Multidisciplinary Digital Publishing Institute (Switzerland)
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Massive Stranding of Macroramphosus gracilis (Lowe, 1839) in the Strait of Messina (Central Mediterranean Sea): Somatic Features of Different Post-Larval Development Stages
No full textThe Strait of Messina (Central Mediterranean Sea) has always been known for the stranding of marine organisms, especially during the spring. We came across an extraordinary event of mass stranding in April 2025, with 453 specimens of Macroramphosus sp. found through a single night. A total of 571 post-larvae and juvenile individuals stranded between February and May 2025 were examined for this study. Clear morphological differences related to the size, especially in post-larvae, were highlighted. The relationship between Body Length (BL) and other morphometric measurements, such as Dorsal Spine Length (DSL), Snout Length (SNL), and Body Height (BH), were studied, with the aim of identifying without any doubt the species Macroramphosus gracilis. A slightly negative allometric relationship between length and weight shows that it grows faster in length and slower in weight. This study aims to improve the state of knowledge on slender snipefish M. gracilis, and particularly on the somatic features of different post-larval development stages, such as the presence of spinules in various parts of the body. All these morphological changes could give us a hint at the ecological adaptation to the habit shift, as relates to development
Dermoscopy-Guided High-Frequency Ultrasound Imaging of Subcentimeter Cutaneous and Subcutaneous Neurofibromas in Patients with Neurofibromatosis Type 1
No full textBackground: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by cutaneous and subcutaneous neurofibromas, which impact quality of life. Dermoscopy-guided high-frequency ultrasound (DG-HFUS) integrates dermoscopy with 33 MHz ultrasound, enabling precise lesion localization and reproducible measurements. Objective: To characterize neurofibromas in NF1 patients using DG-HFUS and identify imaging parameters for diagnosis, monitoring, and treatment planning. Methods: 14 genetically confirmed NF1 patients underwent DG-HFUS imaging (Dermus SkinScanner). 100 neurofibromas were assessed for size, location, shape, contours, surface, echogenicity, global echogenicity, and posterior acoustic features. Results: Lesions were dermal (79%) or subcutaneous (21%), round (28%), ovoid (63%), or spiked (9%). Mean vertical and lateral diameters were 5.37 ± 2.66 mm and 2.28 ± 1.39 mm. All were hypoechoic; 62% homogeneous, 38% heterogeneous. Margins were well-defined in 57% and poorly defined in 43%. Posterior enhancement occurred in 3% and shadowing in 10%. Conclusions: DG-HFUS provides a detailed, reproducible assessment of neurofibromas, supporting differential diagnosis, surgical planning, and longitudinal monitoring. The evaluated imaging parameters offer objective insights for optimizing NF1 management. Future developments, including 3D reconstruction and AI-assisted analysis, may further enhance its clinical utility
Scalp Microbiome Composition in Young Women: Associations with Scalp Type, Sensitivity, and Lifestyle Factors
No full textBackground: The scalp represents a distinct ecological niche within the skin, and the structure of its microbiota, together with the factors shaping it, is considered important for the maintenance of scalp health. Methods: This study systematically analyzed the bacterial and fungal community structures on the scalps of 63 healthy Chinese women aged 18–25, and examined their associations with scalp type, sensitivity, and lifestyle factors. Scalp samples were collected, questionnaire surveys were administered, scalp physiological parameters were measured, and high-throughput sequencing of 16S rRNA and ITS genes was performed. Results: The results showed that, in this unique scalp skin niche, the dominant bacterial phylum was Actinobacteria, while the dominant fungal phylum was Ascomycota. The predominant bacterial genera were Cutibacterium and Staphylococcus, and the fungal community was dominated by Malassezia. When scalp types were categorized according to sebum content, dry scalps showed enrichment of Micrococcus, Streptococcus, Delftia, Staphylococcus aureus, and Staphylococcus hominis, whereas oily scalps, on the other hand, are primarily colonized by Cutibacterium and Staphylococcus species. In addition, we observed microbial interactions under different physiological conditions. The relative abundance of Cutibacterium decreased with increasing scalp sensitivity. Higher psychological stress, insufficient sleep, and high-sugar/high-fat dietary patterns tended to coincide with shifts in the relative abundance of Malassezia, implying that these influences may act through fungal rather than bacterial components of the scalp microbiota. Scalp sensitivity showed the strongest association with β-diversity among the variables examined, although the effect size was modest and did not reach conventional significance in the multivariable PERMANOVA. Conclusions: In young women, the scalp constitutes a distinct cutaneous niche whose microbiota is jointly shaped by sebum level, barrier sensitivity, and lifestyle factors, with sensitivity emerging as one of the more influential dimensions of community variation. These findings provide guidance for future in-depth research on the scalp microbiome network and offer a foundational reference for preventing suboptimal and pathological scalp conditions
Advances in the Ester Accumulation and Regulation in Grape Berries and Wine
No full textEsters are pivotal volatile compounds that shape the floral and fruity attributes of grape berries and wine. In the case of sustainable viticultural system, understanding the formation and regulation of esters is essential for optimizing aroma quality under variable environmental conditions and reducing reliance on intensive cultivation inputs. In this review, the following aspects are comprehensively analyzed: (1) the biosynthetic pathways of esters in grape berries and wine; (2) the main environmental factors affecting ester accumulation in grape berries include light, moisture, temperature, and soil fertility; (3) the impacts of yeast strain selection, inoculation protocols, and post-fermentation processes, such as barrel aging and bottle storage, on ester composition. By integrating biochemical insights with viticultural and enological strategies, this review aims to provide references for developing sustainable approaches to regulate the esters biosynthesis and enhance the aroma quality of grapes and wine
Trophic Drivers of Organochlorine and PFAS Accumulation in Mediterranean Smooth-Hound Sharks: Insights from Stable Isotopes and Human Health Risk
No full textCommercial smooth-hound sharks of the genus Mustelus are commonly landed and consumed in Mediterranean fisheries, raising concerns about potential human exposure to persistent contaminants. This study investigated the occurrence of organochlorine compounds (OCs), including hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (DDT) and its metabolites, and polychlorinated biphenyls (PCBs), together with per- and polyfluoroalkyl substances (PFAS), in muscle and liver tissues of Mustelus mustelus and Mustelus punctulatus collected in the waters of the Egadi Archipelago (central Mediterranean Sea). OCs were detected in all analyzed samples, with total PCB concentrations reaching higher values in liver compared to muscle tissues, reflecting tissue-specific accumulation and detoxification processes. PFAS were detected in all analyzed muscle samples (1.10–58.5 ng/g w.w.), with PFOS, PFOA and PFNA generally below current European regulatory thresholds, although isolated exceedances were observed. Stable isotope analysis (δ13C and δ15N) highlighted differences in trophic ecology between the two species and suggested that feeding habitat and trophic position may influence contaminant exposure patterns, particularly in M. punctulatus. The human health risk assessment, conducted as a screening-level evaluation, indicated potential concern associated with PCB concentrations in liver tissue, while risks associated with muscle consumption were generally lower. Overall, the integration of contaminant analysis and stable isotopes provides insights into organismal exposure pathways and supports the use of smooth-hound sharks as sentinels of contaminant presence in Mediterranean coastal ecosystems
The Role of Temporality in Virtual Reality Interventions for Depressive Episodes—A Scoping Review
No full textBackground/Objectives: People living with depression often experience consistent disruptions in their experience of time, which further contributes to their suffering. We present a scoping review on virtual reality (VR)-based interventions for depression, addressing temporal processing and subjective experiences of time. The paper aims to explore the extent to which therapeutic interventions using VR target the temporal dimension of patients’ experiences. Methods: We conducted a scoping review using the PRISMA 2020 standard. The literature search was further extended using Research Rabbit and by examining the reference lists of relevant articles. Seventeen papers were selected for final analysis. Results: Our scoping review indicates that temporality in VR-based therapeutic interventions for depression remains underrepresented. Of the seventeen papers reviewed, only two explicitly deal with this issue, while the rest touch upon it briefly or implicitly. The studies suggest that VR’s main advantage in modifying the experience of time in depression is its potential to generate immersion and to scaffold imagination through visualization. The main limitations are methodological: most of the available research is exploratory, reports short-term effects, and utilizes a broad variety of empirical designs and therapeutic approaches
Integrating Additive Manufacturing into Dental Production: Innovations, Applications and Challenges
No full textAdditive manufacturing (AM) has emerged as a key enabling technology in contemporary dental manufacturing, driven by its capacity for customization, geometric complexity, and seamless integration with digital design workflows. This article presents a technology-oriented narrative review of additive manufacturing in dental implant production, focusing on dominant processing routes, material systems, and emerging research trends rather than a systematic or critical appraisal of the literature. An indicative descriptive analysis of publications indexed in the Web of Science and Scopus databases between 2014 and 2024 was used to contextualize the technological development of the field and identify major research directions. Emphasis was placed on metal powder bed fusion technologies, specifically Selective Laser Melting (SLM) and Direct Metal Laser Sintering (DMLS), which enable the fabrication of titanium implants with controlled porosity and enhanced osseointegration. Ceramic AM approaches, including SLA, DLP, and PBF, are discussed in relation to their potential for aesthetic dental restorations and customized prosthetic components. The publication trend overview indicates a growing interest in ceramic AM after 2020, an increasing focus on hybrid and functionally graded materials, and persistent challenges related to standardization and the availability of long-term clinical evidence. Key technological limitations—including manufacturing accuracy, material stability, validated metrology, and process reproducibility—are highlighted alongside emerging directions such as artificial intelligence-assisted workflows, nanostructured surface modifications, and concepts enabling accelerated or immediate clinical use of additively manufactured dental restorations
External Root Resorption Associated with Orthodontic Treatment—Descriptive Correlations of Biological and Dental Risk Factors
No full textBackground/Objectives: External root resorption is an undesirable complication of orthodontic treatment, characterized by the loss of dental root structure. The aim of this study was to identify the biological and dental risk factors involved in the development of external root resorption at the end of orthodontic treatment. Methods: A retrospective observational study was conducted on a sample of 120 patients who underwent orthodontic treatment. External root resorption was assessed using pre- and post-treatment panoramic radiographs. Correlations were established between the severity of external root resorption and various biological and dental risk factors. Results: Out of a total of 2639 teeth analyzed, 52.14% exhibited external root resorption, with most cases being mild to moderate (<3 mm). The maxillary central incisors were the most affected teeth. Age showed a statistically significant correlation with the severity of external root resorption in the lower anterior region (p < 0.01). No significant differences were observed in relation to gender, facial growth pattern, or type of dento-maxillary anomaly. Conclusions: External root resorption is a common consequence of orthodontic treatment, most often presenting with low severity. The type of tooth and the patient’s age influence the severity of root resorption, while factors such as gender, facial growth pattern, and type of dento-maxillary anomaly did not prove to be significant in this context
Lean DLY Pig-Derived Fecal Microbiota Promotes Growth Performance by Modulating Gut Microbiota: Serum Metabolic Profiles in Obese Ningxiang Pigs
No full textFecal microbiota transplantation (FMT) has demonstrated potential in reshaping gut microbiota to improve animal phenotypes, yet its application in lean-type to obese-type pigs like Ningxiang (NX) pigs remains unclear. To address this, we investigated the effects of Lean Duroc × Landrace × Yorkshire (DLY) pig-derived fecal microbiota on the growth, gut microbiota composition, and serum metabolism of obese NX pigs. Thirty-six 50-day-old castrated male NX pigs of similar initial body weight were randomly assigned to either a control group or FMT group. The trial lasted for 35 days. Results indicated that FMT significantly improved the average daily gain and increased nutrient digestibility. Serum biochemical analysis revealed elevated levels of globulin and total protein and reduced low-density lipoprotein cholesterol in the FMT group. In addition, 16S rRNA sequencing demonstrated that FMT modified gut microbiota composition and diversity, enriching beneficial genera such as Blautia, Agathobacter, Faecalibacterium, and Eubacterium_coprostanoligenes_group. Untargeted serum metabolomics further revealed altered metabolite profiles linked to lipid and amino acid metabolism. Correlation analysis further revealed a link between these enriched bacteria and metabolites changes. Overall, these findings demonstrate that transplantation of the fecal microbiota from lean DLY pigs significantly improved the growth performance of obese NX pigs by improving nutrient digestibility and modulating the gut microbiota–host metabolic axis
Gut and Joint Microbiome and Dysbiosis: A New Perspective on the Pathogenesis and Treatment of Osteoarthritis
No full textOsteoarthritis (OA) is one of the most common and burdensome musculoskeletal disorders and a major cause of pain, disability, and reduced quality of life worldwide. In recent years, increasing attention has been paid to extra-articular factors influencing its development and progression, opening new avenues of research into pathophysiological mechanisms and potential therapies. One of the most promising areas concerns the role of the gut–joint axis and related alterations in the gut microbiome. Numerous studies indicate that an imbalance of gut bacteria, increased intestinal permeability, and low-grade inflammation may contribute to the progression of degenerative joint processes. The mechanisms through which the microbiota influences the immune system and host metabolism are becoming increasingly well understood, including pathways involving short-chain fatty acids, tryptophan metabolites, and bile acids. Despite growing evidence linking dysbiosis to the pathogenesis of OA, effective therapeutic strategies based on microbiome modulation remain under active investigation. Among the most frequently studied approaches are probiotics, dietary interventions, and more advanced strategies such as gut microbiota transplantation and targeted modulation of microbial metabolites. However, before these methods can become part of routine treatment, extensive clinical trials and a clearer understanding of causal relationships between the microbiome and joint degeneration are required. This article summarises the current state of knowledge regarding the role of the gut microbiome in osteoarthritis, outlines key research findings, and highlights current and potential therapeutic directions