Journal of Experimental Biology and Agricultural Sciences
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DEVELOPMENT OF METRONIDAZOLE MICROSPONGE INCORPORATED INTO CARBOMER-BASED VAGINAL GEL
Get PDFBacterial vaginosis (BV) is a vaginal infection caused by excessive bacterial growth, thus disrupting the natural balance of bacteria inside the vagina. Metronidazole becomes a drug of choice and a widely prescribed drug for the treatment of BV. However, when applied topically, metronidazole has a low vaginal residence time because of the natural washing mechanism of the vagina. This study aimed to improve the retention time of metronidazole inside the vagina and control its release profile. This study was prepared 4 formulas of gel for metronidazole microsponges with some concentration ratio of carbomer and triethanolamine. The evaluations carried out to test the efficacy of the developed formulation included organoleptic, pH measurement, spreadability, viscosity, mucoadhesive properties, permeation test using Franz diffusion cell and retention test. The results showed that the gel appearance was white, odourless and homogenous. The characteristics of all prepared gel for pH, viscosity, spreadability, and mucoadhesive ability were appropriate to the required standard for vaginal delivery. The permeation and retention test showed that F3 with the carbomer and triethanolamine concentration of 1.25%: 1.75% was able to retain and controlled the drug release locally in the vaginal mucosa. This study provides an alternative strategy in drug formulation for the treatment of BV
ECONOMIES OF MANGO CULTIVATION IN A WHOLE-FARM APPROACH FOR SMALLHOLDER FARMERS: A CASE STUDY FROM INDIA
Get PDFThis case study is about farming systems followed by small mango growers of a Srinivaspur sub-district of Kolar district in Karnataka, India. Over the years, the size of landholdings decreased and suitability has become an issue. The integrated farming system is mostly desired but, the kind of cropping pattern which would bring profitability and sustainability for smallholding farmers under dryland conditions has not been extensively explored. This research analyzes and explains the economies of scale and scope for the smallholder mango growers both in irrigated and rain-fed conditions. The data covers the period from April 2016 to March 2017. Total, 320 smallholder mango growers from Srinivaspur; a sub-district of Kolar in India were randomly interviewed in person, using a structured pre-tested interview schedule. Suitable analytical techniques were used with the data obtained. Further, the results of the study suggested the optimum farming pattern to enhance the income and bring more sustainability to the farmers both in rain-fed and irrigated conditions
HETEROSIS IN CHICKPEA FOR GRAIN PRODUCTIVITY IN EMBU COUNTY, KENYA
Get PDFChickpea is a major source of proteins especially in arid and semi-arid areas of Kenya. However, its average yield per hectare is low when compared to neighbouring countries. This research was carried out to determine the levels of hybrid vigour on yield in the F1 generation. To obtain the F1s, reciprocal crossing between Mwanza 2 and Chaina I was carried out with controls being the parental lines. The experimental layout was a randomized block design replicated thrice for three seasons. A spacing of 50x20cm was used in plants, while all other agronomic practices were maintained constant. Data on grain yield and biomass per plant was obtained by measuring the weight, then subjecting it to a one-way ANOVA in SAS 9.4 software. Mwanza 2 expressed the highest biomass (2.56g), while both parents attained a maximum grain yield of 1.69g per plant. Chaina I x Mwanza 2 hybrid expressed maximum means of F1s for biomass (2.31g) and grain yield (1.4g) per plant. Chaina I x Mwanza 2 hybrid recorded the highest biomass and grain yield in better parent heterosis with 14.36% and 330% respectively. Mid-parent heterosis means were also highest at 24.53% and 405.88% for biomass and grain yield respectively. Further, the heritability was maximum for biomass under Mwanza 2 x Chaina I, varying from 93.1% to 100%, while Chaina I x Mwanza 2, expressed maximum grain yield and harvest index. Better parent heterosis and mid-parent heterosis was highest in Chaina I x Mwanza 2 than its reciprocal, Mwanza 2 x Chaina I