Brazilian Journal of Science
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Interação de derivados de benzenossulfonamida com Smyd3 usando um modelo teórico
Get PDFCancer is a serious public health problem worldwide. This clinical pathology is associated with the activation/release of several biomolecules, including the Smyd proteins family. In this way, some studies indicate that Smyd3 is associated with cancer cells growth. It is important to mention that some drugs act as Smyd3 inhibitors in the treat some cancers. However, their interaction is very confusing; for this reason, the aim of this research was to evaluate the theoretical interaction of benzenesulfonamide and their derivatives (compounds 2 to 28) using 7o2c protein, novobiocin, BAY-6035, EPZ031686 and BCI-121 drugs as theoretical tools in DockingServer program. The results showed differences in the aminoacid residues involved in the interaction of benzenesulfonamide and their derivatives with 7o2c protein surface compared with novobiocin, BAY-6035, EPZ031686 and BCI-121 drugs. In additions, the inhibition constant (Ki) for benzenesulfonamide derivatives 2, 7, 8, 13, 14, 17, 20, 21, 24 and 28 was very lower compared to benzenesulfonamide, novobiocin, BAY-6035, EPZ031686 and BCI-121. In conclusion, the benzenesulfonamide derivatives 2, 7, 8, 13, 14, 17, 20, 21, 24 and 28 could be a good alternative as Smyd3 inhibitors to decrease cancer cells growth.El cáncer es un grave problema de salud pública a nivel mundial. Esta patología clínica está asociada a la activación/liberación de varias biomoléculas, entre ellas las proteínas de la familia Smyd. De esta forma, algunos estudios indican que Smyd3 está asociado con el crecimiento de células cancerosas. Es importante mencionar que algunos medicamentos actúan como inhibidores de Smyd3 en el tratamiento de algunos tipos de cáncer. Sin embargo, su interacción es muy confusa; por tal motivo, el objetivo de esta investigación fue evaluar la interacción teórica de la bencenosulfonamida y sus derivados (compuestos 2 al 28) utilizando como herramientas teóricas en el programa DockingServer la proteína 7o2c, novobiocina, BAY-6035, EPZ031686 y BCI-121. . Los resultados mostraron diferencias en los residuos de aminoácidos involucrados en la interacción de la bencenosulfonamida y sus derivados con la superficie de la proteína 7o2c en comparación con los fármacos novobiocina, BAY-6035, EPZ031686 y BCI-121. Además, la constante de inhibición (Ki) para los derivados de bencenosulfonamida 2, 7, 8, 13, 14, 17, 20, 21, 24 y 28 fue mucho menor en comparación con bencenosulfonamida, novobiocina, BAY-6035, EPZ031686 y BCI-121. En conclusión, los derivados de bencenosulfonamida 2, 7, 8, 13, 14, 17, 20, 21, 24 y 28 pueden ser una buena alternativa como inhibidores de Smyd3 para disminuir el crecimiento de células cancerosas.O câncer é um grave problema de saúde pública em todo o mundo. Esta patologia clínica está associada à ativação/liberação de várias biomoléculas, incluindo as proteínas da família Smyd. Desta forma, alguns estudos indicam que o Smyd3 está associado ao crescimento de células cancerígenas. É importante mencionar que algumas drogas atuam como inibidores de Smyd3 no tratamento de alguns tipos de câncer. No entanto, sua interação é muito confusa; por esta razão, o objetivo desta pesquisa foi avaliar a interação teórica de benzenossulfonamida e seus derivados (compostos 2 a 28) usando a proteína 7o2c, novobiocina, BAY-6035, EPZ031686 e drogas BCI-121 como ferramentas teóricas no programa DockingServer. Os resultados mostraram diferenças nos resíduos de aminoácidos envolvidos na interação da benzenossulfonamida e seus derivados com a superfície da proteína 7o2c em comparação com as drogas novobiocina, BAY-6035, EPZ031686 e BCI-121. Além disso, a constante de inibição (Ki) para os derivados de benzenossulfonamida 2, 7, 8, 13, 14, 17, 20, 21, 24 e 28 foi muito menor em comparação com benzenossulfonamida, novobiocina, BAY-6035, EPZ031686 e BCI-121. Em conclusão, os derivados de benzenossulfonamida 2, 7, 8, 13, 14, 17, 20, 21, 24 e 28 podem ser uma boa alternativa como inibidores de Smyd3 para diminuir o crescimento de células cancerígenas
Determination of height in corn (Zea mays L.) crops through the use of images produced by UAVs
No full textBehind only soybean production, corn is the second most produced grain in Brazil. Remote sensing is generally considered one of the most important technologies for precision agriculture and smart agriculture, enabling producers to monitor various parameters in agricultural crops. This work aimed to determine the height of plants in corn crops through the photogrammetry technique using unmanned aerial vehicles (UAVs). The experiment was conducted in the municipality of Montividiu, State of Goiás, Brazil, in the 2023 harvest. The mapped crop was corn, the georeferenced images were captured via drone, with 249 photos generated during approximately 14 min of flight. The geoprocessing of the orthomosaic and digital surface model was ArcGIS, in which the sketch was plotted on the orthophoto (georeferenced image) to later extract the height data for each treatment. The original data were subjected to the normality test with 5% significance and homogeneity test with 5% significance, then the data were subjected to analysis of variance using the F test with p < 0.05 and, when significant, it was used if the Tukey test with p < 0.05. Block A had the best performance for average plant height with values above 0.8 m. The use of UAVs proved to be an important and efficient tool in determining the height of corn plants for future work on phytopathology, nutrient deficits, areas with leaching or even distinguishing different cultivars
Impact of dietary supplementation of Rhamnus prinoides leaf extract on the growth performance, nutrient retention and intestinal microbial count of “japanese quails”
No full textThis research was carried out to investigate the impact of dietary supplementation of Rhamnus prinoides leaf extract (RPL) on the growth performance, nutrient retention and intestinal microbial count of “japanese quails”. 300-2 weeks old “japanese quails” were allocated sixty birds per group and group treatment had four replicates (15 quails per replicate). Corn-soya meal (basal diet) was formulated according to the nutritional needs of birds (NRC, 1994). Quails in group 1(G1) was fed basal diet with no R. prinoides leaf extract, G2, G3, G4 and G5 were fed basal diet with 0.2 mL, 0.4 mL, 0.6 mL and 0.8 mL respectively. Result on the bioactive components in RPL revealed the presence of 15 bioactive compounds with pharmacological properties. Outcome on average daily weight gain showed that G3 (3.20 g), G4 (3.23 g) and G5 (3.24 g) were higher (P < 0.05) relative to G2 (3.06 g) and G1 (2.21 g). These groups also had a better feed conversion ratio (G3, G4 and G5). Average daily feed intake which varied from 703.81-708.33 g were not significantly (P > 0.05) different among the group. Mortality was recorded only among quails in group 1 (2.0%) (P < 0.05). Dry matter, crude protein, ether extract and nitrogen free extracts which varied from 70.12-86.57%, 58.70-68.91% and 50.62-66.05% were higher (P < 0.05) in G3, G4 and G5, intermediate in G2 and lowest in G1. Conversely, crude fibre values were higher in G1 relative to the other groups. Population of Escherichia coli, Salmonella sp. and Staphylococcus sp. count in the gut were lower in G2, G3, G4 and G5 relative to G1 while Lactobacillus sp. count were lowest in G1 (P < 0.05). It was concluded that RPL can be feed to quails up to 0.8 mL/L without causing any negative effect on the growth performance and health status of birds
Rumen fermentation and nutrient utilization of growing Yankasa rams fed a mixed ration containing tiger nut (Cyperus esculentus) residue and cowpea husk (Vigna unguiculata L. Walp)
No full textThirty (30) Yankasa growing rams were used to investigate the effect of feeding cowpea husk and tiger nut residue in a mixed ration on the rumen ecology, nutrient intake, nutrient digestibility, and nitrogen balance of Yankasa rams. Significant differences (p < 0.05) were observed in the rumen ecology, nutrient intake, nutrient digestibility, and nitrogen balance between the treatments. Rumen ecology was influenced by the diet, with variations in rumen pH, temperature, and volatile fatty acid production. The results indicated that the highest rumen pH and temperature were observed in Treatment 2, while acetate, butyrate, and propionate levels varied among treatments. Nutrient intake and digestibility were significantly affected by the diet. Dry matter intake, crude protein intake, nitrogen detergent fiber (NDF), and acid detergent fiber (ADF) intake varied among treatments. Treatment 3 showed the highest dry matter intake, while Treatment 5 had the highest NDF intake. Crude protein intake was highest in Treatment 3, and the highest values for most nutrients were observed from the same treatment. The results for nitrogen balance in Yankasa rams indicate a positive nitrogen balance, suggesting that the rams received adequate amounts of nitrogen from the diets fed. Feeding 20% cowpea husk and 20% tiger nut residue provides optimum performance for rams in terms of rumen fermentation, and nutrient utilisation.
Impactos da estomia instestinal: Perspectivas acerca da vivência do ostomizado
Get PDFStoma is a term that has the meaning of mouth. Intestinal stoma is a surgical procedure, which aims to change the path of effluents, exteriorizing part of the intestine on the surface of the abdomen. Thus, with this change, there are several impacts on the lives of individuals who are submitted to this surgical procedure. To identify through the research of articles the impacts that the ostomized go through during their experience from the religious sphere, to the labor. This is a literature review study of a qualitative approach of the reflective descriptive analysis type. The searches were conducted in the BVS and Google academic databases between February and May 2023. Inclusion and exclusion criteria were applied. Twenty-six articles were selected that were consistent with the descriptors presented and with the objective of this review. After the reflective reading, four points were raised about this population: The repercussion of the intestinal ostomy for mental health; Impacts of the intestinal ostomy in the return of the labor activities; The sexual life of the person with intestinal ostomy; The religiosity and spirituality as a support network for the person with intestinal ostomy. It is concluded that the ostomy, despite being a method that aims at improving the quality of life of the person who has it, either permanently or temporarily, generates several impacts on the experience of the ostomized person, affecting different areas. Therefore, this study is of great value in order to analyze these impacts, as well as to demonstrate them in a succinct way.Estoma é um termo que tem significado de boca. A estomia intestinal é um procedimento cirúrgico, que visa alterar o trajeto dos efluentes, exteriorizando parte do intestino na superfície do abdômen. Assim, com esta mudança, há diversos impactos na vida dos indivíduos que são submetidos a este procedimento cirúrgico. Identificar através da pesquisa de artigos os impactos que o ostomizado perpassa durante sua vivência desde o âmbito religioso, até o laboral. Trata-se de um estudo de revisão bibliográfica da literatura de abordagem qualitativa do tipo análise reflexiva descritiva. As buscas foram realizadas nas bases de dados BVS, Google acadêmico entre fevereiro e maio de 2023. Feito a aplicabilidade de critérios de inclusão e exclusão. Foram selecionados 26 artigos que tinham coerência com os descritores apresentados e com o objetivo desta revisão. Após ser feito a leitura reflexiva quatro pontos foram levantados acerca desta parcela populacional: A repercussão da estomia intestinal para a saúde mental; Impactos da estomia intestinal no retorno das atividades laborativas; A vida sexual da pessoa com estomia intestinal; A religiosidade e espiritualidade como rede de apoio para a pessoa com estomia intestinal. Conclui-se que a estomia, apesar de ser um método que visa melhorar a qualidade de vida da pessoa que a possui, seja de modo permanente, seja temporário, gera diversos impactos na vivência do ostomizado, afetando distintos âmbitos. Portanto, este estudo se mostra de grande valia para que se possa analisar estes impactos, bem como demonstrá-lo de modo suscinto. 
As aplicações de TLBL podem melhorar os aspectos do TEA relacionados a distúrbios no microbioma intestinal, atividade mitocondrial e função da rede neural
Get PDFAutism Spectrum Disorder constitutes a complex, elaborate, and diverse condition at a developmental, biological, and neurophysiological level. It is recognized primarily by the behavioral manifestations of the individual in communication, social interaction, and by extension in his cognitive development and adaptation to society as a whole. A wide range of studies have linked the pathophysiology of autism to dysfunctional elements in the development and function of mitochondria, cells, neurons, and the gastrointestinal microbiome. Low Light Laser Therapy (LLLT) is an innovative, emerging, non-invasive treatment method. It utilizes low levels of red light/near-infrared light positively affecting biological and pathological processes of the body by enhancing cellular, mitochondrial stimulation, neurogenesis, synaptogenesis, and immune system development, regulating the gut microbiome's function. The retrospective literature review focuses on the possibility of effective use of the method in autism. According to the literature, LLLT does not have many applications in patients with ASD and is still in the early stages of its use in the disorder. However, the results of the studies highlight its therapeutic effect in several areas related to the disease, pointing out that it is a promising therapeutic approach for the evolution of autism in the future.El Trastorno del Espectro Autista constituye una condición compleja, elaborada y diversa a nivel del desarrollo, biológico y neurofisiológico. Se reconoce principalmente por las manifestaciones conductuales del individuo en la comunicación, la interacción social y por extensión en su desarrollo cognitivo y adaptación a la sociedad en su conjunto. Una amplia gama de estudios ha relacionado la fisiopatología del autismo con elementos disfuncionales en el desarrollo y función de las mitocondrias, las células, las neuronas y el microbioma gastrointestinal. La terapia con láser con poca luz (LLLT) es un método de tratamiento innovador, emergente y no invasivo. Utiliza niveles bajos de luz roja/luz infrarroja cercana que afectan positivamente los procesos biológicos y patológicos del cuerpo al mejorar la estimulación celular, mitocondrial, la neurogénesis, la sinaptogénesis y el desarrollo del sistema inmunológico, regulando la función del microbioma intestinal. La revisión retrospectiva de la literatura se centra en la posibilidad de un uso eficaz del método en el autismo. Según la literatura, la LLLT no tiene muchas aplicaciones en pacientes con TEA y aún se encuentra en las primeras etapas de su uso en el trastorno. Sin embargo, los resultados de los estudios destacan su efecto terapéutico en varias áreas relacionadas con la enfermedad, señalando que es un enfoque terapéutico prometedor para la evolución del autismo en el futuro.O Transtorno do Espectro Autista constitui uma condição complexa, elaborada e diversificada em nível de desenvolvimento, biológico e neurofisiológico. É reconhecida principalmente pelas manifestações comportamentais do indivíduo na comunicação, interação social e, por extensão, em seu desenvolvimento cognitivo e adaptação à sociedade como um todo. Uma ampla gama de estudos ligou a fisiopatologia do autismo a elementos disfuncionais no desenvolvimento e função das mitocôndrias, células, neurônios e do microbioma gastrointestinal. Terapia a laser de baixa luminosidade (TLBL) é um método de tratamento inovador, emergente e não invasivo. Ele utiliza baixos níveis de luz vermelha/luz quase infravermelha (NIR) afetando positivamente os processos biológicos e patológicos do corpo, melhorando a estimulação celular, mitocondrial, neurogênese, sinaptogênese e desenvolvimento do sistema imunológico, regulando a função do microbioma intestinal. A revisão retrospectiva da literatura enfoca a possibilidade de uso efetivo do método no autismo. De acordo com a literatura, a TLBL não tem muitas aplicações em pacientes com TEA e ainda está em estágios iniciais de seu uso no transtorno. No entanto, os resultados dos estudos destacam seu efeito terapêutico em diversas áreas relacionadas à doença, apontando que é uma abordagem terapêutica promissora para a evolução do autismo no futuro
Investigando a degradação fotocatalítica aprimorada do azul de bromofenol usando nanopartículas de óxido de Estrôncio co-dopadas com Ni/Zn sintetizadas pelo método hidrotérmico
Get PDFExcessive exposure of human to organic contaminants from industrial effluents calls for the implementation of effective pollutants removal techniques. This article investigates the photocatalytic degradation of bromophenol blue dye using Strontium oxide nanoparticles co-doped with Nickel and Zinc. Hydrothermal synthesis produced the nanoparticles, which were subsequently characterized using various analytical techniques. UV/Visible revealed absorption peaks at 294 nm, 306 nm, 311 nm, and 318 nm, while FTIR spectroscopy identified stretching peaks at 416 cm-1, 588 cm-1, and 856 cm-1 for Ni-O and Sr-O bonds. The nanoparticles displayed diameters ranging from 30.50 nm to 36.97 nm. EDX analysis confirmed the elemental composition, with Sr and O comprising of approximately 82.02 %, and Ni and Zn approximately 3.21%. Photocatalytic degradation experiments demonstrated that SrO nanoparticles 85.42% degradation efficiency, while co-doped SrO nanoparticles achieved an impressive 97.97% degradation efficiency. This work highlights the potential co-doped SrO nanoparticles as a promising solution for the efficient removal of organic pollutants from the industrial wastewater, addressing environment contamination concerns.La exposición humana excesiva a los contaminantes orgánicos de los efluentes industriales requiere la implementación de técnicas efectivas de eliminación de contaminantes. Este artículo investiga la degradación fotocatalítica del colorante azul de bromofenol utilizando nanopartículas de óxido de estroncio co-dopadas con níquel y zinc. La síntesis hidrotermal produjo las nanopartículas, que luego se caracterizaron utilizando diversas técnicas analíticas. UV/Visible reveló picos de absorción a 294 nm, 306 nm, 311 nm y 318 nm, mientras que la espectroscopia FTIR identificó picos de elongación a 416 cm-1, 588 cm-1 y 856 cm-1 para Ni-O y Sr- Los títulos. Las nanopartículas tenían diámetros que oscilaban entre 30,50 nm y 36,97 nm. El análisis EDX confirmó la composición elemental, con Sr y O comprendiendo aproximadamente el 82,02 %, y Ni y Zn aproximadamente el 3,21 %. Los experimentos de degradación fotocatalítica mostraron que las nanopartículas de SrO mostraron una eficiencia de degradación del 85,42 %, mientras que las nanopartículas de SrO co-dopadas lograron una impresionante eficiencia de degradación del 97,97 %. Este trabajo destaca las posibles nanopartículas de SrO co-dopadas como una solución prometedora para la eliminación eficiente de contaminantes orgánicos de las aguas residuales industriales, abordando los problemas de contaminación ambiental.A exposição excessiva de humanos a contaminantes orgânicos de efluentes industriais exige a implementação de técnicas eficazes de remoção de poluentes. Este artigo investiga a degradação fotocatalítica do corante azul de bromofenol usando nanopartículas de óxido de Estrôncio co-dopadas com Níquel e Zinco. A síntese hidrotérmica produziu as nanopartículas, que foram posteriormente caracterizadas usando várias técnicas analíticas. UV/Visível revelou picos de absorção em 294 nm, 306 nm, 311 nm e 318 nm, enquanto a espectroscopia FTIR identificou picos de alongamento em 416 cm-1, 588 cm-1 e 856 cm-1 para Ni-O e Sr-O títulos. As nanopartículas apresentaram diâmetros variando de 30,50 nm a 36,97 nm. A análise EDX confirmou a composição elementar, com Sr e O compreendendo aproximadamente 82,02%, e Ni e Zn aproximadamente 3,21%. Experimentos de degradação fotocatalítica demonstraram que as nanopartículas de SrO apresentam 85,42% de eficiência de degradação, enquanto as nanopartículas de SrO co-dopadas alcançaram uma impressionante eficiência de degradação de 97,97%. Este trabalho destaca os potenciais nanopartículas de SrO co-dopadas como uma solução promissora para a remoção eficiente de poluentes orgânicos de águas residuais industriais, abordando as preocupações de contaminação do meio ambiente
Measuring the stress of autistic people with the help of a smartwatch, Internet of Things Technology
Get PDFThis paper presents the outcomes of a research study that aimed to evaluate the anxiety levels of 10 individuals with autism using Internet of Things (IoT) technology, specifically a wireless smart watch. The incorporation of technology into daily life underscores the significance of recognizing its advantages in enhancing the well-being of individuals. The research study was carried out subsequent to an extensive review of the available literature, which explored various approaches to detecting stress utilizing sensors embedded in smart devices through IoT technology. The research was conducted on 10 adults with autism who were instructed to wear the smart watch, which provided measurements of their anxiety levels both in a calm state of mind and when exposed to loud music. The measurements were obtained during periods when the autistic individuals were relaxed, as well as when they were exposed to high volumes of music. The findings are presented in statistical charts after meticulous data analysis and are noteworthy as they validate previous studies on measuring and identifying anxiety in individuals with autism, as well as the disparities found in comparison to neurotypical individuals
Phytochemistry and antifungal activity of floral ethanolic extract of Schultesia aptera Cham. (Gentianaceae f.)
No full textSchultesia aptera is a plant species belonging to the Gentianaceae family found in Cerrado areas of Brazil. S. aptera presents a low number of studies, mainly phytochemical. This study aimed to evaluate the qualitative phytochemical profile and antifungal activity of agricultural interest of the floral ethanolic extract of S. aptera. Flowers were collected in April 2024. The ethanolic extract was obtained by maceration and then freeze-drying. The antifungal assays were carried out at different concentrations (25, 50, 100, 200 and 300 µL mL-1) on the fungal strains of Sclerotinia sclerotiorum, Colletotrichum acutatum, Colletotrichum gloeosporioides and Rhizopus stolonifer. Phytochemical prospecting demonstrated the presence of 10 groups of pharmaceutical, biotechnological and agricultural interest that have antifungal activities. The floral extract of S. aptera demonstrated effectiveness between the highest concentrations 100-300 µL mL-1 with inhibition rates between 33-71 for C. acutatum and between 31-67% for C. gloeosporioides. S. sclerotiorum and R. stolonifer strains were resistant to all concentrations. The floral ethanolic extract of Schultesia aptera demonstrated to be an antifungal agent on the genus Colletotrichum and can be used to control and inhibit Colletotrichum acutatum and Colletotrichum gloeosporioides
Reflexões da teoria de Orem e a aplicabilidade de tecnologias educativas para o autocuidado da pessoa com estomia instestinal
No full textThe empowerment of the individual about his health condition is of paramount importance to obtain his autonomy, thus the importance of encouraging self-care. Dorothea Orem's concepts and postulates are of great relevance to the construction of knowledge in the field of theoretical and philosophical foundations of nursing, as a strong guide to its practice, with regard to self-care needs. Self-care and the promotion of dependent care require availability, acquisition, preparation, and use of resources that determine the need for and provision of care. The present study aims to show the contributions of Orem's theory and the applicability of educational technologies for the self-care of a person with an intestinal ostomy. This is a descriptive, qualitative study of the reflective analysis type, a narrative review. Where narrative review studies are publications with the purpose of describing and discussing the state of the art of a given subject. We selected and analyzed articles published in the last five years, in Portuguese and that approached the theme, with the intention of acquiring greater depth and approximation with the object of study to subsidize the reflections. Three categories were elaborated, being, respectively: Self-care to the person with intestinal ostomy; Main difficulties listed by the patient with intestinal ostomy, to perform self-care; Technologies of education in health for the self-care of the person with intestinal ostomy. Thus, the present study aims to approach, in a brief way, reflections on Orem's Theory and its applicability in educational technologies for the self-care of a person with an intestinal ostomy.O empoderamento do indivíduo sobre sua condição de saúde é de suma importância para obtenção de sua autonomia, por isso a importância de incentivar o autocuidado. Os conceitos e postulados de Dorothea Orem são de grande relevância para a construção do conhecimento no campo das bases teóricas e filosóficas da enfermagem, como forte norteador da prática da mesma, no que se refere às necessidades de autocuidado. O autocuidado e a promoção de cuidado dependentes requerem disponibilidade, aquisição, preparação e utilização de recursos determinantes para a necessidade e prestação de cuidado. O presente estudo tem como objetivo mostrar as contribuições da teoria de Orem e das aplicabilidades de tecnologias educativas para o autocuidado da pessoa com estomia intestinal. Trata-se de um estudo descritivo, qualitativo do tipo análise reflexiva, uma revisão narrativa. Onde, os estudos de revisão narrativa são publicações com a finalidade de descrever e discutir o estado da arte de um determinado assunto. Foram selecionados e analisados artigos publicados nos últimos cincos anos, nos idiomas Português, Inglês e Espanhol que abordassem o tema e no intuito de adquirir maior aprofundamento e aproximação com o objeto de estudo para subsidiar as reflexões. Foram elaboradas 3 categoridas, sendo, respectivamente: Autocuidado a pessoa com estomia intestinal; Principais dificuldades elencadas pelo paciente com estomia intestinal, para realização do autocuidado; Tecnologias de educação em saúde para o autocuidado da pessoa com estomia intestinal. Sendo assim, o presente estudo visa abordará, de forma suscinta, refloxões da Teoria de Orem e a sua aplicabilidade em tecnologias educativas para o autocuidado da pessoa com estomia intestinal