses developed by us were used in combination with video assisted surgery, and in 12 (25.53%), all thoracic and abdominal accesses were performed using only mini-incisions. Surgical interventions on the lungs and liver were performed on 7 patients through separate mini-accesses simultaneously, and 5 patients had cysts removed from the lungs and liver in stages with an interval of four weeks.
The use of minimally invasive approaches and simultaneous operations contributed to a reduction in early postoperative complications from 13.89% (control group) to 9.21% (main group), i.e. by 2 times
Study of Lead Recycling by the Cupola Furnace and Rotary Furnace Using Different Refractory Materials.
Get PDFIn this thesis we are discussing lead recycling by the cupola furnace and the rotary furnace. And the changes are replacing the raw materials with the refractory materials. First, useless batteries have been collected after they broke it and the lead containing materials has been separated. After separating material has been put in the cupola furnace mixing with the coal and then starts firing it and apply pressure by the blower. Which makes it start melting and lead has been exerted out and using moldings and casting making bars by which it can be transferred from one place to another place easily. And after that ace has been collect from bags in chimneys are known as fly ace and the scrape which are left in cupola furnace are containing lead are not separate by primary smelting process in cupola furnace that’s why rotary furnace has been used for secondary smelting process that fly ace and scrape (kita) are used for separating lead. And parts of cupola furnaces and the rotary furnaces parts are described and refractory materials which are used to construct and making some changes for increasing the production rate
Bactericidal Efficacy Of Antibiotic Combinations Against Enterococcus Faecalis – An In Vitro Study
Get PDFEndodontics plays a major role in the eradication of pulpal inflammation, the primary goal includes the treatment of apical periodontitis and maintaining the pulpal health. An immature necrotic tooth poses various challenges in the management of pulpal necrosis which traditionally aims at the formation of calcific barrier that aid in the obturation. The prolonged duration of the procedure with multiple review appointments, and the risk of cervical fracture have posed a challenge in the conventional apexification procedures1. Regenerative endodontics is a biological based procedure designed to replace damaged structures such as dentin, root structures, and cells of the pulp-dentin complex. The evolution of the method of biologically replacing dental tissues by regeneration has overcome the challenges by increasing the root length and thickness of the root canal walls, inducing apexogenesis 2.
The outcomes of regenerative procedures rely on the complete elimination of bacteria, facilitation of root development, and closure of sinus tracts3. The infection of the root canal system is polymicrobial, consisting of predominantly facultative anaerobes and anaerobic bacteria. The existence of bacterial species results in the persistence of apical periodontitis and inflammation4. The virulence of the bacteria on causing disease and tissue damage is proportionate to the type and the numbers of bacteria present5. The microbial flora in failed endodontic teeth normally include varied microorganisms of which Enterococcus faecalis is the most prevalent and highly resistant to intracanal medicaments6.
It is an established fact that regeneration of the pulpal tissue of an infected immature tooth with open apex and apical periodontitis was considered to be impossible due to the presence of various microorganisms. Local antibiotics application has been widely used in the eradication of intracanal infection, hence the systemic routes of administration have been greatly reduced 7.
To encounter the diverse flora in the root canal system, combinations of antibiotics are used known as the TRIPLE ANTIBIOTIC PASTE which comprises of combination of Ciprofloxacin, Metronidazole and Minocycline 8. The synergy of antibiotics used in the triple antibiotic paste is used to efficiently combat the polymicrobial environment in the infected root dentin 9. Minocycline is known for its broad-spectrum activity but has the disadvantage of discoloration of teeth which has led to the necessity of finding an alternative antibiotic. In this study in the triple antibiotic combination minocycline is replaced with clindamycin.
This study aimed at comparing and evaluating the antibacterial efficacy of double or triple antibiotic combinations used as intracanal medicament. A standard strain of Enterococcus faecalis is used as a indicator organism to test the efficacy. The primary objective was to compare the efficacy of clindamycin over minocycline in combination with other antibiotic
Assessment of Antibacterial and Antifungal Efficacy of Endophytic Fungi Isolated from Psoralea Corylifolia Linn.
Get PDFEndophytic fungi that inhabit host plants symbiotically and cause no harm to the host plants. In past few decades variants of endophytic fungi have been isolated and identified with medicinal properties finding wider application as bio-control agents, bio-fertilizer, bio-stimulant and natural products. In lieu of this, the present study aims to isolate, identify, and evaluate the antibacterial and antifungal activities of endophytic fungi obtained from Psoralea corylifolia Linn. Total 4 endophytic fungi were isolated from the root, stem and leaves of host plant that is Piriformospora indica, Alternaria alternate, Aspergillus niger, Penicillium citrinum. Antibacterial activity of three crude extracts including butanol, ethyl acetate, and methanol of different fungal endophytes was appraised against Escherichia coli, Proteus vulgaris, and Salmonella typhi, Bacillus subtilis, and Staphylococcus aureus and Antifungal efficacy of different crude extracts of fungal endophytes was also appraised against three pathogenic fungal strains including Aspergillus niger, A. fumigatus and Candida albicans. The result revealed that the maximum antibacterial efficacy was found in methanol extract of Piriformospora indica in the test organism bacillus subtilis that was 20.3±0.57 followed by ethyl acetate that was 18.66±0.57. The maximum antifungal activity was found in methanol extract of Alternaria alternate in the test organism Aspergillus niger that was 43.1 followed by Penicillium citrinum in the test organism Aspergillus fumigatus that was 42.8. More study will be done in future on exploration and exploitation of these microorganisms for pharmaceuticals applications and also used as a biocontrol agent. The present study is the first report on the investigation of antifungal and antibacterial properties of endophytic fungus that have been isolated from Psoralea corylifolia
Evaluation Of Potential Level In The Municipal Solid Waste Of Dumping Yard Of Mandya By Using Leachate Pollution Index
Get PDFLeachate is one of the most serious environmental hazards associated with landfills, especially those which are unlined and uncontrolled. Considering this, the present study investigates the leachate pollution index (LPI) of the open dumping site of the Mandya district of Karnataka using leachate characteristics from the sample collected from the open dumping site from the Mandya open dumping site. The physicochemical and heavy metals concentrations were also analyzed such as Lead (Pb), Zinc (Zn), Copper (Cu), Iron (Fe), Chromium (Cr), Nickel (Ni) and Mercury (Hg). The LPI value was calculated for the four leachate samples collected namely, L1 (28.85), L2 (28.86), L3 (28.76) and L4 (30.84) respectively. The LPI aggregate value is 29.32 which immensely exceeds the limits of the Indian standards of 7.378 for disposal. There should be immediate action for remediation plans to reduce the environmental risk and better treatment plans and incorporate a better solid waste management (SWM) system to reduce the pollution potential
GREEN SYNTHESIS, DOCKING STUDIES AND ANTI DIABETIC ACTIVITY OF NOVEL AMINO FUSED TRIZOLE SCAFFOLD.
Get PDFIn the present work, the green synthesis of novel amino fused triazole scaffold hybird heterocyclic derivatives have been carried out and substituted,and they were checked for docking scores against the DPP IV topoisomerase II enzyme.From that, ten best docked compounds are selected and synthesized and characterization of spectral data of the synthesized comopunds was obtained from IR, 1H NMR, 13C NMR, and mass spectroscopy,then the ten compounds are subjected to in-vitro antidiabetic study by α-amylase enzyme inhibition assay method. Among the tested compounds, derivative T9 (92.33838%) substituted with furan moiety shows a significant activity against α-amylase enzyme at different concentrations possesses anti-diabetic activity.
 
Basic Environmental Crises That Can Be Investigated In Iran
Get PDFA person with the environment in the world goes back thousands of years, but the environmental environment is a very recent phenomenon that was the product of neglecting the environmental environment. In Iran, like in other parts of the world, some discourses have played a positive and negative role in creating this crisis.
Our country is considered to be in the dry region of the earth due to its geographical location, which has made water natural. Other basic environmental crises in the country include long-term drought crisis, pressure on natural resources, crisis of unstable and disproportionate agricultural management, agricultural risk, climate change, environmental pollution crisis, and in the crisis, the skyrocketing costs of living. Pointing environment.
 
Effectiveness Of Video Assisted Teaching Programme Regarding Parent Centered Developmental Care On Maternal Competency Among Mothers Of Preterm Neonates Admitted To NICU In The Selected Hospital, Puducherry-A Pilot Study Report
Get PDFPreterm birth, defined as birth at less than 37 completed weeks of gestation, remains a significant cause of infant mortality and morbidity worldwide. Preterm births are on the increase globally with about 15 million babies born preterm annually .Parents are central to children’s health and development and successful parenting is a key element in promoting overall parental wellbeing as well as children’s physical and psychosocial development. Family integrated care (FIC) is increasingly becoming a more popular model of care delivery in neonatal units.ObjectiveTo assess the existing level of competency on Parent Centered Developmental Care among the control and experimental group mothers of preterm neonates admitted in NICU
Methodology
Quantitative research approach and Quasi experimental design wasadopted in this study. Simple random sampling Technique was adopted to select the sample for the study. Total 21 Samples - 10 for experimental group and 11 for control group were selected .Result and Findings: Regarding demographic variable of Mother and newborn shows that highest number 3(30%) & 3(27.3%) of Women were in the age group of 31-35years. With regards to level of Competency of mothers result shows that during pretest mothers 8(80%) had incomepetent level of practice and 2(20 %) had competency to perform the care for new born in the experimentalgroup ,10(90%) had incomepetent level of practice and 1(10 %)had competency to perform the care for new born in the control group .Whereas in post test 7(70%) mothers had achieved the level of competency and still 3(30 %) mothers were considered as incompetentin the experimental group and 9(88%) mothers had not achieved the level of competency and 2(12 %) mothers were considered as competent in the control group
ConclusionThis above result of the study clearly indicates that there was significant improvement in the level of Competency after teaching programme and thus the Video assisted teaching programme on PCDC was found effective in improving the level of Competency among mothers of Preterm neonates